Insulin resistance, defective insulin receptor substrate 2-associated phosphatidylinositol-3′ kinase activation, and impaired atypical protein kinase C (ζ/λ) activation in myotubes from obese patients with impaired glucose tolerance

Diabetes

Volumn 51, Issue 4, 2002, Pages 1052-1059

  Vollenweider, Peter ^a   Ménard, Barbara ^a   Nicod, Pascal ^a  

^a LAUSANNE UNIVERSITY HOSPITAL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 4; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN KINASE C; PROTEIN P85; PROTEIN SUBUNIT;

ADULT; ARTICLE; CELL CULTURE; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; HUMAN TISSUE; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; MUSCLE CELL; MYOTUBE; OBESITY; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SKELETAL MUSCLE;

EID: 0036227755     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.51.4.1052     Document Type: Article

References (51)

1. Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: A balanced overview
2. Cellular mechanisms of insulin resistance
3. Insulin induces translocation of GLUT-4 glucose transporters in human skeletal muscle
4. The insulin signalling system and the IRS proteins
5. Expression of a constitutively active Akt Ser/Thr kinase in 3T3-L1 adipocytes stimulates glucose uptake and glucose transporter 4 translocation
6. Requirement of atypical protein kinase clambda for insulin stimulation of glucose uptake but not for Akt activation in 3T3-L1 adipocytes
7. Physiological role of Akt in insulin-stimulated translocation of GLUT 4 in transfected rat adipose cells
8. Requirement for activation of the serine-threonine kinase Akt (protein kinase B) in insulin stimulation of protein synthesis but not of glucose transport
9. Protein kinase C-zeta as a downstream effector of phosphatidylinositol 3-kinase during insulin stimulation in rat adipocytes: Potential role in glucose transport
10. Effects of adenoviral gene transfer of wild-type, constitutively active, and kinase-defective protein kinase C-lambda on insulin-stimulated glucose transport in L6 myotubes
11. Insulin resistance and growth retardation in mice lacking insulin receptor substrate-1
12. Alternative pathway of insulin signalling in mice with targeted disruption of the IRS-1 gene
13. Disruption of IRS-2 causes type 2 diabetes in mice
14. Insulin receptor substrate 3 is not essential for growth or glucose homeostasis
15. Cloning, tissue expression, and chromosomal location of the mouse insulin receptor substrate 4 gene
16. Role of human skeletal muscle insulin receptor kinase in the in vivo insulin resistance of noninsulin-dependent diabetes mellitus and obesity
17. Impaired autophosphorylation of insulin receptors from abdominal skeletal muscles in nonobese subjects with NIDDM
18. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
19. Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
20. Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activity
21. The Whitehall Study: Ten year follow-up report on men with impaired glucose tolerance with reference to worsening to diabetes and predictors of death
22. The ten-year follow-up of the Bedford survey (1962-1972): Glucose tolerance and diabetes
23. Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects: Comparison using human skeletal muscle cell cultures
24. Isolation and characterization of human muscle cells
25. Glucose transport in human skeletal muscle cells in culture: Stimulation by insulin and metformin
26. Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects: Biochemical and molecular mechanisms
27. Acquired defects of glycogen synthase activity in cultured human skeletal muscle cells: Influence of high glucose and insulin levels
28. Human primary myoblast cell cultures from non-diabetic insulin resistant subjects retain defects in insulin action
29. Okadaic acid activates atypical protein kinase C (zeta/lambda) in rat and 3T3/L1 adipocytes: An apparent requirement for activation of Glut 4 translocation and glucose transport
30. Insulin activates protein kinases C-zeta and C-lambda by an autophosphorylation-dependent mechanism and stimulates their translocation to GLUT 4 vesicles and other membrane fractions in rat adipocytes
31. Evidence for defects in the trafficking and translocation of GLUT 4 glucose transporters in skeletal muscle as a cause of human insulin resistance
32. Insulin signaling and action in cultured skeletal muscle cells from lean healthy humans with high and low insulin sensitivity
33. Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats
34. Insulin receptor substrate (IRS) 1 is reduced and IRS-2 is the main docking protein for phosphatidylinositol 3-kinase in adipocytes from subjects with non-insulin-dependent diabetes mellitus
35. Insulin-stimulated GLUT 4 translocation is mediated by a divergent intracellular signaling pathway
36. Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes
37. Essential role of insulin receptor substrate- 2 in insulin stimulation of Glut4 translocation and glucose uptake in brown adipocytes
38. Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes
39. Insulin receptor substrate-2 (IRS-2) can mediate the action of insulin to stimulate translocation of GLUT 4 to the cell surface in rat adipose cells
40. Contrasting effects of IRS-1 versus IRS-2 gene disruption on carbohydrate and lipid metabolism in vivo
41. Insulin receptor substrate-2 is not necessary for insulinand exercise-stimulated glucose transport in skeletal muscle
42. A molecular basis for insulin resistance: Elevated serine/threonine phosphorylation of IRS-1 and IRS-2 inhibits their binding to the juxtamembrane region of the insulin receptor and impairs their ability to undergo insulin-induced tyrosine phosphorylation
43. Protein tyrosine phosphatase-1B negatively regulates insulin signaling in L6 myocytes and Fao heptaoma cells
44. Alterations in skeletal muscle protein-tyrosine phosphatase activity and expression in insulin-resistant human obesity and diabetes
45. Abnormal regulation of protein tyrosine phosphatase activities in skeletal muscle of insulin-resistant humans
46. Activation of protein kinase C (alpha, beta, and zeta) by insulin in 3T3/L1 cells: Transfection studies suggest a role for PKC-zeta in glucose transport
47. In vivo adenoviral delivery of recombinant human protein kinase C-zeta stimulates glucose transport activity in rat skeletal muscle
48. Insulin receptor substrate-2 phosphorylation is necessary for protein kinase C zeta activation by insulin in L6hIR cells
49. Dynamics of insulin signaling in 3T3-L1 adipocytes: Differential compartmentalization and trafficking of insulin receptor substrate (IRS)-1 and IRS-2
50. The IR 1152 mutant insulin receptor selectively impairs insulin action in skeletal muscle but not in liver
51. Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation