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Volumn 2, Issue 6, 2002, Pages 410-416

Suppressors of cytokine signalling (SOCS) in the immune system

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; INTERFERON; PROTEIN; GAMMA INTERFERON; INTERLEUKIN 4; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; REGULATOR PROTEIN; STAT3 PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING; SUPPRESSOR OF CYTOKINE SIGNALING 1; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; T LYMPHOCYTE RECEPTOR; UNCLASSIFIED DRUG;

EID: 0036595049     PISSN: 14741733     EISSN: None     Source Type: Journal    
DOI: 10.1038/nri818     Document Type: Review
Times cited : (564)

References (92)
  • 2
    • 0024846310 scopus 로고
    • Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor
    • Gearing, D. P., King, J. A., Gough, N. M. & Nicola, N. A. Expression cloning of a receptor for human granulocyte-macrophage colony-stimulating factor. EMBO J. 8, 3667-3676 (1989).
    • (1989) EMBO J. , vol.8 , pp. 3667-3676
    • Gearing, D.P.1    King, J.A.2    Gough, N.M.3    Nicola, N.A.4
  • 3
    • 0028845212 scopus 로고
    • Cytokine receptor signalling
    • Ihle, J. N. Cytokine receptor signalling. Nature 377, 591-594 (1995).
    • (1995) Nature , vol.377 , pp. 591-594
    • Ihle, J.N.1
  • 4
    • 0033772659 scopus 로고    scopus 로고
    • Jak-STAT signaling pathways in cells of the immune system
    • Ivashkiv, L. B. Jak-STAT signaling pathways in cells of the immune system. Rev. Immunogenet. 2, 220-230 (2000)
    • (2000) Rev. Immunogenet. , vol.2 , pp. 220-230
    • Ivashkiv, L.B.1
  • 6
    • 0032966863 scopus 로고    scopus 로고
    • Negative regulation of the JAK/STAT pathway
    • Starr, R. & Hilton, D. Negative regulation of the JAK/STAT pathway. Bioessays 21, 47-52 (1999).
    • (1999) Bioessays , vol.21 , pp. 47-52
    • Starr, R.1    Hilton, D.2
  • 7
    • 13144258732 scopus 로고    scopus 로고
    • Twenty proteins containing a C-terminal SOCS box form five structural classes
    • Hilton, D. J. et al. Twenty proteins containing a C-terminal SOCS box form five structural classes. Proc. Natl Acad. Sci. USA 95, 114-119 (1998). This paper describes the extended SOCS family of proteins, which are characterized by a carboxy-terminal SOCS-box motif.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 114-119
    • Hilton, D.J.1
  • 8
    • 0030755934 scopus 로고    scopus 로고
    • Structure and function of a new STAT-induced STAT inhibitor
    • Naka, T. et al. Structure and function of a new STAT-induced STAT inhibitor. Nature 387, 924-929 (1997).
    • (1997) Nature , vol.387 , pp. 924-929
    • Naka, T.1
  • 9
    • 0030792590 scopus 로고    scopus 로고
    • A family of cytokine-inducible inhibitors of signalling
    • Starr, R. et al. A family of cytokine-inducible inhibitors of signalling. Nature 387, 917-921 (1997).
    • (1997) Nature , vol.387 , pp. 917-921
    • Starr, R.1
  • 10
    • 0030839112 scopus 로고    scopus 로고
    • A new protein containing an SH2 domain that inhibits JAK kinases
    • Endo, T. A. et al. A new protein containing an SH2 domain that inhibits JAK kinases. Nature 387, 921-924 (1997).
    • (1997) Nature , vol.387 , pp. 921-924
    • Endo, T.A.1
  • 11
    • 0032772125 scopus 로고    scopus 로고
    • Suppression of STAT5 functions in liver, mammary glands and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice
    • Matsumoto, A. et al. Suppression of STAT5 functions in liver, mammary glands and T cells in cytokine-inducible SH2-containing protein 1 transgenic mice. Mol. Cell. Biol. 19, 6396-6407 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6396-6407
    • Matsumoto, A.1
  • 12
    • 20244389693 scopus 로고    scopus 로고
    • The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop
    • Yasukawa, H. et al. The JAK-binding protein JAB inhibits Janus tyrosine kinase activity through binding in the activation loop. EMBO J. 18, 1309-1320 (1999).
    • (1999) EMBO J. , vol.18 , pp. 1309-1320
    • Yasukawa, H.1
  • 13
    • 0033555258 scopus 로고    scopus 로고
    • Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction
    • Nicholson, S. E. et al. Mutational analyses of the SOCS proteins suggest a dual domain requirement but distinct mechanisms for inhibition of LIF and IL-6 signal transduction. EMBO J. 18, 375-385 (1999). References 12 and 13 describe the SH2- and amino-terminal-domain requirements for the interaction of SOCS1 with JAKs and the inhibition of kinase activity.
    • (1999) EMBO J. , vol.18 , pp. 375-385
    • Nicholson, S.E.1
  • 14
    • 0034703097 scopus 로고    scopus 로고
    • CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    • Sasaki, A. et al. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 29338-29347
    • Sasaki, A.1
  • 15
    • 0034612271 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130
    • Nicholson, S. E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA 97, 6493-6498 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 6493-6498
    • Nicholson, S.E.1
  • 16
    • 0033305402 scopus 로고    scopus 로고
    • Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins
    • Hansen, J. A., Lindberg, K., Hilton, D. J., Nielsen, J. H. & Billestrup, N. Mechanism of inhibition of growth hormone receptor signaling by suppressor of cytokine signaling proteins. Mol. Endocrinol. 13, 1832-1843 (1999).
    • (1999) Mol. Endocrinol. , vol.13 , pp. 1832-1843
    • Hansen, J.A.1    Lindberg, K.2    Hilton, D.J.3    Nielsen, J.H.4    Billestrup, N.5
  • 17
    • 0001421697 scopus 로고    scopus 로고
    • SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985
    • Bjorbaek, C. et al. SOCS3 mediates feedback inhibition of the leptin receptor via Tyr985. J. Biol. Chem. 275, 40649-40657 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 40649-40657
    • Bjorbaek, C.1
  • 18
    • 0033037268 scopus 로고    scopus 로고
    • SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation
    • Cohney, S. J. et al. SOCS-3 is tyrosine phosphorylated in response to interleukin-2 and suppresses STAT5 phosphorylation and lymphocyte proliferation. Mol. Cell. Biol. 19, 4980-4988 (1999).
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 4980-4988
    • Cohney, S.J.1
  • 19
    • 0034703097 scopus 로고    scopus 로고
    • CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2
    • Sasaki, A. et al. CIS3/SOCS-3 suppresses erythropoietin (EPO) signaling by binding the EPO receptor and JAK2. J. Biol. Chem. 275, 29338-29347 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 29338-29347
    • Sasaki, A.1
  • 20
    • 0034724677 scopus 로고    scopus 로고
    • SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130
    • Schmitz, J., Weissenbach, M., Haan, S., Heinrich, P. C. & Schaper, F. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem. 275, 12848-12856 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 12848-12856
    • Schmitz, J.1    Weissenbach, M.2    Haan, S.3    Heinrich, P.C.4    Schaper, F.5
  • 21
    • 0032535364 scopus 로고    scopus 로고
    • The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families
    • Kamura, T. et al. The elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat and ankyrin repeat families. Genes Dev. 12, 3872-3881 (1998).
    • (1998) Genes Dev. , vol.12 , pp. 3872-3881
    • Kamura, T.1
  • 22
    • 13044263097 scopus 로고    scopus 로고
    • The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
    • Zhang, J. G. et al. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation. Proc. Natl Acad. Sci. USA 96, 2071-2076 (1999). References 21 and 22 show that the SOCS-box domain binds elongins B and C, which establishes a link to the proteasomal degradation pathway.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 2071-2076
    • Zhang, J.G.1
  • 23
    • 0030983549 scopus 로고    scopus 로고
    • Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation
    • Yu, C. L. & Burakoff, S. J. Involvement of proteasomes in regulating Jak-STAT pathways upon interleukin-2 stimulation. J. Biol. Chem. 272, 14017-14020 (1997).
    • (1997) J. Biol. Chem. , vol.272 , pp. 14017-14020
    • Yu, C.L.1    Burakoff, S.J.2
  • 24
    • 0032561322 scopus 로고    scopus 로고
    • Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein
    • Verdier, F. et al. Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein J. Biol. Chem. 273, 28185-28190 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 28185-28190
    • Verdier, F.1
  • 25
    • 0034640526 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation
    • De Sepulveda, P., Ilangumaran, S. & Rottapel, R. Suppressor of cytokine signaling-1 inhibits VAV function through protein degradation. J. Biol. Chem. 275, 14005-14008 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 14005-14008
    • De Sepulveda, P.1    Ilangumaran, S.2    Rottapel, R.3
  • 26
    • 0035918239 scopus 로고    scopus 로고
    • The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2
    • Kamizono, S. et al. The SOCS box of SOCS-1 accelerates ubiquitin-dependent proteolysis of TEL-JAK2. J. Biol. Chem. 276, 12530-12538 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 12530-12538
    • Kamizono, S.1
  • 27
    • 0035036625 scopus 로고    scopus 로고
    • Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation
    • Frantsve, J., Schwaller, J., Sternberg, D. W., Kutok, J. & Gilliland, D. G. Socs-1 inhibits TEL-JAK2-mediated transformation of hematopoietic cells through inhibition of JAK2 kinase activity and induction of proteasome-mediated degradation. Mol. Cell. Biol. 21, 3547-3557 (2001).
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3547-3557
    • Frantsve, J.1    Schwaller, J.2    Sternberg, D.W.3    Kutok, J.4    Gilliland, D.G.5
  • 28
    • 0035818573 scopus 로고    scopus 로고
    • The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo
    • Zhang, J. G. et al. The SOCS box of suppressor of cytokine signaling-1 is important for inhibition of cytokine action in vivo. Proc. Natl Acad. Sci. USA 98, 13261-13265 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 13261-13265
    • Zhang, J.G.1
  • 29
    • 0033828672 scopus 로고    scopus 로고
    • SOCS physiological suppressors of cytokine signaling
    • Krebs, D. L. & Hilton, D. J. SOCS: physiological suppressors of cytokine signaling. J. Cell. Sci. 113, 2813-2819 (2000).
    • (2000) J. Cell. Sci. , vol.113 , pp. 2813-2819
    • Krebs, D.L.1    Hilton, D.J.2
  • 30
    • 0034841006 scopus 로고    scopus 로고
    • Negative regulation of cytokine signaling
    • Greenhalgh, C. J. & Hilton, D. J. Negative regulation of cytokine signaling. J. Leukocyte Biol. 70, 348-356 (2001).
    • (2001) J. Leukocyte Biol. , vol.70 , pp. 348-356
    • Greenhalgh, C.J.1    Hilton, D.J.2
  • 31
    • 0034663932 scopus 로고    scopus 로고
    • Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice
    • Fujimoto, M. et al. Defective thymocyte development and perturbed homeostasis of T cells in STAT-induced STAT inhibitor-1/suppressors of cytokine signaling-1 transgenic mice. J. Immunol. 165, 1799-1806 (2000).
    • (2000) J. Immunol. , vol.165 , pp. 1799-1806
    • Fujimoto, M.1
  • 32
    • 0033520467 scopus 로고    scopus 로고
    • SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality
    • Marine, J. C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell 98, 609-616 (1999)
    • (1999) Cell , vol.98 , pp. 609-616
    • Marine, J.C.1
  • 33
    • 13044276245 scopus 로고    scopus 로고
    • Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice
    • Naka, T. et al. Accelerated apoptosis of lymphocytes by augmented induction of Bax in SSI-1 (STAT-induced STAT inhibitor-1)-deficient mice. Proc. Natl Acad. Sci. USA 95, 15577-15582 (1998).
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15577-15582
    • Naka, T.1
  • 34
    • 0032564463 scopus 로고    scopus 로고
    • Liver degeneration and lymphoid deficiencies in mice lacking suppressor of cytokine signaling-1
    • -/- mice.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 14395-14399
    • Starr, R.1
  • 35
    • 0019474347 scopus 로고
    • Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice
    • Gresser, I. et al. Electrophoretically pure mouse interferon inhibits growth, induces liver and kidney lesions, and kills suckling mice. Am. J. Pathol. 102, 396-402 (1981).
    • (1981) Am. J. Pathol. , vol.102 , pp. 396-402
    • Gresser, I.1
  • 37
    • 0033520326 scopus 로고    scopus 로고
    • SOCS1 is a critical inhibitor of interferon-γ signaling and prevents the potentially fatal neonatal actions of this cytokine
    • Alexander, W. S. et al. SOCS1 is a critical inhibitor of interferon-γ signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell 98, 597-608 (1999).
    • (1999) Cell , vol.98 , pp. 597-608
    • Alexander, W.S.1
  • 38
    • 0035933805 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling-1 attenuates the duration of interferon-γ signal transduction in vitro and in vivo
    • Brysha, M. et al. Suppressor of cytokine signaling-1 attenuates the duration of interferon-γ signal transduction in vitro and in vivo. J. Biol. Chem. 276, 22086-22089 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 22086-22089
    • Brysha, M.1
  • 39
    • 0035008978 scopus 로고    scopus 로고
    • SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo
    • Naka, T. et al. SOCS-1/SSI-1-deficient NKT cells participate in severe hepatitis through dysregulated cross-talk inhibition of IFN-γ and IL-4 signaling in vivo. Immunity 14, 535-545 (2001).
    • (2001) Immunity , vol.14 , pp. 535-545
    • Naka, T.1
  • 40
    • 0034255408 scopus 로고    scopus 로고
    • The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene
    • Metcalf, D., Di Rago, L., Mifsud, S., Hartley, L. & Alexander, W. S. The development of fatal myocarditis and polymyositis in mice heterozygous for IFN-γ and lacking the SOCS-1 gene. Proc. Natl Acad. Sci. USA 97, 9174-9179 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 9174-9179
    • Metcalf, D.1    Di Rago, L.2    Mifsud, S.3    Hartley, L.4    Alexander, W.S.5
  • 41
    • 0037154210 scopus 로고    scopus 로고
    • Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1)
    • Metcalf, D, et al. Polycystic kidneys and chronic inflammatory lesions are the delayed consequences of loss of the suppressor of cytokine signaling-1 (SOCS-1). Proc. Natl Acad. Sci. USA 99, 943-948 (2002)
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 943-948
    • Metcalf, D.1
  • 42
    • 0034502224 scopus 로고    scopus 로고
    • H1 differentiation by IL-6 is mediated by SOCS1
    • H1 differentiation by IL-6 is mediated by SOCS1. Immunity 13, 805-815 (2000).
    • (2000) Immunity , vol.13 , pp. 805-815
    • Diehl, S.1
  • 43
    • 0034624986 scopus 로고    scopus 로고
    • Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor-α-induced cell death in fibroblasts
    • Morita, Y. et al. Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor-necrosis-factor-α-induced cell death in fibroblasts. Proc. Natl Acad. Sci. USA 97, 5405-5410 (2000).
    • (2000) Proc. Natl. Acad. Sci. USA , vol.97 , pp. 5405-5410
    • Morita, Y.1
  • 44
    • 0034725044 scopus 로고    scopus 로고
    • SOCS-1 can suppress CD3ζ- and Syk-mediated NF-AT activation in a non-lymphoid cell line
    • Matsuda, T., Yamamoto, T., Kishi, H., Yoshimura, A. & Muraguchi, A. SOCS-1 can suppress CD3ζ- and Syk-mediated NF-AT activation in a non-lymphoid cell line. FEBS Lett. 472, 235-240 (2000).
    • (2000) FEBS Lett. , vol.472 , pp. 235-240
    • Matsuda, T.1    Yamamoto, T.2    Kishi, H.3    Yoshimura, A.4    Muraguchi, A.5
  • 45
    • 0034689007 scopus 로고    scopus 로고
    • Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells
    • Li, S. et al. Cytokine-induced Src-homology 2 protein (CIS) promotes T-cell receptor-mediated proliferation and prolongs survival of activated T cells. J. Exp. Med. 191, 985-994 (2000).
    • (2000) J. Exp. Med. , vol.191 , pp. 985-994
    • Li, S.1
  • 46
    • 0033520389 scopus 로고    scopus 로고
    • SOCS3 is essential in the regulation of fetal liver erythropoiesis
    • Marine, J. C. et al. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell 98, 617-627 (1999).
    • (1999) Cell , vol.98 , pp. 617-627
    • Marine, J.C.1
  • 47
    • 0034729710 scopus 로고    scopus 로고
    • Gigantism in mice lacking suppressor of cytokine signalling-2
    • Metcalf, D. et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature 405, 1069-1073 (2000).
    • (2000) Nature , vol.405 , pp. 1069-1073
    • Metcalf, D.1
  • 48
    • 0035979275 scopus 로고    scopus 로고
    • Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3
    • Roberts, A. W. et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl Acad. Sci. USA 98, 9324-9329 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 9324-9329
    • Roberts, A.W.1
  • 49
    • 13344279401 scopus 로고    scopus 로고
    • STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients
    • Gouilleux-Gruart, V. et al. STAT-related transcription factors are constitutively activated in peripheral blood cells from acute leukemia patients. Blood 87, 1692-1697 (1996).
    • (1996) Blood , vol.87 , pp. 1692-1697
    • Gouilleux-Gruart, V.1
  • 50
    • 0031436969 scopus 로고    scopus 로고
    • B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT) 1 and STAT3 constitutively phosphorylated on serine residues
    • Frank, D. A., Mahajan, S. & Ritz, J. B lymphocytes from patients with chronic lymphocytic leukemia contain signal transducer and activator of transcription (STAT)1 and STAT3 constitutively phosphorylated on serine residues. J. Clin. Invest. 100, 3140-3148 (1997).
    • (1997) J. Clin. Invest. , vol.100 , pp. 3140-3148
    • Frank, D.A.1    Mahajan, S.2    Ritz, J.3
  • 51
    • 0031573141 scopus 로고    scopus 로고
    • Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients
    • Chai, S. K., Nichols, G. L. & Rothman, P. Constitutive activation of JAKs and STATs in BCR-Abl-expressing cell lines and peripheral blood cells derived from leukemic patients. J. Immunol. 159, 4720-4728 (1997).
    • (1997) J. Immunol. , vol.159 , pp. 4720-4728
    • Chai, S.K.1    Nichols, G.L.2    Rothman, P.3
  • 52
    • 0035910753 scopus 로고    scopus 로고
    • CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation
    • Suzuki, A. et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med. 193, 471-481 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 471-481
    • Suzuki, A.1
  • 53
    • 0035667907 scopus 로고    scopus 로고
    • Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis
    • Shouda, T. et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest. 108, 1781-1788 (2001). This study indicated the efficacy of Socs3 gene therapy for the treatment of experimental arthritis in mice.
    • (2001) J. Clin. Invest. , vol.108 , pp. 1781-1788
    • Shouda, T.1
  • 54
    • 0035877256 scopus 로고    scopus 로고
    • Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs
    • Dalpke, A. H., Opper S., Zimmermann, S. & Heeg, K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol. 166, 7082-7089 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 7082-7089
    • Dalpke, A.H.1    Opper, S.2    Zimmermann, S.3    Heeg, K.4
  • 55
    • 0033197958 scopus 로고    scopus 로고
    • Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ
    • Stoiber, D. et al. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ. J. Immunol. 163, 2640-2647 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 2640-2647
    • Stoiber, D.1
  • 56
    • 0033570054 scopus 로고    scopus 로고
    • CIS associates with the interlukin-2 receptor β-chain and inhibits interleukin-2-dependent signaling
    • Aman, M. J. et al. CIS associates with the interlukin-2 receptor β-chain and inhibits interleukin-2-dependent signaling. J. Biol. Chem. 274, 30266-30272 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 30266-30272
    • Aman, M.J.1
  • 57
    • 0029014206 scopus 로고
    • A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors
    • Yoshimura, A. et al. A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin-3 and erythropoietin receptors. EMBO J. 14, 2816-2826 (1995).
    • (1995) EMBO J. , vol.14 , pp. 2816-2826
    • Yoshimura, A.1
  • 58
    • 0035148616 scopus 로고    scopus 로고
    • Interleukin-9 induces expression of three cytokine signal inhibitors: Cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin-9 signalling
    • Lejeune, D., Demoulin, J. B. & Renauld, J. C. Interleukin-9 induces expression of three cytokine signal inhibitors: cytokine-inducible SH2-containing protein, suppressor of cytokine signalling (SOCS)-2 and SOCS-3, but only SOCS-3 overexpression suppresses interleukin-9 signalling. Biochem. J. 353, 109-116 (2001).
    • (2001) Biochem. J. , vol.353 , pp. 109-116
    • Lejeune, D.1    Demoulin, J.B.2    Renauld, J.C.3
  • 59
    • 0034284540 scopus 로고    scopus 로고
    • IL-10 attenuates IFN-α-activated STAT1 in the liver: Involvement of SOCS2 and SOCS3
    • Shen, X., Hong, F., Nguyen, V. A. & Gao, B. IL-10 attenuates IFN-α-activated STAT1 in the liver: involvement of SOCS2 and SOCS3. FEBS Lett. 480, 132-136 (2000).
    • (2000) FEBS Lett. , vol.480 , pp. 132-136
    • Shen, X.1    Hong, F.2    Nguyen, V.A.3    Gao, B.4
  • 60
    • 0031915126 scopus 로고    scopus 로고
    • Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling
    • Adams, T. E. et al. Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling. J. Biol. Chem. 273, 1285-1287 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 1285-1287
    • Adams, T.E.1
  • 61
    • 0033609928 scopus 로고    scopus 로고
    • Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling
    • Pezet, A., Favre, H., Kelly, P. A. & Edery, M. Inhibition and restoration of prolactin signal transduction by suppressors of cytokine signaling. J. Biol. Chem. 274, 24497-24502 (1999).
    • (1999) J. Biol. Chem. , vol.274 , pp. 24497-24502
    • Pezet, A.1    Favre, H.2    Kelly, P.A.3    Edery, M.4
  • 62
    • 0033485438 scopus 로고    scopus 로고
    • Requirement for Stat5 in thymic stromal lymphopoietin-mediated signal transduction
    • Isaksen, D. E. et al. Requirement for Stat5 in thymic stromal lymphopoietin-mediated signal transduction. J. Immunol. 163, 5971-5977 (1999).
    • (1999) J. Immunol. , vol.163 , pp. 5971-5977
    • Isaksen, D.E.1
  • 63
    • 0035827663 scopus 로고    scopus 로고
    • Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal muscle cells is mediated by Stat5*
    • Sadowski, C. L. et al. Insulin induction of SOCS-2 and SOCS-3 mRNA expression in C2C12 skeletal muscle cells is mediated by Stat5*. J. Biol. Chem. 276, 20703-20710 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 20703-20710
    • Sadowski, C.L.1
  • 64
    • 0033324777 scopus 로고    scopus 로고
    • Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor
    • Bjorbaek, C. et al. Activation of SOCS-3 messenger ribonucleic acid in the hypothalamus by ciliary neurotrophic factor. Endocrinology 140, 2035-2043 (1999).
    • (1999) Endocrinology , vol.140 , pp. 2035-2043
    • Bjorbaek, C.1
  • 65
    • 0033001325 scopus 로고    scopus 로고
    • Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues
    • Emilsson, V., Arch, J. R., de Groot, R. P., Lister, C. A. & Cawthorne, M. A. Leptin treatment increases suppressors of cytokine signaling in central and peripheral tissues. FEBS Lett. 455, 170-174 (1999)
    • (1999) FEBS Lett. , vol.455 , pp. 170-174
    • Emilsson, V.1    Arch, J.R.2    De Groot, R.P.3    Lister, C.A.4    Cawthorne, M.A.5
  • 66
    • 0032853513 scopus 로고    scopus 로고
    • Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: Involvement of the ubiquitin proteosome pathway
    • Okabe, S. et al. Thrombopoietin induces an SH2-containing protein, CIS1, which binds to Mpl: involvement of the ubiquitin proteosome pathway. Exp. Hematol. 27, 1542-1547 (1999).
    • (1999) Exp. Hematol. , vol.27 , pp. 1542-1547
    • Okabe, S.1
  • 67
    • 0033544899 scopus 로고    scopus 로고
    • SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms
    • Ram, P. A. & Waxman, D. J. SOCS/CIS protein inhibition of growth hormone-stimulated STAT5 signaling by multiple mechanisms. J. Biol. Chem 274, 35553-35561 (1999).
    • (1999) J. Biol. Chem , vol.274 , pp. 35553-35561
    • Ram, P.A.1    Waxman, D.J.2
  • 68
    • 0034685906 scopus 로고    scopus 로고
    • Mechanism of STAT3 activation by insulin-like growth factor 1 receptor
    • Zong, C. S. et al. Mechanism of STAT3 activation by insulin-like growth factor 1 receptor. J. Biol. Chem. 275, 15099-15105 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 15099-15105
    • Zong, C.S.1
  • 69
    • 0035168683 scopus 로고    scopus 로고
    • JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling
    • Spom, B., Kovanen, P. E., Sasaki, A., Yoshimura, A. & Leonard, W. J. JAB/SOCS1/SSI-1 is an interleukin-2-induced inhibitor of IL-2 signaling Blood 97, 221-226 (2001).
    • (2001) Blood , vol.97 , pp. 221-226
    • Spom, B.1    Kovanen, P.E.2    Sasaki, A.3    Yoshimura, A.4    Leonard, W.J.5
  • 70
    • 17744387312 scopus 로고    scopus 로고
    • Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells
    • Park, E. S. et al. Thyrotropin induces SOCS-1 (suppressor of cytokine signaling-1) and SOCS-3 in FRTL-5 thyroid cells. Mol. Endocrinol. 14, 440-448 (2000).
    • (2000) Mol. Endocrinol. , vol.14 , pp. 440-448
    • Park, E.S.1
  • 71
    • 0033558088 scopus 로고    scopus 로고
    • Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation
    • De Sepulveda, P. et al. Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. EMBO J. 18, 904-915 (1999).
    • (1999) EMBO J. , vol.18 , pp. 904-915
    • De Sepulveda, P.1
  • 72
    • 0035853414 scopus 로고    scopus 로고
    • Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo
    • Hamanaka, I. et al. Induction of JAB/SOCS-1/SSI-1 and CIS3/SOCS-3/SSI-3 is involved in gp130 resistance in cardiovascular system in rat treated with cardiotrophin-1 in vivo. Circ. Res. 88, 727-732 (2001).
    • (2001) Circ. Res. , vol.88 , pp. 727-732
    • Hamanaka, I.1
  • 73
    • 0034665904 scopus 로고    scopus 로고
    • Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1
    • Wang, Q., Miyakawa, Y., Fox, N. & Kaushansky, K. Interferon-α directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. Blood 96, 2093-2099 (2000).
    • (2000) Blood , vol.96 , pp. 2093-2099
    • Wang, Q.1    Miyakawa, Y.2    Fox, N.3    Kaushansky, K.4
  • 74
    • 0032170490 scopus 로고    scopus 로고
    • A Janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons
    • Sakamoto, H. et al. A Janus kinase inhibitor, JAB, is an interferon-γ-inducible gene and confers resistance to interferons. Blood 92, 1668-1676 (1998).
    • (1998) Blood , vol.92 , pp. 1668-1676
    • Sakamoto, H.1
  • 75
    • 0033120880 scopus 로고    scopus 로고
    • Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction
    • Losman, J. A., Chen, X. P., Hilton, D. & Rothman, P. Cutting edge: SOCS-1 is a potent inhibitor of IL-4 signal transduction. J. Immunol. 162, 3770-3774 (1999).
    • (1999) J. Immunol. , vol.162 , pp. 3770-3774
    • Losman, J.A.1    Chen, X.P.2    Hilton, D.3    Rothman, P.4
  • 76
    • 0035871862 scopus 로고    scopus 로고
    • Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes
    • Trop, S., De Sepulveda, P., Zuniga-Pflucker, J. C. & Rottapel, R. Overexpression of suppressor of cytokine signaling-1 impairs pre-T-cell receptor-induced proliferation but not differentiation of immature thymocytes. Blood 97, 2269-2277 (2001).
    • (2001) Blood , vol.97 , pp. 2269-2277
    • Trop, S.1    De Sepulveda, P.2    Zuniga-Pflucker, J.C.3    Rottapel, R.4
  • 77
    • 0035933751 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal
    • Bourette, R. P. et al. Suppressor of cytokine signaling 1 interacts with the macrophage colony-stimulating factor receptor and negatively regulates its proliferation signal. J. Biol. Chem. 276, 22133-22139 (2001).
    • (2001) J. Biol. Chem. , vol.276 , pp. 22133-22139
    • Bourette, R.P.1
  • 78
    • 0035862334 scopus 로고    scopus 로고
    • Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation
    • Kawazoe, Y. et al. Signal transducer and activator of transcription (STAT)-induced STAT inhibitor 1 (SSI-1)/suppressor of cytokine signaling 1 (SOCS1) inhibits insulin signal transduction pathway through modulating insulin receptor substrate 1 (IRS-1) phosphorylation. J. Exp. Med. 193, 263-269 (2001).
    • (2001) J. Exp. Med. , vol.193 , pp. 263-269
    • Kawazoe, Y.1
  • 79
    • 0032567353 scopus 로고    scopus 로고
    • The suppressor of cytokine signaling (SOCS)1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities
    • Song, M. M. & Shuai, K. The suppressor of cytokine signaling (SOCS)1 and SOCS3 but not SOCS2 proteins inhibit interferon-mediated antiviral and antiproliferative activities. J. Biol. Chem. 273, 35056-35062 (1998).
    • (1998) J. Biol. Chem. , vol.273 , pp. 35056-35062
    • Song, M.M.1    Shuai, K.2
  • 80
    • 0031559588 scopus 로고    scopus 로고
    • Cloning and functional analysis of new members of STAT-induced STAT inhibitor (SSI) family: SSI-2 and SSI-3
    • Minamoto, S. et al. Cloning and functional analysis of new members of STAT-induced STAT inhibitor (SSI) family: SSI-2 and SSI-3. Biochem. Biophys. Res. Commun. 237, 79-83 (1997).
    • (1997) Biochem. Biophys. Res. Commun. , vol.237 , pp. 79-83
    • Minamoto, S.1
  • 81
    • 0034635550 scopus 로고    scopus 로고
    • Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1β on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells
    • Boisclair Y. R., Wang, J., Shi, J., Hurst, K. R. & Ooi, G. T. Role of the suppressor of cytokine signaling-3 in mediating the inhibitory effects of interleukin-1β on the growth hormone-dependent transcription of the acid-labile subunit gene in liver cells. J. Biol. Chem. 275, 3841-3847 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 3841-3847
    • Boisclair, Y.R.1    Wang, J.2    Shi, J.3    Hurst, K.R.4    Ooi, G.T.5
  • 82
    • 0035863095 scopus 로고    scopus 로고
    • Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3)
    • Magrangeas, F., Boisteau, O., Denis S., Jacques, Y. & Minvielle, S. Negative cross-talk between interleukin-3 and interleukin-11 is mediated by suppressor of cytokine signalling-3 (SOCS-3). Biochem. J. 353, 223-230 (2001).
    • (2001) Biochem. J. , vol.353 , pp. 223-230
    • Magrangeas, F.1    Boisteau, O.2    Denis, S.3    Jacques, Y.4    Minvielle, S.5
  • 83
    • 0033054062 scopus 로고    scopus 로고
    • Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: Evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis
    • Auernhammer, C. J. & Melmed, S. Interleukin-11 stimulates proopiomelanocortin gene expression and adrenocorticotropin secretion in corticotroph cells: evidence for a redundant cytokine network in the hypothalamo-pituitary-adrenal axis. Endocrinology 140, 1550-1566 (1999).
    • (1999) Endocrinology , vol.140 , pp. 1550-1566
    • Auernhammer, C.J.1    Melmed, S.2
  • 84
    • 0035877120 scopus 로고    scopus 로고
    • Identification, cloning and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity
    • Kotenko, S. V. et al. Identification, cloning and characterization of a novel soluble receptor that binds IL-22 and neutralizes its activity. J. Immunol. 166, 7096-7103 (2001).
    • (2001) J. Immunol. , vol.166 , pp. 7096-7103
    • Kotenko, S.V.1
  • 85
    • 0035006109 scopus 로고    scopus 로고
    • Tyrosine-phosphorated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras
    • Cacalano, N. A., Sanden, D. & Johnston, J. A. Tyrosine-phosphorated SOCS-3 inhibits STAT activation but binds to p120 RasGAP and activates Ras. Nature Cell. Biol. 3, 460-465 (2001).
    • (2001) Nature Cell. Biol. , vol.3 , pp. 460-465
    • Cacalano, N.A.1    Sanden, D.2    Johnston, J.A.3
  • 86
    • 0034705453 scopus 로고    scopus 로고
    • The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130
    • Terstegen, L. et al. The inhibition of interleukin-6-dependent STAT activation by mitogen-activated protein kinases depends on tyrosine 759 in the cytoplasmic tail of glycoprotein 130. J. Biol. Chem. 275, 18810-18817 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 18810-18817
    • Terstegen, L.1
  • 87
    • 0032230273 scopus 로고    scopus 로고
    • Pituitary corticotroph SOCS-3: Novel intra cellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion
    • Auernhammer, C. J., Chesnokova, V., Bousquet, C. & Melmed, S. Pituitary corticotroph SOCS-3: novel intracellular regulation of leukemia-inhibitory factor-mediated proopiomelanocortin gene expression and adrenocorticotropin secretion. Mol. Endocrinol. 12, 954-961 (1998).
    • (1998) Mol. Endocrinol. , vol.12 , pp. 954-961
    • Auernhammer, C.J.1    Chesnokova, V.2    Bousquet, C.3    Melmed, S.4
  • 88
    • 0034982578 scopus 로고    scopus 로고
    • Negative regulation of onconstatin M signaling by suppressor of cytokine signaling (SOCS-3)
    • Magrangeas, F., Boisteau, O., Denis, S., Jacques, Y. & Minvielle, S. Negative regulation of onconstatin M signaling by suppressor of cytokine signaling (SOCS-3). Eur. Cytokine Netw. 12, 309-315 (2001).
    • (2001) Eur. Cytokine Netw. , vol.12 , pp. 309-315
    • Magrangeas, F.1    Boisteau, O.2    Denis, S.3    Jacques, Y.4    Minvielle, S.5
  • 89
    • 0032014178 scopus 로고    scopus 로고
    • Identification of SOCS-3 as a potential mediator of central leptin resistance
    • Bjorbaek, C., Elmquist, J. K., Frantz, J. D., Shoelson, S. E. & Flier, J. S. Identification of SOCS-3 as a potential mediator of central leptin resistance. Mol. Cell. 1, 619-625 (1998).
    • (1998) Mol. Cell. , vol.1 , pp. 619-625
    • Bjorbaek, C.1    Elmquist, J.K.2    Frantz, J.D.3    Shoelson, S.E.4    Flier, J.S.5
  • 90
    • 0035409338 scopus 로고    scopus 로고
    • Tumor-necrosis factor-α attenuates interferon-α signaling in the liver: Involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy
    • Hong, F., Nguyen, V. A. & Gao, B. Tumor-necrosis factor-α attenuates interferon-α signaling in the liver: involvement of SOCS3 and SHP2 and implication in resistance to interferon therapy. FASEB J. 15, 1595-1597 (2001).
    • (2001) FASEB J. , vol.15 , pp. 1595-1597
    • Hong, F.1    Nguyen, V.A.2    Gao, B.3
  • 91
    • 0035834171 scopus 로고    scopus 로고
    • Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ-mediated toxicity
    • Karlsen, A. E. et al. Suppressor of cytokine signaling 3 (SOCS-3) protects β-cells against interleukin-1β- and interferon-γ -mediated toxicity. Proc. Natl Acad. Sci. USA 98, 12191-12196 (2001).
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 12191-12196
    • Karlsen, A.E.1
  • 92
    • 0034717062 scopus 로고    scopus 로고
    • SOCS-3 is an insulin-induced negative regulator of insulin signaling
    • Emanuelli, B. et al. SOCS-3 is an insulin-induced negative regulator of insulin signaling. J. Biol. Chem. 275, 15985-15991 (2000).
    • (2000) J. Biol. Chem. , vol.275 , pp. 15985-15991
    • Emanuelli, B.1


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