cAMP promotes pancreatic β-cell survival via CREB-mediated induction of IRS2

Genes and Development

Volumn 17, Issue 13, 2003, Pages 1575-1580

  Jhala, Ulupi S ^a   Canettieri, Gianluca ^a   Screaton, Robert A ^a   Kulkarni, Rohit N ^d   Krajewski, Stan ^b   Reed, John ^b   Walker, John ^c   Lin, Xueying ^d   White, Morris ^d   Montminy, Marc ^a  

^a SALK INSTITUTE FOR BIOLOGICAL STUDIES   (United States)

^b BURNHAM INSTITUTE   (United States)

^c GENOMICS INSTITUTE OF THE NOVARTIS RESEARCH FOUNDATION   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

cell; Apoptosis; cAMP; CREB

Indexed keywords

CYCLIC AMP; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; GLUCAGON LIKE PEPTIDE 1; INSULIN; INSULIN RECEPTOR SUBSTRATE 2; PROTEIN KINASE B; SOMATOMEDIN C;

A CREB TRANSGENE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL SURVIVAL; DIABETES MELLITUS; DOMINANT GENE; ENZYME ACTIVATION; GENE EXPRESSION; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN INDUCTION; SECOND MESSENGER; SIGNAL TRANSDUCTION; TRANSGENE; TRANSGENIC MOUSE;

ANIMALS; APOPTOSIS; CELL LINE; CELL SURVIVAL; CYCLIC AMP; CYCLIC AMP RESPONSE ELEMENT-BINDING PROTEIN; DIABETES MELLITUS; FORSKOLIN; GENE EXPRESSION REGULATION; GLUCAGON; GLUCAGON-LIKE PEPTIDE 1; GLUCOSE; GLUCOSE INTOLERANCE; HUMANS; INSULIN; INSULIN-LIKE GROWTH FACTOR I; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; ISLETS OF LANGERHANS; MICE; MICE, TRANSGENIC; PEPTIDE FRAGMENTS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROMOTER REGIONS (GENETICS); PROTEIN PRECURSORS; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSFECTION; TRANSGENES; TUMOR CELLS, CULTURED;

ANIMALIA; MUS MUSCULUS;

EID: 0038339191     PISSN: 08909369     EISSN: None     Source Type: Journal    
DOI: 10.1101/gad.1097103     Document Type: Article

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