BMI-related progression of atypical PKC-dependent aberrations in insulin signaling through IRS-1, Akt, FoxO1 and PGC-1α in livers of obese and type 2 diabetic humans

Metabolism: Clinical and Experimental

Volumn 64, Issue 11, 2015, Pages 1454-1465

  Sajan, Mini P ^a,b   Ivey, Robert A ^a   Farese, Robert V ^a,b  

^a VETERANS AFFAIRS MEDICAL CENTER   (United States)

^b UNIVERSITY OF SOUTH FLORIDA   (United States)

Author keywords

Akt; Atypical PKC; Insulin resistance; Liver 2; Obesity

Indexed keywords

CERAMIDE; ENZYME; FAS ANTIGEN; GLUCOSE 6 PHOSPHATASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; PEPCK ENZYME; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PHOSPHATIDIC ACID; PROTEIN KINASE B; PROTEIN KINASE C; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; TRANSCRIPTION FACTOR FKHR; TRIACYLGLYCEROL; UNCLASSIFIED DRUG; FORKHEAD TRANSCRIPTION FACTOR; FOXO1 PROTEIN, HUMAN; INSULIN RECEPTOR SUBSTRATE; IRS1 PROTEIN, HUMAN; PPARGC1A PROTEIN, HUMAN; TRANSCRIPTION FACTOR;

ADULT; ARTICLE; BODY MASS; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYMATIC ASSAY; ENZYME ACTIVITY; ENZYME INHIBITION; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; INSULIN RESISTANCE; INSULIN TREATMENT; LIVER CELL; MALE; MIDDLE AGED; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; ORGAN DONOR; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; ANTAGONISTS AND INHIBITORS; ENZYMOLOGY; LIVER; METABOLISM; PHOSPHORYLATION;

BODY MASS INDEX; DIABETES MELLITUS, TYPE 2; FORKHEAD BOX PROTEIN O1; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; LIVER; OBESITY; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR GAMMA COACTIVATOR 1-ALPHA; PHOSPHORYLATION; PROTEIN KINASE C; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; TRANSCRIPTION FACTORS; TRIGLYCERIDES;

EID: 84944441734     PISSN: 00260495     EISSN: 15328600     Source Type: Journal    
DOI: 10.1016/j.metabol.2015.08.011     Document Type: Article

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