Leptin inhibits epileptiform-like activity in rat hippocampal neurones via PI 3-kinase-driven activation of BK channels

Journal of Physiology

Volumn 545, Issue 3, 2002, Pages 933-944

  Shanley, L J ^a   O'Malley, D ^a   Irving, A J ^a   Ashford, M L ^a   Harvey, J ^a  

^a UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2 HYDROXY 5 TRIFLUOROMETHYLPHENYL) 5 TRIFLUOROMETHYL 2(3H) BENZIMIDAZOLONE; 2 MORPHOLINO 8 PHENYLCHROMONE; CALCIUM ACTIVATED POTASSIUM CHANNEL; CALCIUM ION; CHARYBDOTOXIN; IBERIOTOXIN; LEPTIN RECEPTOR; MAGNESIUM ION; MITOGEN ACTIVATED PROTEIN KINASE; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE INHIBITOR; POTASSIUM CHANNEL; POTASSIUM ION; RECOMBINANT LEPTIN; WORTMANNIN; ADENOSINE TRIPHOSPHATE SENSITIVE POTASSIUM CHANNEL; LARGE CONDUCTANCE CALCIUM ACTIVATED POTASSIUM CHANNEL; LEPTIN;

ANIMAL CELL; ANIMAL TISSUE; ANTICONVULSANT THERAPY; CONTROLLED STUDY; DENDRITE; DRUG TARGETING; EPILEPTIC DISCHARGE; HIPPOCAMPUS; ION CONDUCTANCE; MOLECULAR MIMICRY; NERVE CELL EXCITABILITY; NERVE CELL INHIBITION; NERVE FIBER; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RAT; REVIEW; SIGNAL TRANSDUCTION; SYNAPSE; ARTICLE; HIPPOCAMPAL NEURONAL CULTURE; TEMPORAL LOBE EPILEPSY;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ADENOSINE TRIPHOSPHATE; ANIMALS; CALCIUM; CELLS, CULTURED; CULTURE MEDIA; EPILEPSY; HIPPOCAMPUS; HUMANS; LARGE-CONDUCTANCE CALCIUM-ACTIVATED POTASSIUM CHANNELS; LEPTIN; MAGNESIUM; MITOGEN-ACTIVATED PROTEIN KINASES; NEURONS; POTASSIUM CHANNELS; POTASSIUM CHANNELS, CALCIUM-ACTIVATED; RATS; RECEPTORS, CELL SURFACE; RECOMBINANT PROTEINS;

EID: 0037115192     PISSN: 00223751     EISSN: None     Source Type: Journal    
DOI: 10.1113/jphysiol.2002.029488     Document Type: Review

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