Distributions of leptin receptor mRNA isoforms in the rat brain

Journal of Comparative Neurology

Volumn 395, Issue 4, 1998, Pages 535-547

  Elmquist, Joel K ^a,b   Bjørbæk, Christian ^a   Ahima, Rexford S ^a   Flier, Jeffrey S ^a   Saper, Clifford B ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

Arcuate hypothalamic nucleus; Dorsomedial hypothalamic nucleus; Feeding; OB protein; Obesity; Ventromedial hypothalamic nucleus

Indexed keywords

LEPTIN; LEPTIN RECEPTOR; MESSENGER RNA;

ADIPOCYTE; ARCUATE NUCLEUS; ARTICLE; FEEDING BEHAVIOR; HYPOTHALAMUS; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REGULATORY MECHANISM;

ADIPOCYTES; ANIMALS; BRAIN; CARRIER PROTEINS; DNA PRIMERS; HYPOTHALAMUS; IN SITU HYBRIDIZATION; MALE; ORGAN SPECIFICITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CELL SURFACE; RNA PROBES; RNA, MESSENGER; TRANSCRIPTION, GENETIC;

EID: 0032527071     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1096-9861(19980615)395:4<535::AID-CNE9>3.0.CO;2-2     Document Type: Article

References (50)

1. Ahima, R.S., D. Prabakaran, C. Mantzoros, D. Qu, B. Lowell, E. Maratos-Flier, and J.S. Flier (1996) Role of leptin in the neuroendocrine response to fasting. Nature 382:250-252.
2. Baker, R.A. and M. Herkenham (1995) Arcuate nucleus neurons that project to the hypothalamic paraventricular nucleus: Neuropeptidergic identity and consequences of adrenalectomy on mRNA levels in the rat. J. Comp.Neurol. 358:518-530.
3. Banks, W.A., A.J. Kastin, W. Huang, J.B. Jaspan, and L.M. Maness (1996) Leptin enters the brain by a saturable system independent of insulin. Peptides 17:305-311.
4. Bellinger, L.L., T.W. Castonguay, and L.L. Bernardis (1994) Hormone and somatic changes in rats pair-fed to growth retarded dorsomedial hypothalamic nuclei-lesioned rats. Brain Res. Bull. 34:117-124.
5. Brady, L.S., A.B. Lynn, M. Herkenham, and Z. Gottesfeld (1994) Systemic interleukin-1 induces early and late patterns of c-fos mRNA expression in brain. J. Neurosci. 14:4951-4964.
6. Breder, C.D., C. Hazuka, T. Ghayur, C. Klug, M. Huginin, K. Yasuda, M. Teng, and C.B. Saper (1994) Regional induction of tumor necrosis factor alpha expression in the mouse brain after systemic lipopolysaccharide administration. Proc. Natl. Acad. Sci. U.S.A. 91:11393-11397.
7. Broadwell, R.D. and M.W. Brightman (1976) Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J. Comp. Neurol. 166:257-283.
8. Campfield, L.A., F.J. Smith, Y. Guisez, R. Devos, and P. Burn (1995) Recombinant mouse OB protein: Evidence for a peripheral signal linking adiposity and central neural networks. Science 269:546-549.
9. Canteras, N.S., R.B. Simerly, and L.W. Swanson (1994) Organization of projections from the ventromedial nucleus of the hypothalamus: A Phaseolus vulgaris-leucoagglutinin study in the rat. J. Comp. Neurol. 348:41-79.
10. Caro, J.F., M.K. Sinha, J.W. Kolaczynski, P.L. Zhang, and R.V. Considine (1996) Leptin: The tale of an obesity gene. Diabetes 45:1455-1462.
11. Carro, E., R. Senaris, R. V. Considine, F.F. Casanueva, and C. Dieguez (1997) Regulation of in vivo growth hormone secretion by leptin. Endocrinology 138:2203-2206.
12. Chan, R.K., E.R. Brown, A. Ericsson, K.J. Kovacs, and P.E. Sawchenko (1993) A comparison of two immediate-early genes, c-fos and NGFI-B, as markers for functional activation in stress-related neuroendocrine circuitry. J. Neurosci. 13:5126-5138.
13. Chen, H., O. Charlat, L.A. Tartaglia, E.A. Woolf, X. Weng, S.J. Ellis, N.D. Lakey, J. Culpepper, K.J. Moore, R.E. Breitbart, G.M. Duyk, R.I. Tepper, and J.P. Morgenstern (1996) Evidence that the diabetes gene encodes the leptin receptor: Identification of a mutation in the leptin receptor gene in db/db mice. Cell 84:491-495.
14. Cheung, C.C., D.K. Clifton, and R.A. Steiner (1997) Proopiomelanocortin neurons are direct targets for leptin in the hypothalamus. Endocrinology 138:4489-4492.
15. Couce, M.E., B. Burguera, J.E. Parisi, M.D. Jensen, and R.V. Lloyd (1997) Localization of leptin receptor in the human brain. Neuroendocrinology 66:145-150.
16. Elmquist, J.K., R.S. Ahima, E. Maratos-Flier, J.S. Flier, and C.B. Saper (1997) Leptin activates neurons in ventrobasal hypothalamus and brainstem. Endocrinology 138:839-842.
17. Elmquist, J.K., R.S. Ahima, C.F. Elias, J.S. Flier, and C.B. Saper (1998) Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc. Natl. Acad. Sci. U.S.A. 95:741-746.
18. Erickson, J.C., K.E. Clegg, and R.D. Palmiter (1996a) Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y. Nature 381:415-421.
19. Erickson, J.C., G. Hollopeter, and R.D. Palmiter (1996b) Attenuation of the obesity syndrome of ob/ob mice by the loss of neuropeptide Y. Science 274:1704-1707.
20. Erickson, J.C., R.S. Ahima, G. Hollopeter, J.S. Flier, and R.D. Palmiter (1997) Endocrine function of neuropeptide Y knockout mice. Regul. Pept. 70:199-202.
21. Ericsson, A., C. Liu, R.P. Hart, and P.E. Sawchenko (1995) Type 1 interleukin-1 receptor in the rat brain: Distribution, regulation, and relationship to sites of IL-1-induced cellular activation. J. Comp. Neurol. 361:681-698.
22. Fei, H., H.J. Okano, C. Li, G.H. Lee, C. Zhao, R. Darnell, and J.M. Friedman (1997) Anatomic localization of alternatively spliced leptin receptors (Ob-R) in mouse brain and other tissues. Proc. Natl. Acad. Sci. U.S.A. 94:7001-7005.
23. Guan, X.-M., J.F. Hess, H. Yu, P.J. Hey, and L.H.T. van der Ploeg (1997) Differential expression of mRNA for leptin receptor isoforms in the rat brain. Mol. Cell. Endocrinol. 133:1-7.
24. Håkansson, M.-L., A.-L. Hulling, and B. Meister (1996) Expression of leptin receptor mRNA in the hypothalamic arcuate nucleus-relationship with NPY neurons. NeuroReport. 7:3087-3092.
25. Håkansson, M.-L., H. Brown, N. Ghilardi, R.C. Skoda, and B. Meister (1998) Leptin receptor immunoreactivity in chemically defined target neurons of the hypothalamus. J. Neurosci. 8:559-572.
26. Halaas, J.L., K.S, Gajiwala, M. Maffei, S.L. Cohen, B.T. Chait, D. Rabinowitz, R.L. Lallone, S.K. Burley, and J.M. Friedman (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546.
27. Keesey, R.E. and T.L. Powley (1986) The regulation of body weight. Annu. Rev. Psychol. 37:109-133.
28. Lee, G.H., R. Proenca, J.M. Montez, K.M. Carroll, J.G. Darvishzadeh, J.I. Lee, and J.M. Friedman (1996) Abnormal splicing of the leptin receptor in diabetic mice. Nature 79:632-635.
29. Mercer, J.G., N. Hoggard, L.M. Williams, C.B. Lawrence, L.T. Hannah, and P. Trayhurn (1996a) Localization of leptin receptor mRNA and the long form splice variant (Ob-Rb) in mouse hypothalamus and adjacent brain regions by in situ hybridization. FEBS Lett. 87:113-116.
30. Mercer, J.G., N. Hoggard, L.M. Williams, C.B. Lawrence, L.T. Hannah, P.J. Morgan, and P. Trayhurn (1996b) Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J. Neuroendocrinol. 8:733-735.
31. Mercer, J.G., K. M. Moar, D.V. Rayner, P. Trayhurn, and N. Hoggard (1997) Regulation of leptin receptor and NPY gene expression in hypothalamus of leptin-treated obese (ob/ob) and cold-exposed lean mice. FEBS Lett. 402:185-188.
32. Mercer, J.G., K.M. Moar, and N. Hoggard (1998) Localization of leptin receptor (Ob-R) messenger ribonucleic acid in the rodent hindbrain. Endocrinology 139:29-34.
33. Paxinos, G. and C. Watson (1997) The Rat Brain in Stereotaxic Coordinates, compact 3rd ed. San Diego, CA: Academic Press.
34. Pelleymounter, M.A., M.J. Cullen, M.B. Baker, R. Hecht, D. Winters, T. Boone, and F. Collins (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269:540-543.
35. Price, J.L. (1995) Thalamus. In G. Paxinos (ed): The Rat Nervous System. San Diego: Academic Press, pp. 629-648.
36. Savioz, A., Y. Charnay, C. Huguenin, C. Graviou, B. Greggio, and C. Bouras (1997) Expression of leptin receptor mRNA (long splice form variant) in the human cerebellum. NeuroReport 8:3123-126.
37. Sawchenko, P.E., L.W. Swanson, J. Rivier, and W.W. Vale (1985) The distribution of growth-hormone-releasing factor (GRF) immunoreactivity in the central nervous system of the rat: An immunohistochemical study using antisera directed against rat hypothalamic GRF. J. Comp. Neurol. 237:100-115.
38. Schwartz, M.W., R. J. Seeley, S.C. Woods, D.S. Weigle, L.A. Campfield, P. Burn, and D.G. Baskin (1996) Identification of targets of leptin action in rat hypothalamus. J. Clin. Invest. 8:1101-1106.
39. Schwartz, M.W., R.J. Seeley, L.A. Campfield, P. Burn, and D.G. Baskin (1997) Leptin increases hypothalamic pro-opiomelanocortin mRNA expression in the rostral arcuate nucleus. Diabetes 46:2119-2123.
40. Simmons, D.M., J.L. Arriza, and L.W. Swanson (1989) A complete protocol for in situ hybridization of messenger RNAs in brain and other tissues with radiolabelled single stranded RNA probes. J. Histotechnol. 12:169-181.
41. Spiegelman, B.M. and J.S. Flier (1996) Adipogenesis and obesity: Rounding out the big picture. Cell 87:377-389.
42. Stephens, T.W., M. Basinski, P.K. Bristow, J.M. Bue-Valleskey, S.G. Burgett, L. Craft, J. Hale, J. Hoffmann, H.M. Hsiung, A. Kriauciunas, W. MaKellar, P.R. Roseck Jr., B. Schoner, D. Smith, F.C. Tinsley, X.Y. Zhang, and M. Heiman (1995) The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 377:530-532.
43. Swanson, L.W. (1992) Brain Maps: Structure of the Rat Brain. Amsterdam: Elsevier.
44. Tartaglia, L.A., M. Dembski, X. Weng, N. Deng, J. Culpepper, R. Devos, G.J. Richards, L.A. Campfield, F.T. Clark, J. Deeds, C. Muir, S. Sanker, A. Moriarty, K.J. Moore, J.S. Smutko, G.G. Mays, E.A. Woolf, C.A. Monroe, and R.I. Tepper (1995) Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271.
45. ter Horst, G.J. and P.G. Luiten (1986) The projections of the dorsomedial hypothalamic nucleus in the rat. Brain Res. Bull. 16:231-248.
46. Thompson, R.H., N.S. Canteras, and L.W. Swanson (1996) Organization of projections from the dorsomedial nucleus of the hypothalamus: A PHA-L study in the rat. J. Comp. Neurol. 76:143-173.
47. Thorton, J.E., C.C. Cheung, D.K. Clifton, and R.A. Steiner (1997) Regulation of hypothalamic proopiomelanocortin mRNA by leptin in ob/ob mice. Endocrinology 138:5063-5066.
48. Van Dijk, G., T.E. Thiele, J.C. Donahey, L.A. Campfield, F.J. Smith, P. Burn, I.L. Bernstein, S.C. Woods, and R.J. Seeley (1996) Central infusions of leptin and GLP-1-(7-36) amide differentially stimulate c-FLI in the rat brain. Am. J. Physiol. 271:R1096-1100.
49. Woods, A.J. and M.J. Stock (1996) Leptin activation in hypothalamus. Nature 381:745.
50. Zhang, Y, R. Proenca, M. Maffei, M. Barone, L. Leopold, and J.M. Friedman (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432.