Signaling through the JAK/STAT pathway, recent advances and future challenges

Gene

Volumn 285, Issue 1-2, 2002, Pages 1-24

  Kisseleva, T ^a   Bhattacharya, S ^a   Braunstein, J ^a   Schindler, C W ^a  

^a Columbia University ^*  (United States)

Author keywords

Cytokine; Knockout mouse; Transcriptional activation; Tyrosine phosphorylation

Indexed keywords

ALPHA INTERFERON RECEPTOR; CYTOKINE; G PROTEIN COUPLED RECEPTOR; GAMMA INTERFERON RECEPTOR; GLYCOPROTEIN GP 130; GROWTH FACTOR RECEPTOR; INTERLEUKIN 10 RECEPTOR; INTERLEUKIN 2 RECEPTOR; INTERLEUKIN 3 RECEPTOR; JANUS ACTIVATED KINASE; PROTEIN TYROSINE KINASE; SERINE; STAT PROTEIN; STAT1 PROTEIN; STAT2 PROTEIN; STAT3 PROTEIN; STAT4 PROTEIN; STAT5 PROTEIN; STAT6 PROTEIN; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DEPHOSPHORYLATION; DIMERIZATION; DNA BINDING; GENE EXPRESSION; IMMUNE RESPONSE; KNOCKOUT MOUSE; MOLECULAR EVOLUTION; NEGATIVE FEEDBACK; NONHUMAN; NUCLEOCYTOPLASMIC TRANSPORT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN MODIFICATION; PROTEIN MOTIF; PROTEIN PHOSPHORYLATION; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT; REGULATORY MECHANISM; REVIEW; SIGNAL TRANSDUCTION; STRESS; TARGET CELL; TRANSCRIPTION INITIATION;

ANIMALS; CYTOKINES; DNA-BINDING PROTEINS; EVOLUTION, MOLECULAR; HUMANS; PHOSPHORYLATION; PROTEIN-TYROSINE KINASES; RECEPTORS, CYTOKINE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS;

JANUS; MAMMALIA; MURINAE;

EID: 0037138370     PISSN: 03781119     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-1119(02)00398-0     Document Type: Review

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258. The conserved SOCS box motif in suppressors of cytokine signaling binds to elongins B and C and may couple bound proteins to proteasomal degradation
259. Interacting regions in Stat3 and c-Jun that participate in cooperative transcriptional activation
260. The coiled-coil domain of Stat3 is essential for its SH2 domain-mediated receptor binding and subsequent activation induced by epidermal growth factor and interleukin-6
261. Functional association of Nmi with Stat5 and Stat1 in IL-2 and IFNγ mediated signaling