-
2
-
-
0024846310
-
Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor
-
Gearing, D. P., King, J. A., Gough, N. M. & Nicola, N. A. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 8, 3667-3676 (1989).
-
(1989)
EMBO J.
, vol.8
, pp. 3667-3676
-
-
Gearing, D.P.1
King, J.A.2
Gough, N.M.3
Nicola, N.A.4
-
3
-
-
0028845212
-
Cytokine receptor signalling
-
Ihle, J. N. Cytokine receptor signalling. Nature 377, 591-594 (1995).
-
(1995)
Nature
, vol.377
, pp. 591-594
-
-
Ihle, J.N.1
-
4
-
-
0033772659
-
Jak-STAT signaling pathways in cells of the immune system
-
Ivashkiv, L. B. Jak-STAT signaling pathways in cells of the immune system. Rev. Immunogenet. 2, 220-230 (2000)
-
(2000)
Rev. Immunogenet.
, vol.2
, pp. 220-230
-
-
Ivashkiv, L.B.1
-
5
-
-
0035234774
-
Negative regulation of Janus kinases
-
Duhe, R. J., Wang, L. H. & Farrar, W. L. Negative regulation of Janus kinases. Cell. Biochem. Biophys. 34, 17-59 (2001)
-
(2001)
Cell. Biochem. Biophys.
, vol.34
, pp. 17-59
-
-
Duhe, R.J.1
Wang, L.H.2
Farrar, W.L.3
-
6
-
-
0032966863
-
Negative regulation of the JAK/STAT pathway
-
Starr, R. & Hilton, D. Negative regulation of the JAK/STAT pathway. Bioessays 21, 47-52 (1999).
-
(1999)
Bioessays
, vol.21
, pp. 47-52
-
-
Starr, R.1
Hilton, D.2
-
7
-
-
13144258732
-
Twenty proteins containing a C-terminal SOCS box form five structural classes
-
Hilton, D. J. et al. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl Acad. Sci. USA 95, 114-119 (1998). This paper describes the extended SOCS family of proteins, which are characterized by a carboxy-terminal SOCS-box motif.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 114-119
-
-
Hilton, D.J.1
-
8
-
-
0030755934
-
Structure and function of a new STAT-induced STAT inhibitor
-
Naka, T. et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929 (1997).
-
(1997)
Nature
, vol.387
, pp. 924-929
-
-
Naka, T.1
-
9
-
-
0030792590
-
A family of cytokine-inducible inhibitors of signalling
-
Starr, R. et al. A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921 (1997).
-
(1997)
Nature
, vol.387
, pp. 917-921
-
-
Starr, R.1
-
10
-
-
0030839112
-
A new protein containing an SH2 domain that inhibits JAK kinases
-
Endo, T. A. et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924 (1997).
-
(1997)
Nature
, vol.387
, pp. 921-924
-
-
Endo, T.A.1
-
11
-
-
0032772125
-
Suppression of STAT5 functions in liver, mammary glands and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
-
Matsumoto, A. et al. Suppression of STAT5 functions in liver, mammary glands and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell. Biol. 19, 6396-6407 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6396-6407
-
-
Matsumoto, A.1
-
12
-
-
20244389693
-
The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
-
Yasukawa, H. et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 1309-1320
-
-
Yasukawa, H.1
-
13
-
-
0033555258
-
Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
-
Nicholson, S. E. et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18, 375-385 (1999). References 12 and 13 describe the SH2- and amino-terminal-domain requirements for the interaction of SOCS1 with JAKs and the inhibition of kinase activity.
-
(1999)
EMBO J.
, vol.18
, pp. 375-385
-
-
Nicholson, S.E.1
-
14
-
-
0034703097
-
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
-
Sasaki, A. et al. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29338-29347
-
-
Sasaki, A.1
-
15
-
-
0034612271
-
Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
-
Nicholson, S. E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA 97, 6493-6498 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 6493-6498
-
-
Nicholson, S.E.1
-
16
-
-
0033305402
-
Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
-
Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, J. H. & Billestrup, N. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13, 1832-1843 (1999).
-
(1999)
Mol. Endocrinol.
, vol.13
, pp. 1832-1843
-
-
Hansen, J.A.1
Lindberg, K.2
Hilton, D.J.3
Nielsen, J.H.4
Billestrup, N.5
-
17
-
-
0001421697
-
SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
-
Bjorbaek, C. et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275, 40649-40657 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 40649-40657
-
-
Bjorbaek, C.1
-
18
-
-
0033037268
-
SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
-
Cohney, S. J. et al. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol. 19, 4980-4988 (1999).
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 4980-4988
-
-
Cohney, S.J.1
-
19
-
-
0034703097
-
CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
-
Sasaki, A. et al. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 29338-29347
-
-
Sasaki, A.1
-
20
-
-
0034724677
-
SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
-
Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C. & Schaper, F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275, 12848-12856 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 12848-12856
-
-
Schmitz, J.1
Weissenbach, M.2
Haan, S.3
Heinrich, P.C.4
Schaper, F.5
-
21
-
-
0032535364
-
The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families
-
Kamura, T. et al. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families. Genes Dev. 12, 3872-3881 (1998).
-
(1998)
Genes Dev.
, vol.12
, pp. 3872-3881
-
-
Kamura, T.1
-
22
-
-
13044263097
-
The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
-
Zhang, J. G. et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl Acad. Sci. USA 96, 2071-2076 (1999). References 21 and 22 show that the SOCS-box domain binds elongins B and C, which establishes a link to the proteasomal degradation pathway.
-
(1999)
Proc. Natl. Acad. Sci. USA
, vol.96
, pp. 2071-2076
-
-
Zhang, J.G.1
-
23
-
-
0030983549
-
Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
-
Yu, C. L. & Burakoff, S. J. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J. Biol. Chem. 272, 14017-14020 (1997).
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 14017-14020
-
-
Yu, C.L.1
Burakoff, S.J.2
-
24
-
-
0032561322
-
Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein
-
Verdier, F. et al. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein J. Biol. Chem. 273, 28185-28190 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 28185-28190
-
-
Verdier, F.1
-
25
-
-
0034640526
-
Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
-
De Sepulveda, P., Ilangumaran, S. & Rottapel, R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J. Biol. Chem. 275, 14005-14008 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 14005-14008
-
-
De Sepulveda, P.1
Ilangumaran, S.2
Rottapel, R.3
-
26
-
-
0035918239
-
The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
-
Kamizono, S. et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276, 12530-12538 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 12530-12538
-
-
Kamizono, S.1
-
27
-
-
0035036625
-
Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation
-
Frantsve, J., Schwaller, J., Sternberg, D. W., Kutok, J. & Gilliland, D. G. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21, 3547-3557 (2001).
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 3547-3557
-
-
Frantsve, J.1
Schwaller, J.2
Sternberg, D.W.3
Kutok, J.4
Gilliland, D.G.5
-
28
-
-
0035818573
-
The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
-
Zhang, J. G. et al. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl Acad. Sci. USA 98, 13261-13265 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 13261-13265
-
-
Zhang, J.G.1
-
29
-
-
0033828672
-
SOCS physiological suppressors of cytokine signaling
-
Krebs, D. L. & Hilton, D. J. SOCS: physiological suppressors of cytokine signaling. J. Cell. Sci. 113, 2813-2819 (2000).
-
(2000)
J. Cell. Sci.
, vol.113
, pp. 2813-2819
-
-
Krebs, D.L.1
Hilton, D.J.2
-
30
-
-
0034841006
-
Negative regulation of cytokine signaling
-
Greenhalgh, C. J. & Hilton, D. J. Negative regulation of cytokine signaling. J. Leukocyte Biol. 70, 348-356 (2001).
-
(2001)
J. Leukocyte Biol.
, vol.70
, pp. 348-356
-
-
Greenhalgh, C.J.1
Hilton, D.J.2
-
31
-
-
0034663932
-
Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice
-
Fujimoto, M. et al. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice. J. Immunol. 165, 1799-1806 (2000).
-
(2000)
J. Immunol.
, vol.165
, pp. 1799-1806
-
-
Fujimoto, M.1
-
32
-
-
0033520467
-
SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
-
Marine, J. C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616 (1999)
-
(1999)
Cell
, vol.98
, pp. 609-616
-
-
Marine, J.C.1
-
33
-
-
13044276245
-
Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice
-
Naka, T. et al. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice. Proc. Natl Acad. Sci. USA 95, 15577-15582 (1998).
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 15577-15582
-
-
Naka, T.1
-
34
-
-
0032564463
-
Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
-
-/- mice.
-
(1998)
Proc. Natl. Acad. Sci. USA
, vol.95
, pp. 14395-14399
-
-
Starr, R.1
-
35
-
-
0019474347
-
Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice
-
Gresser, I. et al. Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice. Am. J. Pathol. 102, 396-402 (1981).
-
(1981)
Am. J. Pathol.
, vol.102
, pp. 396-402
-
-
Gresser, I.1
-
37
-
-
0033520326
-
SOCS1 is a critical inhibitor of interferon-γ signaling and prevents the potentially fatal neonatal actions of this cytokine
-
Alexander, W. S. et al. SOCS1 is a critical inhibitor of interferon-γ signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597-608 (1999).
-
(1999)
Cell
, vol.98
, pp. 597-608
-
-
Alexander, W.S.1
-
38
-
-
0035933805
-
Suppressor of cytokine signaling-1 attenuates the duration of interferon-γ signal transduction in vitro and in vivo
-
Brysha, M. et al. Suppressor of cytokine signaling-1 attenuates the duration of interferon-γ signal transduction in vitro and in vivo. J. Biol. Chem. 276, 22086-22089 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22086-22089
-
-
Brysha, M.1
-
39
-
-
0035008978
-
SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo
-
Naka, T. et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo. Immunity 14, 535-545 (2001).
-
(2001)
Immunity
, vol.14
, pp. 535-545
-
-
Naka, T.1
-
40
-
-
0034255408
-
The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene
-
Metcalf, D., Di Rago, L., Mifsud, S., Hartley, L. & Alexander, W. S. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene. Proc. Natl Acad. Sci. USA 97, 9174-9179 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 9174-9179
-
-
Metcalf, D.1
Di Rago, L.2
Mifsud, S.3
Hartley, L.4
Alexander, W.S.5
-
41
-
-
0037154210
-
Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
-
Metcalf, D, et al. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl Acad. Sci. USA 99, 943-948 (2002)
-
(2002)
Proc. Natl. Acad. Sci. USA
, vol.99
, pp. 943-948
-
-
Metcalf, D.1
-
42
-
-
0034502224
-
H1 differentiation by IL-6 is mediated by SOCS1
-
H1 differentiation by IL-6 is mediated by SOCS1. Immunity 13, 805-815 (2000).
-
(2000)
Immunity
, vol.13
, pp. 805-815
-
-
Diehl, S.1
-
43
-
-
0034624986
-
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor-α-induced cell death in fibroblasts
-
Morita, Y. et al. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor-α-induced cell death in fibroblasts. Proc. Natl Acad. Sci. USA 97, 5405-5410 (2000).
-
(2000)
Proc. Natl. Acad. Sci. USA
, vol.97
, pp. 5405-5410
-
-
Morita, Y.1
-
44
-
-
0034725044
-
SOCS-1 can suppress CD3ζ- and Syk-mediated NF-AT activation in a non-lymphoid cell line
-
Matsuda, T., Yamamoto, T., Kishi, H., Yoshimura, A. & Muraguchi, A. SOCS-1 can suppress CD3ζ- and Syk-mediated NF-AT activation in a non-lymphoid cell line. FEBS Lett. 472, 235-240 (2000).
-
(2000)
FEBS Lett.
, vol.472
, pp. 235-240
-
-
Matsuda, T.1
Yamamoto, T.2
Kishi, H.3
Yoshimura, A.4
Muraguchi, A.5
-
45
-
-
0034689007
-
Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells
-
Li, S. et al. Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells. J. Exp. Med. 191, 985-994 (2000).
-
(2000)
J. Exp. Med.
, vol.191
, pp. 985-994
-
-
Li, S.1
-
46
-
-
0033520389
-
SOCS3 is essential in the regulation of fetal liver erythropoiesis
-
Marine, J. C. et al. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell 98, 617-627 (1999).
-
(1999)
Cell
, vol.98
, pp. 617-627
-
-
Marine, J.C.1
-
47
-
-
0034729710
-
Gigantism in mice lacking suppressor of cytokine signalling-2
-
Metcalf, D. et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405, 1069-1073 (2000).
-
(2000)
Nature
, vol.405
, pp. 1069-1073
-
-
Metcalf, D.1
-
48
-
-
0035979275
-
Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
-
Roberts, A. W. et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl Acad. Sci. USA 98, 9324-9329 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 9324-9329
-
-
Roberts, A.W.1
-
49
-
-
13344279401
-
STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
-
Gouilleux-Gruart, V. et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87, 1692-1697 (1996).
-
(1996)
Blood
, vol.87
, pp. 1692-1697
-
-
Gouilleux-Gruart, V.1
-
50
-
-
0031436969
-
B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
-
Frank, D. A., Mahajan, S. & Ritz, J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT)1 and STAT3 constitutively phosphorylated on serine residues. J. Clin. Invest. 100, 3140-3148 (1997).
-
(1997)
J. Clin. Invest.
, vol.100
, pp. 3140-3148
-
-
Frank, D.A.1
Mahajan, S.2
Ritz, J.3
-
51
-
-
0031573141
-
Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
-
Chai, S. K., Nichols, G. L. & Rothman, P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J. Immunol. 159, 4720-4728 (1997).
-
(1997)
J. Immunol.
, vol.159
, pp. 4720-4728
-
-
Chai, S.K.1
Nichols, G.L.2
Rothman, P.3
-
52
-
-
0035910753
-
CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
-
Suzuki, A. et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193, 471-481 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 471-481
-
-
Suzuki, A.1
-
53
-
-
0035667907
-
Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
-
Shouda, T. et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108, 1781-1788 (2001). This study indicated the efficacy of Socs3 gene therapy for the treatment of experimental arthritis in mice.
-
(2001)
J. Clin. Invest.
, vol.108
, pp. 1781-1788
-
-
Shouda, T.1
-
54
-
-
0035877256
-
Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
-
Dalpke, A. H., Opper S., Zimmermann, S. & Heeg, K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166, 7082-7089 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 7082-7089
-
-
Dalpke, A.H.1
Opper, S.2
Zimmermann, S.3
Heeg, K.4
-
55
-
-
0033197958
-
Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ
-
Stoiber, D. et al. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ. J. Immunol. 163, 2640-2647 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 2640-2647
-
-
Stoiber, D.1
-
56
-
-
0033570054
-
CIS associates with the interlukin-2 receptor β-chain and inhibits interleukin-2-dependent signaling
-
Aman, M. J. et al. CIS associates with the interlukin-2 receptor β-chain and inhibits interleukin-2-dependent signaling. J. Biol. Chem. 274, 30266-30272 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 30266-30272
-
-
Aman, M.J.1
-
57
-
-
0029014206
-
A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors
-
Yoshimura, A. et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors. EMBO J. 14, 2816-2826 (1995).
-
(1995)
EMBO J.
, vol.14
, pp. 2816-2826
-
-
Yoshimura, A.1
-
58
-
-
0035148616
-
Interleukin-9 induces expression of three cytokine signal inhibitors: Cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin-9 signalling
-
Lejeune, D., Demoulin, J. B. & Renauld, J. C. Interleukin-9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin-9 signalling. Biochem. J. 353, 109-116 (2001).
-
(2001)
Biochem. J.
, vol.353
, pp. 109-116
-
-
Lejeune, D.1
Demoulin, J.B.2
Renauld, J.C.3
-
59
-
-
0034284540
-
IL-10 attenuates IFN-α-activated STAT1 in the liver: Involvement of SOCS2 and SOCS3
-
Shen, X., Hong, F., Nguyen, V. A. & Gao, B. IL-10 attenuates IFN-α-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. FEBS Lett. 480, 132-136 (2000).
-
(2000)
FEBS Lett.
, vol.480
, pp. 132-136
-
-
Shen, X.1
Hong, F.2
Nguyen, V.A.3
Gao, B.4
-
60
-
-
0031915126
-
Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
-
Adams, T. E. et al. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273, 1285-1287 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 1285-1287
-
-
Adams, T.E.1
-
61
-
-
0033609928
-
Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
-
Pezet, A., Favre, H., Kelly, P. A. & Edery, M. Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. J. Biol. Chem. 274, 24497-24502 (1999).
-
(1999)
J. Biol. Chem.
, vol.274
, pp. 24497-24502
-
-
Pezet, A.1
Favre, H.2
Kelly, P.A.3
Edery, M.4
-
62
-
-
0033485438
-
Requirement for Stat5 in thymic stromal lymphopoietin-mediated signal transduction
-
Isaksen, D. E. et al. Requirement for Stat5 in thymic stromal lymphopoietin-mediated signal transduction. J. Immunol. 163, 5971-5977 (1999).
-
(1999)
J. Immunol.
, vol.163
, pp. 5971-5977
-
-
Isaksen, D.E.1
-
63
-
-
0035827663
-
Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal muscle cells is mediated by Stat5*
-
Sadowski, C. L. et al. Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal muscle cells is mediated by Stat5*. J. Biol. Chem. 276, 20703-20710 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 20703-20710
-
-
Sadowski, C.L.1
-
64
-
-
0033324777
-
Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor
-
Bjorbaek, C. et al. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology 140, 2035-2043 (1999).
-
(1999)
Endocrinology
, vol.140
, pp. 2035-2043
-
-
Bjorbaek, C.1
-
65
-
-
0033001325
-
Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues
-
Emilsson, V., Arch, J. R., de Groot, R. P., Lister, C. A. & Cawthorne, M. A. Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett. 455, 170-174 (1999)
-
(1999)
FEBS Lett.
, vol.455
, pp. 170-174
-
-
Emilsson, V.1
Arch, J.R.2
De Groot, R.P.3
Lister, C.A.4
Cawthorne, M.A.5
-
66
-
-
0032853513
-
Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: Involvement of the ubiquitin proteosome pathway
-
Okabe, S. et al. Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. Exp. Hematol. 27, 1542-1547 (1999).
-
(1999)
Exp. Hematol.
, vol.27
, pp. 1542-1547
-
-
Okabe, S.1
-
67
-
-
0033544899
-
SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
-
Ram, P. A. & Waxman, D. J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem 274, 35553-35561 (1999).
-
(1999)
J. Biol. Chem
, vol.274
, pp. 35553-35561
-
-
Ram, P.A.1
Waxman, D.J.2
-
68
-
-
0034685906
-
Mechanism of STAT3 activation by insulin-like growth factor 1 receptor
-
Zong, C. S. et al. Mechanism of STAT3 activation by insulin-like growth factor 1 receptor. J. Biol. Chem. 275, 15099-15105 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15099-15105
-
-
Zong, C.S.1
-
69
-
-
0035168683
-
JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
-
Spom, B., Kovanen, P. E., Sasaki, A., Yoshimura, A. & Leonard, W. J. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling Blood 97, 221-226 (2001).
-
(2001)
Blood
, vol.97
, pp. 221-226
-
-
Spom, B.1
Kovanen, P.E.2
Sasaki, A.3
Yoshimura, A.4
Leonard, W.J.5
-
70
-
-
17744387312
-
Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells
-
Park, E. S. et al. Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Mol. Endocrinol. 14, 440-448 (2000).
-
(2000)
Mol. Endocrinol.
, vol.14
, pp. 440-448
-
-
Park, E.S.1
-
71
-
-
0033558088
-
Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
-
De Sepulveda, P. et al. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 18, 904-915 (1999).
-
(1999)
EMBO J.
, vol.18
, pp. 904-915
-
-
De Sepulveda, P.1
-
72
-
-
0035853414
-
Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo
-
Hamanaka, I. et al. Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo. Circ. Res. 88, 727-732 (2001).
-
(2001)
Circ. Res.
, vol.88
, pp. 727-732
-
-
Hamanaka, I.1
-
73
-
-
0034665904
-
Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1
-
Wang, Q., Miyakawa, Y., Fox, N. & Kaushansky, K. Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. Blood 96, 2093-2099 (2000).
-
(2000)
Blood
, vol.96
, pp. 2093-2099
-
-
Wang, Q.1
Miyakawa, Y.2
Fox, N.3
Kaushansky, K.4
-
74
-
-
0032170490
-
A Janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons
-
Sakamoto, H. et al. A Janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons. Blood 92, 1668-1676 (1998).
-
(1998)
Blood
, vol.92
, pp. 1668-1676
-
-
Sakamoto, H.1
-
75
-
-
0033120880
-
Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction
-
Losman, J. A., Chen, X. P., Hilton, D. & Rothman, P. Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction. J. Immunol. 162, 3770-3774 (1999).
-
(1999)
J. Immunol.
, vol.162
, pp. 3770-3774
-
-
Losman, J.A.1
Chen, X.P.2
Hilton, D.3
Rothman, P.4
-
76
-
-
0035871862
-
Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes
-
Trop, S., De Sepulveda, P., Zuniga-Pflucker, J. C. & Rottapel, R. Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes. Blood 97, 2269-2277 (2001).
-
(2001)
Blood
, vol.97
, pp. 2269-2277
-
-
Trop, S.1
De Sepulveda, P.2
Zuniga-Pflucker, J.C.3
Rottapel, R.4
-
77
-
-
0035933751
-
Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal
-
Bourette, R. P. et al. Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal. J. Biol. Chem. 276, 22133-22139 (2001).
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 22133-22139
-
-
Bourette, R.P.1
-
78
-
-
0035862334
-
Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
-
Kawazoe, Y. et al. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J. Exp. Med. 193, 263-269 (2001).
-
(2001)
J. Exp. Med.
, vol.193
, pp. 263-269
-
-
Kawazoe, Y.1
-
79
-
-
0032567353
-
The suppressor of cytokine signaling (SOCS)1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
-
Song, M. M. & Shuai, K. The suppressor of cytokine signaling (SOCS)1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273, 35056-35062 (1998).
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 35056-35062
-
-
Song, M.M.1
Shuai, K.2
-
80
-
-
0031559588
-
Cloning and functional analysis of new members of STAT-induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
-
Minamoto, S. et al. Cloning and functional analysis of new members of STAT-induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem. Biophys. Res. Commun. 237, 79-83 (1997).
-
(1997)
Biochem. Biophys. Res. Commun.
, vol.237
, pp. 79-83
-
-
Minamoto, S.1
-
81
-
-
0034635550
-
Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1β on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
-
Boisclair Y. R., Wang, J., Shi, J., Hurst, K. R. & Ooi, G. T. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1β on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J. Biol. Chem. 275, 3841-3847 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 3841-3847
-
-
Boisclair, Y.R.1
Wang, J.2
Shi, J.3
Hurst, K.R.4
Ooi, G.T.5
-
82
-
-
0035863095
-
Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
-
Magrangeas, F., Boisteau, O., Denis S., Jacques, Y. & Minvielle, S. Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3). Biochem. J. 353, 223-230 (2001).
-
(2001)
Biochem. J.
, vol.353
, pp. 223-230
-
-
Magrangeas, F.1
Boisteau, O.2
Denis, S.3
Jacques, Y.4
Minvielle, S.5
-
83
-
-
0033054062
-
Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: Evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis
-
Auernhammer, C. J. & Melmed, S. Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis. Endocrinology 140, 1550-1566 (1999).
-
(1999)
Endocrinology
, vol.140
, pp. 1550-1566
-
-
Auernhammer, C.J.1
Melmed, S.2
-
84
-
-
0035877120
-
Identification, cloning and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
-
Kotenko, S. V. et al. Identification, cloning and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J. Immunol. 166, 7096-7103 (2001).
-
(2001)
J. Immunol.
, vol.166
, pp. 7096-7103
-
-
Kotenko, S.V.1
-
85
-
-
0035006109
-
Tyrosine-phosphorated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
-
Cacalano, N. A., Sanden, D. & Johnston, J. A. Tyrosine-phosphorated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nature Cell. Biol. 3, 460-465 (2001).
-
(2001)
Nature Cell. Biol.
, vol.3
, pp. 460-465
-
-
Cacalano, N.A.1
Sanden, D.2
Johnston, J.A.3
-
86
-
-
0034705453
-
The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
-
Terstegen, L. et al. The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. J. Biol. Chem. 275, 18810-18817 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 18810-18817
-
-
Terstegen, L.1
-
87
-
-
0032230273
-
Pituitary corticotroph SOCS-3: Novel intra cellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion
-
Auernhammer, C. J., Chesnokova, V., Bousquet, C. & Melmed, S. Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion. Mol. Endocrinol. 12, 954-961 (1998).
-
(1998)
Mol. Endocrinol.
, vol.12
, pp. 954-961
-
-
Auernhammer, C.J.1
Chesnokova, V.2
Bousquet, C.3
Melmed, S.4
-
88
-
-
0034982578
-
Negative regulation of onconstatin M signaling by suppressor of cytokine signaling (SOCS-3)
-
Magrangeas, F., Boisteau, O., Denis, S., Jacques, Y. & Minvielle, S. Negative regulation of onconstatin M signaling by suppressor of cytokine signaling (SOCS-3). Eur. Cytokine Netw. 12, 309-315 (2001).
-
(2001)
Eur. Cytokine Netw.
, vol.12
, pp. 309-315
-
-
Magrangeas, F.1
Boisteau, O.2
Denis, S.3
Jacques, Y.4
Minvielle, S.5
-
89
-
-
0032014178
-
Identification of SOCS-3 as a potential mediator of central leptin resistance
-
Bjorbaek, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E. & Flier, J. S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1, 619-625 (1998).
-
(1998)
Mol. Cell.
, vol.1
, pp. 619-625
-
-
Bjorbaek, C.1
Elmquist, J.K.2
Frantz, J.D.3
Shoelson, S.E.4
Flier, J.S.5
-
90
-
-
0035409338
-
Tumor-necrosis factor-α attenuates interferon-α signaling in the liver: Involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy
-
Hong, F., Nguyen, V. A. & Gao, B. Tumor-necrosis factor-α attenuates interferon-α signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy. FASEB J. 15, 1595-1597 (2001).
-
(2001)
FASEB J.
, vol.15
, pp. 1595-1597
-
-
Hong, F.1
Nguyen, V.A.2
Gao, B.3
-
91
-
-
0035834171
-
Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ-mediated toxicity
-
Karlsen, A. E. et al. Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ -mediated toxicity. Proc. Natl Acad. Sci. USA 98, 12191-12196 (2001).
-
(2001)
Proc. Natl. Acad. Sci. USA
, vol.98
, pp. 12191-12196
-
-
Karlsen, A.E.1
-
92
-
-
0034717062
-
SOCS-3 is an insulin-induced negative regulator of insulin signaling
-
Emanuelli, B. et al. SOCS-3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem. 275, 15985-15991 (2000).
-
(2000)
J. Biol. Chem.
, vol.275
, pp. 15985-15991
-
-
Emanuelli, B.1
|