Leptin inhibits glycogen synthase kinase-3β to prevent tau phosphorylation in neuronal cells

Neuroscience Letters

Volumn 455, Issue 3, 2009, Pages 191-194

  Greco, Steven J ^a   Sarkar, Sraboni ^a   Casadesus, Gemma ^b   Zhu, Xiongwei ^c   Smith, Mark A ^c   Ashford, J Wesson ^d   Johnston, Jane M ^a   Tezapsidis, Nikolaos ^a  

^a Neurotez Inc   (United States)

^b CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c CASE WESTERN RESERVE UNIVERSITY   (United States)

^d VA PALO ALTO HEALTH CARE SYSTEM   (United States)

Author keywords

AICAR; Alzheimer's disease; GSK 3 ; Leptin; Tau

Indexed keywords

5 AMINO 4 IMIDAZOLECARBOXAMIDE RIBOSIDE; GLYCOGEN SYNTHASE KINASE 3BETA; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE KINASE; LITHIUM CHLORIDE; RECOMBINANT LEPTIN; SMALL INTERFERING RNA; TAU PROTEIN;

ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; DEPHOSPHORYLATION; ENZYME INHIBITION; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE OVEREXPRESSION; GENE SILENCING; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; INCUBATION TIME; NERVE CELL CULTURE; NUCLEOTIDE SEQUENCE; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALZHEIMER DISEASE; AMINOIMIDAZOLE CARBOXAMIDE; AMP-ACTIVATED PROTEIN KINASES; ANTIMANIC AGENTS; BRAIN; GLYCOGEN SYNTHASE KINASE 3; HUMANS; HYPOGLYCEMIC AGENTS; LEPTIN; LITHIUM CHLORIDE; NEUROFIBRILLARY TANGLES; NEURONS; PHOSPHORYLATION; RIBONUCLEOTIDES; SIGNAL TRANSDUCTION; TAU PROTEINS; TUMOR CELLS, CULTURED;

EID: 64049102108     PISSN: 03043940     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.neulet.2009.03.066     Document Type: Article

References (20)

1. Aghdam S.Y., and Barger S.W. Glycogen synthase kinase-3 in neurodegeneration and neuroprotection: lessons from lithium. Curr. Alzheimer Res. 4 (2007) 21-31
2. Farr S.A., Banks W.A., and Morley J.E. Effects of leptin on memory processing. Peptides 27 (2006) 1420-1425
3. Fewlass D.C., Noboa K., Pi-Sunyer F.X., Johnston J.M., Yan S.D., and Tezapsidis N. Obesity-related leptin regulates Alzheimer's Abeta. FASEB J. 18 (2004) 1870-1878
4. Greco S.J., Sarkar S., Johnston J.M., Zhu X., Su B., Casadesus G., Ashford J.W., Smith M.A., and Tezapsidis N. Leptin reduces Alzheimer's disease-related tau phosphorylation in neuronal cells. Biochem. Biophys. Res. Commun. 376 (2008) 536-541
5. Greco S.J., Sarkar S., Johnston J.M., and Tezapsidis N. Leptin regulates Tau phosphorylation and Amyloid through AMPK in neuronal cells. Biochem. Biophys. Res. Commun. 380 (2009) 98-104
6. Harvey J. Leptin: a diverse regulator of neuronal function. J. Neurochem. 100 (2007) 307-313
7. Hong M., Chen D.C., Klein P.S., and Lee V.M. Lithium reduces tau phosphorylation by inhibition of glycogen synthase kinase-3. J. Biol. Chem. 272 (1997) 25326-25332
8. Hong M., and Lee V.M. Insulin and insulin-like growth factor-1 regulate tau phosphorylation in cultured human neurons. J. Biol. Chem. 272 (1997) 19547-19553
9. Hooper C., Killick R., and Lovestone S. The GSK3 hypothesis of Alzheimer's disease. J. Neurochem. 104 (2008) 1433-1439
10. Horike N., Sakoda H., Kushiyama A., Ono H., Fujishiro M., Kamata H., Nishiyama K., Uchijima Y., Kurihara Y., Kurihara H., and Asano T. AMP-activated protein kinase activation increases phosphorylation of glycogen synthase kinase 3{beta} and thereby reduces cAMP-responsive element transcriptional activity and phosphoenolpyruvate carboxykinase C gene expression in the liver. J. Biol. Chem. 283 (2008) 33902-33910
11. Jequier E. Leptin signaling, adiposity, and energy balance. Ann. N. Y. Acad. Sci. 967 (2002) 379-388
12. King T.D., Song L., and Jope R.S. AMP-activated protein kinase (AMPK) activating agents cause dephosphorylation of Akt and glycogen synthase kinase-3. Biochem. Pharmacol. 71 (2006) 1637-1647
13. Klein P.S., and Melton D.A. A molecular mechanism for the effect of lithium on development. Proc. Natl. Acad. Sci. U.S.A. 93 (1996) 8455-8459
14. Liu F., Li B., Tung E.J., Grundke-Iqbal I., Iqbal K., and Gong C.X. Site-specific effects of tau phosphorylation on its microtubule assembly activity and self-aggregation. Eur. J. Neurosci. 26 (2007) 3429-3436
15. Lovestone S., Davis D.R., Webster M.T., Kaech S., Brion J.P., Matus A., and Anderton B.H. Lithium reduces tau phosphorylation: effects in living cells and in neurons at therapeutic concentrations. Biol. Psychiatry 45 (1999) 995-1003
16. Moult P.R., Milojkovic B., and Harvey J. Leptin reverses long-term potentiation at hippocampal CA1 synapses. J. Neurochem. (2008)
17. Ryder J., Su Y., and Ni B. Akt/GSK3beta serine/threonine kinases: evidence for a signalling pathway mediated by familial Alzheimer's disease mutations. Cell. Signal. 16 (2004) 187-200
18. Schwartz M.W., Woods S.C., Porte Jr. D., Seeley R.J., and Baskin D.G. Central nervous system control of food intake. Nature 404 (2000) 661-671
19. Terwel D., Muyllaert D., Dewachter I., Borghgraef P., Croes S., Devijver H., and Van Leuven F. Amyloid activates GSK-3beta to aggravate neuronal tauopathy in bigenic mice. Am. J. Pathol. 172 (2008) 786-798
20. Valerio A., Ghisi V., Dossena M., Tonello C., Giordano A., Frontini A., Ferrario M., Pizzi M., Spano P., Carruba M.O., and Nisoli E. Leptin increases axonal growth cone size in developing mouse cortical neurons by convergent signals inactivating glycogen synthase kinase-3beta. J. Biol. Chem. 281 (2006) 12950-12958