What's in a name? In search of leptin's physiologic role

Journal of Clinical Endocrinology and Metabolism

Volumn 83, Issue 5, 1998, Pages 1407-1413

  Flier, Jeffrey S ^a  

^a BETH ISRAEL DEACONESS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LEPTIN; PROTEIN;

GENE EXPRESSION; GENOTYPE; HORMONE DETERMINATION; HUMAN; METABOLISM; OBESITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; REVIEW; SIGNAL TRANSDUCTION; STARVATION; ANIMAL; GENETICS; PHYSIOLOGY;

ANIMALS; GENOTYPE; HUMANS; LEPTIN; OBESITY; PROTEINS; STARVATION;

EID: 0032065645     PISSN: 0021972X     EISSN: None     Source Type: Journal    
DOI: 10.1210/jc.83.5.1407     Document Type: Review

References (76)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. 1994 Positional cloning of the mouse ob gene and its human homologue. Nature. 372:425-432.
2. Halaas J, Gajiwala K, Maffei M, et al. 1995 Weight reducing effect of the plasma protein encoded by the obese gene. Science. 269:543-546.
3. Campfield L, Smith F, Guisez Y, Devos R, Burn P. 1995 Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science. 269:546-548.
4. Pellymounter M, Cullen M, Baker M, et al. 1995 Effects of the obese gene product on body weight regulation in ob/ob mice. Science. 269:540-543.
5. Montague CT, Farooqi IS, Whitehead JP, et al. 1997 Congenital leptin deficiency is associated with severe early-onset obesity in humans. Nature. 387:903-908.
6. Weigle DS. 1994 Appetite and the regulation of body composition. [Review]. FASEB J. 8:302-310.
7. Frederich RC, Hamann A, Anderson S, Lollman B, Lowell BB, Flier JS. 1995 Leptin levels reflect body lipid content in mice: evidence for diet induced resistance to leptin action. Nat Med. 1:1311-1314.
8. Maffei M, Halaas J, Ravussin E, et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1155-1161.
9. Van Heek M, Compton DS, France CF, et al. 1997 Diet-induced obese mice develop peripheral, but not central, resistance to leptin. J Clin Invest. 99:385-390
10. Maffei M, Halaas J, Ravussin E, et al. 1995 Leptin levels in human and rodent: measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1155-1161.
11. Considine RV, Sinha M, Heiman M, et al. 1995 Serum immunoreactive leptin concentrations in normal weight and obese humans. N Engl J Med. 334:292-295.
12. Neel J. 1962 Diabetes mellitus: a "thrifty" genotype rendered detrimental by "progress". Am J Hum Genet. 14:353-362.
13. Wendorf M, Goldfine ID. 1991 Archaeology of NIDDM. Excavation of the "thrifty" genotype. Diabetes. 40:161-165.
14. Rothman D, Magnusson I, Cline G, et al. 1995 Decreased muscle glucose transport/phosphorylation is an early defect in the pathogenesis of noninsulin-dependent diabetes. Proc Natl Acad Sci USA. 92:983-987.
15. Moller DE, Chang PY, Yaspelkis BB, Flier JS, Wallberg H, Ivy JL. 1996 Transgenic mice with muscle-specific insulin resistance develop increased adiposity, impaired glucose tolerance, and dyslipidemia. Endocrinology. 137:2397-2405.
16. Coleman DL. 1978 Obese and diabetes: two mutant genes causing diabetesobesity syndromes in mice. [Review]. Diabetologia. 14:141-148.
17. Coleman D. 1979 Obesity genes: beneficial effects in heterozygous mice. Science. 203:663-665.
18. Frederich RC, Lollmann B, Hamann A, et al. 1995 Expression of oh mRNA and its encoded proded in rodents: impact of nutrition and obesity. J Clin Invest. 96:1658-1663.
19. Boden G, Chen X, Mozzoli M, Ryan I. 1996 Effect of fasting on serum leptin in normal human subjects. J Clin Endocrinol Metab. 81:3419-3423.
20. Schwartz MW, Dallman MF, Woods SC. 1995 Hypothalamic response to starvation: implications for the study of wasting disorders. Am J Physiol. 269:R949-R957.
21. Ahima RS, Prabarkarian D, Mantzoros C, et al. 1996 Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
22. Weigle DS. 1994 Appetite and the regulation of body composition. FASEB J. 8:302-310.
23. Collins S, Kuhn CM, Petro AE, Swick AG, Chrunyk BA, Surwit RS. 1996 Role of leptin in fat regulation. Nature. 380:677.
24. Fleury C, Neverova M, Collins S, et al. 1997 Upcoupling protein-2: a novel gene linked to obesity and hyperinsulinemia. Nat Genet. 15:269-272.
25. Gimeno RE, Dembski M, Weng X, et al. 1997 Cloning and characterization of an uncoupling protein homolog: a potential molecular mediator of human thermogenesis. Diabetes. 46:900-906.
26. Boss O, Samec S, Paoloni-Giacobino A, et al. 1997 Uncoupling protein-3: a new member of the mitochondrial carrier family with tissue-specific expression. FEBS Lett. 408:39-42.
27. Solanes G, Vidal-Puig A, Grujic D, Flier JS, Lowell BB. 1997 The human uncoupling protein-3 gene: genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. J Biol Chem. 272:25433-25436.
28. Gong DW, He Y, Karas M, Reitman M. 1997 Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, beta3-adrenergic agonists, and leptin. J Biol Chem. 272:24129-24132.
29. Chipkin S, Kelly K, Ruderman N. 1994 Hormone-fuel interrelationships: fed state, starvation, and diabetes mellitus. In: Kahn C, Weir G, eds. Joslin's diabetes mellitus. Philadelphia: Lea & Febiger; 97-115.
30. Baura GD, Foster DM, Porte Jr D, et al. 1993 Saturable transport of insulin from plasma into the central nervous system of dogs in vivo. J Clin Invest. 92:1824-1830.
31. Schwartz MW, Figlewitz DP, Baskin DG, Woods SC, Porte D. 1994 Insulin and the central regulation of energy balance: update. Endocr Rev. 2:109-113.
32. Deleted in proof.
33. Spencer C, Lum S, Wilbur J, Kaptein E, Nicoloff J. 1983 Dynamics of serum thyrotropin and thyroid hormone changes in fasting. J Clin Endocrinol Metab. 56:56-62.
34. Himms-Hagen J. 1990 Brown adipose tissue thermogenesis: interdisciplinary studies. FASEB J. 4:2890-2898.
35. Ahima RS, Dushay J, Flier SN, Prabakaran D, Flier JS. 1997 Leptin accelerates the onset of puberty in normal female mice. J Clin Invest. 99:391-395.
36. Ahima RS, Prabakaran D, Mantzoros C, et al. 1996 Role of leptin in the neuroendocrine response to fasting. Nature. 382:250-252.
37. Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM. 1997 Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology. 138:2569-2576.
38. Carro E, Senaris R, Considine RV, Casanueva FF, Dieguez C. 1997 Regulation of in vivo growth hormone secretion by leptin. Endocrinology. 138:2203-2206.
39. Snyder DK, Clemmons DR, Underwood LE. 1989 Dietary carbohydrate content determines responsiveness to growth in energy-restricted humans. J Clin Endocrinol Metab. 69:745-752.
40. Stephens TW, Basinski M, Bristow PK, et al. 1995 A role for neuropeptide Y in the antiobesity action of the obese gene product. Nature. 377:530-532.
41. Mercer JG, Hoggard N, Williams LM, et al. 1996 Coexpression of leptin receptor and preproneuropeptide Y mRNA in arcuate nucleus of mouse hypothalamus. J Neuroendocrinol. 8:733-735.
42. Schwartz MW, Seeley RJ, Campfield LA, Burn P, Baskin DG. 1996 Identification of targets of leptin action in rat hypothalamus. J Clin Invest. 98:1101-1106.
43. Liu J, Clarke I, Funder J, Engler D. 1994 Studies of the secretion of corticotropin-releasing factor and arginine vasopressin into the hypophysial-portal circulation of the conscious sheep. J Clin Invest. 93:1439-1450.
44. Kalra S. 1997 Appetite and body weight regulation: is it all in the brain? Neuron. 19:227-230.
45. Erickson JC, Clegg KE, Palmiter RD. 1996 Sensitivity to leptin and susceptibility to seizures of mice lacking neuropeptide Y [see comments]. Nature. 381:415-421.
46. Erickson J, Ahima R, Hollopeter G, Flier JS, Palmiter RD. 1997 Endocrine function of neuropeptide Y knockout mice. Regul Pept. 70:199-202.
47. Yu WH, Kimura M, Walczewska A, Karanth S, McCann SM. 1997 Role of leptin in hypothalamic-pituitary function. Proc Natl Acad Sci USA. 94:1023-1028.
48. Bornstein S, Uhlmann K, Haidan A, Ehrhart-Bornstein M, Scherbaum W. 1997 Evidence for a novel peripheral action of leptin as a metabolic signal to the adrenal gland: leptin inhibits cortisol release directly. Diabetes. 46:1235-1238.
49. Zachow RJ, Magoffin DA. 1997 Direct intraovarian effects of leptin: impairment of the synergistic action of insulin-like growth factor-1 on follicle-stimulating hormone-dependent estradiol-17 beta production by rat ovarian granulosa cells. Endocrinology. 138:847-850.
50. MacDougald OA, Hwang CS, Fan H, Lane MD. 1995 Regulated expression of the obese gene product (leptin) in white adipose tissue and 3T3-L1 adipocytes. Proc Natl Acad Sci USA. 92:9034-9037.
51. Saladin R, De Vos P, Guerre-Millo M, et al. 1995 Transient increase in obese gene expression after food intake or insulin administration. Nature. 377:527-529.
52. Rentsch J, Chiesi M. 1996 Regulation of ob gene mRNA levels in cultured adipocytes. FEBS Lett. 379:55-59.
53. Boden G, Chen X, Kolaczynski JPM. 1997 Effects of prolonged hyperinsulinemia on serum leptin in normal human subjects. J Clin Invest. 100:1107-1113.
54. Rossetti L, Massillon D, Barzilai N, et al. 1997 Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem. 272:27758-27763.
55. Kamohara S, Burcelin R, Halass JL, Friedman J, Charron M. 1997 Acute stimulation of glucose metabolism in mice by leptin treatment. Nature. 389:374-377.
56. Siegrist-Kaiser C, Pauli V, Juge-Aubry C, et al. 1997 Direct effect of leptin on brown and white adipose tissue. J Clin Invest. 100:2858-2864.
57. Sinha MK, Ohannesian JP, Heiman ML, et al. 1996 Nocturnal rise of leptin in lean, obese, and non-insulin-dependent diabetes mellitus subjects. J Clin Invest. 97:1344-1347.
58. Korbonits M, Trainer PJ, Little JA, et al. 1997 Leptin levels do not change acutely with food administration in normal or obese subjects, but are negatively correlated with pituitary-adrenal activity. Clin Endocrinol (Oxf.) 46:751-757.
59. Elmquist JK, Ahima RS, Elias CF, Flier JS, Saper CB. 1998 Leptin activates distinct projections from the dorsomedial and ventromedial hypothalamic nuclei. Proc Natl Acad Sci USA. 95:741-746.
60. Licinio J, Mantzoros C, Negrao AB, et al. 1997 Human leptin levels are pulsatile and inversely related to pituitary-adrenal function. Nat Med. 3:575-579.
61. Heiman ML, Ahima RS, Craft LS, Schoner B, Stephens TW, Flier JS. 1997 Leptin inhibition of the hypothalamic-pituitary-adrenal axis in response to stress. Endocrinology. 138:3859-3863.
62. Schwartz MW, Seeley RJ. 1997 The new biology of body weight regulation. J Am Diet Assoc. 97:54-58.
63. Levine AS, Billington CJ. 1997 Why do we eat? A neural systems approach. Annu Rev Nutr. 17:597-619.
64. Rothwell N. Central effects of CRF on metabolism and energy balance. Neurosci Biobehav Rev. 14:263-271.
65. Egawa M, Yoshimatsu H, Bray GA. 1990 Preoptic area injection of corticotropin-releasing hormone stimulates sympathetic activity. Am J Physiol. 259:R799-R806.
66. Sawchenko PE, Imaki T, Potter E, Kovacs K, Imaki J, Vale W. 1993 The functional neuroanatomy of corticotropin-releasing factor. Ciba Found Symp. 172:5-21.
67. Weeke J, Gundersen HJ. 1978 Circadian and 30 minutes variations in serum TSH and thyroid hormones in normal subjects. Acta Endocrinol (Copenh). 89:659-672.
68. Kerr DJ, Singh VK, McConway MG, et al. 1987 Circadian variation of thyrotrophin, determined by ultrasensitive immunoradiometric assay, and the effect of low dose nocturnal dopamine infusion. Clin Sci. 72:737-741.
69. Chehab FF, Mounzih K, Lu R, Lim ME. 1997 Early onset of reproductive function in normal female mice treated with leptin. Science. 275:88-90.
70. Barash IA, Cheung CC, Weigle DS, et al. 1996 Leptin is a metabolic signal to the reproductive system. Endocrinology. 137:3144-3147.
71. Mantzoros CS, Flier JS, Rogol AD. 1997 A longitudinal assessment of hormonal and physical alterations during normal puberty in boys. V. Rising leptin levels may signal the onset of puberty. J Clin Endocrinol Metab. 82:1066-1070.
72. Chehab FF, Lim ME, Lu R. 1996 Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet. 12:318-320.
73. Plant T, Durrant A. 1997 Circulating leptin does not appear to provide a signal for triggering the initiation of puberty in the male rhesus monkey (Macaca mulatta). Endocrinology. 138:4505-4508.
74. Vannucci S, Gibbs E, Simpson I. 1997 Glucose utilization and glucose transporter proteins GLUT-1 and GLUT-3 in brains of diabetic (db/db) mice. Am J Physiol. 272:E267-E274.
75. Umemoto Y, Tsuji K, Yang F, et al. 1997 Leptin stimulates the proliferation of murine myelocytic and primitive hematopoeitic progenitor cells. Blood. 90:3438-3443.
76. Haynes WG, Sivitz WI, Morgan DA, Walsh SA, Mark AL. 1997 Sympathetic and cardiorenal actions of leptin. Hypertension. 30:619-623.