Leptin promotes invasiveness of kidney and colonic epithelial cells via phosphoinositide 3-kinase-, Rho-, and Rac-dependent signaling pathways

FASEB Journal

Volumn 14, Issue 14, 2000, Pages 2329-2338

  Attoub, Samir ^a   Noe, Veerle ^b   Pirola, Luciano ^c   Bruyneel, Erik ^b   Chastre, Eric ^a   Mareel, Marc ^b   Wymann, Matthias P ^c   Gespach, Christian ^a  

^a HÔPITAL SAINT ANTOINE   (France)

^b GHENT UNIVERSITY   (Belgium)

^c Division of Biochemistry   (Switzerland)

Author keywords

Leptin signaling; MDCK cells; Pertussis toxin; PI3' kinase; Wortmannin

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; LEPTIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE C; PROTEIN TYROSINE KINASE; RAPAMYCIN; WORTMANNIN;

ANIMAL CELL; ARTICLE; BODY WEIGHT; CANCER GROWTH; CANCER RISK; CANCER SURGERY; CANCER SUSCEPTIBILITY; CELL INVASION; CELL MIGRATION; CELL TRANSFORMATION; CONTROLLED STUDY; FOOD INTAKE; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SIGNAL TRANSDUCTION;

ANIMALIA;

EID: 0033747214     PISSN: 08926638     EISSN: None     Source Type: Journal    
DOI: 10.1096/fj.00-0162     Document Type: Article

References (54)

1. Associations of sedentary lifestyle, obesity, smoking, alcohol use, and diabetes with the risk of colorectal cancer
2. Increased blood glucose and insulin, body size, and incident colorectal cancer
3. Physical activity, body mass index, and prostaglandin E2 levels in rectal mucosa
4. The role of SOCS-3 in leptin signaling and leptin resistance
5. Leptin and the regulation of body weight in mammals
6. Positional clotting of the mouse obese gene and its human homologue
7. Serum immunoreactive-leptin concentrations in normal-weight and obese humans
8. Cloning the chicken leptin gene
9. The stomach is a source of leptin
10. Multiple cytokines and acute inflammation raise mouse leptin levels: Potential role in inflammatory anorexia
11. Identification and expression cloning of a leptin receptor, OB-R
12. The role of neuropeptide Y in the antiobesity action of the obese gene product
13. Neuropeptide Y and human pancreatic polypeptide stimulate feeding behavior in rats
14. Leptin can induce proliferation, differentiation, and functional activation of hemopoietic cells
15. Leptin action in intestinal cells
16. Cytokine receptor signalling
17. Divergent signaling capacities of the long and short isoforms of the leptin receptor
18. The leptin receptor activates janus kinase 2 and signals for proliferation in a factor-dependent cell line
19. Leptin induces mitogen-activated protein kinase-dependent proliferation in C3H10T1/2 cells
20. A role for leptin and its cognate receptor in hematopoiesis
21. Leptin modulates the T-cell immune response and reverses starvation-induced immunosuppression
22. Stat3 activation by Src induces specific gene regulation and is required for cell transformation
23. Constitutive activation of Jak-2 and Tyk-2 in a v-Src-transformed human gallbladder adenocarcinoma cell line
24. Induction of epithelial tubules by growth factor HGF depends on the STAT pathway
25. Growth hormone and prolactin stimulate tyrosine phosphorylation of insulin receptor substrate-1, -2, and -3, their association with p85 phosphatidylinositol 3-kinase (PI3-kinase), and concomitantly PI3-kinase activation via JAK2 kinase
26. Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells
27. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/β-catenin complex in cells transformed with a temperature-sensitive v-SRC gene
28. Progression of familial adenomatous polyposis (FAP) colonic cells after transfer of the src or polyoma middle T oncogenes: Cooperation between src and HGF/Met in invasion
29. Matrix adhesion and Ras transformation both activate a phosphoinositide 3-OH kinase and protein kinase B/Akt cellular survival pathway
30. Inhibition by platelet-activating factor of src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3'-kinase is a critical mediator of tumor invasion
31. Effects of regulated expression of mutant RhoA and Rac1 small GTPases on the development of epithelial (MDCK) cell polarity
32. Transition from the noninvasive to the invasive phenotype and loss of α-catenin in human colon cancer cells
33. VEGF, VEGF-B, VEGF-C and their receptors, KDR, FLT-1 and FLT-4 during the neoplastic progression of human colonic mucosa
34. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role
35. OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype
36. Requirement for PI3'-kinase in spontaneous and HGF-mediated invasiveness of epithelial cells transformed by the src oncogene. Inhibition by platelet-activating factor (PAF)
37. Activation of phosphoinositide 3-OH kinase by the α6β4 integrin promotes carcinoma invasion
38. Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitor
39. PI3K: Downstream AKTion blocks apoptosis
40. CDC42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K
41. Matrix-dependent Tiam-1/Rac signaling in epithelial cells promotes either cell-cell adhesion or cell migration and is regulated by phosphatidylinositol 3-kinase
42. The TOR signalling pathway controls nuclear localization of nutrient-regulated transcription factors
43. The p70 kDa S6 kinase complexes with and is activated by the Rho family G-proteins CDC42 and Rac1
44. The role of phosphoinositide 3-kinase lipid products in cell function
45. Evidence that SMAD is a tumor suppressor implicated in the control of cellular invasion
46. Serine phosphorylation and maximal activation of STAT3 during CNTF signaling is mediated by the rapamycin target mTOR
47. The 230 kDa mature form of KDR/Flt-1 (VEGF receptor-2) activates the PLC-γ pathway and partially induces mitotic signals in NIH3T3 fibroblasts
48. EGF receptor transactivation by G-protein-coupled receptors requires metalloproteinase cleavage of prob.-EGF
49. Epac is a guanine-nucleotide-exchange factor directly activated by cyclic AMP
50. Epithelial cell hyperproliferation induced in the exocrine pancreas of mice by a western-style diet
51. Effects of recombinant leptin therapy in a child with congenital leptin deficiency
52. An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene
53. Biological action of leptin as an angiogenic factor
54. Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice