Phosphoinositide 3-kinase-mediated reduction of insulin receptor substrate-1/2 protein expression via different mechanisms contributes to the insulin-induced desensitization of its signaling pathways in L6 muscle cells

Journal of Biological Chemistry

Volumn 278, Issue 18, 2003, Pages 15641-15651

  Pirola, Luciano ^a   Bonnafous, Stephanie ^a   Johnston, Anne M ^a   Chaussade, Claire ^a   Portis, Fiorella ^a   Van Obberghen, Emmanuel ^a  

^a INSERM   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CELLS; CHEMICAL ACTIVATION; GLUCOSE; INSULIN; MUSCLE; PATIENT TREATMENT; REACTION KINETICS;

PHOSPHORYLATION;

ENZYME KINETICS;

2 MORPHOLINO 8 PHENYLCHROMONE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; PHOSPHOTYROSINE; PROTEASOME; PROTEIN KINASE B; SOMATOMEDIN C; 2-(4-MORPHOLINYL)-8-PHENYL-4H-1-BENZOPYRAN-4-ONE; CHROMONE DERIVATIVE; DEOXYGLUCOSE; INSULIN RECEPTOR SUBSTRATE 1 PROTEIN; INSULIN RECEPTOR SUBSTRATE 2 PROTEIN; INSULIN RECEPTOR SUBSTRATE-1 PROTEIN; INSULIN RECEPTOR SUBSTRATE-2 PROTEIN; MAMMALIAN TARGET OF RAPAMYCIN; MORPHOLINE DERIVATIVE; ONCOPROTEIN; PHOSPHOPROTEIN; PROTEIN KINASE; PROTEIN SERINE THREONINE KINASE; SIGNAL PEPTIDE;

ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; CORRELATION ANALYSIS; ENZYME ACTIVATION; GLUCOSE TRANSPORT; HYPERINSULINEMIA; IMPAIRED GLUCOSE TOLERANCE; INSULIN RESISTANCE; MUSCLE CELL; MYOBLAST; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR DOWN REGULATION; SIGNAL TRANSDUCTION; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DRUG EFFECT; METABOLISM; PHYSIOLOGY; RNA INTERFERENCE;

ANIMALIA;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; CELLS, CULTURED; CHROMONES; DEOXYGLUCOSE; INSULIN; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MAP KINASE SIGNALING SYSTEM; MORPHOLINES; MYOBLASTS; PHOSPHOPROTEINS; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RNA INTERFERENCE;

EID: 0038521284     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M208984200     Document Type: Article

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