Leptin Induces Mitochondrial Superoxide Production and Monocyte Chemoattractant Protein-1 Expression in Aortic Endothelial Cells by Increasing Fatty Acid Oxidation via Protein Kinase A

Journal of Biological Chemistry

Volumn 276, Issue 27, 2001, Pages 25096-25100

  Yamagishi, Sho Ichi ^a   Edelstein, Diane ^a   Du, Xue Liang ^a   Kaneda, Yasufumi ^b   Guzmán, Manuel ^c   Brownlee, Michael ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b OSAKA UNIVERSITY MEDICAL SCHOOL   (Japan)

^c UNIVERSIDAD COMPLUTENSE DE MADRID   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; DISEASES; ENZYME INHIBITION; FATTY ACIDS; INSULIN; OXIDATION; OXYGEN; PROTEINS;

ADIPOSE TISSUES; ATHEROSCLEROSIS;

BIOCHEMISTRY;

ACETYL COENZYME A CARBOXYLASE; BENZOIC ACID DERIVATIVE; CARBONYL CYANIDE CHLOROPHENYLHYDRAZONE; CARNITINE PALMITOYLTRANSFERASE; CYCLIC AMP; CYCLIC AMP DEPENDENT PROTEIN KINASE; FATTY ACID; GLUCOSE; LEPTIN; MANGANESE DERIVATIVE; MONOCYTE CHEMOTACTIC PROTEIN 1; REACTIVE OXYGEN METABOLITE; ROTENONE; SUPEROXIDE; THENOYLTRIFLUOROACETONE; CARRIER PROTEIN; GENISTEIN; ION CHANNEL; ISOQUINOLINE DERIVATIVE; LIPOSOME; MANGANESE(III) TETRAKIS(4 BENZOIC ACID)PORPHYRIN; MANGANESE(III)-TETRAKIS(4-BENZOIC ACID)PORPHYRIN; MEMBRANE PROTEIN; METALLOPORPHYRIN; MITOCHONDRIAL PROTEIN; MITOCHONDRIAL UNCOUPLING PROTEIN; N [2 (4 BROMOCINNAMYLAMINO)ETHYL] 5 ISOQUINOLINESULFONAMIDE; SULFONAMIDE; SUPEROXIDE DISMUTASE;

ADIPOSE TISSUE; ANIMAL CELL; AORTA; ARTICLE; ATHEROSCLEROSIS; BLOOD VESSEL WALL; BODY MASS; BODY WEIGHT; CARDIOVASCULAR DISEASE; CARDIOVASCULAR RISK; CATTLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETIC OBESITY; ELECTRON TRANSPORT; ENDOTHELIUM CELL; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; HORMONE ACTION; HUMAN; INSULIN RESISTANCE; MITOCHONDRION; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; CELL CULTURE; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; METABOLISM; OXIDATION REDUCTION REACTION; VASCULAR ENDOTHELIUM;

ANIMALIA; BOS TAURUS; BOVINAE;

ACETYL-COA CARBOXYLASE; ANIMALS; CARBONYL CYANIDE M-CHLOROPHENYL HYDRAZONE; CARRIER PROTEINS; CATTLE; CELLS, CULTURED; CHEMOKINE CCL2; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTRON TRANSPORT; ENDOTHELIUM, VASCULAR; FATTY ACIDS; GENISTEIN; GLUCOSE; HUMANS; ION CHANNELS; ISOQUINOLINES; LEPTIN; LIPOSOMES; MEMBRANE PROTEINS; METALLOPORPHYRINS; MITOCHONDRIA; MITOCHONDRIAL PROTEINS; OXIDATION-REDUCTION; REACTIVE OXYGEN SPECIES; ROTENONE; SULFONAMIDES; SUPEROXIDE DISMUTASE; SUPEROXIDES; THENOYLTRIFLUOROACETONE;

EID: 0035816639     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M007383200     Document Type: Article

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