The β3-adrenergic receptor inhibits insulin-stimulated leptin secretion from isolated rat adipocytes

Endocrinology

Volumn 137, Issue 9, 1996, Pages 4054-4057

  Gettys, Thomas W ^a   Harkness, Peter J ^a   Watson, Patricia M ^a  

^a MEDICAL UNIVERSITY OF SOUTH CAROLINA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

5 [2 [[2 (3 CHLOROPHENYL) 2 HYDROXYETHYL]AMINO]PROPYL] 1,3 BENZODIOXOLE 2,2 DICARBOXYLIC ACID; BETA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 2 ADRENERGIC RECEPTOR BLOCKING AGENT; BETA 3 ADRENERGIC RECEPTOR; CYCLIC AMP DEPENDENT PROTEIN KINASE; GENE PRODUCT; INSULIN; NORADRENALIN;

ADIPOCYTE; ANIMAL CELL; ARTICLE; CONTROLLED STUDY; EPIDIDYMIS FAT; GENE EXPRESSION; INSULIN RELEASE; LIPOLYSIS; MALE; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION; WHITE ADIPOSE TISSUE;

EID: 0029813768     PISSN: 00137227     EISSN: None     Source Type: Journal    
DOI: 10.1210/endo.137.9.8756584     Document Type: Article

References (16)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM 1994 Positional cloning of the mouse obese gene and its human homologue. Nature 372:425-432
2. Tartaglia LA, Dembski M, Weng X, Deng N, Culpepper J, Devos R, Richards GJ, Campfield LA, Clark FT, Deeds J, Muir C, Sanker S, Moriarty A, Moore KJ, Smutko JS, Mays GG, Woolf EA, Monroe CA, Tepper RI 1995 Identification and expression cloning of a leptin receptor, OB-R. Cell 83:1263-1271
3. Halaas JL, Gajiwala KS, Maffei M, Cohen SL, Chait BT, Rabinowitz D, Lallone RL, Burley SK, Friedman JM 1995 Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269:543-546
4. Weigle DS, Bukowski TR, Foster DC, Holderman S, Kramer JM, Lasser G, Lofton-Day CE, Prunkard DE, Raymond C, Kuijper JL 1995 Recombinant ob protein reduces feeding and body weight in the ob/ob mouse. J.Clin.Invest. 96:2065-2070
5. Maffet M, Fei H, Lee G-H, Dani C, Leroy P, Zhang Y, Proenca R, Negrel R, Ailhaud G, Friedman JM 1995 Increased expression in adipocytes of ob RNA in mice with lesions of the hypothalamus and with mutations at the db locus. Proc.Natl.Acad.Sci.USA 92:6957-6960
6. Bray GA, York DA 1979 Genetically transmitted obesity in rodents. Physiol.Rev. 51:598-646
7. Bray GA 1991 Obesity, a disorder of nutrient partitioning: the MONA LISA hypothesis. J.Nutr. 121:1146-1162
8. Rentsch J, Chiesi M 1996 Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379:55-59
9. Leroy P, Dessolin S, Villageois P, Moon BC, Friedman JM, Ailhaud G, Dani C 1996 Expression of ob gene in adipose cells. J.Biol.Chem. 271:2365-2368
10. MacDougald OA, Hwang CS, Fan HY, Lane MD 1995 Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc.Natl.Acad.Sci.USA 92:9034-9037
11. Frederich RC, Löllmann B, Hamann A, Napolitano-Rosen A, Kahn BB, Lowell BB, Flier JS 1995 Expression of ob mRNA and its encoded protein in rodents - Impact of nutrition and obesity. J.Clin.Invest. 96:1658-1663
12. Rodbell M 1964 Metabolism of isolated fat cells. I. Effects of hormones on glucose metabolism and lipolysis. J.Biol.Chem. 239:375-380
13. Gettys TW, Ramkumar V, Uhing RJ, Seger L, Taylor IL 1991 Alterations in mRNA levels, expression, and function of GTP-binding regulatory proteins in adipocytes from obese mice (C57BL/6J-ob/ob). J.Biol.Chem. 266:15949-15955
14. Slicker LJ, Sloop KW, Surface PL, Kriauciunas A, LaQuier F, Manetta J, Bue-Valleskey J, Stephens TW 1996 Regulation of expression of ob mRNA and protein by glucocorticoids and cAMP. J.Biol.Chem. 271:5301-5304
15. Murakami T, Iida M, Shima K 1995 Dexamethasone regulates obese expression in isolated rat adipocytes. Biochem.Biophys.Res.Commun. 214:1260-1267
16. Collins S, Surwit RS 1996 Pharmacologic manipulation of ob expression in a dietary model of obesity. J.Biol.Chem. 271:9437-9440