Insulin activates RSK (p90 ribosomal S6 kinase) to trigger a new negative feedback loop that regulates insulin signaling for glucose metabolism

Journal of Biological Chemistry

Volumn 288, Issue 43, 2013, Pages 31165-31176

  Smadja Lamère, Nicolas ^a   Shum, Michael ^a   Déléris, Paul ^b   Roux, Philippe P ^b,c   Abe, Jun Ichi ^d   Marette, André ^a,d  

^a LAVAL UNIVERSITY   (Canada)

^b INSTITUTE FOR RESEARCH IN IMMUNOLOGY AND CANCER   (Canada)

^c UNIVERSITÉ DE MONTRÉAL   (Canada)

^d UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C-TERMINAL FRAGMENTS; COMPUTATIONAL ANALYSIS; NEGATIVE FEEDBACK LOOP; NEGATIVE REGULATORS; P90 RIBOSOMAL S6 KINASE; PHARMACOLOGICAL INHIBITORS; PHOSPHORYLATION SITES; SERINE PHOSPHORYLATION;

AMINO ACIDS; ASCORBIC ACID; ENZYMES; GLUCOSE; METABOLISM; PHOSPHORYLATION; PHYSIOLOGY;

INSULIN;

GLUCOSE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; S6 KINASE;

ARTICLE; CONTROLLED STUDY; GLUCONEOGENESIS; GLUCOSE METABOLISM; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; INSULIN RESISTANCE; LIVER CELL; MUSCLE CELL; NEGATIVE FEEDBACK; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

AKT; GLUCOSE METABOLISM; HEPATOCYTE; INSULIN RESISTANCE; IRS-1; MUSCLE; RSK; SERINE PHOSPHORYLATION;

AMINO ACID MOTIFS; AMINO ACID SUBSTITUTION; GLUCOSE; HEP G2 CELLS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MUSCLE CELLS; MUTATION, MISSENSE; PHOSPHORYLATION; RIBOSOMAL PROTEIN S6 KINASES, 90-KDA; SIGNAL TRANSDUCTION;

EID: 84886668514     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M113.474148     Document Type: Article

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