Yeast Life-Span Extension by Calorie Restriction Is Independent of NAD Fluctuation

Science

Volumn 302, Issue 5653, 2003, Pages 2124-2126

  Anderson, Rozalyn M ^a   Latorre Esteves, Magda ^a   Neves, Ana Rute ^b   Lavu, Siva ^a,c   Medvedik, Oliver ^a   Taylor, Christopher ^c   Howitz, Konrad T ^c   Santos, Helena ^b   Sinclair, David A ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b INSTITUTO DE TECNOLOGIA QUÍMICA E BIOLÓGICA   (Portugal)

^c BIOMOL Research Laboratories Inc   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ENZYMES; PHYSIOLOGY; VITAMINS;

DEACETYLASE; LIFE-SPAN;

YEAST;

AMITROLE; GLUCOSE; HISTIDINE; LACTIC ACID; NICOTINAMIDE ADENINE DINUCLEOTIDE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; RIBOSOME DNA;

CALORIMETRY; YEAST;

ARTICLE; CALORIC INTAKE; CALORIC RESTRICTION; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; LIFESPAN; NONHUMAN; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; YEAST;

ACETALDEHYDE; AEROBIOSIS; BACTERIAL PROTEINS; CALORIC RESTRICTION; CCAAT-BINDING FACTOR; CULTURE MEDIA; GENES, FUNGAL; GENES, REPORTER; HISTIDINE; HISTONE DEACETYLASES; HYDRO-LYASES; LONGEVITY; MAGNETIC RESONANCE SPECTROSCOPY; NAD; RECOMBINANT FUSION PROTEINS; REPRESSOR PROTEINS; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SILENT INFORMATION REGULATOR PROTEINS, SACCHAROMYCES CEREVISIAE; SIRTUINS; TRANSCRIPTION FACTORS;

SACCHAROMYCES CEREVISIAE;

EID: 0345731468     PISSN: 00368075     EISSN: None     Source Type: Journal    
DOI: 10.1126/science.1088697     Document Type: Article

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25. We are grateful to D. Moazed, P. Frey, M. Agosto, R. Veech, J. Foster (pFW38-46), L. Guarente (pADH-HAP4), and B. Forrester (NSY64) for advice and/or reagents. Synthesis of labeled nicotinic acid was carried out by R. Ventura and C. Maycock. This work was supported by the National Institute on Aging and the Harvard-Armenise Foundation. D.S. is an Ellison Medical Research Foundation Special Fellow. R.A. is supported by a John Taplan Postdoctoral Fellowship, O.M. by the American Federation of Aging Research.