Relation between leptin and the regulation of glucose metabolism

Diabetologia

Volumn 43, Issue 1, 2000, Pages 3-12

  Fruhbeck G ^a   Salvador, J ^a  

^a UNIVERSITY CLINIC OF NAVARRA   (Spain)

Author keywords

Cholecystokinin; Glucagon; Glucose homeostasis; Insulin; Leptin; Ob gene; Obesity; Satiety

Indexed keywords

CHOLECYSTOKININ; CYTOKINE RECEPTOR; FATTY ACID; GLUCAGON; GLUCAGON LIKE PEPTIDE 1; GLUCOKINASE; GLUCOSE; HEXOKINASE; INSULIN; INSULIN RECEPTOR SUBSTRATE 1; JANUS KINASE; LEPTIN; LONG CHAIN TRIACYLGLYCEROL; MESSENGER RNA; PHOSPHOENOLPYRUVATE CARBOXYKINASE (GTP); PHOSPHOLIPASE C; PREPROINSULIN; PROTEIN KINASE C; STAT PROTEIN;

BODY FAT; BODY MASS; CENTRAL NERVOUS SYSTEM; GENE; GENE EXPRESSION; GLUCOSE HOMEOSTASIS; GLUCOSE METABOLISM; INSULIN RELEASE; INTESTINE; NONHUMAN; OBESITY; PANCREAS ISLET; PRIORITY JOURNAL; REVIEW; SATIETY; SKELETAL MUSCLE;

EID: 0034058455     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s001250050002     Document Type: Review

References (94)

1. 1. Zhang Y, Proenca R, Maffei M, Barone M, Leopold L, Friedman JM (1994) Positional cloning of the mouse obese gene and its human homologue. Nature 372: 425-432
2. 2. Pelleymounter MA, Cullen MJ, Baker MB et al. (1995) Effects of the obese gene product on body weight regulation in ob/ob mice. Science 269: 540-543
3. 3. Halaas JL, Gajiwala KS, Maffei M et al. (1995) Weight-reducing effects of the plasma protein encoded by the obese gene. Science 269: 543-546
4. 4. Campfield LA, Smith FJ, Guisez Y, Devos R, Burn P (1995) Recombinant mouse OB protein: evidence for a peripheral signal linking adiposity and central neural networks. Science 269: 546-549
5. 5. Tritos NA, Mantzoros CS (1997) Leptin: its role in obesity and beyond. Diabetologia 40: 1371-1379
6. 6. Frühbeck G, Jebb SA, Prentice AM (1998) Leptin: physiology and pathophysiology. Clin Physiol 18: 399-419
7. 7. Levin N, Nelson C, Gurney A, Vandlen R, de Sauvage F (1996) Decreased food intake does not completely account for adiposity reduction after ob protein infusion. Proc Natl Acad Sci USA 93: 1726-1730
8. 8. Hwa JJ, Fawzi AB, Graziano MP et al. (1997) Leptin increases energy expenditure and selectively promotes fat metabolism in ob/ob mice. Am J Physiol 272: R1204-R1209
9. 9. Shimabukuro M, Koyama K, Chen G et al. (1997) Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94: 4637-4641
10. 10. Chen G, Koyama K, Yuan X et al. (1996) Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 93: 14795-14799
11. 11. Madej T, Boguski MS, Bryant SH (1995) Threading analysis suggests that the obese gene product may be a helical cytokine. FEBS Lett 373: 13-18
12. 12. Chehab FF, Lim ME, Lu RH (1996) Correction of the sterility defect in homozygous obese female mice by treatment with the human recombinant leptin. Nat Genet 12: 318-320
13. 13. Sierra-Honigmann MR, Nath AK, Murakami C et al. (1998) Biological action of leptin as an angiogenic factor. Science 281: 1683-1686
14. 14. Cioffi JA, Shafer AW, Zupancic TJ et al. (1996) Novel B219/OB receptor isoforms: possible role of leptin in haematopoiesis and reproduction. Nat Med 2: 585-589
15. 15. Lord GM, Matarese G, Howard JK, Baker RJ, Bloom SR, Lechler RI (1998) Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression. Nature 394: 897-901
16. 16. Tartaglia LA (1997) The leptin receptor. J Biol Chem 272: 6093-6096
17. 17. Trayhurn P, Hoggard N, Mercer JG, Rayner DV (1999) Leptin: fundamental aspects. Int J Obes 23[Suppl 1]: 22-28
18. 18. Flatt PR (1997) The hormonal and neural control of endocrine pancreatic function. In: Pickup J, Williams G (eds) Textbook of Diabetes. 2nd edn. Vol 1. Blackwell Science Ltd., Oxford, pp 9.1-9.17
19. 19. Koyama K, Chen G, Wang M-Yet al. (1997) Beta-cell function in normal rats made chronically hyperleptinaemic by adenovirus-leptin gene therapy. Diabetes 46: 1276-1280
20. 20. Walder K, Lewandowski P, Morton G et al. (1999) Leptin resistance in a polygenic, hyperleptinaemic animal model of obesity and NIDDM: Psammomys obesus. Int J Obes 23 [Suppl 1]: 83-89
21. 21. Ceddia RB, William WN Jr, Curi R (1998) Leptin increases glucose transport and utilization in skeletal muscle in vitro. Gen Pharmacol 31: 799-801
22. 22. Ishizuka T, Ernsberger P, Liu S et al. (1998) Phenotypic consequences of a nonsense mutation in the leptin receptor gene (fak) in obese spontaneously hypertensive Koletsky rats (SHROB). J Nutr 128: 2299-2306
23. 23. Kieffer TJ, Heller RS, Habener JF (1996) Leptin receptors expressed on pancreatic ß-cells. Biochem Biophys Res Commun 224: 522-527
24. 24. Emilsson V, Liu Y-L, Cawthorne MA, Morton NM, Davenport M (1997) Expression of the functional leptin receptor mRNA in pancreatic islets and direct inhibitory action of leptin on insulin secretion. Diabetes 46: 313-316
25. 25. Leclercq-Meyer V, Considine RV, Sener A, Malaisse WJ (1996) Do leptin receptors play a functional role in the endocrine pancreas? Biochem Biophys Res Commun 229: 794-798
26. 26. Harvey J, McKenna F, Herson PS, Spanswick D, Ashford ML (1997) Leptin activates ATP-sensitive potassium channels in the rat insulin secreting cell line, CRI-GI. J Physiol (Lond) 504: 527-535
27. + channels in pancreatic ß-cells. Diabetes 46: 1087-1093
28. 28. Spanswick D, Smith MA, Groppi VE, Logan SD, Ashford MLJ (1997) Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels. Nature 390: 521-525
29. 29. Lupi R, Marchetti P, Maffei M et al. (1999) Effects of acute or prolonged exposure to human leptin on isolated human islet function. Biochem Biophys Res Commun 256: 637-641
30. 30. Wang M-Y, Koyama K, Shimabukuro M, Mangelsdorf D, Newgard CB, Unger RH (1998) Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase and glucose-stimulated insulin secretion. Proc Natl Acad Sci USA 95: 11921-11926
31. 31. Chen N-G, Swick AG, Romsos DR (1997) Leptin constrains acetylcholine-induced insulin secretion from pancreatic islets of ob/ob mice. J Clin Invest 100: 1174-1179
32. 32. Ookuma M, Ookuma K, York DA (1998) Effects of leptin on insulin secretion from isolated rat pancreatic islets. Diabetes 47: 219-223
33. 33. Ishida K, Murakami T, Mizuno A, Iida M, Kuwajima M, Shima K (1997) Leptin suppresses basal insulin secretion from rat pancreatic islets. Regul Pept 70: 179-182
34. 34. Koyama K, Chen G, Wang M-Yet al. (1997) Beta-cell function in normal rats made chronically hyperleptinaemic by adenovirus-leptin gene therapy. Diabetes 46: 1276-1280
35. 35. Kulkarni RN, Wang Z-L, Wang R-M et al. (1997) Leptin rapidly suppresses insulin release from insulinoma cells, rat and human islets and, in vivo, in mice. J Clin Invest 100: 2729-2733
36. 36. Pallett AL, Morton NM, Cawthorne MA, Emilsson V (1997) Leptin inhibits insulin secretion and reduces insulin mRNA levels in rat isolated pancreatic islets. Biochem Biophys Res Commun 238: 267-270
37. 37. Poitout V, Rouault C, Guerre-Millo M, Briaud I, Reach G (1997) Inhibition of insulin secretion by leptin in normal rodent islets of Langerhans. Endocrinology 139: 822-826
38. 38. Zhao AZ, Bornfeldt KE, Beavo JA (1998) Leptin inhibits insulin secretion by activation of phosphodiesterase 3B. J Clin Invest 102: 869-873
39. 39. Seufert J, Kieffer TJ, Habener JF (1999) Leptin inhibits insulin gene transcription and reverses hyperinsulinaemia in leptin-deficient ob/ob mice. Proc Natl Acad Sci USA 96: 674-679
40. 40. Fehmann HC, Bode HP, Ebert T, Karl A, Göke B (1997) Interaction of GLP-1 and leptin at rat pancreatic ß-cells: effects on insulin secretion and signal transduction. Horm Metab Res 29: 572-576
41. 41. Seufert J, Kieffer TJ, Leech CA et al. (1999) Leptin suppression of insulin secretion and gene expression in human pancreatic islets: implications for the development of adipogenic diabetes mellitus. J Clin Endocrinol Metab 84: 670-676
42. 42. Zhou Y-T, Shimabukuro M, Koyama K et al. (1997) Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 94: 6386-6390
43. 43. Zhou Y-T, Shimabukuro M, Lee Y et al. (1998) Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats. Role in the pathogenesis of lipotoxic diabetes. Diabetes 47: 1904-1908
44. 44. Jansson L (1994) The regulation of pancreatic islet blood flow. Diabetes Metab Rev 10: 407-416
45. 45. Carlsson P-O, Andersson A, Jansson L (1998) Influence of age, hyperglycemia, leptin, and NPY on islet blood flow in obese-hyperglycemic mice. Am J Physiol 275: E594-E601
46. 46. Carlsson P-O, Andersson A, Jansson L (1996) Pancreatic islet blood flow in normal and obese-hyperglycemic (ob/ ob) mice. Am J Physiol 271: E990-E995
47. 47. Rossetti L, Massillon D, Barzilai N et al. (1997) Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272: 27758-27763
48. 48. Liu L, Karkanias GB, Morales JC et al. (1999) Intracerebroventricular leptin regulates hepatic but not peripheral glucose fluxes. J Biol Chem 273: 31160-31167
49. 49. Nemecz M, Preininger K, Englisch R et al. (1999) Acute effect of leptin on hepatic glycogenolysis and gluconeogenesis in perfused rat liver. Hepatology 29: 166-172
50. 50. Cohen B, Novick D, Rubinstein M (1996) Modulation of insulin activities by leptin. Science 274: 1185-1188
51. 51. Wang Y, Kuropatwinski KK, White DW et al. (1997) Leptin receptor action in hepatic cells. J Biol Chem 272: 16216-16223
52. 52. Takahashi Y, Okimura Y, Ishikazu M et al. (1997) Leptin induces mitogen-activated protein kinase-dependent proliferation of 3H10T1/2 cells. J Biol Chem 272: 12897-12900
53. 53. Kamohara S, Burcelin R, Halaas JL, Friedman JM, Charron MJ (1997) Acute stimulation of glucose metabolism in mice by leptin treatment. Nature 389: 374-377
54. 54. Roden M, Perseghin G, Petersen KF et al. (1996) The roles of insulin and glucagon in the regulation of hepatic glycogen synthesis and turnover in humans. J Clin Invest 97: 642-648
55. 55. Bai Y, Zhang S, Kim K-S, Lee J-K, Kim K-H (1996) Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 271: 13939-13942
56. 56. Müller G, Ertl J, Gerl M, Preibisch G (1997) Leptin impairs metabolic actions of insulin in isolated rat adipocytes. J Biol Chem 272: 10585-10593
57. 57. Muoio DM, Dohn GL, Fiedorek FT Jr, Tapscott EB, Coleman RA (1997) Leptin directly alters lipid partitioning in skeletal muscle. Diabetes 46: 1360-1363
58. 58. Wang J, Liu R, Hawkins M, Barzilai N, Rossetti L (1998) A nutrient-sensing pathway regulates leptin gene expression in muscle and fat. Nature 393: 684-688
59. 59. Schwartz MW, Baskin DG, Bukowski TR et al. (1996) Specificity of leptin action on elevated blood glucose levels and hypothalamic neuropeptide Y gene expression in ob/ ob mice. Diabetes 45: 531-535
60. 60. Sivitz WI, Walsh SA, Morgan DA, Thomas MJ, Haynes WG (1997) Effects of leptin on insulin sensitivity in normal rats. Endocrinology 138: 3395-3401
61. 61. Barzilai N, Massillon D, Vuguin P, Hawkins M, Rossetti L (1997) Leptin selectively decreases visceral adiposity and enhances insulin action. J Clin Invest 100: 3105-3110
62. 62. Burcelin R, Kamohara S, Li J, Tannenbaum GS, Charron MJ, Friedman JM (1999) Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob mice. Diabetes 48: 1264-1269
63. 63. Rohner-Jeanrenaud F, Proietto J, Ionescu E, Jeanrenaud B (1986) Mechanism of abnormal oral glucose tolerance of genetically obese (fa/fa) rats. Diabetes 35: 1350-1355
64. 64. Sanchez-Gutierrez J, Sanchez-Arias J, Lechuga CG, Valle JC, Samper B, Feliu JE (1994) Decreased responsiveness of basal gluconeogenesis to insulin action in hepatocytes isolated from genetically obese (fa/fa) Zucker rats. Endocrinology 134: 1868-1873
65. 65. Flier JS (1997) Leptin expression and action: new experimental paradigms. Proc Natl Acad Sci USA 94: 4242-4245
66. 66. Felig P, Wahren J, Hendler R, Brudin T (1974) Splanchnic glucose and amino acid metabolism in obesity. J Clin Invest 53: 582-590
67. 67. Morton NM, Emilsson V, Liu Y-L, Cawthorne MA (1998) Leptin action in intestinal cells. J Biol Chem 273: 26194-26201
68. 68. Lostao MP, Urdaneta E, Martínez-Ansó E, Barber A, Martínez JA (1998) Presence of leptin receptors in rat small intestine and leptin effect on sugar absorption. FEBS Lett 423: 302-306
69. 69. Bado A, Levasseur S, Attoub S et al. (1998) The stomach is a source of leptin. Nature 394: 790-793
70. 70. Coleman RA, Herrmann TS (1999) Nutritional regulation of leptin in humans. Diabetologia 42: 639-646
71. 71. Barrachina MD, Martinez V, Wang L, Wei JY, Taché Y (1997) Synergistic interaction between leptin and cholecystokinin to reduce short-term food intake in lean mice. Proc Natl Acad Sci USA 94: 10455-10460
72. 72. Matson CA, Wiater MF, Kuijper JL, Weigle DS (1997) Synergy between leptin and cholecystokinin (CCK) to control daily caloric intake. Peptides 18: 1275-1278
73. 73. Matson CA, Ritter RC (1999) Long-term CCK-leptin synergy suggests a role for CCK in the regulation of body weight. Am J Physiol 276: R1038-R1045
74. 74. Barrachina MD, Martinez V, Wei JY, Taché Y (1997) Leptin-induced decrease in food intake is not associated with changes in gastric emptying in lean mice. Am J Physiol 272: R1007-R1011
75. 75. Emond M, Schwartz GJ, Ladenheim EE, Moran TH (1999) Central leptin modulates behavioural and neural responsivity to CCK. Am J Physiol 276: R1545-R1549
76. 76. Wang YH, Taché Y, Sheibel AB, Go VLW, Wei JY (1997) Two types of leptin-responsive gastric vagal afferent terminals: an in vitro single-unit study in rats. Am J Physiol 273: R833-R837
77. 77. Muoio DM, Dohm GL, Tapscott EB, Coleman RA (1999) Leptin opposes insulin's effects on fatty acid partitioning in muscles isolated from obese ob/ob mice. Am J Physiol 276: E913-E921
78. 78. Wang J-L, Chinookoswong N, Scully S, Qi M, Shi Z-Q (1999) Differential effects of leptin in regulation of tissue glucose utilization in vivo. Endocrinology 140: 2117-2124
79. 79. Ceddia RB, William WN Jr, Curi R (1999) Comparing effects of leptin and insulin on glucose metabolism in skeletal muscle: evidence for an effect of leptin on glucose uptake and decarboxylation. Int J Obes 23: 75-82
80. 12 myotubes: evidence for a PI3-kinase mediated effect. Diabetologia 1997: 606-609
81. 12 myotubes via janus kinase-2 (JAK-2) and insulin receptor substrate-2 (IRS-2) dependent pathways. Diabetologia 40: 1358-1362
82. 82. Okada T, Kawano Y, Sakakibara T, Hazeki O, Ui M (1994) Essential role of phosphatidylinositol 3-kinase in insulin-induced glucose transport and antilipolysis in rat adipocytes. Studies with a selective inhibitor wortmannin. J Biol Chem 269: 3568-3573
83. 83. Sarmiento U, Benson B, Kaufman S et al. (1997) Morphologic and molecular changes induced by recombinant human leptin in white and brown adipose tissues of C57BL/ 6 mice. Lab Invest 77: 243-256
84. 84. Curi R, Newsholme E (1989) The effect of adenosine nucleotides on the rate and fate of glutamine utilization by incubated mitochondria isolated from rat mesenteric lymph nodes. Mol Cell Biochem 86: 71-76
85. 85. Gong DW, He Y, Karas M, Reitman M (1997) Uncoupling protein-3 is a mediator of thermogenesis regulated by thyroid hormone, ß3-adrenergic agonists, and leptin. J Biol Chem 272: 24129-24132
86. 86. Gómez-Ambrosi J, Frühbeck G, Martínez JA (1999) Leptin, but not a ß3-adrenergic agonist, upregulates muscle uncoupling-3 messenger RNA expression: short-term thermogenic interactions. Cell Mol Life Sci 55: 992-997
87. 87. Rossetti L, Massillon D, Barzilai N et al. (1997) Short term effects of leptin on hepatic gluconeogenesis and in vivo insulin action. J Biol Chem 272: 27758-27763
88. 88. Fürsinn C, Brunmair B, Furtmüller R, Roden M, Englisch R, Waldhäusl W (1998) Failure of leptin to affect basal and insulin-stimulated glucose metabolism of rat skeletal muscle in vitro. Diabetologia 41: 524-529
89. 89. Zierath JR, Frevert EU, Ryder JW, Berggren P-O, Kahn BB (1998) Evidence against a direct effect of leptin on glucose transport in skeletal muscle and adipocytes. Diabetes 47:1-4
90. 90. Ranganathan S, Ciaraldi TP, Henry RR, Mudaliar S, Kern PA (1998) Lack of effect of leptin on glucose transport, lipoprotein lipase, and insulin action in adipose and muscle cells. Endocrinology 139: 2509-2513
91. 91. Frühbeck G, Gómez-Ambrosi J, Martínez JA (1999) Preand postprandial expression of the leptin receptor splice variants OB-Ra and OB-Rb in murine peripheral tissues. Physiol Res 48: 189-195
92. 92. Frühbeck G, García-Granero M, Martínez JA (1998) Age-related differences in the thermogenic and ponderal effects following the administration of fragment peptides from the rat ob protein. Regul Pept 73: 83-87
93. 93. Coldberg SR, Simoneau JA, Thaete FL, Kelley DE (1995) Skeletal muscle utilization of free fatty acids in women with visceral obesity. J Clin Invest 95: 1846-1853
94. 94. Phillips DIW, Caddy S, Iiic V et al. (1996) Intramuscular triglyceride and muscle insulin sensitivity: evidence for a relationship in nondiabetic subjects. Metabolism 45: 947-950