Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1 protein

Journal of Biological Chemistry

Volumn 287, Issue 35, 2012, Pages 29672-29678

  Geetha, Thangiah ^a   Zheng, Chen ^a   Vishwaprakash, Nilmini ^a   Broderick, Tom L ^b   Babu, Jeganathan Ramesh ^a  

^a AUBURN UNIVERSITY   (United States)

^b MIDWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADAPTOR PROTEINS; AMINO TERMINUS; GLUCOSE UPTAKE; INSULIN RECEPTOR SUBSTRATE-1; INSULIN RESISTANCE; INTRACELLULAR SIGNALS; MAPPING STUDIES; METABOLIC SYNDROMES; OVER-EXPRESSION; PROTEIN MODIFICATIONS; PROTEIN-PROTEIN INTERACTIONS; SCAFFOLDING PROTEINS; SEQUESTOSOME; SH2 DOMAIN; SKELETAL MUSCLE; TRANSDUCING; TYPE-2 DIABETES;

GENES; GLUCOSE; INSULIN; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

PROTEINS;

GLUCOSE TRANSPORTER 4; INSULIN RECEPTOR SUBSTRATE 1; PROTEIN KINASE B; PROTEIN P62; PROTEIN SH2; TUMOR NECROSIS FACTOR RECEPTOR ASSOCIATED FACTOR 6;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; GLUCOSE TRANSPORT; HUMAN; HUMAN CELL; IMMUNOPRECIPITATION; NONHUMAN; OLIGOMERIZATION; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; UBIQUITINATION;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID MOTIFS; ANIMALS; CHO CELLS; CRICETINAE; CRICETULUS; DNA-BINDING PROTEINS; HEAT-SHOCK PROTEINS; HUMANS; INSULIN; INSULIN RECEPTOR SUBSTRATE PROTEINS; MICE; PEPTIDE MAPPING; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PROTEIN TRANSPORT; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION; SRC HOMOLOGY DOMAINS; TRANSCRIPTION FACTORS;

EID: 84865467434     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.322404     Document Type: Article

References (40)

1. Bouzakri, K., Koistinen, H. A., and Zierath, J. R. (2005) Molecular mechanisms of skeletal muscle insulin resistance in type 2 diabetes. Curr. Diabetes Rev. 1, 167-174
2. Lee, J., Pilch, P. F., Shoelson, S. E., and Scarlata, S. F. (1997) Conformational changes of the insulin receptor upon insulin binding and activation as monitored by fluorescence spectroscopy. Biochemistry 36, 2701-2708
3. Myers, M. G., Jr., Grammer, T. C., Brooks, J., Glasheen, E. M., Wang, L. M., Sun, X. J., Blenis, J., Pierce, J. H., and White, M. F. (1995) The pleckstrin homology domain in insulin receptor substrate-1 sensitizes insulin signaling. J. Biol. Chem. 270, 11715-11718
4. Myers, M. G., Jr., and White, M. F. (1996) Insulin signal transduction and the IRS proteins. Annu. Rev. Pharmacol. Toxicol. 36, 615-658
5. Craparo, A., O'Neill, T. J., and Gustafson, T. A. (1995) Non-SH2 domains within insulin receptor substrate-1 and SHC mediate their phosphotyrosine- dependent interaction with the NPEY motif of the insulin-like growth factor I receptor. J. Biol. Chem. 270, 15639-15643
6. Quon, M. J., Butte, A. J., and Taylor, S. I. (1994) Insulin signal transduction pathways. Trends Endocrinol. Metab. 5, 369-376
7. Cheatham, B., and Kahn, C. R. (1995) Insulin action and the insulin-signaling network. Endocr. Rev. 16, 117-142
8. Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005) Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101
9. Moscat, J., and Diaz-Meco, M. T. (2000) The atypical protein kinase Cs: functional specificity mediated by specific protein adapters. EMBO Rep. 1, 399-403
10. lck SH2 domain. Proc. Natl. Acad. Sci. U.S.A. 93, 5991-5995
11. Seibenhener, M. L., Babu, J. R., Geetha, T., Wong, H. C., Krishna, N. R., and Wooten, M. W. (2004) Sequestosome 1/p62 is a polyubiquitin chain-binding protein involved in ubiquitin proteasome degradation. Mol. Cell. Biol. 24, 8055-8068
12. Geetha, T., and Wooten, M. W. (2002) Structure and functional properties of the ubiquitin-binding protein p62. FEBS Lett. 512, 19-24
13. Pankiv, S., Clausen, T. H., Lamark, T., Brech, A., Bruun, J. A., Outzen, H., Øvervatn, A., Bjørkøy, G., and Johansen, T. (2007) p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J. Biol. Chem. 282, 24131-24145
14. Geetha, T., and Wooten, M. W. (2003) Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve growth factor receptor TrkA regulates receptor trafficking and Erk5 signaling. J. Biol. Chem. 278, 4730-4739
15. Geetha, T., Jiang, J., and Wooten, M. W. (2005) Lysine 63 polyubiquitination of the nerve growth factor receptor TrkA directs internalization and signaling. Mol. Cell 20, 301-312
16. Babu, J. R., Geetha, T., and Wooten, M. W. (2005) Sequestosome 1/p62 shuttles polyubiquitinated Tau for proteasomal degradation. J. Neurochem. 94, 192-203
17. Ramesh Babu, J., Lamar Seibenhener, M., Peng, J., Strom, A. L., Kemppainen, R., Cox, N., Zhu, H., Wooten, M. C., Diaz-Meco, M. T., Moscat, J., and Wooten, M. W. (2008) Genetic inactivation of p62 leads to accumulation of hyperphosphorylated Tau and neurodegeneration. J. Neurochem. 106, 107-120
18. Rodriguez, A., Durán, A., Selloum, M., Champy, M. F., Diez-Guerra, F. J., Flores, J. M., Serrano, M., Auwerx, J., Diaz-Meco, M. T., and Moscat, J. (2006) Mature-onset obesity and insulin resistance in mice deficient in the signaling adapter p62. Cell Metab. 3, 211-222
19. Okada, K., Yanagawa, T., Warabi, E., Yamastu, K., Uwayama, J., Takeda, K., and Utsunomiya, H., Yoshida, H., Shoda, J., and Ishii, T. (2009) The α-glucosidase inhibitor acarbose prevents obesity and simple steatosis in sequestosome 1/A170/p62-deficient mice. Hepatol. Res. 39, 490-500
20. Samuels, I. S., Seibenhener, M. L., Neidigh, K. B., and Wooten, M. W. (2001) Nerve growth factor stimulates the interaction of ZIP/p62 with atypical protein kinase C and targets endosomal localization: evidence for regulation of nerve growth factor-induced differentiation. J. Cell. Biochem. 82, 452-466
21. S6K pathway in insulin signaling of protein synthesis. FEBS Lett. 446, 122-126
22. Hodgkinson, C. P., Mander, A., and Sale, G. J. (2005) Protein kinase-ζ interacts with munc18c: role in GLUT4 trafficking. Diabetologia 48, 1627-1636
23. Olianas, M. C., Dedoni, S., and Onali, P. (2011) δ-Opioid receptors stimulate GLUT1-mediated glucose uptake through Src- and IGF-1 receptordependent activation of PI3-kinase signaling in CHO cells. Br. J. Pharmacol. 163, 624-637
24. Giovannone, B., Scaldaferri, M. L., Federici, M., Porzio, O., Lauro, D., Fusco, A., Sbraccia, P., Borboni, P., Lauro, R., and Sesti, G. (2000) Insulin receptor substrate (IRS) transduction system: distinct and overlapping signaling potential. Diabetes Metab. Res. Rev. 16, 434-441
25. Sesti, G., Federici, M., Hribal, M. L., Lauro, D., Sbraccia, P., and Lauro, R. (2001) Defects of the insulin receptor substrate (IRS) system in human metabolic disorders. FASEB J. 15, 2099-2111
26. Virkamäki, A., Ueki, K., and Kahn, C. R. (1999) Protein-protein interaction in insulin signaling and the molecular mechanisms of insulin resistance. J. Clin. Invest. 103, 931-943
27. Moscat, J., Diaz-Meco, M. T., and Wooten, M. W. (2007) Signal integration and diversification through the p62 scaffold protein. Trends Biochem. Sci. 32, 95-100
28. Esposito, D. L., Li, Y., Cama, A., and Quon, M. J. (2001) Tyr-612 and Tyr-632 in human insulin receptor substrate-1 are important for full activation of insulin-stimulated phosphatidylinositol 3-kinase activity and translocation of GLUT4 in adipose cells. Endocrinology 142, 2833-2840
29. Rordorf-Nikolic, T., Van Horn, D. J., Chen, D., White, M. F., and Backer, J. M. (1995) Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J. Biol. Chem. 270, 3662-3666
30. Sun, X. J., Crimmins, D. L., Myers, M. G., Jr., Miralpeix, M., and White, M. F. (1993) Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol. Cell. Biol. 13, 7418-7428
31. Kuhné, M. R., Pawson, T., Lienhard, G. E., and Feng, G. S. (1993) The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J. Biol. Chem. 268, 11479-11481
32. Sun, X. J., Pons, S., Asano, T., Myers, M. G., Jr., Glasheen, E., and White, M. F. (1996) The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J. Biol. Chem. 271, 10583-10587
33. Sanz, L., Diaz-Meco, M. T., Nakano, H., and Moscat, J. (2000) The atypical PKC-interacting protein p62 channels NF-κB activation by the IL-1- TRAF6 pathway. EMBO J. 19, 1576-1586
34. Wooten, M. W., Seibenhener, M. L., Mamidipudi, V., Diaz-Meco, M. T., Barker, P. A., and Moscat, J. (2001) The atypical protein kinase C-interacting protein p62 is a scaffold for NF-κB activation by nerve growth factor. J. Biol. Chem. 276, 7709-7712
35. Yang, W. L., Wang, J., Chan, C. H., Lee, S. W., Campos, A. D., Lamothe, B., Hur, L., Grabiner, B. C., Lin, X., Darnay, B. G., and Lin, H. K. (2009) The E3 ligase TRAF6 regulates Akt ubiquitination and activation. Science 325, 1134-1138
36. Wang, C., Deng, L., Hong, M., Akkaraju, G. R., Inoue, J., and Chen, Z. J. (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412, 346-351
37. Ea, C. K., Sun, L., Inoue, J., and Chen, Z. J. (2004) TIFA activates IκB kinase (IKK) by promoting oligomerization and ubiquitination of TRAF6. Proc. Natl. Acad. Sci. U.S.A. 101, 15318-15323
38. Wooten, M. W., Geetha, T., Seibenhener, M. L., Babu, J. R., Diaz-Meco, M. T., and Moscat, J. (2005) The p62 scaffold regulates nerve growth factor-induced NF-κB activation by influencing TRAF6 polyubiquitination. J. Biol. Chem. 280, 35625-35629
39. Leney, S. E., and Tavaré, J. M. (2009) The molecular basis of insulinstimulated glucose uptake: signaling, trafficking, and potential drug targets. J. Endocrinol. 203, 1-18
40. Saltiel, A. R., and Kahn, C. R. (2001) Insulin signaling and the regulation of glucose and lipid metabolism. Nature 414, 799-806