The peroxisome proliferator-activated receptor (PPAR) β/δ agonist GW501516 inhibits IL-6-induced signal transducer and activator of transcription 3 (STAT3) activation and insulin resistance in human liver cells

Diabetologia

Volumn 55, Issue 3, 2012, Pages 743-751

  Serrano Marco, L ^a,b   Barroso, E ^a,b   El Kochairi, I ^c   Palomer, X ^a,b   Michalik, L ^c   Wahli, W ^c   Vazquez Carrera M ^a,b  

^a UNIVERSITY OF BARCELONA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

AMPK; ERK1 2; IL 6; PPAR ; SOCS3; STAT3

Indexed keywords

[2 METHYL 4 [4 METHYL 2 (4 TRIFLUOROMETHYLPHENYL) 5 THIAZOLYLMETHYLTHIO]PHENOXY]ACETIC ACID; ADENOSINE DIPHOSPHATE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; INTERLEUKIN 6; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR DELTA; PROTEIN KINASE B; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 3;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; GENE; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; INSULIN RESISTANCE; INTRACELLULAR SIGNALING; LIVER CELL; MOUSE; NONHUMAN; PHARMACOLOGICAL STIMULATION; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SYNTHESIS INHIBITION; SUPPRESSOR OF CYTOKINE SIGNALLING 3 GENE; TRANSCRIPTION REGULATION;

ANIMALS; CELL NUCLEUS; GENE EXPRESSION REGULATION; HEP G2 CELLS; HEPATOCYTES; HUMANS; INSULIN RESISTANCE; INTERLEUKIN-6; MALE; MICE; MICE, KNOCKOUT; PHOSPHORYLATION; PPAR DELTA; PPAR-BETA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RNA, MESSENGER; SIGNAL TRANSDUCTION; STAT3 TRANSCRIPTION FACTOR; SUPPRESSOR OF CYTOKINE SIGNALING PROTEINS; THIAZOLES;

EID: 84856705923     PISSN: 0012186X     EISSN: 14320428     Source Type: Journal    
DOI: 10.1007/s00125-011-2401-4     Document Type: Article

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