메뉴 건너뛰기




Volumn 494, Issue 7437, 2013, Pages 375-379

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; INSULIN RECEPTOR SUBSTRATE 1; MITSUGUMIN 53; MUSCLE PROTEIN; UBIQUITIN PROTEIN LIGASE E3; UNCLASSIFIED DRUG;

EID: 84874189145     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature11834     Document Type: Article
Times cited : (238)

References (31)
  • 1
    • 17144380822 scopus 로고    scopus 로고
    • The metabolic syndrome
    • Eckel, R. H., Grundy, S. M. & Zimmet, P. Z. The metabolic syndrome. Lancet 365, 1415-1428 (2005).
    • (2005) Lancet , vol.365 , pp. 1415-1428
    • Eckel, R.H.1    Grundy, S.M.2    Zimmet, P.Z.3
  • 2
    • 0019762341 scopus 로고
    • The effect of insulin on the disposal of intravenous glucose. Results fromindirect calorimetry and hepatic and femoral venous catheterization
    • DeFronzo, R. A. et al. The effect of insulin on the disposal of intravenous glucose. Results fromindirect calorimetry and hepatic and femoral venous catheterization. Diabetes 30, 1000-1007 (1981).
    • (1981) Diabetes , vol.30 , pp. 1000-1007
    • DeFronzo, R.A.1
  • 3
    • 0025098765 scopus 로고
    • Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy
    • Shulman, G. I. et al. Quantitation of muscle glycogen synthesis in normal subjects and subjects with non-insulin-dependent diabetes by 13C nuclear magnetic resonance spectroscopy. N. Engl. J. Med. 322, 223-228 (1990).
    • (1990) N. Engl. J. Med. , vol.322 , pp. 223-228
    • Shulman, G.I.1
  • 4
    • 15544369982 scopus 로고    scopus 로고
    • Developmental origins of the metabolic syndrome: Prediction, plasticity, and programming
    • McMillen, I. C.& Robinson, J. S. Developmental origins of the metabolic syndrome: prediction, plasticity, and programming. Physiol. Rev. 85, 571-633 (2005).
    • (2005) Physiol. Rev. , vol.85 , pp. 571-633
    • McMillen, I.C.1    Robinson, J.S.2
  • 5
    • 33644898538 scopus 로고    scopus 로고
    • Metabolic syndrome: Connecting and reconciling cardiovascular and diabetes worlds
    • Grundy, S. M. Metabolic syndrome: connecting and reconciling cardiovascular and diabetes worlds. J. Am. Coll. Cardiol. 47, 1093-1100 (2006).
    • (2006) J. Am. Coll. Cardiol. , vol.47 , pp. 1093-1100
    • Grundy, S.M.1
  • 6
    • 75549085755 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance is the primary defect in type 2 diabetes
    • DeFronzo, R. A. & Tripathy, D. Skeletal muscle insulin resistance is the primary defect in type 2 diabetes. Diabetes Care 32 (Suppl. 2), S157-S163 (2009).
    • (2009) Diabetes Care , vol.32 , Issue.SUPPL. 2
    • DeFronzo, R.A.1    Tripathy, D.2
  • 7
    • 0027762766 scopus 로고
    • Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus Prospective studies of Pima Indians
    • Lillioja, S. et al. Insulin resistance and insulin secretory dysfunction as precursors of non-insulin-dependent diabetes mellitus. Prospective studies of Pima Indians. N. Engl. J. Med. 329, 1988-1992 (1993).
    • (1993) N. Engl. J. Med. , vol.329 , pp. 1988-1992
    • Lillioja, S.1
  • 8
    • 0026793446 scopus 로고
    • Role of glucose and insulin resistance in development of type 2 diabetes mellitus: Results of a25-year follow-up study
    • Martin, B. C. et al. Role of glucose and insulin resistance in development of type 2 diabetes mellitus: results of a25-year follow-up study. Lancet340,925-929(1992).
    • (1992) Lancet , vol.340 , pp. 925-929
    • Martin, B.C.1
  • 9
    • 58149326805 scopus 로고    scopus 로고
    • MG53 nucleates assembly of cellmembrane repair machinery
    • Cai, C. et al.MG53 nucleates assembly of cellmembrane repair machinery. Nature Cell Biol. 11, 56-64 (2009).
    • (2009) Nature Cell Biol. , vol.11 , pp. 56-64
    • Cai, C.1
  • 10
    • 77953812567 scopus 로고    scopus 로고
    • MG53 constitutes a primary determinant of cardiac ischemic preconditioning
    • Cao, C. M. et al. MG53 constitutes a primary determinant of cardiac ischemic preconditioning. Circulation 121, 2565-2574 (2010).
    • (2010) Circulation , vol.121 , pp. 2565-2574
    • Cao, C.M.1
  • 11
    • 0041321275 scopus 로고    scopus 로고
    • Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-A
    • Fu, J. et al. Oleylethanolamide regulates feeding and body weight through activation of the nuclear receptor PPAR-a. Nature 425, 90-93 (2003).
    • (2003) Nature , vol.425 , pp. 90-93
    • Fu, J.1
  • 12
    • 0027305652 scopus 로고
    • Insulin resistance in spontaneously hypertensive rats. Difference in interpretation based on insulin infusion rate or on plasmainsulin in glucose clamp studies
    • Rao, R. H. Insulin resistance in spontaneously hypertensive rats. Difference in interpretation based on insulin infusion rate or on plasmainsulin in glucose clamp studies. Diabetes 42, 1364-1371 (1993).
    • (1993) Diabetes , vol.42 , pp. 1364-1371
    • Rao, R.H.1
  • 13
    • 79960364957 scopus 로고    scopus 로고
    • Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone
    • Zhang, X. et al. Rhesus macaques develop metabolic syndrome with reversible vascular dysfunction responsive to pioglitazone. Circulation 124, 77-86 (2011).
    • (2011) Circulation , vol.124 , pp. 77-86
    • Zhang, X.1
  • 14
    • 0018139377 scopus 로고
    • Obese and diabetes: Two mutant genes causing diabetes-obesity syndromes in mice
    • Coleman, D. L. Obese and diabetes: two mutant genes causing diabetes-obesity syndromes in mice. Diabetologia 14, 141-148 (1978).
    • (1978) Diabetologia , vol.14 , pp. 141-148
    • Coleman, D.L.1
  • 15
    • 0035856949 scopus 로고    scopus 로고
    • Insulin signalling and the regulation of glucose and lipid metabolism
    • Saltiel, A. R. & Kahn, C. R. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806 (2001).
    • (2001) Nature , vol.414 , pp. 799-806
    • Saltiel, A.R.1    Kahn, C.R.2
  • 16
    • 33644514920 scopus 로고    scopus 로고
    • Tissue-specific roles of IRS proteins in insulin signaling and glucose transport
    • Thirone, A. C., Huang, C. & Klip, A. Tissue-specific roles of IRS proteins in insulin signaling and glucose transport. Trends Endocrinol. Metab. 17, 72-78 (2006).
    • (2006) Trends Endocrinol. Metab. , vol.17 , pp. 72-78
    • Thirone, A.C.1    Huang, C.2    Klip, A.3
  • 17
    • 2642683510 scopus 로고    scopus 로고
    • Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse
    • Kerouz, N. J., Horsch, D., Pons, S. & Kahn, C. R. Differential regulation of insulin receptor substrates-1 and -2 (IRS-1 and IRS-2) and phosphatidylinositol 3-kinase isoforms in liver and muscle of the obese diabetic (ob/ob) mouse. J. Clin. Invest. 100, 3164-3172 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 3164-3172
    • Kerouz, N.J.1    Horsch, D.2    Pons, S.3    Kahn, C.R.4
  • 18
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • Goodyear, L. J. et al. Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J. Clin. Invest. 95, 2195-2204 (1995).
    • (1995) J. Clin. Invest. , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1
  • 19
    • 0017259606 scopus 로고
    • Insulin receptors of skeletal muscle: Specific insulin binding sites and demonstration of decreased numbers of sites in obese rats
    • Olefsky, J., Bacon, V. C. & Baur, S. Insulin receptors of skeletal muscle: specific insulin binding sites and demonstration of decreased numbers of sites in obese rats. Metabolism 25, 179-191 (1976).
    • (1976) Metabolism , vol.25 , pp. 179-191
    • Olefsky, J.1    Bacon, V.C.2    Baur, S.3
  • 20
    • 21144453387 scopus 로고    scopus 로고
    • Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle
    • Capozza, F. et al. Caveolin-3 knockout mice show increased adiposity and whole body insulin resistance, with ligand-induced insulin receptor instability in skeletal muscle. Am. J. Physiol. Cell Physiol. 288, C1317-C1331 (2005).
    • (2005) Am. J. Physiol. Cell Physiol. , vol.288
    • Capozza, F.1
  • 21
    • 0033834248 scopus 로고    scopus 로고
    • Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance
    • Zisman, A. et al. Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance. Nature Med. 6, 924-928 (2000).
    • (2000) Nature Med. , vol.6 , pp. 924-928
    • Zisman, A.1
  • 22
    • 0032214652 scopus 로고    scopus 로고
    • Amuscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance
    • Bru? ning, J. C. et al. Amuscle-specific insulin receptor knockout exhibits features of the metabolic syndrome of NIDDM without altering glucose tolerance. Mol. Cell 2, 559-569 (1998).
    • (1998) Mol. Cell , vol.2 , pp. 559-569
    • Bruning, J.C.1
  • 23
    • 33847216159 scopus 로고    scopus 로고
    • Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function
    • Laustsen, P. G. et al. Essential role of insulin and insulin-like growth factor 1 receptor signaling in cardiac development and function. Mol. Cell. Biol. 27, 1649-1664 (2007).
    • (2007) Mol. Cell. Biol. , vol.27 , pp. 1649-1664
    • Laustsen, P.G.1
  • 24
    • 68849087517 scopus 로고    scopus 로고
    • Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading
    • Nakao, R. et al. Ubiquitin ligase Cbl-b is a negative regulator for insulin-like growth factor 1 signaling during muscle atrophy caused by unloading. Mol. Cell. Biol. 29, 4798-4811 (2009).
    • (2009) Mol. Cell. Biol. , vol.29 , pp. 4798-4811
    • Nakao, R.1
  • 25
    • 33744928862 scopus 로고    scopus 로고
    • Grb10 mediates insulinstimulated degradation of the insulin receptor: A mechanism of negative regulation
    • Ramos, F. J., Langlais, P. R., Hu, D., Dong, L. Q. & Liu, F. Grb10 mediates insulinstimulated degradation of the insulin receptor: A mechanism of negative regulation. Am. J. Physiol. Endocrinol. Metab. 290, E1262-E1266 (2006).
    • (2006) Am. J. Physiol. Endocrinol. Metab. , vol.290
    • Ramos, F.J.1    Langlais, P.R.2    Hu, D.3    Dong, L.Q.4    Liu, F.5
  • 26
    • 0036830636 scopus 로고    scopus 로고
    • SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2
    • Rui, L., Yuan, M., Frantz, D., Shoelson, S. & White, M. F. SOCS-1 and SOCS-3 block insulin signaling by ubiquitin-mediated degradation of IRS1 and IRS2. J. Biol. Chem. 277, 42394-42398 (2002).
    • (2002) J. Biol. Chem. , vol.277 , pp. 42394-42398
    • Rui, L.1    Yuan, M.2    Frantz, D.3    Shoelson, S.4    White, M.F.5
  • 27
    • 43449092174 scopus 로고    scopus 로고
    • The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation
    • Xu, X. et al. The CUL7 E3 ubiquitin ligase targets insulin receptor substrate 1 for ubiquitin-dependent degradation. Mol. Cell 30, 403-414 (2008).
    • (2008) Mol. Cell , vol.30 , pp. 403-414
    • Xu, X.1
  • 28
    • 80755175849 scopus 로고    scopus 로고
    • The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling
    • Shi, J., Luo, L., Eash, J., Ibebunjo, C.& Glass, D. J. The SCF-Fbxo40 complex induces IRS1 ubiquitination in skeletal muscle, limiting IGF1 signaling. Dev. Cell 21, 835-847 (2011).
    • (2011) Dev. Cell , vol.21 , pp. 835-847
    • Shi, J.1    Luo, L.2    Eash, J.3    Ibebunjo, C.4    Glass, D.J.5
  • 29
    • 0033536637 scopus 로고    scopus 로고
    • The tyrosine kinase negative regulator c-Cbl as a RING-type E2- dependent ubiquitin-protein ligase
    • Joazeiro, C. A. et al.The tyrosine kinase negative regulator c-Cbl as a RING-type, E2- dependent ubiquitin-protein ligase. Science 286, 309-312 (1999).
    • (1999) Science , vol.286 , pp. 309-312
    • Joazeiro, C.A.1
  • 30
    • 75649121811 scopus 로고    scopus 로고
    • Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs
    • Huang, H. et al. Profiling of mismatch discrimination in RNAi enabled rational design of allele-specific siRNAs. Nucleic Acids Res. 37, 7560-7569 (2009).
    • (2009) Nucleic Acids Res. , vol.37 , pp. 7560-7569
    • Huang, H.1
  • 31
    • 74549142287 scopus 로고    scopus 로고
    • The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1a
    • Zhong, L. et al. The histone deacetylase Sirt6 regulates glucose homeostasis via Hif1a. Cell 140, 280-293 (2010).
    • (2010) Cell , vol.140 , pp. 280-293
    • Zhong, L.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.