Serum immunoreactive-leptin concentrations in normal-weight and obese humans

New England Journal of Medicine

Volumn 334, Issue 5, 1996, Pages 292-295

  Considine, Robert V ^a,c   Sinha, Madhur K ^a   Heiman, Mark L ^b   Kriauciunas, Aidas ^b   Stephens, Thomas W ^b   Nyce, Mark R ^a   Ohannesian, Joanna P ^a   Marco, Cheryl C ^a   Mckee, Linda J ^a   Bauer, Thomas L ^a   Caro, José F ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b ELI LILLY AND COMPANY   (United States)

^c THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HORMONE; LEPTIN; MESSENGER RNA; PROTEIN;

ADIPOCYTE; ADULT; ARTICLE; CONTROLLED STUDY; FEMALE; GENE EXPRESSION; HUMAN; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; RNA ANALYSIS;

EID: 13344295079     PISSN: 00284793     EISSN: None     Source Type: Journal    
DOI: 10.1056/NEJM199602013340503     Document Type: Article

References (19)

1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM. Positional cloning of the mouse obese gene and its human homologue. Nature 1994;372:425-32 [Erratum, Nature 1995;374.479.]
2. Pelleymounter MA, Cullen MJ, Baker MB, et al Effects of the obese gene product on body weight regulation in ob/ob mice. Science 1995;269:540-3.
3. Halaas JL, Gajiwala KS, Maffei M, et al. Weight-reducing effects of the plasma protein encoded by the obese gene Science 1995;269.543-6.
4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P. Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks Science 1995;269:546-9.
5. Considine RV, Considine EL, Williams CJ, et al. Evidence against either a premature stop codon or the absence of obese gene mRNA in human obesity. J Clin Invest 1995,95:2986-8.
6. Masuzaki H, Ogawa Y, Isse N, et al Human obese gene expression: adipocyte-specific expression and regional differences in the adipose tissue. Diabetes 1995;44 855-8.
7. Lönnqvist F, Arner P, Nordfors L, Schalling M Overexpression of the obese (ob) gene in adipose tissue of human obese subjects Nat Med 1995;1:950-3.
8. Hamilton BS, Paglia D, Kwan AYM, Deitel M Increased obese mRNA expression in omental fat cells from massively obese humans Nat Med 1995; 1:953-6.
9. NIH Technology Assessment Conference Panel. Methods for voluntary weight loss and control. Ann Intern Med 1992,116:942-9
10. Kolaczynski JW, Morales LM, Moore JH Jr, et al. A new technique for biopsy of human abdominal fat under local anaesthesia with lidocaine. Int J Obes Relat Metab Disord 1994;18:161-6.
11. Stephens TW, Basinski M, Bristow PK, et al. The role of neuropeptide Y in the antiobesity action of the obese gene product. Nature 1995;377:530-2
12. Bolton AE, Hunter WM. The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent Biochem J 1973;133:529-39
13. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 1987,162.156-9
14. Saiki RK, Scharf S, Faloona F, et al Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science 1985;230:1350-4.
15. Jebb SA, Elia M. Techniques for the measurement of body composition: a practical guide Int J Obes Relat Metab Disord 1993;17.611-21.
16. De Vos P, Saladin R, Auwerx J, Staels B. Induction of ob gene expression by corticosteroids is accompanied by body weight loss and reduced food intake J Biol Chem 1995;270:15958-61.
17. Funahashi T, Shimomura I, Hiraoka H, et al. Enhanced expression of rat obese (ob) gene in adipose tissues of ventromedial hypothalamus (VMH)-lesioned rats. Biochem Biophys Res Commun 1995,211:469-75.
18. Murakami T, Shima K. Cloning of rat obese cDNA and its expression in obese rats. Biochem Biophys Res Commun 1995,209:944-52.
19. Leibel RL, Rosenbaum M, Hirsch J. Changes in energy expenditure resulting from altered body weight. N Engl J Med 1995;332:621-8.