Altered expression levels and impaired steps in the pathway to phosphatidylinositol 3-kinase activation via insulin receptor substrates 1 and 2 in Zucker fatty rats

Diabetes

Volumn 47, Issue 1, 1998, Pages 13-23

  Anai, Motonobu ^b   Funaki, Makoto ^a   Ogihara, Takehide ^a   Terasaki, Jungo ^a   Inukai, Kouichi ^b   Katagiri, Hideki ^a   Fukushima, Yasushi ^a   Yazaki, Yoshio ^a   Kikuchi, Masatoshi ^b   Oka, Yoshitomo ^c   Asano, Tomoichiro ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b INSTITUTE FOR ADULT DISEASES   (Japan)

^c YAMAGUCHI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; RECEPTOR SUBTYPE;

ANIMAL CELL; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BINDING SITE; CLINICAL PATHWAY; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME ACTIVE SITE; FEMALE; INSULIN METABOLISM; INSULIN RESISTANCE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; RAT; RECEPTOR BINDING;

EID: 0031984952     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diab.47.1.13     Document Type: Article

References (61)

1. White MF, Kahn CR: The insulin signaling system. J Biol Chem 269:1-4, 1994
2. Gould GW, Jess TJ, Andrews GC, Herbst JJ, Plevin RJ, Gibbs EM: Evidence for a role of phosphatidylinositol 3-kinase in the regulation of glucose transport in Xenopus oocytes. J Biol Chem 269:26622-26625, 1994
3. Yeh JI, Gulve EA, Rameh L, Birnbaum J: The effects of wortmannin on rat skeletal muscle: dissociation of signaling pathways for insulin- and contraction-activated hexose transport. J Biol Chem 270:2107-2111, 1995
4. Clarke JF, Young PW, Yonezawa K, Kasuga M, Holman GD: Inhibition of the translocation of GLUT1 and GLUT4 in 3T3-L1 cells by the phosphatidylinositol 3-kinase inhibitor, wortmannin. Biochem J 300:631-635, 1994
5. Sakaue H, Hara K, Noguchi T, Matozaki T, Kotani K, Ogawa W, Yonezawa K, Waterfield MD, Kasuga M: Ras-independent and wortmannin-sensitive activation of glycogen synthase by insulin in Chinese hamster ovary cells. J Biol Chem 270:11304-11309, 1995
6. Shepherd PR, Nave BT, Siddle K: Insulin stimulation of glycogen synthesis and glycogen synthase activity is blocked by wortmannin and rapamycin in 3T3-L1 adipocytes: evidence for the involvement of phosphoinositide 3-kinase and p70 ribosomal protein-S6 kinase. Biochem J 305:25-28, 1995
7. Sun XJ, Crimmins DL, Myers Jr MG, Miralpeix M, White MF: Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1. Mol Cell Biol 13:7418-7428, 1993
8. Sun XJ, Wang LM, Zhang Y, Yenush L, Myers MG Jr, Glasheen E, Lane WS, Pierce JH, White MF: Role of IRS-2 in insulin and cytokine signalling. Nature 377:173-177, 1995
9. Cheatham B, Vlahos CJ, Cheatham L, Wang L, Blenis J, Kahn CR: Phosphatidylinositol 3-kinase activation is required for insulin stimulation of pp70 S6 kinase, DNA synthesis, and glucose transporter translocation. Mol Cell Biol 14:4902-4911, 1994
10. Kanal F, Ito K, Todaka M, Hayashi H, Kamohara S, Ishii K, Okada T, Hazeki O, Ui M, Ebina Y: Insulin-stimulated GLUT4 translocation is relevant to the phosphorylation of IRS-1 and the activity of PI3-kinase. Biochem Biophys Res Commun 195:762-768, 1993
11. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M: Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes: studies with a selective inhibitor wortmannin J Biol Chem 269:3568-3573, 1994
12. Sutherland C, O'Brien RM, Granner DK. Phosphatidylinositol 3-kinase, but not p70/p85 ribosomal S6 protein kinase, is required for the regulation of phosphoenolpyruvate carboxykinase (PEPCK) gene expression by insulin: dissociation of signaling pathways for insulin and phorbol ester regulation of PEPCK gene expression. J Biol Chem 270:15501-15506, 1995
13. Gabbay RA, Sutherland C, Gnudi L, Kahn BB, O'Brien RM, Granner DK, Flier JS: Insulin regulation of phosphoenolpyruvate carboxykinase gene expression does not require activation of the Ras/mitogen-activated protein kinase signaling pathway. J Biol Chem 271:1890-1897, 1996
14. Bonini JA, Colca J, Hofmann C: Altered expression of insulin signaling components in streptozotocin-treated rats. Biochem Biophys Res Commun 212:9133-938, 1995
15. Saad MJ, Araki E, Miralpeix M, Rothenberg PL, White MF, Kahn CR: Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance. J Clin Invest 90:1839-1849, 1992
16. Bonini JA, Colca JR, Dailey C, White M, Hofmann C: Compensatory alterations for insulin signal transduction and glucose transport in insulin-resistant diabetes. Am J Physiol 269:E759-E765, 1995
17. Saad MJ, Folli JF, Kahn CR: Insulin and dexamethasone regulate insulin receptors, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in Fao hepatoma cells. Endocrinology 136:1579-1588, 1995
18. Sherman WM, Katz AL, Cutler CL, Withers RT, Ivy JL: Glucose transport: locus of muscle insulin resistance in obese Zucker rats. Am J Physiol 255:E374-E382, 1988
19. King PA, Horton ED, Hirshman MF, Horton ES: Insulin resistance in obese Zucker rat (fa/fa) skeletal muscle is associated with a failure of glucose transporter translocation. J Clin Invest 90:1568-1575, 1992
20. Uphues I, Kolter T, Goud B, Eckel J: Failure of insulin-regulated recruitment of the glucose transporter GLUT4 in cardiac muscle of obese Zucker rats is associated with alterations of small-molecular-mass GTP-binding proteins. Biochem J 311:161-166, 1995
21. Slieker LJ, Roberts EF, Shaw WN, Johnson WT: Effect of streptozocin-induced diabetes on insulin-receptor tyrosine kinase activity in obese Zucker rats. Diabetes 39:619-625, 1990
22. Phillips MS, Liu Q, Hammond HA, Dugan V, Hey PJ, Caskey CJ, Hess JF: Leptin receptor missense mutation in the fatty Zucker rat [letter]. Nat Genet 13:18-19, 1996
23. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K: Phenotype-linked amino acid alteration in leptin receptor cDNA from Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 222:19-26, 1996
24. Bray GA: The Zucker-fatty rat: a review. Fed Proc 36:148-153, 1977
25. Terrettaz J, Jeanrenaud B: In vivo hepatic and peripheral insulin resistance in genetically obese (fa/fa) rats. Endocrinology 112:1346-1351, 1983
26. Ionescu E, Sauter JF, Jeanrenaud B: Abnormal oral glucose tolerance in genetically obese (fa/fa) rats. Am J Physiol 248:E500-E506, 1985
27. Terrettaz J, Assimacopoulos-Jeannet F, Jeanrenaud B: Severe hepatic and peripheral insulin resistance as evidenced by euglycemic clamps in genetically obese fa/fa rats. Endocrinology 118:674-678, 1986
28. Crettaz M, Prentki M, Zaninetti D, Jeanrenaud B: Insulin resistance in soleus muscle from obese Zucker rats: involvement of several defective sites. Biochem J 186:525-534, 1980
29. Kemmer FW, Berger M, Herberg L, Gries FA, Wirdeier A, Becker K: Glucose metabolism in perfused skeletal muscle: demonstration of insulin resistance in the obese Zucker rat. Biochem J 178:733-741, 1979
30. Ogihara T, Shin BC, Anai M, Katagiri H, Inukai K, Funaki M, Fukushima Y, Ishihara H, Takata K, Kikuchi M, Yazaki Y, Oka Y, Asano T: Insulin receptor substrate (IRS)-2 is dephosphorylated more rapidly than IRS-1 via its association with phosphatidylinositol 3-kinase in skeletal muscle cells. J Biol Chem 272:12868-12873, 1997
31. Inukai K, Anai M, Van Breda E, Hosaka T, Katagiri H, Funaki M, Fukushima Y, Ogihara T, Yazaki Y, Kikuchi M, Oka Y, Asano T: A novel 55-kDa regulatory subunit for phosphatidylinositol 3-kinase structurally similar to p55PIK is generated by alternative splicing of the p85alpha gene. J Biol Chem 271:5317-5320, 1996
32. Inukai K, Funaki M, Ogihara T, Katagiri H, Kanda A, Anai M, Fukushima Y, Hosaka T, Suzuki M, Shin BC, Takata K, Yazaki Y, Kikuchi M, Oka Y, Asano T: p85α gene generates three isoforms of regulatory subunit for phosphatidylinositol 3-kinase (PI 3-kinase), p50α, p55α and p85α, with different PI 3-kinase activity elevating responses to insulin. J Biol Chem 272:7873-7882, 1997
33. Kimball SR, Horetsky RL, Jefferson LS: Hormonal regulation of albumin gene expression in primary cultures of rat hepatocytes. Am J Physiol 268:E6-E14, 1995
34. Decaux JF, Marcillat O, Pichard AL, Henry J, Kahn A: Glucose-dependent and -independent effect of insulin on gene expression. J Biol Chem 266:3432-3438, 1991
35. Pons S, Asano T, Glasheen E, Miralpeix M, Zhang Y, Fisher TL, Myers MG Jr, Sun XJ, White MF: The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase. Mol Cell Biol 15:4453-4465, 1995
36. Fruman DA, Cantley LC, Carpenter CL: Structural organization and alternative splicing of the murine phosphoinositide 3-kinase p85 alpha gene. Genomics 37:113-121, 1996
37. Lee CH, Li W, Nishimura R, Zhou M, Batzer AG, Myers MG Jr, White MF, Schlessinger J, Skolnik EY: Nek associates with the SH2 domain-docking protein IRS-1 in insulin-stimulated cells. Proc Natl Acad Sci USA 90:11713-11717, 1993
38. Skolnik EY, Lee CH, Batzer A, Vicentini LM, Zhou M, Daly R, Myers MJ Jr, Backer JM, Ullrich A, White MF, Schlessinger J: The SH2/SH3 domain-containing protein GRB2 interacts with tyrosine-phosphorylated IRS1 and Shc: implications for insulin control of ras signalling. EMBO J 12:1929-1936, 1993
39. Kuhne MR, Pawson T, Lienhard GE, Feng GS: The insulin receptor substrate 1 associates with the SH2-containing phosphotyrosine phosphatase Syp. J Biol Chem 268:11479-11481, 1993
40. Sun XJ, Pons S, Asano T, Myers Jr MG, Glasheen E, White MF: The Fyn tyrosine kinase binds Irs-1 and forms a distinct signaling complex during insulin stimulation. J Biol Chem 271:10583-10587, 1996
41. Sanchez-Margalet V, Goldfine ID, Vlahos CJ, Sung CK: Role of phosphatidylinositol-3-kinase in insulin receptor signaling: studies with inhibitor, LY294002. Biochem Biophys Res Commun 204:446-452, 1994
42. Haruta T, Morris AJ, Rose DW, Nelson JG, Mueckler M, Olefsky JM: Insulin-stimulated GLUT4 translocation is mediated by a divergent intracellular signaling pathway. J Biol Chem 270:27991-27994, 1995
43. Quon MJ, Chen H, Ing BL, Liu ML, Zarnowski MJ, Yonezawa K, Kasuga M, Cushman SW, Taylor SI: Roles of 1-phosphatidylinositol 3-kinase and ras in regulating translocation of GLUT4 in transfected rat adipose cells. Mot Cell Biol 15:5403-5411, 1995
44. Kotani K, Carozzi AJ, Sakaue H, Hara K, Robinson LJ, Clark SF, Yonezawa K, James DE, Kasuga M: Requirement for phosphoinositide 3-kinase in insulin-stimulated GLUT4 translocation in 3T3-L1 adipocytes. Biochem Biophys Res Commun 209:343-348, 1995
45. Katagiri H, Asano T, Inukai K, Ogihara T, Ishihara H, Shibasaki Y, Murata T, Terasaki J, Kikuchi M, Yazaki Y, Oka Y: Roles of PI 3-kinase and Ras on insulin-stimulated glucose transport in 3T3-L1 adipocytes. Am J Physiol 272:E326-E331, 1997
46. Katagiri H, Asano T, Ishihara H, Inukai K, Shibasaki Y, Kikuchi M, Yazaki Y, Oka Y: Overexpression of catalytic subunit p110alpha of phosphatidylinositol 3-kinase increases glucose transport activity with translocation of glucose transporters in 3T3-L1 adipocytes. J Biol Chem 271:16987-16990, 1996
47. Martin SS, Haruta T, Morris AJ, Kuppel A, Williams LT, Olefsky JM: Activated phosphatidylinositol 3-kinase is sufficient to mediate actin rearrangement and GLUT4 translocation in 3T3-L1 adipocytes. J Biol Chem 271:17605-17608, 1996
48. Cross DA, Alessi DR, Cohen P, Anojelkovich M, Hemmings BA: Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 378:785-789, 1995
49. Cross DA, Alessi DR, Vandenheede JR, McDowell HE, Hundal HS, Cohen P: The inhibition of glycogen synthase kinase-3 by insulin or insulin-like growth factor 1 in the rat skeletal muscle cell line L6 is blocked by wortmannin, but not by rapamycin: evidence that wortmannin blocks activation of the mitogen-activated protein kinase pathway in L6 cells between Ras and Raf. Biochem J 303:21-26, 1994
50. Welsh GI, Foulstone EJ, Young SW, Tavare JM, Proud CG: Wortmannin inhibits the effects of insulin and serum on the activities of glycogen synthase kinase-3 and mitogen-activated protein kinase. Biochem J 303:15-20, 1994
51. Folli F, Saad MJ, Backer JM, Kahn CR: Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus. J Clin Invest 92:1787-1794, 1993
52. Saad MJ, Folli F, Kahn JAA, Kahn CR: Modulation of insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats. J Clin Invest 92:2065-2072, 1993
53. Carvalho CR, Brenelli SL, Silva AC, Nunes AL, Velloso LA, Saad MJ: Effect of aging on insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of rats. Endocrinology 137:151-159, 1996
54. Saad MJ, Maeda L, Brenelli SL, Carvalho CR, Paiva RS, Velloso LA: Defects in insulin signal transduction in liver and muscle of pregnant rats. Diabetologia 40:179-186, 1997
55. Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL: Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95:2195-2204, 1995
56. Apweiler R, Kuhnle HF, Ritter G, Schell R, Freund P: Effect of the new oral antidiabetic agent (-)-BM 13.0913.Na on insulin resistance in lean and obese Zucker rats. Metabolism 44:577-583, 1995
57. Bowen L, Stein PP, Stevenson R, Shulman GI: The effect of CP 68,722, a thiozolidinedione derivative, on insulin sensitivity in lean and obese Zucker rats. Metabolism 40:1025-1030, 1991
58. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM: Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes: central role of tumor necrosis factor-alpha. J Clin Invest 94:1543-1549, 1994
59. Backer JM, Myers MG Jr, Shoelson SE, Chin DJ, Sun XJ, Miralpeix M, Hu P, Margolis B, Skolnik EY, Schlessinger J, White MF: Phosphatidylinositol 3′-kinase is activated by association with IRS-1 during insulin stimulation. EMBO J 11:3460-3479, 1992
60. Rordorf-Nikolic T, Van Horn DJ , Chen D, White MF, Backer JM: Regulation of phosphatidylinositol 3′-kinase by tyrosyl phosphoproteins: full activation requires occupancy of both SH2 domains in the 85-kDa regulatory subunit. J Biol Chem 270:3662-3666, 1995
61. Gout I, Dhand R, Hiles ID, Fry J, Panayotou G, Das P, Truong O, Tonny NF, Hsuan J, Booker GW, Campbel ID, Waterfield MD: The GTPase dynamin binds to and is activated by a subset of SH3 domains. Cell 75:25-36, 1993