메뉴 건너뛰기




Volumn 47, Issue 7, 2004, Pages 1314-1323

WY-14643 and 9-cis-retinoic acid induce IRS-2/PI 3-kinase signalling pathway and increase glucose transport in human skeletal muscle cells: Differential effect in myotubes from healthy subjects and Type 2 diabetic patients

Author keywords

Fibrates; Gene expression; Glucose uptake; Insulin resistance; Insulin signalling; Nuclear receptors; PI 3 kinase; Rexinoids

Indexed keywords

ALITRETINOIN; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR AGONIST; PHOSPHATIDYLINOSITOL 3 KINASE; PIRINIXIC ACID; PROTEIN KINASE B; PROTEIN P85;

EID: 4143051437     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1428-1     Document Type: Article
Times cited : (15)

References (42)
  • 1
    • 0026572747 scopus 로고
    • Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: A balanced overview
    • DeFronzo RA (1992) Pathogenesis of type 2 (non-insulin dependent) diabetes mellitus: a balanced overview. Diabetologia 35:389-397
    • (1992) Diabetologia , vol.35 , pp. 389-397
    • DeFronzo, R.A.1
  • 2
    • 0028880997 scopus 로고
    • Role of insulin resistance in the pathogenesis of NIDDM
    • Yki-Jarvinen H (1995) Role of insulin resistance in the pathogenesis of NIDDM. Diabetologia 38:1378-1388
    • (1995) Diabetologia , vol.38 , pp. 1378-1388
    • Yki-Jarvinen, H.1
  • 3
    • 0031057526 scopus 로고    scopus 로고
    • Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation
    • Bjornholm M, Kawano Y, Lehtihet M, Zierath JR (1997) Insulin receptor substrate-1 phosphorylation and phosphatidylinositol 3-kinase activity in skeletal muscle from NIDDM subjects after in vivo insulin stimulation. Diabetes 46:524-527
    • (1997) Diabetes , vol.46 , pp. 524-527
    • Bjornholm, M.1    Kawano, Y.2    Lehtihet, M.3    Zierath, J.R.4
  • 4
    • 0032698470 scopus 로고    scopus 로고
    • Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes
    • Kim YB, Nikoulina SE, Ciaraldi TP, Henry RR, Kahn BB (1999) Normal insulin-dependent activation of Akt/protein kinase B, with diminished activation of phosphoinositide 3-kinase, in muscle in type 2 diabetes. J Clin Invest 104:733-741
    • (1999) J Clin Invest , vol.104 , pp. 733-741
    • Kim, Y.B.1    Nikoulina, S.E.2    Ciaraldi, T.P.3    Henry, R.R.4    Kahn, B.B.5
  • 5
    • 0033968126 scopus 로고    scopus 로고
    • Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle
    • Cusi K, Maezono K, Osman A et al. (2000) Insulin resistance differentially affects the PI3-kinase- and MAP kinase-mediated signaling in human muscle. J Clin Invest 105:311-320
    • (2000) J Clin Invest , vol.105 , pp. 311-320
    • Cusi, K.1    Maezono, K.2    Osman, A.3
  • 6
    • 0343314906 scopus 로고    scopus 로고
    • Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients
    • Krook A, Bjornholm M, Galuska D et al. (2000) Characterization of signal transduction and glucose transport in skeletal muscle from type 2 diabetic patients. Diabetes 49:284-292
    • (2000) Diabetes , vol.49 , pp. 284-292
    • Krook, A.1    Bjornholm, M.2    Galuska, D.3
  • 7
    • 0035511730 scopus 로고    scopus 로고
    • Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation
    • Pratipanawatr W, Pratipanawatr T, Cusi K et al. (2001) Skeletal muscle insulin resistance in normoglycemic subjects with a strong family history of type 2 diabetes is associated with decreased insulin-stimulated insulin receptor substrate-1 tyrosine phosphorylation. Diabetes 50:2572-2578
    • (2001) Diabetes , vol.50 , pp. 2572-2578
    • Pratipanawatr, W.1    Pratipanawatr, T.2    Cusi, K.3
  • 8
    • 0027953703 scopus 로고
    • Insulin action, diabetogenes, and the cause of type II diabetes
    • Kahn CR (1994) Insulin action, diabetogenes, and the cause of type II diabetes. Diabetes 43:1066-1084
    • (1994) Diabetes , vol.43 , pp. 1066-1084
    • Kahn, C.R.1
  • 9
    • 0032143284 scopus 로고    scopus 로고
    • Phosphoinositide 3-kinase: The key switch mechanism in insulin signalling
    • Shepherd PR, Withers DJ, Siddle K (1998) Phosphoinositide 3-kinase: the key switch mechanism in insulin signalling. Biochem J 333:471-490
    • (1998) Biochem J , vol.333 , pp. 471-490
    • Shepherd, P.R.1    Withers, D.J.2    Siddle, K.3
  • 10
    • 0033942001 scopus 로고    scopus 로고
    • Insulin action and insulin resistance in human skeletal muscle
    • Zierath JR, Krook A, Wallberg-Henriksson H (2000) Insulin action and insulin resistance in human skeletal muscle. Diabetologia 43:821-835
    • (2000) Diabetologia , vol.43 , pp. 821-835
    • Zierath, J.R.1    Krook, A.2    Wallberg-Henriksson, H.3
  • 11
    • 0035029812 scopus 로고    scopus 로고
    • Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes
    • Ducluzeau PH, Perretti N, Laville M et al. (2001) Regulation by insulin of gene expression in human skeletal muscle and adipose tissue. Evidence for specific defects in type 2 diabetes. Diabetes 50:1134-1142
    • (2001) Diabetes , vol.50 , pp. 1134-1142
    • Ducluzeau, P.H.1    Perretti, N.2    Laville, M.3
  • 12
    • 0035890960 scopus 로고    scopus 로고
    • Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients
    • Lefai E, Roques M, Vega N, Laville M, Vidal H (2001) Expression of the splice variants of the p85alpha regulatory subunit of phosphoinositide 3-kinase in muscle and adipose tissue of healthy subjects and type 2 diabetic patients. Biochem J 15:117-126
    • (2001) Biochem J , vol.15 , pp. 117-126
    • Lefai, E.1    Roques, M.2    Vega, N.3    Laville, M.4    Vidal, H.5
  • 13
    • 0028903232 scopus 로고
    • Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects
    • Goodyear LJ, Giorgino F, Sherman LA, Carey J, Smith RJ, Dohm GL (1995) Insulin receptor phosphorylation, insulin receptor substrate-1 phosphorylation, and phosphatidylinositol 3-kinase activity are decreased in intact skeletal muscle strips from obese subjects. J Clin Invest 95:2195-2204
    • (1995) J Clin Invest , vol.95 , pp. 2195-2204
    • Goodyear, L.J.1    Giorgino, F.2    Sherman, L.A.3    Carey, J.4    Smith, R.J.5    Dohm, G.L.6
  • 14
    • 0032909703 scopus 로고    scopus 로고
    • Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase
    • Terauchi Y, Tsuji Y, Satoh S et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21:230-235
    • (1999) Nat Genet , vol.21 , pp. 230-235
    • Terauchi, Y.1    Tsuji, Y.2    Satoh, S.3
  • 15
    • 0036853886 scopus 로고    scopus 로고
    • Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver
    • Miyake K, Ogawa W, Matsumoto M, Nakamura T, Sakaue H, Kasuga M (2002) Hyperinsulinemia, glucose intolerance, and dyslipidemia induced by acute inhibition of phosphoinositide 3-kinase signaling in the liver. J Clin Invest 110:1483-1491
    • (2002) J Clin Invest , vol.110 , pp. 1483-1491
    • Miyake, K.1    Ogawa, W.2    Matsumoto, M.3    Nakamura, T.4    Sakaue, H.5    Kasuga, M.6
  • 16
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists
    • Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-activated receptor gamma agonists. J Clin Invest 106:467-472
    • (2000) J Clin Invest , vol.106 , pp. 467-472
    • Olefsky, J.M.1
  • 17
    • 0034744183 scopus 로고    scopus 로고
    • The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes
    • Rieusset J, Chambrier C, Bouzakri K et al. (2001) The expression of the p85alpha subunit of phosphatidylinositol 3-kinase is induced by activation of the peroxisome proliferator-activated receptor gamma in human adipocytes. Diabetologia 44:544-554
    • (2001) Diabetologia , vol.44 , pp. 544-554
    • Rieusset, J.1    Chambrier, C.2    Bouzakri, K.3
  • 18
    • 0035800338 scopus 로고    scopus 로고
    • Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells
    • Rieusset J, Roques M, Bouzakri K, Chevillotte E, Vidal H (2001) Regulation of p85alpha phosphatidylinositol-3-kinase expression by peroxisome proliferator-activated receptors (PPARs) in human muscle cells. FEBS Lett 502:98-102
    • (2001) FEBS Lett , vol.502 , pp. 98-102
    • Rieusset, J.1    Roques, M.2    Bouzakri, K.3    Chevillotte, E.4    Vidal, H.5
  • 19
    • 0034595980 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity
    • Guerre-Millo M, Gervois P, Raspe E et al. (2000) Peroxisome proliferator-activated receptor alpha activators improve insulin sensitivity and reduce adiposity. J Biol Chem 275:16638-16642
    • (2000) J Biol Chem , vol.275 , pp. 16638-16642
    • Guerre-Millo, M.1    Gervois, P.2    Raspe, E.3
  • 20
    • 17444442152 scopus 로고    scopus 로고
    • Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists
    • Mukherjee R, Davies PJ, Crombie DL et al. (1997) Sensitization of diabetic and obese mice to insulin by retinoid X receptor agonists. Nature 386:407-410
    • (1997) Nature , vol.386 , pp. 407-410
    • Mukherjee, R.1    Davies, P.J.2    Crombie, D.L.3
  • 21
    • 0029134591 scopus 로고
    • Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures
    • Henry RR, Abrams L, Nikoulina S, Ciaraldi TP (1995) Insulin action and glucose metabolism in nondiabetic control and NIDDM subjects. Comparison using human skeletal muscle cell cultures. Diabetes 44:936-946
    • (1995) Diabetes , vol.44 , pp. 936-946
    • Henry, R.R.1    Abrams, L.2    Nikoulina, S.3    Ciaraldi, T.P.4
  • 22
    • 0033607647 scopus 로고    scopus 로고
    • A phosphatidylinositol 3-kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85 alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells
    • Roques M, Vidal H (1999) A phosphatidylinositol 3-kinase/p70 ribosomal S6 protein kinase pathway is required for the regulation by insulin of the p85 alpha regulatory subunit of phosphatidylinositol 3-kinase gene expression in human muscle cells. J Biol Chem 274:34005-34010
    • (1999) J Biol Chem , vol.274 , pp. 34005-34010
    • Roques, M.1    Vidal, H.2
  • 23
    • 0028799952 scopus 로고
    • Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects
    • Ciaraldi TP, Abrams L, Nikoulina S, Mudaliar S, Henry RR (1995) Glucose transport in cultured human skeletal muscle cells. Regulation by insulin and glucose in nondiabetic and non-insulin-dependent diabetes mellitus subjects. J Clin Invest 96:2820-2827
    • (1995) J Clin Invest , vol.96 , pp. 2820-2827
    • Ciaraldi, T.P.1    Abrams, L.2    Nikoulina, S.3    Mudaliar, S.4    Henry, R.R.5
  • 24
    • 0029739976 scopus 로고    scopus 로고
    • Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms
    • Henry RR, Ciaraldi TP, Abrams-Carter L, Mudaliar S, Park KS, Nikoulina SE (1996) Glycogen synthase activity is reduced in cultured skeletal muscle cells of non-insulin-dependent diabetes mellitus subjects. Biochemical and molecular mechanisms. J Clin Invest 98:1231-1236
    • (1996) J Clin Invest , vol.98 , pp. 1231-1236
    • Henry, R.R.1    Ciaraldi, T.P.2    Abrams-Carter, L.3    Mudaliar, S.4    Park, K.S.5    Nikoulina, S.E.6
  • 25
    • 0033938499 scopus 로고    scopus 로고
    • Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families
    • Jackson S, Bagstaff SM, Lynn S, Yeaman SJ, Turnbull DM, Walker M (2000) Decreased insulin responsiveness of glucose uptake in cultured human skeletal muscle cells from insulin-resistant nondiabetic relatives of type 2 diabetic families. Diabetes 49:1169-1177
    • (2000) Diabetes , vol.49 , pp. 1169-1177
    • Jackson, S.1    Bagstaff, S.M.2    Lynn, S.3    Yeaman, S.J.4    Turnbull, D.M.5    Walker, M.6
  • 26
    • 0034841515 scopus 로고    scopus 로고
    • Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation
    • Nikoulina SE, Ciaraldi TP, Carter L, Mudaliar S, Park KS, Henry RR (2001) Impaired muscle glycogen synthase in type 2 diabetes is associated with diminished phosphatidylinositol 3-kinase activation. J Clin Endocrinol Metab 86:4307-4314
    • (2001) J Clin Endocrinol Metab , vol.86 , pp. 4307-4314
    • Nikoulina, S.E.1    Ciaraldi, T.P.2    Carter, L.3    Mudaliar, S.4    Park, K.S.5    Henry, R.R.6
  • 27
    • 0036224284 scopus 로고    scopus 로고
    • The diabetic phenotype is conserved in myotubes established from diabetic subjects: Evidence for primary defects in glucose transport and glycogen synthase activity
    • Gaster M, Petersen I, Hojlund K, Poulsen P, Beck-Nielsen H (2002) The diabetic phenotype is conserved in myotubes established from diabetic subjects: evidence for primary defects in glucose transport and glycogen synthase activity. Diabetes 51:921-927
    • (2002) Diabetes , vol.51 , pp. 921-927
    • Gaster, M.1    Petersen, I.2    Hojlund, K.3    Poulsen, P.4    Beck-Nielsen, H.5
  • 28
    • 0038321436 scopus 로고    scopus 로고
    • Reduced activation of phosphatidylinositol-3-kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes
    • Bouzakri K, Roques M, Gual P et al. (2003) Reduced activation of phosphatidylinositol-3-kinase and increased serine 636 phosphorylation of insulin receptor substrate-1 in primary culture of skeletal muscle cells from patients with type 2 diabetes. Diabetes 52:1319-1325
    • (2003) Diabetes , vol.52 , pp. 1319-1325
    • Bouzakri, K.1    Roques, M.2    Gual, P.3
  • 29
    • 0026723385 scopus 로고
    • Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM
    • Garvey WT, Maianu L, Hancock JA, Golichowski AM, Baron A (1992) Gene expression of GLUT4 in skeletal muscle from insulin-resistant patients with obesity, IGT, GDM, and NIDDM. Diabetes 41:465-475
    • (1992) Diabetes , vol.41 , pp. 465-475
    • Garvey, W.T.1    Maianu, L.2    Hancock, J.A.3    Golichowski, A.M.4    Baron, A.5
  • 30
    • 0037494999 scopus 로고    scopus 로고
    • Insulin action in cultured human skeletal muscle cells during differentiation: Assessment of cell surface GLUT4 and GLUT1 content
    • Al-Khalili L, Chibalin AV, Kannisto K et al. (2003) Insulin action in cultured human skeletal muscle cells during differentiation: assessment of cell surface GLUT4 and GLUT1 content. Cell Mol Life Sci 60:991-998
    • (2003) Cell Mol Life Sci , vol.60 , pp. 991-998
    • Al-Khalili, L.1    Chibalin, A.V.2    Kannisto, K.3
  • 31
    • 0036434431 scopus 로고    scopus 로고
    • Insulin regulation of glucose uptake: A complex interplay of intracellular signalling pathways
    • Khan AH, Pessin JE (2002) Insulin regulation of glucose uptake: a complex interplay of intracellular signalling pathways. Diabetologia 45:1475-1483
    • (2002) Diabetologia , vol.45 , pp. 1475-1483
    • Khan, A.H.1    Pessin, J.E.2
  • 32
    • 15844389443 scopus 로고    scopus 로고
    • Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action
    • Mothe I, Van Obberghen E (1996) Phosphorylation of insulin receptor substrate-1 on multiple serine residues, 612, 632, 662, and 731, modulates insulin action. J Biol Chem 271:11222-11227
    • (1996) J Biol Chem , vol.271 , pp. 11222-11227
    • Mothe, I.1    Van Obberghen, E.2
  • 33
    • 0036092239 scopus 로고    scopus 로고
    • Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes
    • McGarry JD (2002) Dysregulation of fatty acid metabolism in the etiology of type 2 diabetes. Diabetes 51:7-18
    • (2002) Diabetes , vol.51 , pp. 7-18
    • McGarry, J.D.1
  • 34
    • 0033927667 scopus 로고    scopus 로고
    • Cellular mechanisms of insulin resistance
    • Shulman GI (2000) Cellular mechanisms of insulin resistance. J Clin Invest 102:171-176
    • (2000) J Clin Invest , vol.102 , pp. 171-176
    • Shulman, G.I.1
  • 36
    • 0037184925 scopus 로고    scopus 로고
    • Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle
    • Yu C, Chen Y, Cline GW et al. (2002) Mechanism by which fatty acids inhibit insulin activation of insulin receptor substrate-1 (IRS-1)-associated phosphatidylinositol 3-kinase activity in muscle. J Biol Chem 277:50230-50236
    • (2002) J Biol Chem , vol.277 , pp. 50230-50236
    • Yu, C.1    Chen, Y.2    Cline, G.W.3
  • 37
    • 0035141142 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: Comparison with PPAR-gamma activation
    • Ye JM, Doyle PJ, Iglesias MA, Watson DG, Cooney GJ, Kraegen EW (2001) Peroxisome proliferator-activated receptor (PPAR)-alpha activation lowers muscle lipids and improves insulin sensitivity in high fat-fed rats: comparison with PPAR-gamma activation. Diabetes 50:411-417
    • (2001) Diabetes , vol.50 , pp. 411-417
    • Ye, J.M.1    Doyle, P.J.2    Iglesias, M.A.3    Watson, D.G.4    Cooney, G.J.5    Kraegen, E.W.6
  • 38
    • 0036224157 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells
    • Muoio DM, Way JM, Tanner CJ et al. (2002) Peroxisome proliferator- activated receptor-alpha regulates fatty acid utilization in primary human skeletal muscle cells. Diabetes 51:901-909
    • (2002) Diabetes , vol.51 , pp. 901-909
    • Muoio, D.M.1    Way, J.M.2    Tanner, C.J.3
  • 39
    • 0033305213 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptors: Nuclear control of metabolism
    • Desvergne B, Wahli W (1999) Peroxisome proliferator-activated receptors: nuclear control of metabolism. Endocr Rev 20:649-688
    • (1999) Endocr Rev , vol.20 , pp. 649-688
    • Desvergne, B.1    Wahli, W.2
  • 40
    • 0027959552 scopus 로고
    • Human and rat peroxisome proliferator-activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators
    • Mukherjee R, Jow L, Noonan D, McDonnell DP (1994) Human and rat peroxisome proliferator-activated receptors (PPARs) demonstrate similar tissue distribution but different responsiveness to PPAR activators. J Steroid Biochem Mol Biol 51:157-166
    • (1994) J Steroid Biochem Mol Biol , vol.51 , pp. 157-166
    • Mukherjee, R.1    Jow, L.2    Noonan, D.3    McDonnell, D.P.4
  • 41
    • 0030854677 scopus 로고    scopus 로고
    • PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents
    • Keller H, Devchand PR, Perroud M, Wahli W (1997) PPAR alpha structure-function relationships derived from species-specific differences in responsiveness to hypolipidemic agents. Biol Chem 378:651-655
    • (1997) Biol Chem , vol.378 , pp. 651-655
    • Keller, H.1    Devchand, P.R.2    Perroud, M.3    Wahli, W.4
  • 42
    • 0035172839 scopus 로고    scopus 로고
    • Thiazolidinediones (PPARgamma agonists) but not PPARalpha agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes
    • Smith U, Gogg S, Johansson A, Olausson T, Rotter V, Svalstedt B (2001) Thiazolidinediones (PPARgamma agonists) but not PPARalpha agonists increase IRS-2 gene expression in 3T3-L1 and human adipocytes. FASEB J 15:215-220
    • (2001) FASEB J , vol.15 , pp. 215-220
    • Smith, U.1    Gogg, S.2    Johansson, A.3    Olausson, T.4    Rotter, V.5    Svalstedt, B.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.