-
1
-
-
0028139089
-
Positional cloning of the mouse obese gene and its human homologue
-
Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994; 372: 425-432.
-
(1994)
Nature
, vol.372
, pp. 425-432
-
-
Zhang, Y.1
Proenca, R.2
Maffei, M.3
Barone, M.4
Leopold, L.5
Friedman, J.M.6
-
2
-
-
0028863211
-
Structural organization and chromosomal assignment of the human obese gene
-
Isse N, Ogawa Y, Tamura N, Masuzaki H, Mori K, Okazaki T, Satoh N, Shigemoto M, Yoshimasa Y, Nishi S. Structural organization and chromosomal assignment of the human obese gene. J Biol Chem 1995; 270: 27728-27733.
-
(1995)
J Biol Chem
, vol.270
, pp. 27728-27733
-
-
Isse, N.1
Ogawa, Y.2
Tamura, N.3
Masuzaki, H.4
Mori, K.5
Okazaki, T.6
Satoh, N.7
Shigemoto, M.8
Yoshimasa, Y.9
Nishi, S.10
-
3
-
-
84960613492
-
Obese, a new mutation in the house mouse
-
Ingalls AM, Dickie MM, Snell GD. Obese, a new mutation in the house mouse. J Hered 1950; 41: 317-318.
-
(1950)
J Hered
, vol.41
, pp. 317-318
-
-
Ingalls, A.M.1
Dickie, M.M.2
Snell, G.D.3
-
4
-
-
0014004384
-
Diabetes, a new mutation in the mouse
-
Hummel KP, DICKIE MM, Coleman DL. Diabetes, a new mutation in the mouse. Science 1966; 153: 1127-1128.
-
(1966)
Science
, vol.153
, pp. 1127-1128
-
-
Hummel, K.P.1
Dickie, M.M.2
Coleman, D.L.3
-
5
-
-
2442654859
-
Identification and expression cloning of a leptin receptor, OBR
-
Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Wool EA, Monroe CA, Tepper RI. Identification and expression cloning of a leptin receptor, OBR. Cell 1995; 83: 1263-1271.
-
(1995)
Cell
, vol.83
, pp. 1263-1271
-
-
Tartaglia, L.A.1
Dembski, M.2
Weng, X.3
Deng, N.4
Culpepper, J.5
Devos, R.6
Richards, G.J.7
Campfield, L.A.8
Clark, F.T.9
Deeds, J.10
Muir, C.11
Sanker, S.12
Moriarty, A.13
Moore, K.J.14
Smutko, J.S.15
Mays, G.G.16
Wool, E.A.17
Monroe, C.A.18
Tepper, R.I.19
-
6
-
-
0014608866
-
Effects of parabiosis of normal with genetically diabetic mice
-
Coleman DL, Hummel KP. Effects of parabiosis of normal with genetically diabetic mice. Am J Physiol 1969; 217: 1298-1304.
-
(1969)
Am J Physiol
, vol.217
, pp. 1298-1304
-
-
Coleman, D.L.1
Hummel, K.P.2
-
7
-
-
0015792424
-
Effects of parabiosis of obese with diabetes and normal mice
-
Coleman DL. Effects of parabiosis of obese with diabetes and normal mice. Diabetologia 1973; 9: 294-298.
-
(1973)
Diabetologia
, vol.9
, pp. 294-298
-
-
Coleman, D.L.1
-
8
-
-
13344259300
-
Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice
-
Chen H, Charlat O, Tartaglia LA, Woolf EA, Weng X, Ellis SJ, Lakey ND, Culpepper J, Moore KJ, Breitbart RE, Duyk GM, Tepper RI, Morgenstern JP. Evidence that the diabetes gene encodes the leptin receptor: identification of a mutation in the leptin receptor gene in db/db mice. Cell 1996; 84: 491-495.
-
(1996)
Cell
, vol.84
, pp. 491-495
-
-
Chen, H.1
Charlat, O.2
Tartaglia, L.A.3
Woolf, E.A.4
Weng, X.5
Ellis, S.J.6
Lakey, N.D.7
Culpepper, J.8
Moore, K.J.9
Breitbart, R.E.10
Duyk, G.M.11
Tepper, R.I.12
Morgenstern, J.P.13
-
9
-
-
0030028959
-
Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor
-
Chua SC Jr, Chung WK, Wu-Peng XS, Zhang Y, Liu SM, Tartaglia L, Leibel RL. Phenotypes of mouse diabetes and rat fatty due to mutations in the OB (leptin) receptor. Science 1996; 271: 994-996.
-
(1996)
Science
, vol.271
, pp. 994-996
-
-
Chua, S.C.1
Chung, W.K.2
Wu-Peng, X.S.3
Zhang, Y.4
Liu, S.M.5
Tartaglia, L.6
Leibel, R.L.7
-
10
-
-
0030015417
-
Defective STAT signaling by the leptin receptor in diabetic mice
-
Ghilardi N, Ziegler S, Wiestner A, Stoffel R, Heim MH, Skoda RC. Defective STAT signaling by the leptin receptor in diabetic mice. Proc Natl Acad Sci USA 1996; 93: 6231-6235.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 6231-6235
-
-
Ghilardi, N.1
Ziegler, S.2
Wiestner, A.3
Stoffel, R.4
Heim, M.H.5
Skoda, R.C.6
-
11
-
-
0030039272
-
Abnormal splicing of the leptin receptor in diabetic mice
-
Lee GH, Proenca R, Montez JM, Carroll KM, Darvishzadeh JG, Lee JI, Friedman JM. Abnormal splicing of the leptin receptor in diabetic mice. Nature 1996; 379: 632-635.
-
(1996)
Nature
, vol.379
, pp. 632-635
-
-
Lee, G.H.1
Proenca, R.2
Montez, J.M.3
Carroll, K.M.4
Darvishzadeh, J.G.5
Lee, J.I.6
Friedman, J.M.7
-
12
-
-
0029739826
-
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ ob mice but not db/db mice
-
Vaisse C, Halaas JL, Horvath CM, Darnell JE Jr, Stoffel M, Friedman JM. Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ ob mice but not db/db mice. Nat Genet 1996; 14: 95-97.
-
(1996)
Nat Genet
, vol.14
, pp. 95-97
-
-
Vaisse, C.1
Halaas, J.L.2
Horvath, C.M.3
Darnell, J.E.4
Stoffel, M.5
Friedman, J.M.6
-
13
-
-
0029073613
-
Weight-reducing effects of the plasma protein encoded by the obese gene
-
Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM. Weight-reducing effects of the plasma protein encoded by the obese gene. Science 1995; 269: 543-546.
-
(1995)
Science
, vol.269
, pp. 543-546
-
-
Halaas, J.L.1
Gajiwala, K.S.2
Maffei, M.3
Cohen, S.L.4
Chait, B.T.5
Rabinowitz, D.6
Lallone, R.L.7
Burley, S.K.8
Friedman, J.M.9
-
14
-
-
0029066265
-
Effects of the obese gene product on body weight regulation in ob/ob mice
-
Pelleymounter MA, Cullen MJ, Baker MB, Hecht R, Winters D, Boone T, Collins F. Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995; 269: 540-543.
-
(1995)
Science
, vol.269
, pp. 540-543
-
-
Pelleymounter, M.A.1
Cullen, M.J.2
Baker, M.B.3
Hecht, R.4
Winters, D.5
Boone, T.6
Collins, F.7
-
15
-
-
0029088115
-
Recombinant ob -gene product reduces food intake in fasted mice
-
Rentsch J, Levens N, Chiesi M. Recombinant ob -gene product reduces food intake in fasted mice. Biochem Biophys Res Commun 1995; 214: 131-136.
-
(1995)
Biochem Biophys Res Commun
, vol.214
, pp. 131-136
-
-
Rentsch, J.1
Levens, N.2
Chiesi, M.3
-
16
-
-
0030977992
-
Crystal structure of the obese protein leptin-E100
-
Zhang F, Basinski MB, Beals JM, Briggs SL, Churgay LM, Clawson DK, DiMarchi RD, Furman TC, Hale JE, Hsiung HM, Schoner BE, Smith DP, Zhang XY, Wery JP, Schevitz RW. Crystal structure of the obese protein leptin-E100. Nature 1997; 387: 206-209.
-
(1997)
Nature
, vol.387
, pp. 206-209
-
-
Zhang, F.1
Basinski, M.B.2
Beals, J.M.3
Briggs, S.L.4
Churgay, L.M.5
Clawson, D.K.6
DiMarchi, R.D.7
Furman, T.C.8
Hale, J.E.9
Hsiung, H.M.10
Schoner, B.E.11
Smith, D.P.12
Zhang, X.Y.13
Wery, J.P.14
Schevitz, R.W.15
-
17
-
-
0026598960
-
Human growth hormone and extracellular domain of its receptor: Crystal structure of the complex
-
de Vos AM, Ultsch M, Kossiakoff AA. Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 1992; 255: 306-312.
-
(1992)
Science
, vol.255
, pp. 306-312
-
-
de Vos, A.M.1
Ultsch, M.2
Kossiakoff, A.A.3
-
18
-
-
0028363673
-
The crystal structure and biological function of leukemia inhibitory factor: Implications for receptor binding
-
Robinson RC, Grey LM, Staunton D, Vankelecom H, Vernallis AB, Moreau JF, Stuart DI, Heath JK, Jones EY. The crystal structure and biological function of leukemia inhibitory factor: implications for receptor binding. Cell 1994; 77: 1101-1116.
-
(1994)
Cell
, vol.77
, pp. 1101-1116
-
-
Robinson, R.C.1
Grey, L.M.2
Staunton, D.3
Vankelecom, H.4
Vernallis, A.B.5
Moreau, J.F.6
Stuart, D.I.7
Heath, J.K.8
Jones, E.Y.9
-
19
-
-
0027251453
-
Crystal structure of a ubiquitin-dependent degradation substrate: A three-disulfide form of lysozyme
-
Hill CP, Johnston NL, Cohen RE. Crystal structure of a ubiquitin-dependent degradation substrate: a three-disulfide form of lysozyme. Proc Natl Acad Sci USA 1993; 90: 4136-4140.
-
(1993)
Proc Natl Acad Sci USA
, vol.90
, pp. 4136-4140
-
-
Hill, C.P.1
Johnston, N.L.2
Cohen, R.E.3
-
20
-
-
0030982940
-
Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes
-
Mandrup S, Loftus TM, MacDougald OA, Kuhajda FP, Lane MD. Obese gene expression at in vivo levels by fat pads derived from s.c. implanted 3T3-F442A preadipocytes. Proc Natl Acad Sci USA 1997; 94: 4300-4305.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4300-4305
-
-
Mandrup, S.1
Loftus, T.M.2
MacDougald, O.A.3
Kuhajda, F.P.4
Lane, M.D.5
-
21
-
-
0028793697
-
Leptin levels reflect body lipid content in mice: Evidence for diet-induced resistance to leptin action
-
Frederich RC, Hamann A, Anderson S, Lollmann B, Lowell BB, Flier JS. Leptin levels reflect body lipid content in mice: evidence for diet-induced resistance to leptin action. Nat Med 1995; 1: 1311-1314.
-
(1995)
Nat Med
, vol.1
, pp. 1311-1314
-
-
Frederich, R.C.1
Hamann, A.2
Anderson, S.3
Lollmann, B.4
Lowell, B.B.5
Flier, J.S.6
-
22
-
-
0028845877
-
Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects
-
Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S. Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med 1995; 1: 1155-1161.
-
(1995)
Nat Med
, vol.1
, pp. 1155-1161
-
-
Maffei, M.1
Halaas, J.2
Ravussin, E.3
Pratley, R.E.4
Lee, G.H.5
Zhang, Y.6
Fei, H.7
Kim, S.8
Lallone, R.9
Ranganathan, S.10
-
23
-
-
0029090011
-
Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue
-
Masuzaki H, Ogawa Y, Isse N, Satoh N, Okazaki T, Shigemoto M, Mori K, Tamura N, Hosoda K, Yoshimasa Y. Human obese gene expression. Adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995; 44: 855-858.
-
(1995)
Diabetes
, vol.44
, pp. 855-858
-
-
Masuzaki, H.1
Ogawa, Y.2
Isse, N.3
Satoh, N.4
Okazaki, T.5
Shigemoto, M.6
Mori, K.7
Tamura, N.8
Hosoda, K.9
Yoshimasa, Y.10
-
24
-
-
0030453726
-
Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans
-
Hube F, Lietz U, Igel M, Jensen PB, Tornqvist H, Joost HG, Hauner H. Difference in leptin mRNA levels between omental and subcutaneous abdominal adipose tissue from obese humans. Horm Metab Res 1996; 28: 690-693.
-
(1996)
Horm Metab Res
, vol.28
, pp. 690-693
-
-
Hube, F.1
Lietz, U.2
Igel, M.3
Jensen, P.B.4
Tornqvist, H.5
Joost, H.G.6
Hauner, H.7
-
25
-
-
0031054698
-
Depot- and sex-specific differences in human leptin mRNA expression: Implications for the control of regional fat distribution
-
Montague CT, Prins JB, Sanders L, Digby JE, O'Rahilly S. Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution. Diabetes 1997; 46: 342-347.
-
(1997)
Diabetes
, vol.46
, pp. 342-347
-
-
Montague, C.T.1
Prins, J.B.2
Sanders, L.3
Digby, J.E.4
O'Rahilly, S.5
-
26
-
-
0031802865
-
Leptin secretion from subcutaneous and visceral adipose tissue in women
-
Van HV, Reynisdottir S, Eriksson P, Thorne A, Hoffstedt J, Lonnqvist F, Arner P. Leptin secretion from subcutaneous and visceral adipose tissue in women. Diabetes 1998; 47: 913-917.
-
(1998)
Diabetes
, vol.47
, pp. 913-917
-
-
Van, H.V.1
Reynisdottir, S.2
Eriksson, P.3
Thorne, A.4
Hoffstedt, J.5
Lonnqvist, F.6
Arner, P.7
-
27
-
-
0029050937
-
Overexpression of the obese (ob) gene in adipose tissue of human obese subjects
-
Lonnqvist F, Arner P, Nordfors L, Schalling M. Overexpression of the obese (ob) gene in adipose tissue of human obese subjects. Nat Med 1995; 1: 950-953.
-
(1995)
Nat Med
, vol.1
, pp. 950-953
-
-
Lonnqvist, F.1
Arner, P.2
Nordfors, L.3
Schalling, M.4
-
28
-
-
0029816596
-
Effects of gender, body composition, and menopause on plasma concentrations of leptin
-
Rosenbaum M, Nicolson M, Hirsch J, Heymsfield SB, Gallagher D, Chu F, Leibel RL. Effects of gender, body composition, and menopause on plasma concentrations of leptin. J Clin Endocrinol Metab 1996; 81: 3424-3427.
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 3424-3427
-
-
Rosenbaum, M.1
Nicolson, M.2
Hirsch, J.3
Heymsfield, S.B.4
Gallagher, D.5
Chu, F.6
Leibel, R.L.7
-
29
-
-
0030936047
-
The metabolic significance of leptin in humans: Gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure
-
Kennedy A, Gettys TW, Watson P, Wallace P, Ganaway E, Pan Q, Garvey WT. The metabolic significance of leptin in humans: gender-based differences in relationship to adiposity, insulin sensitivity, and energy expenditure. J Clin Endocrinol Metab 1997; 82: 1293-1300.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 1293-1300
-
-
Kennedy, A.1
Gettys, T.W.2
Watson, P.3
Wallace, P.4
Ganaway, E.5
Pan, Q.6
Garvey, W.T.7
-
30
-
-
0032552112
-
The stomach is a source of leptin
-
Bado A, Levasseur S, Attoub S, Kermorgant S, Laigneau JP, Bortoluzzi MN, Moizo L, Lehy T, Guerre-Millo M, Le Marchand-Brustel Y, Lewin MJ. The stomach is a source of leptin. Nature 1998; 394: 790-793.
-
(1998)
Nature
, vol.394
, pp. 790-793
-
-
Bado, A.1
Levasseur, S.2
Attoub, S.3
Kermorgant, S.4
Laigneau, J.P.5
Bortoluzzi, M.N.6
Moizo, L.7
Lehy, T.8
Guerre-Millo, M.9
Le Marchand-Brustel, Y.10
Lewin, M.J.11
-
31
-
-
0033930048
-
Leptin secretion and leptin receptor in the human stomach
-
Sobhani I, Bado A, Vissuzaine C, Buyse M, Kermorgant S, Laigneau JP, Attoub S, Lehy T, Henin D, Mignon M, Lewin MJ. Leptin secretion and leptin receptor in the human stomach. Gut 2000; 47: 178-183.
-
(2000)
Gut
, vol.47
, pp. 178-183
-
-
Sobhani, I.1
Bado, A.2
Vissuzaine, C.3
Buyse, M.4
Kermorgant, S.5
Laigneau, J.P.6
Attoub, S.7
Lehy, T.8
Henin, D.9
Mignon, M.10
Lewin, M.J.11
-
32
-
-
0031724837
-
Leptin expression in human mammary epithelial cells and breast milk
-
Smith-Kirwin SM, O'Connor DM, De JJ, Lancey ED, Hassink SG, Funanage VL. Leptin expression in human mammary epithelial cells and breast milk. J Clin Endocrinol Metab 1998; 83: 1810-1813.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 1810-1813
-
-
Smith-Kirwin, S.M.1
O'Connor, D.M.2
De, J.J.3
Lancey, E.D.4
Hassink, S.G.5
Funanage, V.L.6
-
33
-
-
0030866843
-
Nonadipose tissue production of leptin: Leptin as a novel placenta- derived hormone in humans
-
Masuzaki H, Ogawa Y, Sagawa N, Hosoda K, Matsumoto T, Mise H, Nishimura H, Yoshimasa Y, Tanaka I, Mori T, Nakao K. Nonadipose tissue production of leptin: leptin as a novel placenta- derived hormone in humans. Nat Med 1997; 3: 1029-1033.
-
(1997)
Nat Med
, vol.3
, pp. 1029-1033
-
-
Masuzaki, H.1
Ogawa, Y.2
Sagawa, N.3
Hosoda, K.4
Matsumoto, T.5
Mise, H.6
Nishimura, H.7
Yoshimasa, Y.8
Tanaka, I.9
Mori, T.10
Nakao, K.11
-
34
-
-
0030007116
-
Novel B219/OB receptor isoforms: Possible role of leptin in hematopoiesis and reproduction
-
Cioffi JA, Shafer AW, Zupancic TJ, Smith-Gbur J, Mikhail A, Platika D, Snodgrass HR. Novel B219/OB receptor isoforms: possible role of leptin in hematopoiesis and reproduction. Nat Med 1996; 2: 585-589.
-
(1996)
Nat Med
, vol.2
, pp. 585-589
-
-
Cioffi, J.A.1
Shafer, A.W.2
Zupancic, T.J.3
Smith-Gbur, J.4
Mikhail, A.5
Platika, D.6
Snodgrass, H.R.7
-
36
-
-
0032543680
-
A nutrient-sensing pathway regulates leptin gene expression in muscle and fat
-
Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L. A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 1998; 393: 684-688.
-
(1998)
Nature
, vol.393
, pp. 684-688
-
-
Wang, J.1
Liu, R.2
Hawkins, M.3
Barzilai, N.4
Rossetti, L.5
-
37
-
-
0033304752
-
Leptin gene expression in the brain and pituitary gland
-
Morash B, Li A, Murphy PR, Wilkinson M, Ur E. Leptin gene expression in the brain and pituitary gland. Endocrinology 1999; 140: 5995- 5998.
-
(1999)
Endocrinology
, vol.140
, pp. 5995-5998
-
-
Morash, B.1
Li, A.2
Murphy, P.R.3
Wilkinson, M.4
Ur, E.5
-
38
-
-
0033525137
-
Leptin immunoreactivity in the central nervous system in normal and diabetic rats
-
Li HY, Wang LL, Yeh RS. Leptin immunoreactivity in the central nervous system in normal and diabetic rats. Neuroreport 1999; 10: 437-442.
-
(1999)
Neuroreport
, vol.10
, pp. 437-442
-
-
Li, H.Y.1
Wang, L.L.2
Yeh, R.S.3
-
41
-
-
13344295079
-
Serum immunoreactive- leptin concentrations in normalweight and obese humans
-
Considine RV, Sinha MK, Heiman ML, Kriauciunas A, Stephens TW, Nyce MR, Ohannesian JP, Marco CC, McKee LJ, Bauer TL. Serum immunoreactive- leptin concentrations in normalweight and obese humans. N Engl J Med 1996; 334: 292-295.
-
(1996)
N Engl J Med
, vol.334
, pp. 292-295
-
-
Considine, R.V.1
Sinha, M.K.2
Heiman, M.L.3
Kriauciunas, A.4
Stephens, T.W.5
Nyce, M.R.6
Ohannesian, J.P.7
Marco, C.C.8
McKee, L.J.9
Bauer, T.L.10
-
42
-
-
0031587418
-
In vitro lipolytic effect of leptin on mouse adipocytes: Evidence for a possible autocrine/paracrine role of leptin
-
Fruhbeck G, Aguado M, Martinez JA. In vitro lipolytic effect of leptin on mouse adipocytes: evidence for a possible autocrine/paracrine role of leptin. Biochem Biophys Res Commun 1997; 240: 590-594.
-
(1997)
Biochem Biophys Res Commun
, vol.240
, pp. 590-594
-
-
Fruhbeck, G.1
Aguado, M.2
Martinez, J.A.3
-
43
-
-
0042221558
-
Ultradian oscillations of leptin secretion in humans
-
Sinha MK, Sturis J, Ohannesian J, Magosin S, Stephens T, Heiman ML, Polonsky KS, Caro JF. Ultradian oscillations of leptin secretion in humans. Biochem Biophys Res Commun 1996; 228: 733-738.
-
(1996)
Biochem Biophys Res Commun
, vol.228
, pp. 733-738
-
-
Sinha, M.K.1
Sturis, J.2
Ohannesian, J.3
Magosin, S.4
Stephens, T.5
Heiman, M.L.6
Polonsky, K.S.7
Caro, J.F.8
-
44
-
-
0030885398
-
Entrainment of the diurnal rhythm of plasma leptin to meal timing
-
Schoeller DA, Cella LK, Sinha MK, Caro JF. Entrainment of the diurnal rhythm of plasma leptin to meal timing. J Clin Invest 1997; 100: 1882-1887.
-
(1997)
J Clin Invest
, vol.100
, pp. 1882-1887
-
-
Schoeller, D.A.1
Cella, L.K.2
Sinha, M.K.3
Caro, J.F.4
-
45
-
-
16944364768
-
Human leptin levels are pulsatile and inversely related to pituitaryadrenal function
-
Licinio J, Mantzoros C, Negrao AB, Cizza G, Wong ML, Bongiorno PB, Chrousos GP, Karp B, Allen C, Flier JS, Gold PW. Human leptin levels are pulsatile and inversely related to pituitaryadrenal function. Nat Med 1997; 3: 575-579.
-
(1997)
Nat Med
, vol.3
, pp. 575-579
-
-
Licinio, J.1
Mantzoros, C.2
Negrao, A.B.3
Cizza, G.4
Wong, M.L.5
Bongiorno, P.B.6
Chrousos, G.P.7
Karp, B.8
Allen, C.9
Flier, J.S.10
Gold, P.W.11
-
47
-
-
0029964871
-
Responses of leptin to short-term fasting and refeeding in humans: A link with ketogenesis but not ketones themselves
-
Kolaczynski JW, Considine RV, Ohannesian J, Marco C, Opentanova I, Nyce MR, Myint M, Caro JF. Responses of leptin to short-term fasting and refeeding in humans: a link with ketogenesis but not ketones themselves. Diabetes 1996; 45: 1511-1515.
-
(1996)
Diabetes
, vol.45
, pp. 1511-1515
-
-
Kolaczynski, J.W.1
Considine, R.V.2
Ohannesian, J.3
Marco, C.4
Opentanova, I.5
Nyce, M.R.6
Myint, M.7
Caro, J.F.8
-
48
-
-
0030735128
-
Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women
-
Grinspoon SK, Askari H, Landt ML, Nathan DM, Schoenfeld DA, Hayden DL, Laposata M, Hubbard J, Klibanski A. Effects of fasting and glucose infusion on basal and overnight leptin concentrations in normal-weight women. Am J Clin Nutr 1997; 66: 1352-1356.
-
(1997)
Am J Clin Nutr
, vol.66
, pp. 1352-1356
-
-
Grinspoon, S.K.1
Askari, H.2
Landt, M.L.3
Nathan, D.M.4
Schoenfeld, D.A.5
Hayden, D.L.6
Laposata, M.7
Hubbard, J.8
Klibanski, A.9
-
49
-
-
0029166158
-
Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (oblob) mice
-
Trayhurn P, Thomas ME, Duncan JS, Rayner DV. Effects of fasting and refeeding on ob gene expression in white adipose tissue of lean and obese (oblob) mice. FEBS Lett 1995; 368: 488-490.
-
(1995)
FEBS Lett
, vol.368
, pp. 488-490
-
-
Trayhurn, P.1
Thomas, M.E.2
Duncan, J.S.3
Rayner, D.V.4
-
50
-
-
0030601101
-
Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA
-
Hardie LJ, Rayner DV, Holmes S, Trayhurn P. Circulating leptin levels are modulated by fasting, cold exposure and insulin administration in lean but not Zucker (fa/fa) rats as measured by ELISA. Biochem Biophys Res Commun 1996; 223: 660-665.
-
(1996)
Biochem Biophys Res Commun
, vol.223
, pp. 660-665
-
-
Hardie, L.J.1
Rayner, D.V.2
Holmes, S.3
Trayhurn, P.4
-
51
-
-
0029157428
-
Transient increase in obese gene expression after food intake or insulin administration
-
Saladin R, De VP, Guerre-Millo M, Leturque A, Girard J, Staels B, Auwerx J. Transient increase in obese gene expression after food intake or insulin administration. Nature 1995; 377: 527- 529.
-
(1995)
Nature
, vol.377
, pp. 527-529
-
-
Saladin, R.1
De, V.P.2
Guerre-Millo, M.3
Leturque, A.4
Girard, J.5
Staels, B.6
Auwerx, J.7
-
52
-
-
0030063976
-
Expression of ob gene in adipose cells. Regulation by insulin
-
Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM, Ailhaud G, Dani C. Expression of ob gene in adipose cells. Regulation by insulin. J Biol Chem 1996; 271: 2365-2368.
-
(1996)
J Biol Chem
, vol.271
, pp. 2365-2368
-
-
Leroy, P.1
Dessolin, S.2
Villageois, P.3
Moon, B.C.4
Friedman, J.M.5
Ailhaud, G.6
Dani, C.7
-
53
-
-
0029784397
-
Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects
-
Utriainen T, Malmstrom R, Makimattila S, Yki- Jarvinen H. Supraphysiological hyperinsulinemia increases plasma leptin concentrations after 4 h in normal subjects. Diabetes 1996; 45: 1364-1366.
-
(1996)
Diabetes
, vol.45
, pp. 1364-1366
-
-
Utriainen, T.1
Malmstrom, R.2
Makimattila, S.3
Yki-Jarvinen, H.4
-
54
-
-
0032059793
-
Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men
-
Mantzoros CS, Liolios AD, Tritos NA, Kaklamani VG, Doulgerakis DE, Griveas I, Moses AC, Flier JS. Circulating insulin concentrations, smoking, and alcohol intake are important independent predictors of leptin in young healthy men. Obes Res 1998; 6: 179-186.
-
(1998)
Obes Res
, vol.6
, pp. 179-186
-
-
Mantzoros, C.S.1
Liolios, A.D.2
Tritos, N.A.3
Kaklamani, V.G.4
Doulgerakis, D.E.5
Griveas, I.6
Moses, A.C.7
Flier, J.S.8
-
55
-
-
0031954415
-
Physiological insulinemia acutely modulates plasma leptin
-
Saad MF, Khan A, Sharma A, Michael R, Riad-Gabriel MG, Boyadjian R, Jinagouda SD, Steil GM, Kamdar V. Physiological insulinemia acutely modulates plasma leptin. Diabetes 1998; 47: 544-549.
-
(1998)
Diabetes
, vol.47
, pp. 544-549
-
-
Saad, M.F.1
Khan, A.2
Sharma, A.3
Michael, R.4
Riad-Gabriel, M.G.5
Boyadjian, R.6
Jinagouda, S.D.7
Steil, G.M.8
Kamdar, V.9
-
56
-
-
0030452084
-
Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects
-
Miell JP, Englaro P, Blum WF. Dexamethasone induces an acute and sustained rise in circulating leptin levels in normal human subjects. Horm Metab Res 1996; 28: 704-707.
-
(1996)
Horm Metab Res
, vol.28
, pp. 704-707
-
-
Miell, J.P.1
Englaro, P.2
Blum, W.F.3
-
57
-
-
0029976448
-
Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP
-
Slieker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW. Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J Biol Chem 1996; 271: 5301-5304.
-
(1996)
J Biol Chem
, vol.271
, pp. 5301-5304
-
-
Slieker, L.J.1
Sloop, K.W.2
Surface, P.L.3
Kriauciunas, A.4
LaQuier, F.5
Manetta, J.6
Bue-Valleskey, J.7
Stephens, T.W.8
-
58
-
-
0030847432
-
Acute stimulation of glucose metabolism in mice by leptin treatment
-
Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ. Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 1997; 389: 374-377.
-
(1997)
Nature
, vol.389
, pp. 374-377
-
-
Kamohara, S.1
Burcelin, R.2
Halaas, J.L.3
Friedman, J.M.4
Charron, M.J.5
-
59
-
-
0033969577
-
Tumour necrosis factor-alpha exerts dual effects on human adipose leptin synthesis and release
-
Zhang HH, Kumar S, Barnett AH, Eggo MC. Tumour necrosis factor-alpha exerts dual effects on human adipose leptin synthesis and release. Mol Cell Endocrinol 2000; 159: 79-88.
-
(2000)
Mol Cell Endocrinol
, vol.159
, pp. 79-88
-
-
Zhang, H.H.1
Kumar, S.2
Barnett, A.H.3
Eggo, M.C.4
-
60
-
-
0030811942
-
Estrogen increases in vivo leptin production in rats and human subjects
-
Shimizu H, Shimomura Y, Nakanishi Y, Futawatari T, Ohtani K, Sato N, Mori M. Estrogen increases in vivo leptin production in rats and human subjects. J Endocrinol 1997; 154: 285- 292.
-
(1997)
J Endocrinol
, vol.154
, pp. 285-292
-
-
Shimizu, H.1
Shimomura, Y.2
Nakanishi, Y.3
Futawatari, T.4
Ohtani, K.5
Sato, N.6
Mori, M.7
-
61
-
-
0033019136
-
In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: Evidence for a regional specific regulation by sex steroid hormones
-
Machinal F, Dieudonne MN, Leneveu MC, Pecquery R, Giudicelli Y. In vivo and in vitro ob gene expression and leptin secretion in rat adipocytes: evidence for a regional specific regulation by sex steroid hormones. Endocrinology 1999; 140: 1567-1574.
-
(1999)
Endocrinology
, vol.140
, pp. 1567-1574
-
-
Machinal, F.1
Dieudonne, M.N.2
Leneveu, M.C.3
Pecquery, R.4
Giudicelli, Y.5
-
62
-
-
0033082293
-
Leptin mRNA expression and serum leptin concentrations as influenced by age, weight, and estradiol in pigs
-
Qian H, Barb CR, Compton MM, Hausman GJ, Azain MJ, Kraeling RR, Baile CA. Leptin mRNA expression and serum leptin concentrations as influenced by age, weight, and estradiol in pigs. Domest Anim Endocrinol 1999; 16: 135-143.
-
(1999)
Domest Anim Endocrinol
, vol.16
, pp. 135-143
-
-
Qian, H.1
Barb, C.R.2
Compton, M.M.3
Hausman, G.J.4
Azain, M.J.5
Kraeling, R.R.6
Baile, C.A.7
-
63
-
-
0029863684
-
Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters
-
Grunfeld C, Zhao C, Fuller J, Pollack A, Moser A, Friedman J, Feingold KR. Endotoxin and cytokines induce expression of leptin, the ob gene product, in hamsters. J Clin Invest 1996; 97: 2152-2157.
-
(1996)
J Clin Invest
, vol.97
, pp. 2152-2157
-
-
Grunfeld, C.1
Zhao, C.2
Fuller, J.3
Pollack, A.4
Moser, A.5
Friedman, J.6
Feingold, K.R.7
-
64
-
-
0030959788
-
Interleukin 1 alpha increases serum leptin concentrations in humans
-
Janik JE, Curti BD, Considine RV, Rager HC, Powers GC, Alvord WG, Smith JW, Gause BL, Kopp WC. Interleukin 1 alpha increases serum leptin concentrations in humans. J Clin Endocrinol Metab 1997; 82: 3084-3086.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 3084-3086
-
-
Janik, J.E.1
Curti, B.D.2
Considine, R.V.3
Rager, H.C.4
Powers, G.C.5
Alvord, W.G.6
Smith, J.W.7
Gause, B.L.8
Kopp, W.C.9
-
65
-
-
0030848557
-
Contribution of androgens to the gender difference in leptin production in obese children and adolescents
-
Wabitsch M, Blum WF, Muche R, Braun M, Hube F, Rascher W, Heinze E, Teller W, Hauner H. Contribution of androgens to the gender difference in leptin production in obese children and adolescents. J Clin Invest 1997; 100: 808-813.
-
(1997)
J Clin Invest
, vol.100
, pp. 808-813
-
-
Wabitsch, M.1
Blum, W.F.2
Muche, R.3
Braun, M.4
Hube, F.5
Rascher, W.6
Heinze, E.7
Teller, W.8
Hauner, H.9
-
66
-
-
0030937007
-
Regulation of in vivo growth hormone secretion by leptin
-
Carro E, Senaris R, Considine RV, Casanueva FF, Dieguez C. Regulation of in vivo growth hormone secretion by leptin. Endocrinology 1997; 138: 2203-2206.
-
(1997)
Endocrinology
, vol.138
, pp. 2203-2206
-
-
Carro, E.1
Senaris, R.2
Considine, R.V.3
Casanueva, F.F.4
Dieguez, C.5
-
67
-
-
0031858623
-
Serum leptin is suppressed by growth hormone therapy in growth hormonedeficient children
-
Rauch F, Westermann F, Englaro P, Blum WF, Schonau E. Serum leptin is suppressed by growth hormone therapy in growth hormonedeficient children. Horm Res 1998; 50: 18-21.
-
(1998)
Horm Res
, vol.50
, pp. 18-21
-
-
Rauch, F.1
Westermann, F.2
Englaro, P.3
Blum, W.F.4
Schonau, E.5
-
68
-
-
0004564368
-
Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion
-
Carro E, Senaris RM, Seoane LM, Frohman LA, Arimura A, Casanueva FF, Dieguez C. Role of growth hormone (GH)-releasing hormone and somatostatin on leptin-induced GH secretion. Neuroendocrinology 1999; 69: 3-10.
-
(1999)
Neuroendocrinology
, vol.69
, pp. 3-10
-
-
Carro, E.1
Senaris, R.M.2
Seoane, L.M.3
Frohman, L.A.4
Arimura, A.5
Casanueva, F.F.6
Dieguez, C.7
-
69
-
-
0033002926
-
Growth hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats
-
Isozaki O, Tsushima T, Miyakawa M, Nozoe Y, Demura H, Seki H. Growth hormone directly inhibits leptin gene expression in visceral fat tissue in fatty Zucker rats. J Endocrinol 1999; 161: 511-516.
-
(1999)
J Endocrinol
, vol.161
, pp. 511-516
-
-
Isozaki, O.1
Tsushima, T.2
Miyakawa, M.3
Nozoe, Y.4
Demura, H.5
Seki, H.6
-
70
-
-
0030735541
-
Isoproterenol and somatostatin decrease plasma leptin in humans: A novel mechanism regulating leptin secretion
-
Donahoo WT, Jensen DR, Yost TJ, Eckel RH. Isoproterenol and somatostatin decrease plasma leptin in humans: a novel mechanism regulating leptin secretion. J Clin Endocrinol Metab 1997; 82: 4139-4143.
-
(1997)
J Clin Endocrinol Metab
, vol.82
, pp. 4139-4143
-
-
Donahoo, W.T.1
Jensen, D.R.2
Yost, T.J.3
Eckel, R.H.4
-
71
-
-
0028826355
-
Acute coldinduced suppression of ob (obese) gene expression in white adipose tissue of mice: Mediation by the sympathetic system
-
Trayhurn P, Duncan JS, Rayner DV. Acute coldinduced suppression of ob (obese) gene expression in white adipose tissue of mice: mediation by the sympathetic system. Biochem J 1995; 311: 729-733.
-
(1995)
Biochem J
, vol.311
, pp. 729-733
-
-
Trayhurn, P.1
Duncan, J.S.2
Rayner, D.V.3
-
72
-
-
0343114363
-
Cold exposure inhibits leptin secretion in vitro by a direct and non-specific action on adipose tissue
-
Peino R, Pineiro V, Gualillo O, Menendez C, Brenlla J, Casabiell X, Dieguez C, Casanueva FF. Cold exposure inhibits leptin secretion in vitro by a direct and non-specific action on adipose tissue. Eur J Endocrinol 2000; 142: 195-199.
-
(2000)
Eur J Endocrinol
, vol.142
, pp. 195-199
-
-
Peino, R.1
Pineiro, V.2
Gualillo, O.3
Menendez, C.4
Brenlla, J.5
Casabiell, X.6
Dieguez, C.7
Casanueva, F.F.8
-
73
-
-
0030015246
-
Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptinindependent inhibition of food intake in mice
-
Mantzoros CS, Qu D, Frederich RC, Susulic VS, Lowell BB, Maratos-Flier E, Flier JS. Activation of beta(3) adrenergic receptors suppresses leptin expression and mediates a leptinindependent inhibition of food intake in mice. Diabetes 1996; 45: 909-914.
-
(1996)
Diabetes
, vol.45
, pp. 909-914
-
-
Mantzoros, C.S.1
Qu, D.2
Frederich, R.C.3
Susulic, V.S.4
Lowell, B.B.5
Maratos-Flier, E.6
Flier, J.S.7
-
74
-
-
0030581666
-
Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079
-
Trayhurn P, Duncan JS, Rayner DV, Hardie LJ. Rapid inhibition of ob gene expression and circulating leptin levels in lean mice by the beta 3-adrenoceptor agonists BRL 35135A and ZD2079. Biochem Biophys Res Commun 1996; 228: 605-610.
-
(1996)
Biochem Biophys Res Commun
, vol.228
, pp. 605-610
-
-
Trayhurn, P.1
Duncan, J.S.2
Rayner, D.V.3
Hardie, L.J.4
-
75
-
-
0029813768
-
The beta 3-adrenergic receptor inhibits insulinstimulated leptin secretion from isolated rat adipocytes
-
Gettys TW, Harkness PJ, Watson PM. The beta 3-adrenergic receptor inhibits insulinstimulated leptin secretion from isolated rat adipocytes. Endocrinology 1996; 137: 4054- 4057.
-
(1996)
Endocrinology
, vol.137
, pp. 4054-4057
-
-
Gettys, T.W.1
Harkness, P.J.2
Watson, P.M.3
-
76
-
-
0030786368
-
Beta 3- Adrenergic-mediated suppression of leptin gene expression in rats
-
Li H, Matheny M, Scarpace PJ. beta 3- Adrenergic-mediated suppression of leptin gene expression in rats. Am J Physiol 1997; 272: E1031-E1036.
-
(1997)
Am J Physiol
, vol.272
, pp. E1031-E1036
-
-
Li, H.1
Matheny, M.2
Scarpace, P.J.3
-
77
-
-
0029795319
-
Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women
-
Kohrt WM, Landt M, Birge SJ Jr. Serum leptin levels are reduced in response to exercise training, but not hormone replacement therapy, in older women. J Clin Endocrinol Metab 1996; 81: 3980-3985.
-
(1996)
J Clin Endocrinol Metab
, vol.81
, pp. 3980-3985
-
-
Kohrt, W.M.1
Landt, M.2
Birge, S.J.3
-
79
-
-
0029894050
-
Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes
-
Kallen CB, Lazar MA. Antidiabetic thiazolidinediones inhibit leptin (ob) gene expression in 3T3-L1 adipocytes. Proc Natl Acad Sci USA 1996; 93: 5793-5796.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 5793-5796
-
-
Kallen, C.B.1
Lazar, M.A.2
-
80
-
-
0031039824
-
Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture
-
Deng C, Moinat M, Curtis L, Nadakal A, Preitner F, Boss O, Assimacopoulos-Jeannet F, Seydoux J, Giacobino JP. Effects of beta-adrenoceptor subtype stimulation on obese gene messenger ribonucleic acid and on leptin secretion in mouse brown adipocytes differentiated in culture. Endocrinology 1997; 138: 548-552.
-
(1997)
Endocrinology
, vol.138
, pp. 548-552
-
-
Deng, C.1
Moinat, M.2
Curtis, L.3
Nadakal, A.4
Preitner, F.5
Boss, O.6
Assimacopoulos-Jeannet, F.7
Seydoux, J.8
Giacobino, J.P.9
-
81
-
-
0030942844
-
The leptin receptor
-
Tartaglia LA. The leptin receptor. J Biol Chem 1997; 272: 6093-6096.
-
(1997)
J Biol Chem
, vol.272
, pp. 6093-6096
-
-
Tartaglia, L.A.1
-
82
-
-
2342444310
-
Leptin receptor signaling and the regulation of mammalian physiology
-
Myers MG Jr. Leptin receptor signaling and the regulation of mammalian physiology. Recent Prog Horm Res 2004; 59: 287-304.
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 287-304
-
-
Myers, M.G.1
-
83
-
-
0025162844
-
Structural design and molecular evolution of a cytokine receptor superfamily
-
Bazan JF. Structural design and molecular evolution of a cytokine receptor superfamily. Proc Natl Acad Sci USA 1990; 87: 6934-6938.
-
(1990)
Proc Natl Acad Sci USA
, vol.87
, pp. 6934-6938
-
-
Bazan, J.F.1
-
84
-
-
0029084805
-
Interleukin- 6 family of cytokines and gp130
-
Kishimoto T, Akira S, Narazaki M, Taga T. Interleukin- 6 family of cytokines and gp130. Blood 1995; 86: 1243-1254.
-
(1995)
Blood
, vol.86
, pp. 1243-1254
-
-
Kishimoto, T.1
Akira, S.2
Narazaki, M.3
Taga, T.4
-
85
-
-
30044434035
-
Intracellular signalling pathways activated by leptin
-
Fruhbeck G. Intracellular signalling pathways activated by leptin. Biochem J 2006; 393: 7-20.
-
(2006)
Biochem J
, vol.393
, pp. 7-20
-
-
Fruhbeck, G.1
-
86
-
-
0034805384
-
Soluble leptin receptor represents the main leptin binding activity in human blood
-
Lammert A, Kiess W, Bottner A, Glasow A, Kratzsch J. Soluble leptin receptor represents the main leptin binding activity in human blood. Biochem Biophys Res Commun 2001; 283: 982-988.
-
(2001)
Biochem Biophys Res Commun
, vol.283
, pp. 982-988
-
-
Lammert, A.1
Kiess, W.2
Bottner, A.3
Glasow, A.4
Kratzsch, J.5
-
87
-
-
0036307849
-
Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: Observational and interventional studies in humans
-
Chan JL, Bluher S, Yiannakouris N, Suchard MA, Kratzsch J, Mantzoros CS. Regulation of circulating soluble leptin receptor levels by gender, adiposity, sex steroids, and leptin: observational and interventional studies in humans. Diabetes 2002; 51: 2105-2112.
-
(2002)
Diabetes
, vol.51
, pp. 2105-2112
-
-
Chan, J.L.1
Bluher, S.2
Yiannakouris, N.3
Suchard, M.A.4
Kratzsch, J.5
Mantzoros, C.S.6
-
88
-
-
0036168190
-
Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity
-
Hileman SM, Pierroz DD, Masuzaki H, Bjorbaek C, El-Haschimi K, Banks WA, Flier JS. Characterizaton of short isoforms of the leptin receptor in rat cerebral microvessels and of brain uptake of leptin in mouse models of obesity. Endocrinology 2002; 143: 775-783.
-
(2002)
Endocrinology
, vol.143
, pp. 775-783
-
-
Hileman, S.M.1
Pierroz, D.D.2
Masuzaki, H.3
Bjorbaek, C.4
El-Haschimi, K.5
Banks, W.A.6
Flier, J.S.7
-
89
-
-
2342439732
-
Leptin signaling in the central nervous system and the periphery
-
Bjorbaek C, Kahn BB. Leptin signaling in the central nervous system and the periphery. Recent Prog Horm Res 2004; 59: 305-331.
-
(2004)
Recent Prog Horm Res
, vol.59
, pp. 305-331
-
-
Bjorbaek, C.1
Kahn, B.B.2
-
90
-
-
0029739970
-
Identification of targets of leptin action in rat hypothalamus
-
Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. Identification of targets of leptin action in rat hypothalamus. J Clin Invest 1996; 98: 1101-1106.
-
(1996)
J Clin Invest
, vol.98
, pp. 1101-1106
-
-
Schwartz, M.W.1
Seeley, R.J.2
Campfield, L.A.3
Burn, P.4
Baskin, D.G.5
-
91
-
-
0030768058
-
Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum
-
Savioz A, Charnay Y, Huguenin C, Graviou C, Greggio B, Bouras C. Expression of leptin receptor mRNA (long form splice variant) in the human cerebellum. Neuroreport 1997; 8: 3123- 3126.
-
(1997)
Neuroreport
, vol.8
, pp. 3123-3126
-
-
Savioz, A.1
Charnay, Y.2
Huguenin, C.3
Graviou, C.4
Greggio, B.5
Bouras, C.6
-
92
-
-
0032527071
-
Distributions of leptin receptor mRNA isoforms in the rat brain
-
Elmquist JK, Bjorbaek C, Ahima RS, Flier JS, Saper CB. Distributions of leptin receptor mRNA isoforms in the rat brain. J Comp Neurol 1998; 395: 535-547.
-
(1998)
J Comp Neurol
, vol.395
, pp. 535-547
-
-
Elmquist, J.K.1
Bjorbaek, C.2
Ahima, R.S.3
Flier, J.S.4
Saper, C.B.5
-
93
-
-
0031963436
-
Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus
-
Hakansson ML, Brown H, Ghilardi N, Skoda RC, Meister B. Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J Neurosci 1998; 18: 559-572.
-
(1998)
J Neurosci
, vol.18
, pp. 559-572
-
-
Hakansson, M.L.1
Brown, H.2
Ghilardi, N.3
Skoda, R.C.4
Meister, B.5
-
94
-
-
0031436148
-
Divergent signaling capacities of the long and short isoforms of the leptin receptor
-
Bjorbaek C, Uotani S, da SB, Flier JS. Divergent signaling capacities of the long and short isoforms of the leptin receptor. J Biol Chem 1997; 272: 32686-32695.
-
(1997)
J Biol Chem
, vol.272
, pp. 32686-32695
-
-
Bjorbaek, C.1
Uotani, S.2
da, S.B.3
Flier, J.S.4
-
95
-
-
0029895233
-
Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization
-
Mercer JG, Hoggard N, Williams LM, Lawrence CB, Hannah LT, Trayhurn P. Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett 1996; 387: 113-116.
-
(1996)
FEBS Lett
, vol.387
, pp. 113-116
-
-
Mercer, J.G.1
Hoggard, N.2
Williams, L.M.3
Lawrence, C.B.4
Hannah, L.T.5
Trayhurn, P.6
-
96
-
-
0037458468
-
Expression of receptors for insulin and leptin in the ventral tegmental area/ substantia nigra (VTA/SN) of the rat
-
Figlewicz DP, Evans SB, Murphy J, Hoen M, Baskin DG. Expression of receptors for insulin and leptin in the ventral tegmental area/ substantia nigra (VTA/SN) of the rat. Brain Res 2003; 964: 107-115.
-
(2003)
Brain Res
, vol.964
, pp. 107-115
-
-
Figlewicz, D.P.1
Evans, S.B.2
Murphy, J.3
Hoen, M.4
Baskin, D.G.5
-
97
-
-
0037115192
-
Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinasedriven activation of BK channels
-
Shanley LJ, O'Malley D, Irving AJ, Ashford ML, Harvey J. Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinasedriven activation of BK channels. J Physiol 2002; 545: 933-944.
-
(2002)
J Physiol
, vol.545
, pp. 933-944
-
-
Shanley, L.J.1
O'Malley, D.2
Irving, A.J.3
Ashford, M.L.4
Harvey, J.5
-
98
-
-
0029048408
-
Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks
-
Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 1995; 269: 546-549.
-
(1995)
Science
, vol.269
, pp. 546-549
-
-
Campfield, L.A.1
Smith, F.J.2
Guisez, Y.3
Devos, R.4
Burn, P.5
-
99
-
-
0030737953
-
Physiological response to long-term peripheral and central leptin infusion in lean and obese mice
-
Halaas JL, Boozer C, Blair-West J, Fidahusein N, Denton DA, Friedman JM. Physiological response to long-term peripheral and central leptin infusion in lean and obese mice. Proc Natl Acad Sci USA 1997; 94: 8878-8883.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 8878-8883
-
-
Halaas, J.L.1
Boozer, C.2
Blair-West, J.3
Fidahusein, N.4
Denton, D.A.5
Friedman, J.M.6
-
100
-
-
0030898516
-
Direct antidiabetic effect of leptin through triglyceride depletion of tissues
-
Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH. Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 1997; 94: 4637-4641.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 4637-4641
-
-
Shimabukuro, M.1
Koyama, K.2
Chen, G.3
Wang, M.Y.4
Trieu, F.5
Lee, Y.6
Newgard, C.B.7
Unger, R.H.8
-
101
-
-
0030297919
-
Adipogenesis and obesity: Rounding out the big picture
-
Spiegelman BM, Flier JS. Adipogenesis and obesity: rounding out the big picture. Cell 1996; 87: 377-389.
-
(1996)
Cell
, vol.87
, pp. 377-389
-
-
Spiegelman, B.M.1
Flier, J.S.2
-
102
-
-
0032065645
-
Clinical review 94: What's in a name? In search of leptin's physiologic role
-
Flier JS. Clinical review 94: What's in a name? In search of leptin's physiologic role. J Clin Endocrinol Metab 1998; 83: 1407-1413.
-
(1998)
J Clin Endocrinol Metab
, vol.83
, pp. 1407-1413
-
-
Flier, J.S.1
-
103
-
-
0032558725
-
Leptin and the regulation of body weight in mammals
-
Friedman JM, Halaas JL. Leptin and the regulation of body weight in mammals. Nature 1998; 395: 763-770.
-
(1998)
Nature
, vol.395
, pp. 763-770
-
-
Friedman, J.M.1
Halaas, J.L.2
-
104
-
-
0030010388
-
Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin
-
Chehab FF, Lim ME, Lu R. Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 1996; 12: 318-320.
-
(1996)
Nat Genet
, vol.12
, pp. 318-320
-
-
Chehab, F.F.1
Lim, M.E.2
Lu, R.3
-
105
-
-
0030868077
-
Leptin accelerates the onset of puberty in normal female mice
-
Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. Leptin accelerates the onset of puberty in normal female mice. J Clin Invest 1997; 99: 391-395.
-
(1997)
J Clin Invest
, vol.99
, pp. 391-395
-
-
Ahima, R.S.1
Dushay, J.2
Flier, S.N.3
Prabakaran, D.4
Flier, J.S.5
-
106
-
-
0031014413
-
Early onset of reproductive function in normal female mice treated with leptin
-
Chehab FF, Mounzih K, Lu R, Lim ME. Early onset of reproductive function in normal female mice treated with leptin. Science 1997; 275: 88-90.
-
(1997)
Science
, vol.275
, pp. 88-90
-
-
Chehab, F.F.1
Mounzih, K.2
Lu, R.3
Lim, M.E.4
-
107
-
-
0030997649
-
Leptin facilitates and inhibits sexual behavior in female hamsters
-
Wade GN, Lempicki RL, Panicker AK, Frisbee RM, Blaustein JD. Leptin facilitates and inhibits sexual behavior in female hamsters. Am J Physiol 1997; 272: R1354-R1358.
-
(1997)
Am J Physiol
, vol.272
, pp. R1354-R1358
-
-
Wade, G.N.1
Lempicki, R.L.2
Panicker, A.K.3
Frisbee, R.M.4
Blaustein, J.D.5
-
108
-
-
0031019763
-
Role of leptin in hypothalamic pituitary function
-
Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. Role of leptin in hypothalamic pituitary function. Proc Natl Acad Sci USA 1997; 94: 1023-1028.
-
(1997)
Proc Natl Acad Sci USA
, vol.94
, pp. 1023-1028
-
-
Yu, W.H.1
Kimura, M.2
Walczewska, A.3
Karanth, S.4
McCann, S.M.5
-
109
-
-
0031046147
-
Direct intraovarian effects of leptin: Impairment of the synergistic action of insulin-like growth factor-I on folliclestimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells
-
Zachow RJ, Magoffin DA. Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-I on folliclestimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology 1997; 138: 847-850.
-
(1997)
Endocrinology
, vol.138
, pp. 847-850
-
-
Zachow, R.J.1
Magoffin, D.A.2
-
110
-
-
0030914157
-
Stimulation of corticotroph in releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants
-
Costa A, Poma A, Martignoni E, Nappi G, Ur E, Grossman A. Stimulation of corticotroph in releasing hormone release by the obese (ob) gene product, leptin, from hypothalamic explants. Neuroreport 1997; 8: 1131-1134.
-
(1997)
Neuroreport
, vol.8
, pp. 1131-1134
-
-
Costa, A.1
Poma, A.2
Martignoni, E.3
Nappi, G.4
Ur, E.5
Grossman, A.6
-
111
-
-
0030855190
-
Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress
-
Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS. Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology 1997; 138: 3859- 3863.
-
(1997)
Endocrinology
, vol.138
, pp. 3859-3863
-
-
Heiman, M.L.1
Ahima, R.S.2
Craft, L.S.3
Schoner, B.4
Stephens, T.W.5
Flier, J.S.6
-
112
-
-
0030919919
-
Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: Leptin inhibits cortisol release directly
-
Bornstein SR, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum WA. Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes 1997; 46: 1235- 1238.
-
(1997)
Diabetes
, vol.46
, pp. 1235-1238
-
-
Bornstein, S.R.1
Uhlmann, K.2
Haidan, A.3
Ehrhart-Bornstein, M.4
Scherbaum, W.A.5
-
113
-
-
0031734449
-
Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland
-
Pralong FP, Roduit R, Waeber G, Castillo E, Mosimann F, Thorens B, Gaillard RC. Leptin inhibits directly glucocorticoid secretion by normal human and rat adrenal gland. Endocrinology 1998; 139: 4264-4268.
-
(1998)
Endocrinology
, vol.139
, pp. 4264-4268
-
-
Pralong, F.P.1
Roduit, R.2
Waeber, G.3
Castillo, E.4
Mosimann, F.5
Thorens, B.6
Gaillard, R.C.7
-
114
-
-
0031157855
-
The expression of leptin and its receptors in pre-ovulatory human follicles
-
Cioffi JA, Van BJ, Antczak M, Shafer A, Wittmer S, Snodgrass HR. The expression of leptin and its receptors in pre-ovulatory human follicles. Mol Hum Reprod 1997; 3: 467-472.
-
(1997)
Mol Hum Reprod
, vol.3
, pp. 467-472
-
-
Cioffi, J.A.1
Van, B.J.2
Antczak, M.3
Shafer, A.4
Wittmer, S.5
Snodgrass, H.R.6
-
115
-
-
0029952911
-
Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
-
Gainsford T, Willson TA, Metcalf D, Handman E, McFarlane C, Ng A, Nicola NA, Alexander WS, Hilton DJ. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells. Proc Natl Acad Sci USA 1996; 93: 14564-14568.
-
(1996)
Proc Natl Acad Sci USA
, vol.93
, pp. 14564-14568
-
-
Gainsford, T.1
Willson, T.A.2
Metcalf, D.3
Handman, E.4
McFarlane, C.5
Ng, A.6
Nicola, N.A.7
Alexander, W.S.8
Hilton, D.J.9
-
117
-
-
0032971218
-
Leptin promotes aggregation of human platelets via the long form of its receptor
-
Nakata M, Yada T, Soejima N, Maruyama I. Leptin promotes aggregation of human platelets via the long form of its receptor. Diabetes 1999; 48: 426-429.
-
(1999)
Diabetes
, vol.48
, pp. 426-429
-
-
Nakata, M.1
Yada, T.2
Soejima, N.3
Maruyama, I.4
-
118
-
-
0032538875
-
Leptin, the product of Ob gene, promotes angiogenesis
-
Bouloumie A, Drexler HC, Lafontan M, Busse R. Leptin, the product of Ob gene, promotes angiogenesis. Circ Res 1998; 83: 1059-1066.
-
(1998)
Circ Res
, vol.83
, pp. 1059-1066
-
-
Bouloumie, A.1
Drexler, H.C.2
Lafontan, M.3
Busse, R.4
-
119
-
-
0032508682
-
Biological action of leptin as an angiogenic factor
-
Sierra-Honigmann MR, Nath AK, Murakami C, Garcia-Cardena G, Papapetropoulos A, Sessa WC, Madge LA, Schechner JS, Schwabb MB, Polverini PJ, Flores-Riveros JR. Biological action of leptin as an angiogenic factor. Science 1998; 281: 1683-1686.
-
(1998)
Science
, vol.281
, pp. 1683-1686
-
-
Sierra-Honigmann, M.R.1
Nath, A.K.2
Murakami, C.3
Garcia-Cardena, G.4
Papapetropoulos, A.5
Sessa, W.C.6
Madge, L.A.7
Schechner, J.S.8
Schwabb, M.B.9
Polverini, P.J.10
Flores-Riveros, J.R.11
-
120
-
-
0033082380
-
From lesions to leptin. hypothalamic control of food intake and body weight
-
Elmquist JK, Elias CF, Saper CB. From lesions to leptin. hypothalamic control of food intake and body weight. Neuron 1999; 22: 221-232.
-
(1999)
Neuron
, vol.22
, pp. 221-232
-
-
Elmquist, J.K.1
Elias, C.F.2
Saper, C.B.3
-
121
-
-
0033065587
-
Leptin receptor long-form splicevariant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus
-
Baskin DG, Schwartz MW, Seeley RJ, Woods SC, Porte D Jr, Breininger JF, Jonak Z, Schaefer J, Krouse M, Burghardt C, Campfield LA, Burn P, Kochan JP. Leptin receptor long-form splicevariant protein expression in neuron cell bodies of the brain and co-localization with neuropeptide Y mRNA in the arcuate nucleus. J Histochem Cytochem 1999; 47: 353-362.
-
(1999)
J Histochem Cytochem
, vol.47
, pp. 353-362
-
-
Baskin, D.G.1
Schwartz, M.W.2
Seeley, R.J.3
Woods, S.C.4
Porte, D.5
Breininger, J.F.6
Jonak, Z.7
Schaefer, J.8
Krouse, M.9
Burghardt, C.10
Campfield, L.A.11
Burn, P.12
Kochan, J.P.13
-
122
-
-
0034611732
-
Central nervous system control of food intake
-
Schwartz MW, Woods SC, Porte D Jr, Seeley RJ, Baskin DG. Central nervous system control of food intake. Nature 2000; 404: 661-671.
-
(2000)
Nature
, vol.404
, pp. 661-671
-
-
Schwartz, M.W.1
Woods, S.C.2
Porte, D.3
Seeley, R.J.4
Baskin, D.G.5
-
123
-
-
0030889192
-
Targeted disruption of the melanocortin-4 receptor results in obesity in mice
-
Huszar D, Lynch CA, Fairchild-Huntress V, Dunmore JH, Fang Q, Berkemeier LR, Gu W, Kesterson RA, Boston BA, Cone RD, Smith FJ, Campfield LA, Burn P, Lee F. Targeted disruption of the melanocortin-4 receptor results in obesity in mice. Cell 1997; 88: 131-141.
-
(1997)
Cell
, vol.88
, pp. 131-141
-
-
Huszar, D.1
Lynch, C.A.2
Fairchild-Huntress, V.3
Dunmore, J.H.4
Fang, Q.5
Berkemeier, L.R.6
Gu, W.7
Kesterson, R.A.8
Boston, B.A.9
Cone, R.D.10
Smith, F.J.11
Campfield, L.A.12
Burn, P.13
Lee, F.14
-
124
-
-
0032900284
-
Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides
-
Marsh DJ, Hollopeter G, Huszar D, Laufer R, Yagaloff KA, Fisher SL, Burn P, Palmiter RD. Response of melanocortin-4 receptor-deficient mice to anorectic and orexigenic peptides. Nat Genet 1999; 21: 119-122.
-
(1999)
Nat Genet
, vol.21
, pp. 119-122
-
-
Marsh, D.J.1
Hollopeter, G.2
Huszar, D.3
Laufer, R.4
Yagaloff, K.A.5
Fisher, S.L.6
Burn, P.7
Palmiter, R.D.8
-
125
-
-
0034456398
-
A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse
-
Butler AA, Kesterson RA, Khong K, Cullen MJ, Pelleymounter MA, Dekoning J, Baetscher M, Cone RD. A unique metabolic syndrome causes obesity in the melanocortin-3 receptor-deficient mouse. Endocrinology 2000; 141: 3518-3521.
-
(2000)
Endocrinology
, vol.141
, pp. 3518-3521
-
-
Butler, A.A.1
Kesterson, R.A.2
Khong, K.3
Cullen, M.J.4
Pelleymounter, M.A.5
Dekoning, J.6
Baetscher, M.7
Cone, R.D.8
-
126
-
-
0033818103
-
Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass
-
Chen AS, Marsh DJ, Trumbauer ME, Frazier EG, Guan XM, Yu H, Rosenblum CI, Vongs A, Feng Y, Cao L, Metzger JM, Strack AM, Camacho RE, Mellin TN, Nunes CN, Min W, Fisher J, Gopal-Truter S, MacIntyre DE, Chen HY, Van der Ploeg LH. Inactivation of the mouse melanocortin-3 receptor results in increased fat mass and reduced lean body mass. Nat Genet 2000; 26: 97-102.
-
(2000)
Nat Genet
, vol.26
, pp. 97-102
-
-
Chen, A.S.1
Marsh, D.J.2
Trumbauer, M.E.3
Frazier, E.G.4
Guan, X.M.5
Yu, H.6
Rosenblum, C.I.7
Vongs, A.8
Feng, Y.9
Cao, L.10
Metzger, J.M.11
Strack, A.M.12
Camacho, R.E.13
Mellin, T.N.14
Nunes, C.N.15
Min, W.16
Fisher, J.17
Gopal-Truter, S.18
MacIntyre, D.E.19
Chen, H.Y.20
Van der Ploeg, L.H.21
more..
-
127
-
-
0036553037
-
The melanocortin receptors: Lessons from knockout models
-
Butler AA, Cone RD. The melanocortin receptors: lessons from knockout models. Neuropeptides 2002; 36: 77-84.
-
(2002)
Neuropeptides
, vol.36
, pp. 77-84
-
-
Butler, A.A.1
Cone, R.D.2
-
128
-
-
0035942777
-
Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus
-
Cowley MA, Smart JL, Rubinstein M, Cerdan MG, Diano S, Horvath TL, Cone RD, Low MJ. Leptin activates anorexigenic POMC neurons through a neural network in the arcuate nucleus. Nature 2001; 411: 480-484.
-
(2001)
Nature
, vol.411
, pp. 480-484
-
-
Cowley, M.A.1
Smart, J.L.2
Rubinstein, M.3
Cerdan, M.G.4
Diano, S.5
Horvath, T.L.6
Cone, R.D.7
Low, M.J.8
-
129
-
-
33646789779
-
Effects of leptin on memory processing
-
Farr SA, Banks WA, Morley JE. Effects of leptin on memory processing. Peptides 2006; 27: 1420-1425.
-
(2006)
Peptides
, vol.27
, pp. 1420-1425
-
-
Farr, S.A.1
Banks, W.A.2
Morley, J.E.3
-
130
-
-
0037008873
-
Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents
-
Li XL, Aou S, Oomura Y, Hori N, Fukunaga K, Hori T. Impairment of long-term potentiation and spatial memory in leptin receptor-deficient rodents. Neuroscience 2002; 113: 607-615.
-
(2002)
Neuroscience
, vol.113
, pp. 607-615
-
-
Li, X.L.1
Aou, S.2
Oomura, Y.3
Hori, N.4
Fukunaga, K.5
Hori, T.6
-
131
-
-
33750091967
-
Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats
-
Oomura Y, Hori N, Shiraishi T, Fukunaga K, Takeda H, Tsuji M, Matsumiya T, Ishibashi M, Aou S, Li XL, Kohno D, Uramura K, Sougawa H, Yada T, Wayner MJ, Sasaki K. Leptin facilitates learning and memory performance and enhances hippocampal CA1 long-term potentiation and CaMK II phosphorylation in rats. Peptides 2006; 27: 2738-2749.
-
(2006)
Peptides
, vol.27
, pp. 2738-2749
-
-
Oomura, Y.1
Hori, N.2
Shiraishi, T.3
Fukunaga, K.4
Takeda, H.5
Tsuji, M.6
Matsumiya, T.7
Ishibashi, M.8
Aou, S.9
Li, X.L.10
Kohno, D.11
Uramura, K.12
Sougawa, H.13
Yada, T.14
Wayner, M.J.15
Sasaki, K.16
-
132
-
-
0035893251
-
Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity
-
Shanley LJ, Irving AJ, Harvey J. Leptin enhances NMDA receptor function and modulates hippocampal synaptic plasticity. J Neurosci 2001; 21: RC186.
-
(2001)
J Neurosci
, vol.21
-
-
Shanley, L.J.1
Irving, A.J.2
Harvey, J.3
-
134
-
-
49649118850
-
Leptin increases adult hippocampal neurogenesis in vivo and in vitro
-
Garza JC, Guo M, Zhang W, Lu XY. Leptin increases adult hippocampal neurogenesis in vivo and in vitro. J Biol Chem 2008; 283: 18238-18247.
-
(2008)
J Biol Chem
, vol.283
, pp. 18238-18247
-
-
Garza, J.C.1
Guo, M.2
Zhang, W.3
Lu, X.Y.4
-
135
-
-
38349143059
-
Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization
-
Guo Z, Jiang H, Xu X, Duan W, Mattson MP. Leptin-mediated cell survival signaling in hippocampal neurons mediated by JAK STAT3 and mitochondrial stabilization. J Biol Chem 2008; 283: 1754-1763.
-
(2008)
J Biol Chem
, vol.283
, pp. 1754-1763
-
-
Guo, Z.1
Jiang, H.2
Xu, X.3
Duan, W.4
Mattson, M.P.5
-
136
-
-
0030956390
-
The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
-
Ghilardi N, Skoda RC. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line. Mol Endocrinol 1997; 11: 393-399.
-
(1997)
Mol Endocrinol
, vol.11
, pp. 393-399
-
-
Ghilardi, N.1
Skoda, R.C.2
-
137
-
-
0033578334
-
Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction
-
Li C, Friedman JM. Leptin receptor activation of SH2 domain containing protein tyrosine phosphatase 2 modulates Ob receptor signal transduction. Proc Natl Acad Sci USA 1999; 96: 9677-9682.
-
(1999)
Proc Natl Acad Sci USA
, vol.96
, pp. 9677-9682
-
-
Li, C.1
Friedman, J.M.2
-
138
-
-
0034640508
-
Activation of downstream signals by the long form of the leptin receptor
-
Banks AS, Davis SM, Bates SH, Myers MG Jr. Activation of downstream signals by the long form of the leptin receptor. J Biol Chem 2000; 275: 14563-14572.
-
(2000)
J Biol Chem
, vol.275
, pp. 14563-14572
-
-
Banks, A.S.1
Davis, S.M.2
Bates, S.H.3
Myers, M.G.4
-
139
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjorbak C, Lavery HJ, Bates SH, Olson RK, Davis SM, Flier JS, Myers MG Jr. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J Biol Chem 2000; 275: 40649- 40657.
-
(2000)
J Biol Chem
, vol.275
, pp. 40649-40657
-
-
Bjorbak, C.1
Lavery, H.J.2
Bates, S.H.3
Olson, R.K.4
Davis, S.M.5
Flier, J.S.6
Myers, M.G.7
-
140
-
-
0032499801
-
Threedimensional structure of the Stat3beta homodimer bound to DNA
-
Becker S, Groner B, Muller CW. Threedimensional structure of the Stat3beta homodimer bound to DNA. Nature 1998; 394: 145-151.
-
(1998)
Nature
, vol.394
, pp. 145-151
-
-
Becker, S.1
Groner, B.2
Muller, C.W.3
-
141
-
-
0032577678
-
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA
-
Chen X, Vinkemeier U, Zhao Y, Jeruzalmi D, Darnell JE Jr, Kuriyan J. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell 1998; 93: 827-839.
-
(1998)
Cell
, vol.93
, pp. 827-839
-
-
Chen, X.1
Vinkemeier, U.2
Zhao, Y.3
Jeruzalmi, D.4
Darnell, J.E.5
Kuriyan, J.6
-
142
-
-
0037138370
-
Signaling through the JAK/STAT pathway, recent advances and future challenges
-
Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene 2002; 285: 1-24.
-
(2002)
Gene
, vol.285
, pp. 1-24
-
-
Kisseleva, T.1
Bhattacharya, S.2
Braunstein, J.3
Schindler, C.W.4
-
143
-
-
0030936627
-
GAS elements: A few nucleotides with a major impact on cytokine- induced gene expression
-
Decker T, Kovarik P, Meinke A. GAS elements: a few nucleotides with a major impact on cytokine- induced gene expression. J Interferon Cytokine Res 1997; 17: 121-134.
-
(1997)
J Interferon Cytokine Res
, vol.17
, pp. 121-134
-
-
Decker, T.1
Kovarik, P.2
Meinke, A.3
-
144
-
-
0037204953
-
A road map for those who don't know JAK-STAT
-
Aaronson DS, Horvath CM. A road map for those who don't know JAK-STAT. Science 2002; 296: 1653-1655.
-
(2002)
Science
, vol.296
, pp. 1653-1655
-
-
Aaronson, D.S.1
Horvath, C.M.2
-
145
-
-
0036108577
-
IFNs and STATs in innate immunity to microorganisms
-
Decker T, Stockinger S, Karaghiosoff M, Muller M, Kovarik P. IFNs and STATs in innate immunity to microorganisms. J Clin Invest 2002; 109: 1271-1277.
-
(2002)
J Clin Invest
, vol.109
, pp. 1271-1277
-
-
Decker, T.1
Stockinger, S.2
Karaghiosoff, M.3
Muller, M.4
Kovarik, P.5
-
146
-
-
0036233585
-
Cytokine signaling in 2002: New surprises in the Jak/ Stat pathway
-
O'Shea JJ, Gadina M, Schreiber RD. Cytokine signaling in 2002: new surprises in the Jak/ Stat pathway. Cell 2002; 109 Suppl: S121- S131.
-
(2002)
Cell
, vol.109
, pp. S121-S131
-
-
O'Shea, J.J.1
Gadina, M.2
Schreiber, R.D.3
-
147
-
-
0034669111
-
Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor
-
McBride KM, McDonald C, Reich NC. Nuclear export signal located within theDNA-binding domain of the STAT1transcription factor. EMBO J 2000; 19: 6196-6206.
-
(2000)
EMBO J
, vol.19
, pp. 6196-6206
-
-
McBride, K.M.1
McDonald, C.2
Reich, N.C.3
-
148
-
-
0034142208
-
A small amphipathic alpha-helical region is required for transcriptional activities and proteasomedependent turnover of the tyrosine phosphorylated Stat5
-
Wang D, Moriggl R, Stravopodis D, Carpino N, Marine JC, Teglund S, Feng J, Ihle JN. A small amphipathic alpha-helical region is required for transcriptional activities and proteasomedependent turnover of the tyrosine phosphorylated Stat5. EMBO J 2000; 19: 392- 399.
-
(2000)
EMBO J
, vol.19
, pp. 392-399
-
-
Wang, D.1
Moriggl, R.2
Stravopodis, D.3
Carpino, N.4
Marine, J.C.5
Teglund, S.6
Feng, J.7
Ihle, J.N.8
-
149
-
-
0034841006
-
Negative regulation of cytokine signaling
-
Greenhalgh CJ, Hilton DJ. Negative regulation of cytokine signaling. J Leukoc Biol 2001; 70: 348 -356.
-
(2001)
J Leukoc Biol
, vol.70
, pp. 348-356
-
-
Greenhalgh, C.J.1
Hilton, D.J.2
-
150
-
-
0036595049
-
Suppressors of cytokine signalling (SOCS) in the immune system
-
Alexander WS. Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2002; 2: 410-416.
-
(2002)
Nat Rev Immunol
, vol.2
, pp. 410-416
-
-
Alexander, W.S.1
-
152
-
-
1242270639
-
Leptin-induced signal transduction pathways
-
Hegyi K, Fulop K, Kovacs K, Toth S, Falus A. Leptin-induced signal transduction pathways. Cell Biol Int 2004; 28: 159-169.
-
(2004)
Cell Biol Int
, vol.28
, pp. 159-169
-
-
Hegyi, K.1
Fulop, K.2
Kovacs, K.3
Toth, S.4
Falus, A.5
-
153
-
-
0000430395
-
Divergent roles of SHP-2 in ERK activation by leptin receptors
-
Bjorbaek C, Buchholz RM, Davis SM, Bates SH, Pierroz DD, Gu H, Neel BG, Myers MG Jr, Flier JS. Divergent roles of SHP-2 in ERK activation by leptin receptors. J Biol Chem 2001; 276: 4747-4755.
-
(2001)
J Biol Chem
, vol.276
, pp. 4747-4755
-
-
Bjorbaek, C.1
Buchholz, R.M.2
Davis, S.M.3
Bates, S.H.4
Pierroz, D.D.5
Gu, H.6
Neel, B.G.7
Myers, M.G.8
Flier, J.S.9
-
154
-
-
0034452029
-
Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase
-
van den Brink GR, O'Toole T, Hardwick JC, van den Boogaardt DE, Versteeg HH, van Deventer SJ, Peppelenbosch MP. Leptin signaling in human peripheral blood mononuclear cells, activation of p38 and p42/44 mitogen-activated protein (MAP) kinase and p70 S6 kinase. Mol Cell Biol Res Commun 2000; 4: 144-150.
-
(2000)
Mol Cell Biol Res Commun
, vol.4
, pp. 144-150
-
-
van den Brink, G.R.1
O'Toole, T.2
Hardwick, J.C.3
van den Boogaardt, D.E.4
Versteeg, H.H.5
van Deventer, S.J.6
Peppelenbosch, M.P.7
-
155
-
-
0036000280
-
Leptin signalling
-
Sweeney G. Leptin signalling. Cell Signal 2002; 14: 655-663.
-
(2002)
Cell Signal
, vol.14
, pp. 655-663
-
-
Sweeney, G.1
-
156
-
-
21844468939
-
Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells
-
Shen J, Sakaida I, Uchida K, Terai S, Okita K. Leptin enhances TNF-alpha production via p38 and JNK MAPK in LPS-stimulated Kupffer cells. Life Sci 2005; 77: 1502-1515.
-
(2005)
Life Sci
, vol.77
, pp. 1502-1515
-
-
Shen, J.1
Sakaida, I.2
Uchida, K.3
Terai, S.4
Okita, K.5
-
157
-
-
13844280463
-
Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells
-
Shin HJ, Oh J, Kang SM, Lee JH, Shin MJ, Hwang KC, Jang Y, Chung JH. Leptin induces hypertrophy via p38 mitogen-activated protein kinase in rat vascular smooth muscle cells. Biochem Biophys Res Commun 2005; 329: 18- 24.
-
(2005)
Biochem Biophys Res Commun
, vol.329
, pp. 18-24
-
-
Shin, H.J.1
Oh, J.2
Kang, S.M.3
Lee, J.H.4
Shin, M.J.5
Hwang, K.C.6
Jang, Y.7
Chung, J.H.8
-
158
-
-
0029860791
-
Modulation of insulin activities by leptin
-
Cohen B, Novick D, Rubinstein M. Modulation of insulin activities by leptin. Science 1996; 274: 1185-1188.
-
(1996)
Science
, vol.274
, pp. 1185-1188
-
-
Cohen, B.1
Novick, D.2
Rubinstein, M.3
-
159
-
-
0034058455
-
Relation between leptin and the regulation of glucose metabolism
-
Fruhbeck G, Salvador J. Relation between leptin and the regulation of glucose metabolism. Diabetologia 2000; 43: 3-12.
-
(2000)
Diabetologia
, vol.43
, pp. 3-12
-
-
Fruhbeck, G.1
Salvador, J.2
-
160
-
-
0037288941
-
Insulin and leptin revisited: Adiposity signals with overlapping physiological and intracellular signaling capabilities
-
Niswender KD, Schwartz MW. Insulin and leptin revisited: adiposity signals with overlapping physiological and intracellular signaling capabilities. Front Neuroendocrinol 2003; 24: 1-10.
-
(2003)
Front Neuroendocrinol
, vol.24
, pp. 1-10
-
-
Niswender, K.D.1
Schwartz, M.W.2
-
161
-
-
21744454840
-
Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line
-
Benomar Y, Roy AF, Aubourg A, Djiane J, Taouis M. Cross down-regulation of leptin and insulin receptor expression and signalling in a human neuronal cell line. Biochem J 2005; 388: 929- 939.
-
(2005)
Biochem J
, vol.388
, pp. 929-939
-
-
Benomar, Y.1
Roy, A.F.2
Aubourg, A.3
Djiane, J.4
Taouis, M.5
-
162
-
-
0030828823
-
Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways
-
Kellerer M, Koch M, Metzinger E, Mushack J, Capp E, Haring HU. Leptin activates PI-3 kinase in C2C12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 1997; 40: 1358-1362.
-
(1997)
Diabetologia
, vol.40
, pp. 1358-1362
-
-
Kellerer, M.1
Koch, M.2
Metzinger, E.3
Mushack, J.4
Capp, E.5
Haring, H.U.6
-
163
-
-
0033747214
-
Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways
-
Attoub S, Noe V, Pirola L, Bruyneel E, Chastre E, Mareel M, Wymann MP, Gespach C. Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, rho-, and rac-dependent signaling pathways. FASEB J 2000; 14: 2329-2338.
-
(2000)
FASEB J
, vol.14
, pp. 2329-2338
-
-
Attoub, S.1
Noe, V.2
Pirola, L.3
Bruyneel, E.4
Chastre, E.5
Mareel, M.6
Wymann, M.P.7
Gespach, C.8
-
164
-
-
0036091969
-
Leptin effect on endothelial nitric oxide is mediated through Aktendothelial nitric oxide synthase phosphorylation pathway
-
Vecchione C, Maffei A, Colella S, Aretini A, Poulet R, Frati G, Gentile MT, Fratta L, Trimarco V, Trimarco B, Lembo G. Leptin effect on endothelial nitric oxide is mediated through Aktendothelial nitric oxide synthase phosphorylation pathway. Diabetes 2002; 51: 168-173.
-
(2002)
Diabetes
, vol.51
, pp. 168-173
-
-
Vecchione, C.1
Maffei, A.2
Colella, S.3
Aretini, A.4
Poulet, R.5
Frati, G.6
Gentile, M.T.7
Fratta, L.8
Trimarco, V.9
Trimarco, B.10
Lembo, G.11
-
165
-
-
0029587224
-
Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B
-
Cross DA, Alessi DR, Cohen P, Andjelkovich M, Hemmings BA. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B. Nature 1995; 378: 785-789.
-
(1995)
Nature
, vol.378
, pp. 785-789
-
-
Cross, D.A.1
Alessi, D.R.2
Cohen, P.3
Andjelkovich, M.4
Hemmings, B.A.5
-
166
-
-
0030712317
-
Further evidence that the inhibition of glycogen synthase kinase- 3beta by IGF-1 is mediated by PDK1/PKBinduced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216
-
Shaw M, Cohen P, Alessi DR. Further evidence that the inhibition of glycogen synthase kinase- 3beta by IGF-1 is mediated by PDK1/PKBinduced phosphorylation of Ser-9 and not by dephosphorylation of Tyr-216. FEBS Lett 1997; 416: 307-311.
-
(1997)
FEBS Lett
, vol.416
, pp. 307-311
-
-
Shaw, M.1
Cohen, P.2
Alessi, D.R.3
-
167
-
-
39849110726
-
The GSK3 hypothesis of Alzheimer's disease
-
Hooper C, Killick R, Lovestone S. The GSK3 hypothesis of Alzheimer's disease. J Neurochem 2008; 104: 1433-1439.
-
(2008)
J Neurochem
, vol.104
, pp. 1433-1439
-
-
Hooper, C.1
Killick, R.2
Lovestone, S.3
-
168
-
-
33646582664
-
Hypothalamic mTOR signaling regulates food intake
-
Cota D, Proulx K, Smith KA, Kozma SC, Thomas G, Woods SC, Seeley RJ. Hypothalamic mTOR signaling regulates food intake. Science 2006; 312: 927-930.
-
(2006)
Science
, vol.312
, pp. 927-930
-
-
Cota, D.1
Proulx, K.2
Smith, K.A.3
Kozma, S.C.4
Thomas, G.5
Woods, S.C.6
Seeley, R.J.7
-
169
-
-
38349174747
-
Leptin induces macrophage lipid body formation by a phosphatidy linositol 3- kinase- and mammalian target of rapamycindependent mechanism
-
Maya-Monteiro CM, Almeida PE, D'Avila H, Martins AS, Rezende AP, Castro-Faria-Neto H, Bozza PT. Leptin induces macrophage lipid body formation by a phosphatidylinositol 3- kinase- and mammalian target of rapamycindependent mechanism. J Biol Chem 2008; 283: 2203-2210.
-
(2008)
J Biol Chem
, vol.283
, pp. 2203-2210
-
-
Maya-Monteiro, C.M.1
Almeida, P.E.2
D'Avila, H.3
Martins, A.S.4
Rezende, A.P.5
Castro-Faria-Neto, H.6
Bozza, P.T.7
-
170
-
-
4043171462
-
Upstream and downstream of mTOR
-
Hay N, Sonenberg N. Upstream and downstream of mTOR. Genes Dev 2004; 18: 1926- 1945.
-
(2004)
Genes Dev
, vol.18
, pp. 1926-1945
-
-
Hay, N.1
Sonenberg, N.2
-
171
-
-
0030881836
-
Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin
-
Brunn GJ, Hudson CC, Sekulic A, Williams JM, Hosoi H, Houghton PJ, Lawrence JC Jr, Abraham RT. Phosphorylation of the translational repressor PHAS-I by the mammalian target of rapamycin. Science 1997; 277: 99-101.
-
(1997)
Science
, vol.277
, pp. 99-101
-
-
Brunn, G.J.1
Hudson, C.C.2
Sekulic, A.3
Williams, J.M.4
Hosoi, H.5
Houghton, P.J.6
Lawrence, J.C.7
Abraham, R.T.8
-
172
-
-
0032539664
-
RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4EBP1
-
Burnett PE, Barrow RK, Cohen NA, Snyder SH, Sabatini DM. RAFT1 phosphorylation of the translational regulators p70 S6 kinase and 4EBP1. Proc Natl Acad Sci USA 1998; 95: 1432- 1437.
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 1432-1437
-
-
Burnett, P.E.1
Barrow, R.K.2
Cohen, N.A.3
Snyder, S.H.4
Sabatini, D.M.5
-
173
-
-
0033153166
-
Regulation of 4E-BP1 phosphorylation: A novel two-step mechanism
-
Gingras AC, Gygi SP, Raught B, Polakiewicz RD, Abraham RT, Hoekstra MF, Aebersold R, Sonenberg N. Regulation of 4E-BP1 phosphorylation: a novel two-step mechanism. Genes Dev 1999; 13: 1422-1437.
-
(1999)
Genes Dev
, vol.13
, pp. 1422-1437
-
-
Gingras, A.C.1
Gygi, S.P.2
Raught, B.3
Polakiewicz, R.D.4
Abraham, R.T.5
Hoekstra, M.F.6
Aebersold, R.7
Sonenberg, N.8
-
174
-
-
0032849890
-
Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase
-
Heesom KJ, Denton RM. Dissociation of the eukaryotic initiation factor-4E/4E-BP1 complex involves phosphorylation of 4E-BP1 by an mTOR-associated kinase. FEBS Lett 1999; 457: 489-493.
-
(1999)
FEBS Lett
, vol.457
, pp. 489-493
-
-
Heesom, K.J.1
Denton, R.M.2
-
175
-
-
0035498939
-
Hierarchical phosphorylation of the translation inhibitor 4E-BP1
-
Gingras AC, Raught B, Gygi SP, Niedzwiecka A, Miron M, Burley SK, Polakiewicz RD, Wyslouch-Cieszynska A, Aebersold R, Sonenberg N. Hierarchical phosphorylation of the translation inhibitor 4E-BP1. Genes Dev 2001; 15: 2852- 2864.
-
(2001)
Genes Dev
, vol.15
, pp. 2852-2864
-
-
Gingras, A.C.1
Raught, B.2
Gygi, S.P.3
Niedzwiecka, A.4
Miron, M.5
Burley, S.K.6
Polakiewicz, R.D.7
Wyslouch-Cieszynska, A.8
Aebersold, R.9
Sonenberg, N.10
-
176
-
-
0033604521
-
Ribosomal S6 kinase signaling and the control of translation
-
Dufner A, Thomas G. Ribosomal S6 kinase signaling and the control of translation. Exp Cell Res 1999; 253: 100-109.
-
(1999)
Exp Cell Res
, vol.253
, pp. 100-109
-
-
Dufner, A.1
Thomas, G.2
-
177
-
-
2342545519
-
Target of rapamycin (TOR). an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression
-
Fingar DC, Blenis J. Target of rapamycin (TOR). an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression. Oncogene 2004; 23: 3151- 3171.
-
(2004)
Oncogene
, vol.23
, pp. 3151-3171
-
-
Fingar, D.C.1
Blenis, J.2
-
178
-
-
0029103330
-
Control of p70 s6 kinase by kinase activity of FRAP in vivo
-
Brown EJ, Beal PA, Keith CT, Chen J, Shin TB, Schreiber SL. Control of p70 s6 kinase by kinase activity of FRAP in vivo. Nature 1995; 377: 441-446.
-
(1995)
Nature
, vol.377
, pp. 441-446
-
-
Brown, E.J.1
Beal, P.A.2
Keith, C.T.3
Chen, J.4
Shin, T.B.5
Schreiber, S.L.6
-
179
-
-
0034629365
-
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
-
Peterson RT, Beal PA, Comb MJ, Schreiber SL. FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions. J Biol Chem 2000; 275: 7416-7423.
-
(2000)
J Biol Chem
, vol.275
, pp. 7416-7423
-
-
Peterson, R.T.1
Beal, P.A.2
Comb, M.J.3
Schreiber, S.L.4
-
180
-
-
0036713778
-
TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
-
Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat Cell Biol 2002; 4: 648-657.
-
(2002)
Nat Cell Biol
, vol.4
, pp. 648-657
-
-
Inoki, K.1
Li, Y.2
Zhu, T.3
Wu, J.4
Guan, K.L.5
-
181
-
-
0033429554
-
Mammalian target of rapamycin is a direct target for protein kinase B: Identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation
-
Nave BT, Ouwens M, Withers DJ, Alessi DR, Shepherd PR. Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation. Biochem J 1999; 344 Pt 2: 427- 431.
-
(1999)
Biochem J
, vol.344
, pp. 427-431
-
-
Nave, B.T.1
Ouwens, M.2
Withers, D.J.3
Alessi, D.R.4
Shepherd, P.R.5
-
182
-
-
76449100739
-
mTOR phosphorylated at S2448 binds to raptor and rictor
-
Rosner M, Siegel N, Valli A, Fuchs C, Hengstschlager M. mTOR phosphorylated at S2448 binds to raptor and rictor. Amino Acids 2010; 38: 223-228.
-
(2010)
Amino Acids
, vol.38
, pp. 223-228
-
-
Rosner, M.1
Siegel, N.2
Valli, A.3
Fuchs, C.4
Hengstschlager, M.5
-
183
-
-
67650914230
-
AMPK in Health and Disease
-
Steinberg GR, Kemp BE. AMPK in Health and Disease. Physiol Rev 2009; 89: 1025-1078.
-
(2009)
Physiol Rev
, vol.89
, pp. 1025-1078
-
-
Steinberg, G.R.1
Kemp, B.E.2
-
184
-
-
0024786438
-
Purification and characterization of the AMPactivated protein kinase. Copurification of acetyl- CoA carboxylase kinase and 3-hydroxy-3- methylglutaryl-CoA reductase kinase activities
-
Carling D, Clarke PR, Zammit VA, Hardie DG. Purification and characterization of the AMPactivated protein kinase. Copurification of acetyl- CoA carboxylase kinase and 3-hydroxy-3- methylglutaryl-CoA reductase kinase activities. Eur J Biochem 1989; 186: 129-136.
-
(1989)
Eur J Biochem
, vol.186
, pp. 129-136
-
-
Carling, D.1
Clarke, P.R.2
Zammit, V.A.3
Hardie, D.G.4
-
185
-
-
0024460580
-
Role of reversible phosphorylation of acetyl -CoA carboxylase in long-chain fatty acid synthesis
-
Kim KH, Lopez-Casillas F, Bai DH, Luo X, Pape ME. Role of reversible phosphorylation of acetyl -CoA carboxylase in long-chain fatty acid synthesis. FASEB J 1989; 3: 2250-2256.
-
(1989)
FASEB J
, vol.3
, pp. 2250-2256
-
-
Kim, K.H.1
Lopez-Casillas, F.2
Bai, D.H.3
Luo, X.4
Pape, M.E.5
-
186
-
-
0035816639
-
Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A
-
Yamagishi SI, Edelstein D, Du XL, Kaneda Y, Guzman M, Brownlee M. Leptin induces mitochondrial superoxide production and monocyte chemoattractant protein-1 expression in aortic endothelial cells by increasing fatty acid oxidation via protein kinase A. J Biol Chem 2001; 276: 25096-25100.
-
(2001)
J Biol Chem
, vol.276
, pp. 25096-25100
-
-
Yamagishi, S.I.1
Edelstein, D.2
Du, X.L.3
Kaneda, Y.4
Guzman, M.5
Brownlee, M.6
-
187
-
-
0037122766
-
Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase
-
Minokoshi Y, Kim YB, Peroni OD, Fryer LG, Muller C, Carling D, Kahn BB. Leptin stimulates fatty-acid oxidation by activating AMP-activated protein kinase. Nature 2002; 415: 339-343.
-
(2002)
Nature
, vol.415
, pp. 339-343
-
-
Minokoshi, Y.1
Kim, Y.B.2
Peroni, O.D.3
Fryer, L.G.4
Muller, C.5
Carling, D.6
Kahn, B.B.7
-
188
-
-
34250182374
-
Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase
-
Suzuki A, Okamoto S, Lee S, Saito K, Shiuchi T, Minokoshi Y. Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha2 form of AMP-activated protein kinase. Mol Cell Biol 2007; 27: 4317- 4327.
-
(2007)
Mol Cell Biol
, vol.27
, pp. 4317-4327
-
-
Suzuki, A.1
Okamoto, S.2
Lee, S.3
Saito, K.4
Shiuchi, T.5
Minokoshi, Y.6
-
189
-
-
1842582870
-
AMPactivated protein kinase plays a role in the control of food intake
-
Andersson U, Filipsson K, Abbott CR, Woods A, Smith K, Bloom SR, Carling D, Small CJ. AMPactivated protein kinase plays a role in the control of food intake. J Biol Chem 2004; 279: 12005-12008.
-
(2004)
J Biol Chem
, vol.279
, pp. 12005-12008
-
-
Andersson, U.1
Filipsson, K.2
Abbott, C.R.3
Woods, A.4
Smith, K.5
Bloom, S.R.6
Carling, D.7
Small, C.J.8
-
190
-
-
1842484296
-
AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus
-
Minokoshi Y, Alquier T, Furukawa N, Kim YB, Lee A, Xue B, Mu J, Foufelle F, Ferre P, Birnbaum MJ, Stuck BJ, Kahn BB. AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamus. Nature 2004; 428: 569-574.
-
(2004)
Nature
, vol.428
, pp. 569-574
-
-
Minokoshi, Y.1
Alquier, T.2
Furukawa, N.3
Kim, Y.B.4
Lee, A.5
Xue, B.6
Mu, J.7
Foufelle, F.8
Ferre, P.9
Birnbaum, M.J.10
Stuck, B.J.11
Kahn, B.B.12
-
191
-
-
84863535512
-
p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake
-
Dagon Y, Hur E, Zheng B, Wellenstein K, Cantley LC, Kahn BB. p70S6 Kinase Phosphorylates AMPK on Serine 491 to Mediate Leptin's Effect on Food Intake. Cell Metab 2012; 16: 104-112.
-
(2012)
Cell Metab
, vol.16
, pp. 104-112
-
-
Dagon, Y.1
Hur, E.2
Zheng, B.3
Wellenstein, K.4
Cantley, L.C.5
Kahn, B.B.6
-
192
-
-
43049121395
-
Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt
-
Fulco M, Cen Y, Zhao P, Hoffman EP, McBurney MW, Sauve AA, Sartorelli V. Glucose restriction inhibits skeletal myoblast differentiation by activating SIRT1 through AMPK-mediated regulation of Nampt. Dev Cell 2008; 14: 661-673.
-
(2008)
Dev Cell
, vol.14
, pp. 661-673
-
-
Fulco, M.1
Cen, Y.2
Zhao, P.3
Hoffman, E.P.4
McBurney, M.W.5
Sauve, A.A.6
Sartorelli, V.7
-
193
-
-
67349276169
-
AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity
-
Canto C, Gerhart-Hines Z, Feige JN, Lagouge M, Noriega L, Milne JC, Elliott PJ, Puigserver P, Auwerx J. AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity. Nature 2009; 458: 1056-1060.
-
(2009)
Nature
, vol.458
, pp. 1056-1060
-
-
Canto, C.1
Gerhart-Hines, Z.2
Feige, J.N.3
Lagouge, M.4
Noriega, L.5
Milne, J.C.6
Elliott, P.J.7
Puigserver, P.8
Auwerx, J.9
-
194
-
-
0033214237
-
The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms
-
Kaeberlein M, McVey M, Guarente L. The SIR2/3/4 complex and SIR2 alone promote longevity in Saccharomyces cerevisiae by two different mechanisms. Genes Dev 1999; 13: 2570-2580.
-
(1999)
Genes Dev
, vol.13
, pp. 2570-2580
-
-
Kaeberlein, M.1
McVey, M.2
Guarente, L.3
-
195
-
-
0034677535
-
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
-
Imai S, Armstrong CM, Kaeberlein M, Guarente L. Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase. Nature 2000; 403: 795-800.
-
(2000)
Nature
, vol.403
, pp. 795-800
-
-
Imai, S.1
Armstrong, C.M.2
Kaeberlein, M.3
Guarente, L.4
-
196
-
-
0038329323
-
Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae
-
Anderson RM, Bitterman KJ, Wood JG, Medvedik O, Sinclair DA. Nicotinamide and PNC1 govern lifespan extension by calorie restriction in Saccharomyces cerevisiae. Nature 2003; 423: 181-185.
-
(2003)
Nature
, vol.423
, pp. 181-185
-
-
Anderson, R.M.1
Bitterman, K.J.2
Wood, J.G.3
Medvedik, O.4
Sinclair, D.A.5
-
197
-
-
0345731468
-
Yeast life-span extension by calorie restriction is independent of NAD fluctuation
-
Anderson RM, Latorre-Esteves M, Neves AR, Lavu S, Medvedik O, Taylor C, Howitz KT, Santos H, Sinclair DA. Yeast life-span extension by calorie restriction is independent of NAD fluctuation. Science 2003; 302: 2124-2126.
-
(2003)
Science
, vol.302
, pp. 2124-2126
-
-
Anderson, R.M.1
Latorre-Esteves, M.2
Neves, A.R.3
Lavu, S.4
Medvedik, O.5
Taylor, C.6
Howitz, K.T.7
Santos, H.8
Sinclair, D.A.9
-
198
-
-
3142740860
-
Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase
-
Cohen HY, Miller C, Bitterman KJ, Wall NR, Hekking B, Kessler B, Howitz KT, Gorospe M, de CR, Sinclair DA. Calorie restriction promotes mammalian cell survival by inducing the SIRT1 deacetylase. Science 2004; 305: 390-392.
-
(2004)
Science
, vol.305
, pp. 390-392
-
-
Cohen, H.Y.1
Miller, C.2
Bitterman, K.J.3
Wall, N.R.4
Hekking, B.5
Kessler, B.6
Howitz, K.T.7
Gorospe, M.8
de, C.R.9
Sinclair, D.A.10
-
199
-
-
3042681042
-
Sirt1 promotes fat mobilization in white adipocytes by repressing PPARgamma
-
Picard F, Kurtev M, Chung N, Topark-Ngarm A, Senawong T, Machado De OR, Leid M, McBurney MW, Guarente L. Sirt1 promotes fat mobilization in white adipocytes by repressing PPARgamma. Nature 2004; 429: 771-776.
-
(2004)
Nature
, vol.429
, pp. 771-776
-
-
Picard, F.1
Kurtev, M.2
Chung, N.3
Topark-Ngarm, A.4
Senawong, T.5
Machado De, O.R.6
Leid, M.7
McBurney, M.W.8
Guarente, L.9
-
200
-
-
34948883324
-
SIRT1 deacetylates and positively regulates the nuclear receptor LXR
-
Li X, Zhang S, Blander G, Tse JG, Krieger M, Guarente L. SIRT1 deacetylates and positively regulates the nuclear receptor LXR. Mol Cell 2007; 28: 91-106.
-
(2007)
Mol Cell
, vol.28
, pp. 91-106
-
-
Li, X.1
Zhang, S.2
Blander, G.3
Tse, J.G.4
Krieger, M.5
Guarente, L.6
-
201
-
-
77956644726
-
SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against dietinduced obesity
-
Ramadori G, Fujikawa T, Fukuda M, Anderson J, Morgan DA, Mostoslavsky R, Stuart RC, Perello M, Vianna CR, Nillni EA, Rahmouni K, Coppari R. SIRT1 deacetylase in POMC neurons is required for homeostatic defenses against dietinduced obesity. Cell Metab 2010; 12: 78-87.
-
(2010)
Cell Metab
, vol.12
, pp. 78-87
-
-
Ramadori, G.1
Fujikawa, T.2
Fukuda, M.3
Anderson, J.4
Morgan, D.A.5
Mostoslavsky, R.6
Stuart, R.C.7
Perello, M.8
Vianna, C.R.9
Nillni, E.A.10
Rahmouni, K.11
Coppari, R.12
-
202
-
-
0019494341
-
Some morphometric aspects of the brain in senile dementia of the Alzheimer type
-
Terry RD, Peck A, DeTeresa R, Schechter R, Horoupian DS. Some morphometric aspects of the brain in senile dementia of the Alzheimer type. Ann Neurol 1981; 10: 184-192.
-
(1981)
Ann Neurol
, vol.10
, pp. 184-192
-
-
Terry, R.D.1
Peck, A.2
DeTeresa, R.3
Schechter, R.4
Horoupian, D.S.5
-
203
-
-
0025863618
-
Neuropathological stageing of Alzheimer-related changes
-
Braak H, Braak E. Neuropathological stageing of Alzheimer-related changes. Acta Neuropathol 1991; 82: 239-259.
-
(1991)
Acta Neuropathol
, vol.82
, pp. 239-259
-
-
Braak, H.1
Braak, E.2
-
204
-
-
10044238914
-
Obesity-related leptin regulates Alzheimer's Abeta
-
Fewlass DC, Noboa K, Pi-Sunyer FX, Johnston JM, Yan SD, Tezapsidis N. Obesity-related leptin regulates Alzheimer's Abeta. FASEB J 2004; 18: 1870-1878.
-
(2004)
FASEB J
, vol.18
, pp. 1870-1878
-
-
Fewlass, D.C.1
Noboa, K.2
Pi-Sunyer, F.X.3
Johnston, J.M.4
Yan, S.D.5
Tezapsidis, N.6
-
205
-
-
53149140231
-
Leptin reduces Alzheimer's diseaserelated tau phosphorylation in neuronal cells
-
Greco SJ, Sarkar S, Johnston JM, Zhu X, Su B, Casadesus G, Ashford JW, Smith MA, Tezapsidis N. Leptin reduces Alzheimer's diseaserelated tau phosphorylation in neuronal cells. Biochem Biophys Res Commun 2008; 376: 536-541.
-
(2008)
Biochem Biophys Res Commun
, vol.376
, pp. 536-541
-
-
Greco, S.J.1
Sarkar, S.2
Johnston, J.M.3
Zhu, X.4
Su, B.5
Casadesus, G.6
Ashford, J.W.7
Smith, M.A.8
Tezapsidis, N.9
-
207
-
-
64049102108
-
Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells
-
Greco SJ, Sarkar S, Casadesus G, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N. Leptin inhibits glycogen synthase kinase-3beta to prevent tau phosphorylation in neuronal cells. Neurosci Lett 2009; 455: 191-194.
-
(2009)
Neurosci Lett
, vol.455
, pp. 191-194
-
-
Greco, S.J.1
Sarkar, S.2
Casadesus, G.3
Zhu, X.4
Smith, M.A.5
Ashford, J.W.6
Johnston, J.M.7
Tezapsidis, N.8
-
208
-
-
72549091935
-
Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging
-
Lieb W, Beiser AS, Vasan RS, Tan ZS, Au R, Harris TB, Roubenoff R, Auerbach S, DeCarli C, Wolf PA, Seshadri S. Association of plasma leptin levels with incident Alzheimer disease and MRI measures of brain aging. JAMA 2009; 302: 2565-2572.
-
(2009)
JAMA
, vol.302
, pp. 2565-2572
-
-
Lieb, W.1
Beiser, A.S.2
Vasan, R.S.3
Tan, Z.S.4
Au, R.5
Harris, T.B.6
Roubenoff, R.7
Auerbach, S.8
DeCarli, C.9
Wolf, P.A.10
Seshadri, S.11
-
209
-
-
67349228783
-
Relationship between plasma leptin level and brain structure in elderly: A voxelbased morphometric study
-
Narita K, Kosaka H, Okazawa H, Murata T, Wada Y. Relationship between plasma leptin level and brain structure in elderly: a voxelbased morphometric study. Biol Psychiatry 2009; 65: 992-994.
-
(2009)
Biol Psychiatry
, vol.65
, pp. 992-994
-
-
Narita, K.1
Kosaka, H.2
Okazawa, H.3
Murata, T.4
Wada, Y.5
-
210
-
-
0023105114
-
The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
-
Kang J, Lemaire HG, Unterbeck A, Salbaum JM, Masters CL, Grzeschik KH, Multhaup G, Beyreuther K, Muller-Hill B. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor. Nature 1987; 325: 733-736.
-
(1987)
Nature
, vol.325
, pp. 733-736
-
-
Kang, J.1
Lemaire, H.G.2
Unterbeck, A.3
Salbaum, J.M.4
Masters, C.L.5
Grzeschik, K.H.6
Multhaup, G.7
Beyreuther, K.8
Muller-Hill, B.9
-
211
-
-
0033382226
-
Identification of a novel aspartic protease (Asp 2) as betasecretase
-
Hussain I, Powell D, Howlett DR, Tew DG, Meek TD, Chapman C, Gloger IS, Murphy KE, Southan CD, Ryan DM, Smith TS, Simmons DL, Walsh FS, Dingwall C, Christie G. Identification of a novel aspartic protease (Asp 2) as betasecretase. Mol Cell Neurosci 1999; 14: 419- 427.
-
(1999)
Mol Cell Neurosci
, vol.14
, pp. 419-427
-
-
Hussain, I.1
Powell, D.2
Howlett, D.R.3
Tew, D.G.4
Meek, T.D.5
Chapman, C.6
Gloger, I.S.7
Murphy, K.E.8
Southan, C.D.9
Ryan, D.M.10
Smith, T.S.11
Simmons, D.L.12
Walsh, F.S.13
Dingwall, C.14
Christie, G.15
-
212
-
-
0033518251
-
Purification and cloning of amyloid precursor protein beta-secretase from human brain
-
Sinha S, Anderson JP, Barbour R, Basi GS, Caccavello R, Davis D, Doan M, Dovey HF, Frigon N, Hong J, Jacobson-Croak K, Jewett N, Keim P, Knops J, Lieberburg I, Power M, Tan H, Tatsuno G, Tung J, Schenk D, Seubert P, Suomensaari SM, Wang S, Walker D, Zhao J, McConlogue L, John V. Purification and cloning of amyloid precursor protein beta-secretase from human brain. Nature 1999; 402: 537-540.
-
(1999)
Nature
, vol.402
, pp. 537-540
-
-
Sinha, S.1
Anderson, J.P.2
Barbour, R.3
Basi, G.S.4
Caccavello, R.5
Davis, D.6
Doan, M.7
Dovey, H.F.8
Frigon, N.9
Hong, J.10
Jacobson-Croak, K.11
Jewett, N.12
Keim, P.13
Knops, J.14
Lieberburg, I.15
Power, M.16
Tan, H.17
Tatsuno, G.18
Tung, J.19
Schenk, D.20
Seubert, P.21
Suomensaari, S.M.22
Wang, S.23
Walker, D.24
Zhao, J.25
McConlogue, L.26
John, V.27
more..
-
213
-
-
0033595706
-
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
-
Vassar R, Bennett BD, Babu-Khan S, Kahn S, Mendiaz EA, Denis P, Teplow DB, Ross S, Amarante P, Loeloff R, Luo Y, Fisher S, Fuller J, Edenson S, Lile J, Jarosinski MA, Biere AL, Curran E, Burgess T, Louis JC, Collins F, Treanor J, Rogers G, Citron M. Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE. Science 1999; 286: 735-741.
-
(1999)
Science
, vol.286
, pp. 735-741
-
-
Vassar, R.1
Bennett, B.D.2
Babu-Khan, S.3
Kahn, S.4
Mendiaz, E.A.5
Denis, P.6
Teplow, D.B.7
Ross, S.8
Amarante, P.9
Loeloff, R.10
Luo, Y.11
Fisher, S.12
Fuller, J.13
Edenson, S.14
Lile, J.15
Jarosinski, M.A.16
Biere, A.L.17
Curran, E.18
Burgess, T.19
Louis, J.C.20
Collins, F.21
Treanor, J.22
Rogers, G.23
Citron, M.24
more..
-
214
-
-
0033518264
-
Membrane- anchored aspartyl protease with Alzheimer's disease beta-secretase activity
-
Yan R, Bienkowski MJ, Shuck ME, Miao H, Tory MC, Pauley AM, Brashier JR, Stratman NC, Mathews WR, Buhl AE, Carter DB, Tomasselli AG, Parodi LA, Heinrikson RL, Gurney ME. Membrane- anchored aspartyl protease with Alzheimer's disease beta-secretase activity. Nature 1999; 402: 533-537.
-
(1999)
Nature
, vol.402
, pp. 533-537
-
-
Yan, R.1
Bienkowski, M.J.2
Shuck, M.E.3
Miao, H.4
Tory, M.C.5
Pauley, A.M.6
Brashier, J.R.7
Stratman, N.C.8
Mathews, W.R.9
Buhl, A.E.10
Carter, D.B.11
Tomasselli, A.G.12
Parodi, L.A.13
Heinrikson, R.L.14
Gurney, M.E.15
-
215
-
-
0034652309
-
Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein
-
Lin X, Koelsch G, Wu S, Downs D, Dashti A, Tang J. Human aspartic protease memapsin 2 cleaves the beta-secretase site of beta-amyloid precursor protein. Proc Natl Acad Sci USA 2000; 97: 1456-1460.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 1456-1460
-
-
Lin, X.1
Koelsch, G.2
Wu, S.3
Downs, D.4
Dashti, A.5
Tang, J.6
-
216
-
-
18444417998
-
APH-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J, Ruddy DA, Sym M, Apfeld J, Nicoll M, Maxwell M, Hai B, Ellis MC, Parks AL, Xu W, Li J, Gurney M, Myers RL, Himes CS, Hiebsch R, Ruble C, Nye JS, Curtis D. aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 2002; 3: 85-97.
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
Ruddy, D.A.4
Sym, M.5
Apfeld, J.6
Nicoll, M.7
Maxwell, M.8
Hai, B.9
Ellis, M.C.10
Parks, A.L.11
Xu, W.12
Li, J.13
Gurney, M.14
Myers, R.L.15
Himes, C.S.16
Hiebsch, R.17
Ruble, C.18
Nye, J.S.19
Curtis, D.20
more..
-
217
-
-
0041355557
-
Notch and Presenilin: Regulated intramembrane proteolysis links development and degeneration
-
Selkoe D, Kopan R. Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci 2003; 26: 565-597.
-
(2003)
Annu Rev Neurosci
, vol.26
, pp. 565-597
-
-
Selkoe, D.1
Kopan, R.2
-
218
-
-
0037468759
-
The role of presenilin cofactors in the gamma-secretase complex
-
Takasugi N, Tomita T, Hayashi I, Tsuruoka M, Niimura M, Takahashi Y, Thinakaran G, Iwatsubo T. The role of presenilin cofactors in the gamma-secretase complex. Nature 2003; 422: 438-441.
-
(2003)
Nature
, vol.422
, pp. 438-441
-
-
Takasugi, N.1
Tomita, T.2
Hayashi, I.3
Tsuruoka, M.4
Niimura, M.5
Takahashi, Y.6
Thinakaran, G.7
Iwatsubo, T.8
-
219
-
-
0025899041
-
Amyloid deposition as the central event in the aetiology of Alzheimer's disease
-
Hardy J, Allsop D. Amyloid deposition as the central event in the aetiology of Alzheimer's disease. Trends Pharmacol Sci 1991; 12: 383- 388.
-
(1991)
Trends Pharmacol Sci
, vol.12
, pp. 383-388
-
-
Hardy, J.1
Allsop, D.2
-
220
-
-
79957512544
-
Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease
-
Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Chronic Leptin Supplementation Ameliorates Pathology and Improves Cognitive Performance in a Transgenic Mouse Model of Alzheimer's Disease. J Alzheimers Dis 2009.
-
(2009)
J Alzheimers Dis
-
-
Greco, S.J.1
Bryan, K.J.2
Sarkar, S.3
Zhu, X.4
Smith, M.A.5
Ashford, J.W.6
Johnston, J.M.7
Tezapsidis, N.8
Casadesus, G.9
-
221
-
-
77950358315
-
Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease
-
Greco SJ, Bryan KJ, Sarkar S, Zhu X, Smith MA, Ashford JW, Johnston JM, Tezapsidis N, Casadesus G. Leptin reduces pathology and improves memory in a transgenic mouse model of Alzheimer's disease. J Alzheimers Dis 2010; 19: 1155-1167.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 1155-1167
-
-
Greco, S.J.1
Bryan, K.J.2
Sarkar, S.3
Zhu, X.4
Smith, M.A.5
Ashford, J.W.6
Johnston, J.M.7
Tezapsidis, N.8
Casadesus, G.9
-
222
-
-
80054072264
-
Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and betaamyloid in neurons
-
Greco SJ, Hamzelou A, Johnston JM, Smith MA, Ashford JW, Tezapsidis N. Leptin boosts cellular metabolism by activating AMPK and the sirtuins to reduce tau phosphorylation and betaamyloid in neurons. Biochem Biophys Res Commun 2011; 414: 170-174.
-
(2011)
Biochem Biophys Res Commun
, vol.414
, pp. 170-174
-
-
Greco, S.J.1
Hamzelou, A.2
Johnston, J.M.3
Smith, M.A.4
Ashford, J.W.5
Tezapsidis, N.6
-
223
-
-
77149145513
-
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27- hydroxycholesterol in rabbit organotypic slices
-
Marwarha G, Dasari B, Prasanthi JR, Schommer J, Ghribi O. Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27- hydroxycholesterol in rabbit organotypic slices. J Alzheimers Dis 2010; 19: 1007-1019.
-
(2010)
J Alzheimers Dis
, vol.19
, pp. 1007-1019
-
-
Marwarha, G.1
Dasari, B.2
Prasanthi, J.R.3
Schommer, J.4
Ghribi, O.5
-
224
-
-
0032577177
-
Leptin regulation of peroxisome proliferator-activated receptor-gamma, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues
-
Qian H, Hausman GJ, Compton MM, Azain MJ, Hartzell DL, Baile CA. Leptin regulation of peroxisome proliferator-activated receptor-gamma, tumor necrosis factor, and uncoupling protein-2 expression in adipose tissues. Biochem Biophys Res Commun 1998; 246: 660-667.
-
(1998)
Biochem Biophys Res Commun
, vol.246
, pp. 660-667
-
-
Qian, H.1
Hausman, G.J.2
Compton, M.M.3
Azain, M.J.4
Hartzell, D.L.5
Baile, C.A.6
-
225
-
-
33747347875
-
Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
-
Rossner S, Sastre M, Bourne K, Lichtenthaler SF. Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease. Prog Neurobiol 2006; 79: 95- 111.
-
(2006)
Prog Neurobiol
, vol.79
, pp. 95-111
-
-
Rossner, S.1
Sastre, M.2
Bourne, K.3
Lichtenthaler, S.F.4
-
226
-
-
6944231363
-
Gene structure and organization of the human beta-secretase (BACE) promoter
-
Sambamurti K, Kinsey R, Maloney B, Ge YW, Lahiri DK. Gene structure and organization of the human beta-secretase (BACE) promoter. FASEB J 2004; 18: 1034-1036.
-
(2004)
FASEB J
, vol.18
, pp. 1034-1036
-
-
Sambamurti, K.1
Kinsey, R.2
Maloney, B.3
Ge, Y.W.4
Lahiri, D.K.5
-
227
-
-
19944433845
-
Betasite APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stressactivated protein kinases pathways
-
Tamagno E, Parola M, Bardini P, Piccini A, Borghi R, Guglielmotto M, Santoro G, Davit A, Danni O, Smith MA, Perry G, Tabaton M. Betasite APP cleaving enzyme up-regulation induced by 4-hydroxynonenal is mediated by stressactivated protein kinases pathways. J Neurochem 2005; 92: 628-636.
-
(2005)
J Neurochem
, vol.92
, pp. 628-636
-
-
Tamagno, E.1
Parola, M.2
Bardini, P.3
Piccini, A.4
Borghi, R.5
Guglielmotto, M.6
Santoro, G.7
Davit, A.8
Danni, O.9
Smith, M.A.10
Perry, G.11
Tabaton, M.12
-
228
-
-
40249114794
-
Transcriptional regulation of betasecretase by p25/cdk5 leads to enhanced amyloidogenic processing
-
Wen Y, Yu WH, Maloney B, Bailey J, Ma J, Marie I, Maurin T, Wang L, Figueroa H, Herman M, Krishnamurthy P, Liu L, Planel E, Lau LF, Lahiri DK, Duff K. Transcriptional regulation of betasecretase by p25/cdk5 leads to enhanced amyloidogenic processing. Neuron 2008; 57: 680-690.
-
(2008)
Neuron
, vol.57
, pp. 680-690
-
-
Wen, Y.1
Yu, W.H.2
Maloney, B.3
Bailey, J.4
Ma, J.5
Marie, I.6
Maurin, T.7
Wang, L.8
Figueroa, H.9
Herman, M.10
Krishnamurthy, P.11
Liu, L.12
Planel, E.13
Lau, L.F.14
Lahiri, D.K.15
Duff, K.16
-
229
-
-
67649726068
-
Leptin: A novel therapeutic strategy for Alzheimer's disease
-
Tezapsidis N, Johnston JM, Smith MA, Ashford JW, Casadesus G, Robakis NK, Wolozin B, Perry G, Zhu X, Greco SJ, Sarkar S. Leptin: a novel therapeutic strategy for Alzheimer's disease. J Alzheimers Dis 2009; 16: 731-740.
-
(2009)
J Alzheimers Dis
, vol.16
, pp. 731-740
-
-
Tezapsidis, N.1
Johnston, J.M.2
Smith, M.A.3
Ashford, J.W.4
Casadesus, G.5
Robakis, N.K.6
Wolozin, B.7
Perry, G.8
Zhu, X.9
Greco, S.J.10
Sarkar, S.11
-
230
-
-
44349140124
-
NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42
-
Buggia-Prevot V, Sevalle J, Rossner S, Checler F. NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42. J Biol Chem 2008; 283: 10037-10047.
-
(2008)
J Biol Chem
, vol.283
, pp. 10037-10047
-
-
Buggia-Prevot, V.1
Sevalle, J.2
Rossner, S.3
Checler, F.4
-
231
-
-
0029013727
-
Staging of Alzheimer's disease- related neurofibrillary changes
-
Braak H, Braak E. Staging of Alzheimer's disease- related neurofibrillary changes. Neurobiol Aging 1995; 16: 271-278.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 271-278
-
-
Braak, H.1
Braak, E.2
-
232
-
-
12944268979
-
Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5
-
Ahlijanian MK, Barrezueta NX, Williams RD, Jakowski A, Kowsz KP, McCarthy S, Coskran T, Carlo A, Seymour PA, Burkhardt JE, Nelson RB, McNeish JD. Hyperphosphorylated tau and neurofilament and cytoskeletal disruptions in mice overexpressing human p25, an activator of cdk5. Proc Natl Acad Sci USA 2000; 97: 2910-2915.
-
(2000)
Proc Natl Acad Sci USA
, vol.97
, pp. 2910-2915
-
-
Ahlijanian, M.K.1
Barrezueta, N.X.2
Williams, R.D.3
Jakowski, A.4
Kowsz, K.P.5
McCarthy, S.6
Coskran, T.7
Carlo, A.8
Seymour, P.A.9
Burkhardt, J.E.10
Nelson, R.B.11
McNeish, J.D.12
-
233
-
-
0037111833
-
Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease
-
Fath T, Eidenmuller J, Brandt R. Tau-mediated cytotoxicity in a pseudohyperphosphorylation model of Alzheimer's disease. J Neurosci 2002; 22: 9733-9741.
-
(2002)
J Neurosci
, vol.22
, pp. 9733-9741
-
-
Fath, T.1
Eidenmuller, J.2
Brandt, R.3
-
234
-
-
0345405447
-
Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles
-
Cruz JC, Tseng HC, Goldman JA, Shih H, Tsai LH. Aberrant Cdk5 activation by p25 triggers pathological events leading to neurodegeneration and neurofibrillary tangles. Neuron 2003; 40: 471-483.
-
(2003)
Neuron
, vol.40
, pp. 471-483
-
-
Cruz, J.C.1
Tseng, H.C.2
Goldman, J.A.3
Shih, H.4
Tsai, L.H.5
-
235
-
-
0038689162
-
Cdk5 is a key factor in tau aggregation and tangle formation in vivo
-
Noble W, Olm V, Takata K, Casey E, Mary O, Meyerson J, Gaynor K, LaFrancois J, Wang L, Kondo T, Davies P, Burns M, Veeranna Nixon R, Dickson D, Matsuoka Y, Ahlijanian M, Lau LF, Duff K. Cdk5 is a key factor in tau aggregation and tangle formation in vivo. Neuron 2003; 38: 555-565.
-
(2003)
Neuron
, vol.38
, pp. 555-565
-
-
Noble, W.1
Olm, V.2
Takata, K.3
Casey, E.4
Mary, O.5
Meyerson, J.6
Gaynor, K.7
LaFrancois, J.8
Wang, L.9
Kondo, T.10
Davies, P.11
Burns, M.12
Veeranna Nixon, R.13
Dickson, D.14
Matsuoka, Y.15
Ahlijanian, M.16
Lau, L.F.17
Duff, K.18
-
236
-
-
1042266624
-
CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival
-
Shimura H, Schwartz D, Gygi SP, Kosik KS. CHIP-Hsc70 complex ubiquitinates phosphorylated tau and enhances cell survival. J Biol Chem 2004; 279: 4869-4876.
-
(2004)
J Biol Chem
, vol.279
, pp. 4869-4876
-
-
Shimura, H.1
Schwartz, D.2
Gygi, S.P.3
Kosik, K.S.4
-
237
-
-
78651277918
-
Beta-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway
-
Marwarha G, Dasari B, Prabhakara JP, Schommer J, Ghribi O. beta-Amyloid regulates leptin expression and tau phosphorylation through the mTORC1 signaling pathway. J Neurochem 2010; 115: 373-384.
-
(2010)
J Neurochem
, vol.115
, pp. 373-384
-
-
Marwarha, G.1
Dasari, B.2
Prabhakara, J.P.3
Schommer, J.4
Ghribi, O.5
-
238
-
-
0023106967
-
A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease
-
Davies CA, Mann DM, Sumpter PQ, Yates PO. A quantitative morphometric analysis of the neuronal and synaptic content of the frontal and temporal cortex in patients with Alzheimer's disease. J Neurol Sci 1987; 78: 151-164.
-
(1987)
J Neurol Sci
, vol.78
, pp. 151-164
-
-
Davies, C.A.1
Mann, D.M.2
Sumpter, P.Q.3
Yates, P.O.4
-
239
-
-
0024595972
-
Synaptic loss in Alzheimer's disease and other dementias
-
Hamos JE, DeGennaro LJ, Drachman DA. Synaptic loss in Alzheimer's disease and other dementias. Neurology 1989; 39: 355-361.
-
(1989)
Neurology
, vol.39
, pp. 355-361
-
-
Hamos, J.E.1
DeGennaro, L.J.2
Drachman, D.A.3
-
240
-
-
0024364877
-
Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease
-
Masliah E, Terry RD, DeTeresa RM, Hansen LA. Immunohistochemical quantification of the synapse-related protein synaptophysin in Alzheimer disease. Neurosci Lett 1989; 103: 234- 239.
-
(1989)
Neurosci Lett
, vol.103
, pp. 234-239
-
-
Masliah, E.1
Terry, R.D.2
DeTeresa, R.M.3
Hansen, L.A.4
-
241
-
-
0025217385
-
Quantitative assessment of cortical synaptic density in Alzheimer's disease
-
Scheff SW, DeKosky ST, Price DA. Quantitative assessment of cortical synaptic density in Alzheimer's disease. Neurobiol Aging 1990; 11: 29-37.
-
(1990)
Neurobiol Aging
, vol.11
, pp. 29-37
-
-
Scheff, S.W.1
DeKosky, S.T.2
Price, D.A.3
-
242
-
-
0025970091
-
Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease
-
Masliah E, Hansen L, Albright T, Mallory M, Terry RD. Immunoelectron microscopic study of synaptic pathology in Alzheimer's disease. Acta Neuropathol 1991; 81: 428-433.
-
(1991)
Acta Neuropathol
, vol.81
, pp. 428-433
-
-
Masliah, E.1
Hansen, L.2
Albright, T.3
Mallory, M.4
Terry, R.D.5
-
243
-
-
0026032039
-
Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease
-
Masliah E, Terry RD, Alford M, DeTeresa R, Hansen LA. Cortical and subcortical patterns of synaptophysinlike immunoreactivity in Alzheimer's disease. Am J Pathol 1991; 138: 235- 246.
-
(1991)
Am J Pathol
, vol.138
, pp. 235-246
-
-
Masliah, E.1
Terry, R.D.2
Alford, M.3
DeTeresa, R.4
Hansen, L.A.5
-
244
-
-
0026563496
-
Alzheimer's disease and aging: Effects on perforant pathway perikarya and synapses
-
Lippa CF, Hamos JE, Pulaski-Salo D, DeGennaro LJ, Drachman DA. Alzheimer's disease and aging: effects on perforant pathway perikarya and synapses. Neurobiol Aging 1992; 13: 405- 411.
-
(1992)
Neurobiol Aging
, vol.13
, pp. 405-411
-
-
Lippa, C.F.1
Hamos, J.E.2
Pulaski-Salo, D.3
DeGennaro, L.J.4
Drachman, D.A.5
-
245
-
-
0025269152
-
Synapse loss in frontal cortex biopsies in Alzheimer's disease: Correlation with cognitive severity
-
DeKosky ST, Scheff SW. Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity. Ann Neurol 1990; 27: 457-464.
-
(1990)
Ann Neurol
, vol.27
, pp. 457-464
-
-
DeKosky, S.T.1
Scheff, S.W.2
-
246
-
-
0026440987
-
Cortical biopsy in Alzheimer's disease: Diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group
-
DeKosky ST, Harbaugh RE, Schmitt FA, Bakay RA, Chui HC, Knopman DS, Reeder TM, Shetter AG, Senter HJ, Markesbery WR. Cortical biopsy in Alzheimer's disease: diagnostic accuracy and neurochemical, neuropathological, and cognitive correlations. Intraventricular Bethanecol Study Group. Ann Neurol 1992; 32: 625-632.
-
(1992)
Ann Neurol
, vol.32
, pp. 625-632
-
-
DeKosky, S.T.1
Harbaugh, R.E.2
Schmitt, F.A.3
Bakay, R.A.4
Chui, H.C.5
Knopman, D.S.6
Reeder, T.M.7
Shetter, A.G.8
Senter, H.J.9
Markesbery, W.R.10
-
247
-
-
33747760358
-
Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment
-
Scheff SW, Price DA, Schmitt FA, Mufson EJ. Hippocampal synaptic loss in early Alzheimer's disease and mild cognitive impairment. Neurobiol Aging 2006; 27: 1372-1384.
-
(2006)
Neurobiol Aging
, vol.27
, pp. 1372-1384
-
-
Scheff, S.W.1
Price, D.A.2
Schmitt, F.A.3
Mufson, E.J.4
-
248
-
-
34247611481
-
Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment
-
Scheff SW, Price DA, Schmitt FA, DeKosky ST, Mufson EJ. Synaptic alterations in CA1 in mild Alzheimer disease and mild cognitive impairment. Neurology 2007; 68: 1501-1508.
-
(2007)
Neurology
, vol.68
, pp. 1501-1508
-
-
Scheff, S.W.1
Price, D.A.2
Schmitt, F.A.3
DeKosky, S.T.4
Mufson, E.J.5
-
249
-
-
0025987048
-
Physical basis of cognitive alterations in Alzheimer's disease: Synapse loss is the major correlate of cognitive impairment
-
Terry RD, Masliah E, Salmon DP, Butters N, DeTeresa R, Hill R, Hansen LA, Katzman R. Physical basis of cognitive alterations in Alzheimer's disease: synapse loss is the major correlate of cognitive impairment. Ann Neurol 1991; 30: 572-580.
-
(1991)
Ann Neurol
, vol.30
, pp. 572-580
-
-
Terry, R.D.1
Masliah, E.2
Salmon, D.P.3
Butters, N.4
DeTeresa, R.5
Hill, R.6
Hansen, L.A.7
Katzman, R.8
-
251
-
-
0029078972
-
Correlations of synaptic and pathological markers with cognition of the elderly
-
Dickson DW, Crystal HA, Bevona C, Honer W, Vincent I, Davies P. Correlations of synaptic and pathological markers with cognition of the elderly. Neurobiol Aging 1995; 16: 285-298.
-
(1995)
Neurobiol Aging
, vol.16
, pp. 285-298
-
-
Dickson, D.W.1
Crystal, H.A.2
Bevona, C.3
Honer, W.4
Vincent, I.5
Davies, P.6
-
252
-
-
0028801680
-
Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease
-
Heinonen O, Soininen H, Sorvari H, Kosunen O, Paljarvi L, Koivisto E, Riekkinen PJ Sr. Loss of synaptophysin-like immunoreactivity in the hippocampal formation is an early phenomenon in Alzheimer's disease. Neuroscience 1995; 64: 375-384.
-
(1995)
Neuroscience
, vol.64
, pp. 375-384
-
-
Heinonen, O.1
Soininen, H.2
Sorvari, H.3
Kosunen, O.4
Paljarvi, L.5
Koivisto, E.6
Riekkinen, P.J.7
-
253
-
-
0028235419
-
Synaptic and neuritic alterations during the progression of Alzheimer's disease
-
Masliah E, Mallory M, Hansen L, DeTeresa R, Alford M, Terry R. Synaptic and neuritic alterations during the progression of Alzheimer's disease. Neurosci Lett 1994; 174: 67-72.
-
(1994)
Neurosci Lett
, vol.174
, pp. 67-72
-
-
Masliah, E.1
Mallory, M.2
Hansen, L.3
DeTeresa, R.4
Alford, M.5
Terry, R.6
-
254
-
-
0014036452
-
The contribution of altered synapses in the senile plaque: An electron microscopic study in Alzheimer's dementia
-
Gonatas NK, Anderson W, Evangelista I. The contribution of altered synapses in the senile plaque: an electron microscopic study in Alzheimer's dementia. J Neuropathol Exp Neurol 1967; 26: 25-39.
-
(1967)
J Neuropathol Exp Neurol
, vol.26
, pp. 25-39
-
-
Gonatas, N.K.1
Anderson, W.2
Evangelista, I.3
-
255
-
-
0021063927
-
EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia
-
Gibson PH. EM study of the numbers of cortical synapses in the brains of ageing people and people with Alzheimer-type dementia. Acta Neuropathol 1983; 62: 127-133.
-
(1983)
Acta Neuropathol
, vol.62
, pp. 127-133
-
-
Gibson, P.H.1
-
256
-
-
0025283380
-
Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease
-
Bertoni-Freddari C, Fattoretti P, Casoli T, Meier-Ruge W, Ulrich J. Morphological adaptive response of the synaptic junctional zones in the human dentate gyrus during aging and Alzheimer's disease. Brain Res 1990; 517: 69-75.
-
(1990)
Brain Res
, vol.517
, pp. 69-75
-
-
Bertoni-Freddari, C.1
Fattoretti, P.2
Casoli, T.3
Meier-Ruge, W.4
Ulrich, J.5
-
257
-
-
0025327264
-
A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease
-
Weiler R, Lassmann H, Fischer P, Jellinger K, Winkler H. A high ratio of chromogranin A to synaptin/synaptophysin is a common feature of brains in Alzheimer and Pick disease. FEBS Lett 1990; 263: 337-339.
-
(1990)
FEBS Lett
, vol.263
, pp. 337-339
-
-
Weiler, R.1
Lassmann, H.2
Fischer, P.3
Jellinger, K.4
Winkler, H.5
-
258
-
-
0026567733
-
Synaptic pathology in Alzheimer's disease: Immunological data for markers of synaptic and large dense-core vesicles
-
Lassmann H, Weiler R, Fischer P, Bancher C, Jellinger K, Floor E, Danielczyk W, Seitelberger F, Winkler H. Synaptic pathology in Alzheimer's disease: immunological data for markers of synaptic and large dense-core vesicles. Neuroscience 1992; 46: 1-8.
-
(1992)
Neuroscience
, vol.46
, pp. 1-8
-
-
Lassmann, H.1
Weiler, R.2
Fischer, P.3
Bancher, C.4
Jellinger, K.5
Floor, E.6
Danielczyk, W.7
Seitelberger, F.8
Winkler, H.9
-
259
-
-
0028898888
-
Mechanisms of synaptic dysfunction in Alzheimer's disease
-
Masliah. Mechanisms of synaptic dysfunction in Alzheimer's disease. Histol Histopathol 1995; 10: 509-519.
-
(1995)
Histol Histopathol
, vol.10
, pp. 509-519
-
-
Masliah1
-
260
-
-
0031922359
-
Frontal cortical synaptophysin in Lewy body diseases: Relation to Alzheimer's disease and dementia
-
Hansen LA, Daniel SE, Wilcock GK, Love S. Frontal cortical synaptophysin in Lewy body diseases: relation to Alzheimer's disease and dementia. J Neurol Neurosurg Psychiatry 1998; 64: 653-656.
-
(1998)
J Neurol Neurosurg Psychiatry
, vol.64
, pp. 653-656
-
-
Hansen, L.A.1
Daniel, S.E.2
Wilcock, G.K.3
Love, S.4
-
261
-
-
0035830408
-
Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease
-
Masliah E, Mallory M, Alford M, DeTeresa R, Hansen LA, McKeel DW Jr, Morris JC. Altered expression of synaptic proteins occurs early during progression of Alzheimer's disease. Neurology 2001; 56: 127-129.
-
(2001)
Neurology
, vol.56
, pp. 127-129
-
-
Masliah, E.1
Mallory, M.2
Alford, M.3
DeTeresa, R.4
Hansen, L.A.5
McKeel, D.W.6
Morris, J.C.7
-
262
-
-
70449514914
-
Therapeutic approaches of leptin in Alzheimer's disease
-
Carro EM. Therapeutic approaches of leptin in Alzheimer's disease. Recent Pat CNS Drug Discov 2009; 4: 200-208.
-
(2009)
Recent Pat CNS Drug Discov
, vol.4
, pp. 200-208
-
-
Carro, E.M.1
-
263
-
-
26844500788
-
Leptin induces a novel form of NMDA receptordependent long-term depression
-
Durakoglugil M, Irving AJ, Harvey J. Leptin induces a novel form of NMDA receptordependent long-term depression. J Neurochem 2005; 95: 396-405.
-
(2005)
J Neurochem
, vol.95
, pp. 396-405
-
-
Durakoglugil, M.1
Irving, A.J.2
Harvey, J.3
-
264
-
-
1842536210
-
Trophic action of leptin on hypothalamic neurons that regulate feeding
-
Bouret SG, Draper SJ, Simerly RB. Trophic action of leptin on hypothalamic neurons that regulate feeding. Science 2004; 304: 108-110.
-
(2004)
Science
, vol.304
, pp. 108-110
-
-
Bouret, S.G.1
Draper, S.J.2
Simerly, R.B.3
-
265
-
-
1842529267
-
Rapid rewiring of arcuate nucleus feeding circuits by leptin
-
Pinto S, Roseberry AG, Liu H, Diano S, Shanabrough M, Cai X, Friedman JM, Horvath TL. Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science 2004; 304: 110-115.
-
(2004)
Science
, vol.304
, pp. 110-115
-
-
Pinto, S.1
Roseberry, A.G.2
Liu, H.3
Diano, S.4
Shanabrough, M.5
Cai, X.6
Friedman, J.M.7
Horvath, T.L.8
-
266
-
-
33947191565
-
Long -lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits
-
Walker CD, Long H, Williams S, Richard D. Long -lasting effects of elevated neonatal leptin on rat hippocampal function, synaptic proteins and NMDA receptor subunits. J Neurosci Res 2007; 85: 816-828.
-
(2007)
J Neurosci Res
, vol.85
, pp. 816-828
-
-
Walker, C.D.1
Long, H.2
Williams, S.3
Richard, D.4
-
267
-
-
34547603656
-
Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
-
O'Malley D, MacDonald N, Mizielinska S, Connolly CN, Irving AJ, Harvey J. Leptin promotes rapid dynamic changes in hippocampal dendritic morphology. Mol Cell Neurosci 2007; 35: 559-572.
-
(2007)
Mol Cell Neurosci
, vol.35
, pp. 559-572
-
-
O'Malley, D.1
MacDonald, N.2
Mizielinska, S.3
Connolly, C.N.4
Irving, A.J.5
Harvey, J.6
-
268
-
-
4344676199
-
Antiapoptotic effects of leptin in human neuroblastoma cells
-
Russo VC, Metaxas S, Kobayashi K, Harris M, Werther GA. Antiapoptotic effects of leptin in human neuroblastoma cells. Endocrinology 2004; 145: 4103-4112.
-
(2004)
Endocrinology
, vol.145
, pp. 4103-4112
-
-
Russo, V.C.1
Metaxas, S.2
Kobayashi, K.3
Harris, M.4
Werther, G.A.5
-
269
-
-
36348980042
-
Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling
-
Weng Z, Signore AP, Gao Y, Wang S, Zhang F, Hastings T, Yin XM, Chen J. Leptin protects against 6-hydroxydopamine-induced dopaminergic cell death via mitogen-activated protein kinase signaling. J Biol Chem 2007; 282: 34479-34491.
-
(2007)
J Biol Chem
, vol.282
, pp. 34479-34491
-
-
Weng, Z.1
Signore, A.P.2
Gao, Y.3
Wang, S.4
Zhang, F.5
Hastings, T.6
Yin, X.M.7
Chen, J.8
-
270
-
-
79958071918
-
Molecular interplay between leptin, insulin-like growth factor-1, and beta-amyloid in organotypic slices from rabbit hippocampus
-
Marwarha G, Prasanthi JR, Schommer J, Dasari B, Ghribi O. Molecular interplay between leptin, insulin-like growth factor-1, and beta-amyloid in organotypic slices from rabbit hippocampus. Mol Neurodegener 2011; 6: 41.
-
(2011)
Mol Neurodegener
, vol.6
, pp. 41
-
-
Marwarha, G.1
Prasanthi, J.R.2
Schommer, J.3
Dasari, B.4
Ghribi, O.5
-
271
-
-
34548256784
-
Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia
-
Zhang F, Wang S, Signore AP, Chen J. Neuroprotective effects of leptin against ischemic injury induced by oxygen-glucose deprivation and transient cerebral ischemia. Stroke 2007; 38: 2329-2336.
-
(2007)
Stroke
, vol.38
, pp. 2329-2336
-
-
Zhang, F.1
Wang, S.2
Signore, A.P.3
Chen, J.4
-
272
-
-
77953941374
-
Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells
-
Ho PW, Liu HF, Ho JW, Zhang WY, Chu AC, Kwok KH, Ge X, Chan KH, Ramsden DB, Ho SL. Mitochondrial uncoupling protein-2 (UCP2) mediates leptin protection against MPP+ toxicity in neuronal cells. Neurotox Res 2010; 17: 332- 343.
-
(2010)
Neurotox Res
, vol.17
, pp. 332-343
-
-
Ho, P.W.1
Liu, H.F.2
Ho, J.W.3
Zhang, W.Y.4
Chu, A.C.5
Kwok, K.H.6
Ge, X.7
Chan, K.H.8
Ramsden, D.B.9
Ho, S.L.10
-
273
-
-
77956572863
-
Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation
-
Wang CH, Wang WT, Cheng SY, Hung WT, Wu TL, Hsueh CM. Leptin and interleukin-1beta modulate neuronal glutamate release and protect against glucose-oxygen-serum deprivation. Curr Neurovasc Res 2010; 7: 223-237.
-
(2010)
Curr Neurovasc Res
, vol.7
, pp. 223-237
-
-
Wang, C.H.1
Wang, W.T.2
Cheng, S.Y.3
Hung, W.T.4
Wu, T.L.5
Hsueh, C.M.6
-
274
-
-
84864351716
-
Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: A microelectrode array study
-
Gavello D, Rojo-Ruiz J, Marcantoni A, Franchino C, Carbone E, Carabelli V. Leptin counteracts the hypoxia-induced inhibition of spontaneously firing hippocampal neurons: a microelectrode array study. PLoS One 2012; 7: e41530.
-
(2012)
PLoS One
, vol.7
-
-
Gavello, D.1
Rojo-Ruiz, J.2
Marcantoni, A.3
Franchino, C.4
Carbone, E.5
Carabelli, V.6
-
275
-
-
84864352752
-
Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3beta/beta-catenin signaling
-
Garza JC, Guo M, Zhang W, Lu XY. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3beta/beta-catenin signaling. Mol Psychiatry 2012; 17: 790-808.
-
(2012)
Mol Psychiatry
, vol.17
, pp. 790-808
-
-
Garza, J.C.1
Guo, M.2
Zhang, W.3
Lu, X.Y.4
-
276
-
-
82155166723
-
Leptin induces neuroprotection neurogenesis and angiogenesis after stroke
-
Avraham Y, Davidi N, Lassri V, Vorobiev L, Kabesa M, Dayan M, Chernoguz D, Berry E, Leker RR. Leptin induces neuroprotection neurogenesis and angiogenesis after stroke. Curr Neurovasc Res 2011; 8: 313-322.
-
(2011)
Curr Neurovasc Res
, vol.8
, pp. 313-322
-
-
Avraham, Y.1
Davidi, N.2
Lassri, V.3
Vorobiev, L.4
Kabesa, M.5
Dayan, M.6
Chernoguz, D.7
Berry, E.8
Leker, R.R.9
|