Targeted disruption of iNOS prevents LPS-induced S-nitrosation of IRβ/IRS-1 and Akt and insulin resistance in muscle of mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 291, Issue 3, 2006, Pages

  Carvalho Filho, Marco A ^a   Ueno, Mirian ^a   Carvalheira, José B C ^a   Velloso, Lício A ^a   Saad, Mario J A ^a  

^a UNIVERSITY OF CAMPINAS   (Brazil)

Author keywords

Inducible nitric oxide synthase; Insulin receptor subunit; Insulin receptor substrate 1; Lipopolysaccharide

Indexed keywords

INDUCIBLE NITRIC OXIDE SYNTHASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; LIPOPOLYSACCHARIDE; PROTEIN KINASE B; PROTEIN SERINE KINASE; PROTEIN TYROSINE KINASE; SERINE; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; AUTOPHOSPHORYLATION; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONAL REGULATION; INSULIN RESISTANCE; INSULIN SENSITIVITY; MOUSE; MUSCLE METABOLISM; NITROSATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION;

ADIPOSE TISSUE; ANIMALS; BLOOD GLUCOSE; INSULIN; INSULIN RESISTANCE; LIPOPOLYSACCHARIDES; LIVER; MICE; MICE, INBRED BALB C; MICE, KNOCKOUT; MUSCLE, SKELETAL; NITRIC OXIDE SYNTHASE TYPE II; NITROSATION; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTOR, INSULIN;

EID: 33748470543     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00422.2005     Document Type: Article

References (26)

1. Barreiro GC, Prattali RR, Caliseo CT, Fugiwara FY, Ueno M, Prada PO, Velloso LA, Saad MJ, and Carvalheira JB. Aspirin inhibits serine phosphorylation of IRS-1 in muscle and adipose tissue of septic rats. Biochem Biophys Res Commun 320: 992-997, 2004.
2. Bonora E, Moghetti P, Zancanaro C, Cigolini M, Querena M, Cacciatori V, Corgnati A, and Muggeo M. Estimates of in vivo insulin action in man: comparison of insulin tolerance tests with euglycemic and hyperglycemic glucose clamp studies. In: J Clin Endocrinol Metab 68: 374-378, 1989.
3. Carvalho-Filho MA, Ueno M, Hirabara SM, Seabra AB, Carvalheira JB, de Oliveira MG, Velloso LA, Curi R, and Saad MJ. S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt: a novel mechanism of insulin resistance. Diabetes 54: 959-967, 2005.
4. Elchebly M , Payette P, Michaliszyn E, Cromlish W, Collins S, Loy AL, Normandin D, Cheng A, Himms-Hagen J, Chan CC, Ramachandran C, Gresser MJ, Tremblay ML, and Kennedy BP. Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene. Science 283: 1544-1548, 1999.
5. Fong YM, Marano MA, Moldawer LL, Wei H, Calvano SE, Kenney JS, Allison AC, Cerami A, Shires GT, and Lowry SF. The acute splanchnic and peripheral tissue metabolic response to endotoxin in humans. J Clin Invest 85: 1896-1904, 1990.
6. Hirosumi J, Tuncman G, Chang L, Gorgun CZ, Uysal KT, Maeda K, Karin M, and Hotamisligil GS. A central role for JNK in obesity and insulin resistance. Nature 420: 333-336, 2002.
7. Jaffrey SR and Snyder SH. The biotin switch method for the detection of S-nitrosylated proteins. Sci STKE 2001: PL1, 2001.
8. Kapur S, Bedard S, Marcotte B, Cote CH, and Marette A. Expression of nitric oxide synthase in skeletal muscle: a novel role for nitric oxide as a modulator of insulin action. Diabetes 46: 1691-1700, 1997.
9. Kim S, Wing SS, and Ponka P. S-nitrosylation or IRP2 regulates its stability via the ubiquitin-proteasome pathway. Mol Cell Biol 24: 330-337, 2004.
10. Ling PR, Bistrian BR, Mendez B, and Istfan NW. Effects of systemic infusions of endotoxin, tumor necrosis factor, and interleukin-1 on glucose metabolism in the rat: relationship to endogenous glucose production and peripheral tissue glucose uptake. Metabolism 43: 279-284, 1994.
11. Martinez-Ruiz A and Lamas S. Detection and proteomic identification of S-nitrosylated proteins in endothelial cells. Arch Biochem Biophys 423: 192-199, 2004.
12. Michie HR, Manogue KR, Spriggs DR, Revhaug A, O'Dwyer S, Dinarello CA, Cerami A, Wolff SM, and Wilmore DW. Detection of circulating tumor necrosis factor after endotoxin administration. N Engl J Med 318: 1481-1486, 1988.
13. Peraldi P, Hotamisligil GS, Buurman WA, White MF, and Spiegelman BM. Tumor necrosis factor (TNF)-α inhibits insulin signaling through stimulation of the p55 TNF receptor and activation of sphingomyelinase. J Biol Chem 271: 13018-13022, 1996.
14. Perreault M and Marette A. Targeted disruption of inducible nitric oxide synthase protects against obesity-linked insulin resistance in muscle. Nat Med 7: 1138-1143, 2001.
15. Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, and Kahn CR. Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90: 1839-1849, 1992.
16. Saad MJ, Carvalho CR, Thirone AC, and Velloso LA. Insulin induces tyrosine phosphorylation of JAK2 in insulin-sensitive tissues of the intact rat. In: J Biol Chem 271: 22100-22104, 1996.
17. Sugita H, Fujimoto M, Yasukawa T, Shimizu N, Sugita M, Yasuhara S, Martyn JA, and Kaneki M. Inducible nitric-oxide synthase and NO donor induce insulin receptor substrate-1 degradation in skeletal muscle cells. J Biol Chem 280: 14203-14211, 2005.
18. Symeonides S and Balk RA. Nitric oxide in the pathogenesis of sepsis. Infect Dis Clin North Am 13: 449-463, 1999.
19. Tremblay F, Lavigne C, Jacques H, and Marette A. Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (ζ/λ) activities. Diabetes 50: 1901-1910, 2001.
20. Virkamaki A, Puhakainen I, Koivisto VA, Vuorinen-Markkola H, and Yki-Jarvinen H. Mechanisms of hepatic and peripheral insulin resistance during acute infections in humans. J Clin Endocrinol Metab 74: 673-679, 1992.
21. Virkamaki A and Yki-Jarvinen H. Role of prostaglandins in mediating alterations in glucose metabolism during acute endotoxemia in the rat. Endocrinology 136: 1701-1706, 1995.
22. Weimann J, Bloch KD, Takata M, Steudel W, and Zapol WM. Congenital NOS2 deficiency protects mice from LPS-induced hyporesponsiveness to inhaled nitric oxide. Anesthesiology 91: 1744-1753, 1999.
23. Westfall MV and Sayeed MM. Basal and insulin-stimulated skeletal muscle sugar transport in endotoxic and bacteremic rats. Am J Physiol Regul Integr Comp Physiol 254: R673-R679, 1988.
24. White RH, Frayn KN, Little RA, Threlfall CJ, Stoner HB, and Irving MH. Hormonal and metabolic responses to glucose infusion in sepsis studied by the hyperglycemic glucose clamp technique. JPEN J Parenter Enteral Nutr 11: 345-353, 1987.
25. Wong JM and Billiar TR. Regulation and function of inducible nitric oxide synthase during sepsis and acute inflammation. Adv Pharmacol 34: 155-170, 1995.
26. Yasukawa T, Tokunaga E, Ota H, Sugita H, Martyn JA, and Kaneki M. S-nitrosylation-dependent inactivation of Akt/protein kinase B in insulin resistance. J Biol Chem 280: 7511-7518, 2005.