메뉴 건너뛰기




Volumn 213, Issue 6, 2016, Pages 617-629

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CASPASE 8; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME;

EID: 84975453384     PISSN: 00219525     EISSN: 15408140     Source Type: Journal    
DOI: 10.1083/jcb.201602089     Document Type: Review
Times cited : (575)

References (163)
  • 2
    • 84865130689 scopus 로고    scopus 로고
    • NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens
    • Anand, P.K., R.K. Malireddi, J.R. Lukens, P. Vogel, J. Bertin, M. Lamkanfi, and T.D. Kanneganti. 2012. NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens. Nature. 488:389-393. http://dx.doi.org/10.1038/nature11250
    • (2012) Nature , vol.488 , pp. 389-393
    • Anand, P.K.1    Malireddi, R.K.2    Lukens, J.R.3    Vogel, P.4    Bertin, J.5    Lamkanfi, M.6    Kanneganti, T.D.7
  • 3
    • 84893718631 scopus 로고    scopus 로고
    • Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection
    • published erratum appears in PLoS Pathog. 2014. 10:e1004258
    • Ataide, M.A., W.A. Andrade, D.S. Zamboni, D. Wang, M.C. Souza, B.S. Franklin, S. Elian, F.S. Martins, D. Pereira, G. Reed, et al. 2014. Malaria-induced NLRP12/NLRP3-dependent caspase-1 activation mediates inflammation and hypersensitivity to bacterial superinfection. PLoS Pathog. 10:e1003885.(published erratum appears in PLoS Pathog. 2014. 10:e1004258) http://dx.doi.org/10.1371/journal.ppat.1003885
    • (2014) PLoS Pathog , vol.10
    • Ataide, M.A.1    Andrade, W.A.2    Zamboni, D.S.3    Wang, D.4    Souza, M.C.5    Franklin, B.S.6    Elian, S.7    Martins, F.S.8    Pereira, D.9    Reed, G.10
  • 5
    • 77955390094 scopus 로고    scopus 로고
    • Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
    • Broz, P., K. Newton, M. Lamkanfi, S. Mariathasan, V.M. Dixit, and D.M. Monack. 2010a. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J. Exp. Med. 207:1745-1755. http://dx.doi.org/10.1084/jem.20100257
    • (2010) J. Exp. Med , vol.207 , pp. 1745-1755
    • Broz, P.1    Newton, K.2    Lamkanfi, M.3    Mariathasan, S.4    Dixit, V.M.5    Monack, D.M.6
  • 6
    • 78650210802 scopus 로고    scopus 로고
    • Differential requirement for Caspase-1 autoproteolysis in pathogeninduced cell death and cytokine processing
    • Broz, P., J. von Moltke, J.W. Jones, R.E. Vance, and D.M. Monack. 2010b. Differential requirement for Caspase-1 autoproteolysis in pathogeninduced cell death and cytokine processing. Cell Host Microbe. 8:471-483. http://dx.doi.org/10.1016/j.chom.2010.11.007
    • (2010) Cell Host Microbe , vol.8 , pp. 471-483
    • Broz, P.1    von Moltke, J.2    Jones, J.W.3    Vance, R.E.4    Monack, D.M.5
  • 7
    • 84870275730 scopus 로고    scopus 로고
    • Extensive evolutionary and functional diversity among mammalian AIM2-like receptors
    • Brunette, R.L., J.M. Young, D.G. Whitley, I.E. Brodsky, H.S. Malik, and D.B. Stetson. 2012. Extensive evolutionary and functional diversity among mammalian AIM2-like receptors. J. Exp. Med. 209:1969-1983. http://dx.doi.org/10.1084/jem.20121960
    • (2012) J. Exp. Med , vol.209 , pp. 1969-1983
    • Brunette, R.L.1    Young, J.M.2    Whitley, D.G.3    Brodsky, I.E.4    Malik, H.S.5    Stetson, D.B.6
  • 9
    • 84896381627 scopus 로고    scopus 로고
    • Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation
    • Cai, X., J. Chen, H. Xu, S. Liu, Q.X. Jiang, R. Halfmann, and Z.J. Chen. 2014. Prion-like polymerization underlies signal transduction in antiviral immune defense and inflammasome activation. Cell. 156:1207-1222. http://dx.doi.org/10.1016/j.cell.2014.01.063
    • (2014) Cell , vol.156 , pp. 1207-1222
    • Cai, X.1    Chen, J.2    Xu, H.3    Liu, S.4    Jiang, Q.X.5    Halfmann, R.6    Chen, Z.J.7
  • 10
  • 12
    • 84901367888 scopus 로고    scopus 로고
    • A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage
    • Cavailles, P., P. Flori, O. Papapietro, C. Bisanz, D. Lagrange, L. Pilloux, C. Massera, S. Cristinelli, D. Jublot, O. Bastien, et al. 2014. A highly conserved Toxo1 haplotype directs resistance to toxoplasmosis and its associated caspase-1 dependent killing of parasite and host macrophage. PLoS Pathog. 10:e1004005. http://dx.doi.org/10.1371/journal.ppat.1004005
    • (2014) PLoS Pathog , vol.10
    • Cavailles, P.1    Flori, P.2    Papapietro, O.3    Bisanz, C.4    Lagrange, D.5    Pilloux, L.6    Massera, C.7    Cristinelli, S.8    Jublot, D.9    Bastien, O.10
  • 13
    • 79956299492 scopus 로고    scopus 로고
    • Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice
    • Chae, J.J., Y.H. Cho, G.S. Lee, J. Cheng, P.P. Liu, L. Feigenbaum, S.I. Katz, and D.L. Kastner. 2011. Gain-of-function Pyrin mutations induce NLRP3 protein-independent interleukin-1β activation and severe autoinflammation in mice. Immunity. 34:755-768. http://dx.doi.org/10.1016/j.immuni.2011.02.020
    • (2011) Immunity , vol.34 , pp. 755-768
    • Chae, J.J.1    Cho, Y.H.2    Lee, G.S.3    Cheng, J.4    Liu, P.P.5    Feigenbaum, L.6    Katz, S.I.7    Kastner, D.L.8
  • 14
    • 84879508269 scopus 로고    scopus 로고
    • Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor
    • Chavarría-Smith, J., and R.E. Vance. 2013. Direct proteolytic cleavage of NLRP1B is necessary and sufficient for inflammasome activation by anthrax lethal factor. PLoS Pathog. 9:e1003452. http://dx.doi.org/10.1371/journal.ppat.1003452
    • (2013) PLoS Pathog , vol.9
    • Chavarría-Smith, J.1    Vance, R.E.2
  • 15
    • 79959540809 scopus 로고    scopus 로고
    • A functional role for Nlrp6 in intestinal inflammation and tumorigenesis
    • Chen, G.Y., M. Liu, F. Wang, J. Bertin, and G. Núñez. 2011. A functional role for Nlrp6 in intestinal inflammation and tumorigenesis. J. Immunol. 186:7187-7194. http://dx.doi.org/10.4049/jimmunol.1100412
    • (2011) J. Immunol , vol.186 , pp. 7187-7194
    • Chen, G.Y.1    Liu, M.2    Wang, F.3    Bertin, J.4    Núñez, G.5
  • 16
    • 84904792729 scopus 로고    scopus 로고
    • The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge
    • Chen, K.W., C.J. Groß, F.V. Sotomayor, K.J. Stacey, J. Tschopp, M.J. Sweet, and K. Schroder. 2014. The neutrophil NLRC4 inflammasome selectively promotes IL-1β maturation without pyroptosis during acute Salmonella challenge. Cell Reports. 8:570-582. http://dx.doi.org/10.1016/j.celrep.2014.06.028
    • (2014) Cell Reports , vol.8 , pp. 570-582
    • Chen, K.W.1    Groß, C.J.2    Sotomayor, F.V.3    Stacey, K.J.4    Tschopp, J.5    Sweet, M.J.6    Schroder, K.7
  • 18
    • 84865394537 scopus 로고    scopus 로고
    • Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility
    • Choubey, D. 2012. Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility. Immunol. Lett. 147:10-17. http://dx.doi.org/10.1016/j.imlet.2012.07.003
    • (2012) Immunol. Lett , vol.147 , pp. 10-17
    • Choubey, D.1
  • 22
    • 34047261260 scopus 로고    scopus 로고
    • ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages
    • Cruz, C.M., A. Rinna, H.J. Forman, A.L. Ventura, P.M. Persechini, and D.M. Ojcius. 2007. ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J. Biol. Chem. 282:2871-2879. http://dx.doi.org/10.1074/jbc.M608083200
    • (2007) J. Biol. Chem , vol.282 , pp. 2871-2879
    • Cruz, C.M.1    Rinna, A.2    Forman, H.J.3    Ventura, A.L.4    Persechini, P.M.5    Ojcius, D.M.6
  • 23
    • 84949201317 scopus 로고    scopus 로고
    • Cryoelectron tomography of the NAIP5/NLRC4 inflammasome: implications for NLR Activation
    • Diebolder, C.A., E.F. Halff, A.J. Koster, E.G. Huizinga, and R.I. Koning. 2015. Cryoelectron tomography of the NAIP5/NLRC4 inflammasome: implications for NLR Activation. Structure. 23:2349-2357. http://dx.doi.org/10.1016/j.str.2015.10.001
    • (2015) Structure , vol.23 , pp. 2349-2357
    • Diebolder, C.A.1    Halff, E.F.2    Koster, A.J.3    Huizinga, E.G.4    Koning, R.I.5
  • 24
    • 84902655075 scopus 로고    scopus 로고
    • Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms
    • Dihlmann, S., P. Erhart, A. Mehrabi, A. Nickkholgh, F. Lasitschka, D. Böckler, and M. Hakimi. 2014. Increased expression and activation of absent in melanoma 2 inflammasome components in lymphocytic infiltrates of abdominal aortic aneurysms. Mol. Med. 20:230-237. http://dx.doi.org/10.2119/molmed.2013.00162
    • (2014) Mol. Med , vol.20 , pp. 230-237
    • Dihlmann, S.1    Erhart, P.2    Mehrabi, A.3    Nickkholgh, A.4    Lasitschka, F.5    Böckler, D.6    Hakimi, M.7
  • 26
    • 43249125839 scopus 로고    scopus 로고
    • Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica
    • Dostert, C., V. Pétrilli, R. Van Bruggen, C. Steele, B.T. Mossman, and J. Tschopp. 2008. Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science. 320:674-677. http://dx.doi.org/10.1126/science.1156995
    • (2008) Science , vol.320 , pp. 674-677
    • Dostert, C.1    Pétrilli, V.2    Van Bruggen, R.3    Steele, C.4    Mossman, B.T.5    Tschopp, J.6
  • 27
    • 84901651706 scopus 로고    scopus 로고
    • The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis
    • Dumas, A., N. Amiable, J.P. de Rivero Vaccari, J.J. Chae, R.W. Keane, S. Lacroix, and L. Vallières. 2014. The inflammasome pyrin contributes to pertussis toxin-induced IL-1β synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis. PLoS Pathog. 10:e1004150. http://dx.doi.org/10.1371/journal.ppat.1004150
    • (2014) PLoS Pathog , vol.10
    • Dumas, A.1    Amiable, N.2    de Rivero Vaccari, J.P.3    Chae, J.J.4    Keane, R.W.5    Lacroix, S.6    Vallières, L.7
  • 28
    • 0036001057 scopus 로고    scopus 로고
    • Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells
    • Edgeworth, J.D., J. Spencer, A. Phalipon, G.E. Griffin, and P.J. Sansonetti. 2002. Cytotoxicity and interleukin-1beta processing following Shigella flexneri infection of human monocyte-derived dendritic cells. Eur. J. Immunol. 32:1464-1471. http://dx.doi.org/10.1002/1521-4141(200205)32:5<1464::AID-IMMU1464>3.0.CO;2-G
    • (2002) Eur. J. Immunol , vol.32 , pp. 1464-1471
    • Edgeworth, J.D.1    Spencer, J.2    Phalipon, A.3    Griffin, G.E.4    Sansonetti, P.J.5
  • 30
    • 0033832614 scopus 로고    scopus 로고
    • Genomic sequence analysis of the mouse Naip gene array
    • Endrizzi, M.G., V. Hadinoto, J.D. Growney, W. Miller, and W.F. Dietrich. 2000. Genomic sequence analysis of the mouse Naip gene array. Genome Res. 10:1095-1102. http://dx.doi.org/10.1101/gr.10.8.1095
    • (2000) Genome Res , vol.10 , pp. 1095-1102
    • Endrizzi, M.G.1    Hadinoto, V.2    Growney, J.D.3    Miller, W.4    Dietrich, W.F.5
  • 31
    • 84890831999 scopus 로고    scopus 로고
    • NLRP1 is an inflammasome sensor for Toxoplasma gondii
    • Ewald, S.E., J. Chavarria-Smith, and J.C. Boothroyd. 2014. NLRP1 is an inflammasome sensor for Toxoplasma gondii. Infect. Immun. 82:460-468. http://dx.doi.org/10.1128/IAI.01170-13
    • (2014) Infect. Immun , vol.82 , pp. 460-468
    • Ewald, S.E.1    Chavarria-Smith, J.2    Boothroyd, J.C.3
  • 32
    • 63649145255 scopus 로고    scopus 로고
    • AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA
    • Fernandes-Alnemri, T., J.W. Yu, P. Datta, J. Wu, and E.S. Alnemri. 2009. AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA. Nature. 458:509-513. http://dx.doi.org/10.1038/nature07710
    • (2009) Nature , vol.458 , pp. 509-513
    • Fernandes-Alnemri, T.1    Yu, J.W.2    Datta, P.3    Wu, J.4    Alnemri, E.S.5
  • 34
    • 84864110446 scopus 로고    scopus 로고
    • Autolytic proteolysis within the function to find domain (FII ND) is required for NLRP1 inflammasome activity
    • Finger, J.N., J.D. Lich, L.C. Dare, M.N. Cook, K.K. Brown, C. Duraiswami, J. Bertin, and P.J. Gough. 2012. Autolytic proteolysis within the function to find domain (FII ND) is required for NLRP1 inflammasome activity. J. Biol. Chem. 287:25030-25037. http://dx.doi.org/10.1074/jbc.M112.378323
    • (2012) J. Biol. Chem , vol.287 , pp. 25030-25037
    • Finger, J.N.1    Lich, J.D.2    Dare, L.C.3    Cook, M.N.4    Brown, K.K.5    Duraiswami, C.6    Bertin, J.7    Gough, P.J.8
  • 35
    • 33749576792 scopus 로고    scopus 로고
    • Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages
    • Fink, S.L., and B.T. Cookson. 2006. Caspase-1-dependent pore formation during pyroptosis leads to osmotic lysis of infected host macrophages. Cell. Microbiol. 8:1812-1825. http://dx.doi.org/10.1111/j.1462-5822.2006.00751.x
    • (2006) Cell. Microbiol , vol.8 , pp. 1812-1825
    • Fink, S.L.1    Cookson, B.T.2
  • 36
    • 41949127121 scopus 로고    scopus 로고
    • Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms
    • Fink, S.L., T. Bergsbaken, and B.T. Cookson. 2008. Anthrax lethal toxin and Salmonella elicit the common cell death pathway of caspase-1-dependent pyroptosis via distinct mechanisms. Proc. Natl. Acad. Sci. USA. 105:4312-4317. http://dx.doi.org/10.1073/pnas.0707370105
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 4312-4317
    • Fink, S.L.1    Bergsbaken, T.2    Cookson, B.T.3
  • 39
    • 84861215715 scopus 로고    scopus 로고
    • Proteolytic processing of Nlrp1b is required for inflammasome activity
    • Frew, B.C., V.R. Joag, and J. Mogridge. 2012. Proteolytic processing of Nlrp1b is required for inflammasome activity. PLoS Pathog. 8:e1002659. http://dx.doi.org/10.1371/journal.ppat.1002659
    • (2012) PLoS Pathog , vol.8
    • Frew, B.C.1    Joag, V.R.2    Mogridge, J.3
  • 41
    • 84859945146 scopus 로고    scopus 로고
    • Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking
    • Ge, J., Y.N. Gong, Y. Xu, and F. Shao. 2012. Preventing bacterial DNA release and absent in melanoma 2 inflammasome activation by a Legionella effector functioning in membrane trafficking. Proc. Natl. Acad. Sci. USA. 109:6193-6198. http://dx.doi.org/10.1073/pnas.1117490109
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 6193-6198
    • Ge, J.1    Gong, Y.N.2    Xu, Y.3    Shao, F.4
  • 43
    • 84857175933 scopus 로고    scopus 로고
    • Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome
    • Gringhuis, S.I., T.M. Kaptein, B.A. Wevers, B. Theelen, M. van der Vlist, T. Boekhout, and T.B. Geijtenbeek. 2012. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome. Nat. Immunol. 13:246-254. http://dx.doi.org/10.1038/ni.2222
    • (2012) Nat. Immunol , vol.13 , pp. 246-254
    • Gringhuis, S.I.1    Kaptein, T.M.2    Wevers, B.A.3    Theelen, B.4    van der Vlist, M.5    Boekhout, T.6    Geijtenbeek, T.B.7
  • 44
    • 84914132432 scopus 로고    scopus 로고
    • Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function
    • Guey, B., M. Bodnar, S.N. Manié, A. Tardivel, and V. Petrilli. 2014. Caspase-1 autoproteolysis is differentially required for NLRP1b and NLRP3 inflammasome function. Proc. Natl. Acad. Sci. USA. 111:17254-17259. http://dx.doi.org/10.1073/pnas.1415756111
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 17254-17259
    • Guey, B.1    Bodnar, M.2    Manié, S.N.3    Tardivel, A.4    Petrilli, V.5
  • 45
    • 84936891896 scopus 로고    scopus 로고
    • Inflammasomes: mechanism of action, role in disease, and therapeutics
    • Guo, H., J.B. Callaway, and J.P. Ting. 2015. Inflammasomes: mechanism of action, role in disease, and therapeutics. Nat. Med. 21:677-687. http://dx.doi.org/10.1038/nm.3893
    • (2015) Nat. Med , vol.21 , pp. 677-687
    • Guo, H.1    Callaway, J.B.2    Ting, J.P.3
  • 46
    • 33748598700 scopus 로고    scopus 로고
    • Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival
    • Gurcel, L., L. Abrami, S. Girardin, J. Tschopp, and F.G. van der Goot. 2006. Caspase-1 activation of lipid metabolic pathways in response to bacterial pore-forming toxins promotes cell survival. Cell. 126:1135-1145. http://dx.doi.org/10.1016/j.cell.2006.07.033
    • (2006) Cell , vol.126 , pp. 1135-1145
    • Gurcel, L.1    Abrami, L.2    Girardin, S.3    Tschopp, J.4    van der Goot, F.G.5
  • 48
    • 84964402403 scopus 로고    scopus 로고
    • NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis
    • Gurung, P., A. Burton, and T.D. Kanneganti. 2016. NLRP3 inflammasome plays a redundant role with caspase 8 to promote IL-1β-mediated osteomyelitis. Proc. Natl. Acad. Sci. USA. 113:4452-4457. http://dx.doi.org/10.1073/pnas.1601636113
    • (2016) Proc. Natl. Acad. Sci. USA , vol.113 , pp. 4452-4457
    • Gurung, P.1    Burton, A.2    Kanneganti, T.D.3
  • 51
    • 84949091051 scopus 로고    scopus 로고
    • Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion
    • He, W.T., H. Wan, L. Hu, P. Chen, X. Wang, Z. Huang, Z.H. Yang, C.Q. Zhong, and J. Han. 2015. Gasdermin D is an executor of pyroptosis and required for interleukin-1β secretion. Cell Res. 25:1285-1298. http://dx.doi.org/10.1038/cr.2015.139
    • (2015) Cell Res , vol.25 , pp. 1285-1298
    • He, W.T.1    Wan, H.2    Hu, L.3    Chen, P.4    Wang, X.5    Huang, Z.6    Yang, Z.H.7    Zhong, C.Q.8    Han, J.9
  • 52
    • 84958971929 scopus 로고    scopus 로고
    • NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux
    • He, Y., M.Y. Zeng, D. Yang, B. Motro, and G. Núñez. 2016. NEK7 is an essential mediator of NLRP3 activation downstream of potassium efflux. Nature. 530:354-357. http://dx.doi.org/10.1038/nature16959
    • (2016) Nature , vol.530 , pp. 354-357
    • He, Y.1    Zeng, M.Y.2    Yang, D.3    Motro, B.4    Núñez, G.5
  • 54
    • 0035179970 scopus 로고    scopus 로고
    • Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome
    • Hoffman, H.M., J.L. Mueller, D.H. Broide, A.A. Wanderer, and R.D. Kolodner. 2001. Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle-Wells syndrome. Nat. Genet. 29:301-305. http://dx.doi.org/10.1038/ng756
    • (2001) Nat. Genet , vol.29 , pp. 301-305
    • Hoffman, H.M.1    Mueller, J.L.2    Broide, D.H.3    Wanderer, A.A.4    Kolodner, R.D.5
  • 55
    • 47849097202 scopus 로고    scopus 로고
    • Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization
    • Hornung, V., F. Bauernfeind, A. Halle, E.O. Samstad, H. Kono, K.L. Rock, K.A. Fitzgerald, and E. Latz. 2008. Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 9:847-856. http://dx.doi.org/10.1038/ni.1631
    • (2008) Nat. Immunol , vol.9 , pp. 847-856
    • Hornung, V.1    Bauernfeind, F.2    Halle, A.3    Samstad, E.O.4    Kono, H.5    Rock, K.L.6    Fitzgerald, K.A.7    Latz, E.8
  • 58
    • 84944748927 scopus 로고    scopus 로고
    • Structural and biochemical basis for induced self-propagation of NLRC4
    • Hu, Z., Q. Zhou, C. Zhang, S. Fan, W. Cheng, Y. Zhao, F. Shao, H.W. Wang, S.F. Sui, and J. Chai. 2015. Structural and biochemical basis for induced self-propagation of NLRC4. Science. 350:399-404. http://dx.doi.org/10.1126/science.aac5489
    • (2015) Science , vol.350 , pp. 399-404
    • Hu, Z.1    Zhou, Q.2    Zhang, C.3    Fan, S.4    Cheng, W.5    Zhao, Y.6    Shao, F.7    Wang, H.W.8    Sui, S.F.9    Chai, J.10
  • 61
    • 84923325462 scopus 로고    scopus 로고
    • Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy
    • Jabir, M.S., L. Hopkins, N.D. Ritchie, I. Ullah, H.K. Bayes, D. Li, P. Tourlomousis, A. Lupton, D. Puleston, A.K. Simon, et al. 2015. Mitochondrial damage contributes to Pseudomonas aeruginosa activation of the inflammasome and is downregulated by autophagy. Autophagy. 11:166-182. http://dx.doi.org/10.4161/15548627.2014.981915
    • (2015) Autophagy , vol.11 , pp. 166-182
    • Jabir, M.S.1    Hopkins, L.2    Ritchie, N.D.3    Ullah, I.4    Bayes, H.K.5    Li, D.6    Tourlomousis, P.7    Lupton, A.8    Puleston, D.9    Simon, A.K.10
  • 62
    • 84859986329 scopus 로고    scopus 로고
    • Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor
    • Jin, T., A. Perry, J. Jiang, P. Smith, J.A. Curry, L. Unterholzner, Z. Jiang, G. Horvath, V.A. Rathinam, R.W. Johnstone, et al. 2012. Structures of the HIN domain:DNA complexes reveal ligand binding and activation mechanisms of the AIM2 inflammasome and IFI16 receptor. Immunity. 36:561-571. http://dx.doi.org/10.1016/j.immuni.2012.02.014
    • (2012) Immunity , vol.36 , pp. 561-571
    • Jin, T.1    Perry, A.2    Jiang, J.3    Smith, P.4    Curry, J.A.5    Unterholzner, L.6    Jiang, Z.7    Horvath, G.8    Rathinam, V.A.9    Johnstone, R.W.10
  • 63
    • 84879419551 scopus 로고    scopus 로고
    • Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1
    • Jin, T., J. Curry, P. Smith, J. Jiang, and T.S. Xiao. 2013a. Structure of the NLRP1 caspase recruitment domain suggests potential mechanisms for its association with procaspase-1. Proteins. 81:1266-1270. http://dx.doi.org/10.1002/prot.24287
    • (2013) Proteins , vol.81 , pp. 1266-1270
    • Jin, T.1    Curry, J.2    Smith, P.3    Jiang, J.4    Xiao, T.S.5
  • 64
    • 84877692253 scopus 로고    scopus 로고
    • Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly
    • Jin, T., A. Perry, P. Smith, J. Jiang, and T.S. Xiao. 2013b. Structure of the absent in melanoma 2 (AIM2) pyrin domain provides insights into the mechanisms of AIM2 autoinhibition and inflammasome assembly. J. Biol. Chem. 288:13225-13235. http://dx.doi.org/10.1074/jbc.M113.468033
    • (2013) J. Biol. Chem , vol.288 , pp. 13225-13235
    • Jin, T.1    Perry, A.2    Smith, P.3    Jiang, J.4    Xiao, T.S.5
  • 67
    • 79251588741 scopus 로고    scopus 로고
    • NLRP4 negatively regulates autophagic processes through an association with beclin1
    • Jounai, N., K. Kobiyama, M. Shiina, K. Ogata, K.J. Ishii, and F. Takeshita. 2011. NLRP4 negatively regulates autophagic processes through an association with beclin1. J. Immunol. 186:1646-1655. http://dx.doi.org/10.4049/jimmunol.1001654
    • (2011) J. Immunol , vol.186 , pp. 1646-1655
    • Jounai, N.1    Kobiyama, K.2    Shiina, M.3    Ogata, K.4    Ishii, K.J.5    Takeshita, F.6
  • 68
    • 84926164932 scopus 로고    scopus 로고
    • Concerted activation of the AIM2 and NLRP3. inflammasomes orchestrates host protection against Aspergillus infection
    • Karki, R., S.M. Man, R.K. Malireddi, P. Gurung, P. Vogel, M. Lamkanfi, and T.D. Kanneganti. 2015. Concerted activation of the AIM2 and NLRP3. inflammasomes orchestrates host protection against Aspergillus infection. Cell Host Microbe. 17:357-368. http://dx.doi.org/10.1016/j.chom.2015.01.006
    • (2015) Cell Host Microbe , vol.17 , pp. 357-368
    • Karki, R.1    Man, S.M.2    Malireddi, R.K.3    Gurung, P.4    Vogel, P.5    Lamkanfi, M.6    Kanneganti, T.D.7
  • 71
    • 79956061094 scopus 로고    scopus 로고
    • IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection
    • Kerur, N., M.V. Veettil, N. Sharma-Walia, V. Bottero, S. Sadagopan, P. Otageri, and B. Chandran. 2011. IFI16 acts as a nuclear pathogen sensor to induce the inflammasome in response to Kaposi Sarcoma-associated herpesvirus infection. Cell Host Microbe. 9:363-375. http://dx.doi.org/10.1016/j.chom.2011.04.008
    • (2011) Cell Host Microbe , vol.9 , pp. 363-375
    • Kerur, N.1    Veettil, M.V.2    Sharma-Walia, N.3    Bottero, V.4    Sadagopan, S.5    Otageri, P.6    Chandran, B.7
  • 74
    • 84911922142 scopus 로고    scopus 로고
    • An inherited mutation in NLRC4 causes autoinflammation in human and mice
    • Kitamura, A., Y. Sasaki, T. Abe, H. Kano, and K. Yasutomo. 2014. An inherited mutation in NLRC4 causes autoinflammation in human and mice. J. Exp. Med. 211:2385-2396. http://dx.doi.org/10.1084/jem.20141091
    • (2014) J. Exp. Med , vol.211 , pp. 2385-2396
    • Kitamura, A.1    Sasaki, Y.2    Abe, T.3    Kano, H.4    Yasutomo, K.5
  • 75
    • 80053379974 scopus 로고    scopus 로고
    • Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity
    • Kofoed, E.M., and R.E. Vance. 2011. Innate immune recognition of bacterial ligands by NAIPs determines inflammasome specificity. Nature. 477:592-595. http://dx.doi.org/10.1038/nature10394
    • (2011) Nature , vol.477 , pp. 592-595
    • Kofoed, E.M.1    Vance, R.E.2
  • 76
    • 84937706079 scopus 로고    scopus 로고
    • Cutting edge: inflammasome activation in primary human macrophages is dependent on flagellin
    • Kortmann, J., S.W. Brubaker, and D.M. Monack. 2015. Cutting edge: inflammasome activation in primary human macrophages is dependent on flagellin. J. Immunol. 195:815-819. http://dx.doi.org/10.4049/jimmunol.1403100
    • (2015) J. Immunol , vol.195 , pp. 815-819
    • Kortmann, J.1    Brubaker, S.W.2    Monack, D.M.3
  • 79
    • 84949255269 scopus 로고    scopus 로고
    • Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling
    • Levy, M., C.A. Thaiss, D. Zeevi, L. Dohnalová, G. Zilberman-Schapira, J.A. Mahdi, E. David, A. Savidor, T. Korem, Y. Herzig, et al. 2015. Microbiota-modulated metabolites shape the intestinal microenvironment by regulating NLRP6 inflammasome signaling. Cell. 163:1428-1443. http://dx.doi.org/10.1016/j.cell.2015.10.048
    • (2015) Cell , vol.163 , pp. 1428-1443
    • Levy, M.1    Thaiss, C.A.2    Zeevi, D.3    Dohnalová, L.4    Zilberman-Schapira, G.5    Mahdi, J.A.6    David, E.7    Savidor, A.8    Korem, T.9    Herzig, Y.10
  • 80
    • 84905376754 scopus 로고    scopus 로고
    • Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Acta Crystallogr
    • Li, H., J. Wang, J. Wang, L.S. Cao, Z.X. Wang, and J.W. Wu. 2014. Structural mechanism of DNA recognition by the p202 HINa domain: insights into the inhibition of Aim2-mediated inflammatory signalling. Acta Crystallogr. F Struct. Biol. Commun. 70:21-29. http://dx.doi.org/10.1107/S2053230X1303135X
    • (2014) F Struct. Biol. Commun , vol.70 , pp. 21-29
    • Li, H.1    Wang, J.2    Wang, J.3    Cao, L.S.4    Wang, Z.X.5    Wu, J.W.6
  • 81
    • 33846473862 scopus 로고    scopus 로고
    • Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes
    • Lich, J.D., K.L. Williams, C.B. Moore, J.C. Arthur, B.K. Davis, D.J. Taxman, and J.P. Ting. 2007. Monarch-1 suppresses non-canonical NF-kappaB activation and p52-dependent chemokine expression in monocytes. J. Immunol. 178:1256-1260. http://dx.doi.org/10.4049/jimmunol.178.3.1256
    • (2007) J. Immunol , vol.178 , pp. 1256-1260
    • Lich, J.D.1    Williams, K.L.2    Moore, C.B.3    Arthur, J.C.4    Davis, B.K.5    Taxman, D.J.6    Ting, J.P.7
  • 85
    • 84928196080 scopus 로고    scopus 로고
    • The NLRP12 Sensor negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells
    • Lukens, J.R., P. Gurung, P.J. Shaw, M.J. Barr, M.H. Zaki, S.A. Brown, P. Vogel, H. Chi, and T.D. Kanneganti. 2015. The NLRP12 Sensor negatively regulates autoinflammatory disease by modulating interleukin-4 production in T cells. Immunity. 42:654-664. http://dx.doi.org/10.1016/j.immuni.2015.03.006
    • (2015) Immunity , vol.42 , pp. 654-664
    • Lukens, J.R.1    Gurung, P.2    Shaw, P.J.3    Barr, M.J.4    Zaki, M.H.5    Brown, S.A.6    Vogel, P.7    Chi, H.8    Kanneganti, T.D.9
  • 86
    • 84876685141 scopus 로고    scopus 로고
    • Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection
    • Lupfer, C., P.G. Thomas, P.K. Anand, P. Vogel, S. Milasta, J. Martinez, G. Huang, M. Green, M. Kundu, H. Chi, et al. 2013. Receptor interacting protein kinase 2-mediated mitophagy regulates inflammasome activation during virus infection. Nat. Immunol. 14:480-488. http://dx.doi.org/10.1038/ni.2563
    • (2013) Nat. Immunol , vol.14 , pp. 480-488
    • Lupfer, C.1    Thomas, P.G.2    Anand, P.K.3    Vogel, P.4    Milasta, S.5    Martinez, J.6    Huang, G.7    Green, M.8    Kundu, M.9    Chi, H.10
  • 87
    • 84927732725 scopus 로고    scopus 로고
    • Regulation of inflammasome activation
    • Man, S.M., and T.D. Kanneganti. 2015. Regulation of inflammasome activation. Immunol. Rev. 265:6-21. http://dx.doi.org/10.1111/imr.12296
    • (2015) Immunol. Rev , vol.265 , pp. 6-21
    • Man, S.M.1    Kanneganti, T.D.2
  • 88
    • 84952630550 scopus 로고    scopus 로고
    • Converging roles of caspases in inflammasome activation, cell death and innate immunity
    • Man, S.M., and T.-D. Kanneganti. 2016. Converging roles of caspases in inflammasome activation, cell death and innate immunity. Nat. Rev. Immunol. 16:7-21. http://dx.doi.org/10.1038/nri.2015.7
    • (2016) Nat. Rev. Immunol , vol.16 , pp. 7-21
    • Man, S.M.1    Kanneganti, T.-D.2
  • 89
    • 84887439544 scopus 로고    scopus 로고
    • Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production
    • Man, S.M., P. Tourlomousis, L. Hopkins, T.P. Monie, K.A. Fitzgerald, and C.E. Bryant. 2013. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1β production. J. Immunol. 191:5239-5246. http://dx.doi.org/10.4049/jimmunol.1301581
    • (2013) J. Immunol , vol.191 , pp. 5239-5246
    • Man, S.M.1    Tourlomousis, P.2    Hopkins, L.3    Monie, T.P.4    Fitzgerald, K.A.5    Bryant, C.E.6
  • 92
    • 84928545520 scopus 로고    scopus 로고
    • The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection
    • Man, S.M., R. Karki, R.K. Malireddi, G. Neale, P. Vogel, M. Yamamoto, M. Lamkanfi, and T.D. Kanneganti. 2015a. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection. Nat. Immunol. 16:467-475. http://dx.doi.org/10.1038/ni.3118
    • (2015) Nat. Immunol , vol.16 , pp. 467-475
    • Man, S.M.1    Karki, R.2    Malireddi, R.K.3    Neale, G.4    Vogel, P.5    Yamamoto, M.6    Lamkanfi, M.7    Kanneganti, T.D.8
  • 93
    • 84934346989 scopus 로고    scopus 로고
    • Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer
    • Man, S.M., Q. Zhu, L. Zhu, Z. Liu, R. Karki, A. Malik, D. Sharma, L. Li, R.K. Malireddi, P. Gurung, et al. 2015b. Critical role for the DNA sensor AIM2 in stem cell proliferation and cancer. Cell. 162:45-58. http://dx.doi.org/10.1016/j.cell.2015.06.001
    • (2015) Cell , vol.162 , pp. 45-58
    • Man, S.M.1    Zhu, Q.2    Zhu, L.3    Liu, Z.4    Karki, R.5    Malik, A.6    Sharma, D.7    Li, L.8    Malireddi, R.K.9    Gurung, P.10
  • 95
    • 0036671894 scopus 로고    scopus 로고
    • The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta
    • Martinon, F., K. Burns, and J. Tschopp. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell. 10:417-426. http://dx.doi.org/10.1016/S1097-2765(02)00599-3
    • (2002) Mol. Cell , vol.10 , pp. 417-426
    • Martinon, F.1    Burns, K.2    Tschopp, J.3
  • 96
    • 67650736238 scopus 로고    scopus 로고
    • Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease
    • Masters, S.L., A. Simon, I. Aksentijevich, and D.L. Kastner. 2009. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu. Rev. Immunol. 27:621-668. http://dx.doi.org/10.1146/annurev.immunol.25.022106.141627
    • (2009) Annu. Rev. Immunol , vol.27 , pp. 621-668
    • Masters, S.L.1    Simon, A.2    Aksentijevich, I.3    Kastner, D.L.4
  • 99
    • 84927732728 scopus 로고    scopus 로고
    • CARD-and pyrin-only proteins regulating inflammasome activation and immunity
    • Matusiak, M., N. Van Opdenbosch, and M. Lamkanfi. 2015. CARD-and pyrin-only proteins regulating inflammasome activation and immunity. Immunol. Rev. 265:217-230. http://dx.doi.org/10.1111/imr.12282
    • (2015) Immunol. Rev , vol.265 , pp. 217-230
    • Matusiak, M.1    Van Opdenbosch, N.2    Lamkanfi, M.3
  • 101
    • 33744493091 scopus 로고    scopus 로고
    • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf
    • Miao, E.A., C.M. Alpuche-Aranda, M. Dors, A.E. Clark, M.W. Bader, S.I. Miller, and A. Aderem. 2006. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. Nat. Immunol. 7:569-575. http://dx.doi.org/10.1038/ni1344
    • (2006) Nat. Immunol , vol.7 , pp. 569-575
    • Miao, E.A.1    Alpuche-Aranda, C.M.2    Dors, M.3    Clark, A.E.4    Bader, M.W.5    Miller, S.I.6    Aderem, A.7
  • 102
    • 78449269290 scopus 로고    scopus 로고
    • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria
    • Miao, E.A., I.A. Leaf, P.M. Treuting, D.P. Mao, M. Dors, A. Sarkar, S.E. Warren, M.D. Wewers, and A. Aderem. 2010a. Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. Nat. Immunol. 11:1136-1142. http://dx.doi.org/10.1038/ni.1960
    • (2010) Nat. Immunol , vol.11 , pp. 1136-1142
    • Miao, E.A.1    Leaf, I.A.2    Treuting, P.M.3    Mao, D.P.4    Dors, M.5    Sarkar, A.6    Warren, S.E.7    Wewers, M.D.8    Aderem, A.9
  • 104
    • 84876567161 scopus 로고    scopus 로고
    • Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome
    • Misawa, T., M. Takahama, T. Kozaki, H. Lee, J. Zou, T. Saitoh, and S. Akira. 2013. Microtubule-driven spatial arrangement of mitochondria promotes activation of the NLRP3 inflammasome. Nat. Immunol. 14:454-460. http://dx.doi.org/10.1038/ni.2550
    • (2013) Nat. Immunol , vol.14 , pp. 454-460
    • Misawa, T.1    Takahama, M.2    Kozaki, T.3    Lee, H.4    Zou, J.5    Saitoh, T.6    Akira, S.7
  • 105
    • 33645843633 scopus 로고    scopus 로고
    • Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection
    • Molofsky, A.B., B.G. Byrne, N.N. Whitfield, C.A. Madigan, E.T. Fuse, K. Tateda, and M.S. Swanson. 2006. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J. Exp. Med. 203:1093-1104. http://dx.doi.org/10.1084/jem.20051659
    • (2006) J. Exp. Med , vol.203 , pp. 1093-1104
    • Molofsky, A.B.1    Byrne, B.G.2    Whitfield, N.N.3    Madigan, C.A.4    Fuse, E.T.5    Tateda, K.6    Swanson, M.S.7
  • 106
    • 0029793103 scopus 로고    scopus 로고
    • Salmonella typhimurium invasion induces apoptosis in infected macrophages
    • Monack, D.M., B. Raupach, A.E. Hromockyj, and S. Falkow. 1996. Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc. Natl. Acad. Sci. USA. 93:9833-9838. http://dx.doi.org/10.1073/pnas.93.18.9833
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 9833-9838
    • Monack, D.M.1    Raupach, B.2    Hromockyj, A.E.3    Falkow, S.4
  • 107
    • 12144284412 scopus 로고    scopus 로고
    • Role of charged and hydrophobic residues in the oligomerization of the PYR IN domain of ASC
    • Moriya, M., S. Taniguchi, P. Wu, E. Liepinsh, G. Otting, and J. Sagara. 2005. Role of charged and hydrophobic residues in the oligomerization of the PYR IN domain of ASC. Biochemistry. 44:575-583. http://dx.doi.org/10.1021/bi048374i
    • (2005) Biochemistry , vol.44 , pp. 575-583
    • Moriya, M.1    Taniguchi, S.2    Wu, P.3    Liepinsh, E.4    Otting, G.5    Sagara, J.6
  • 109
    • 84879596906 scopus 로고    scopus 로고
    • K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter
    • Muñoz-Planillo, R., P. Kuffa, G. Martínez-Colón, B.L. Smith, T.M. Rajendiran, and G. Núñez. 2013. K+ efflux is the common trigger of NLRP3 inflammasome activation by bacterial toxins and particulate matter. Immunity. 38:1142-1153. http://dx.doi.org/10.1016/j.immuni.2013.05.016
    • (2013) Immunity , vol.38 , pp. 1142-1153
    • Muñoz-Planillo, R.1    Kuffa, P.2    Martínez-Colón, G.3    Smith, B.L.4    Rajendiran, T.M.5    Núñez, G.6
  • 110
    • 84863978096 scopus 로고    scopus 로고
    • Critical role for calcium mobilization in activation of the NLRP3 inflammasome
    • Murakami, T., J. Ockinger, J. Yu, V. Byles, A. McColl, A.M. Hofer, and T. Horng. 2012. Critical role for calcium mobilization in activation of the NLRP3 inflammasome. Proc. Natl. Acad. Sci. USA. 109:11282-11287. http://dx.doi.org/10.1073/pnas.1117765109
    • (2012) Proc. Natl. Acad. Sci. USA , vol.109 , pp. 11282-11287
    • Murakami, T.1    Ockinger, J.2    Yu, J.3    Byles, V.4    McColl, A.5    Hofer, A.M.6    Horng, T.7
  • 111
  • 112
    • 62449101446 scopus 로고    scopus 로고
    • Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages
    • Nour, A.M., Y.G. Yeung, L. Santambrogio, E.D. Boyden, E.R. Stanley, and J. Brojatsch. 2009. Anthrax lethal toxin triggers the formation of a membrane-associated inflammasome complex in murine macrophages. Infect. Immun. 77:1262-1271. http://dx.doi.org/10.1128/IAI.01032-08
    • (2009) Infect. Immun , vol.77 , pp. 1262-1271
    • Nour, A.M.1    Yeung, Y.G.2    Santambrogio, L.3    Boyden, E.D.4    Stanley, E.R.5    Brojatsch, J.6
  • 114
    • 67650021805 scopus 로고    scopus 로고
    • The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis
    • O'Regan, L., and A.M. Fry. 2009. The Nek6 and Nek7 protein kinases are required for robust mitotic spindle formation and cytokinesis. Mol. Cell. Biol. 29:3975-3990. http://dx.doi.org/10.1128/MCB.01867-08
    • (2009) Mol. Cell. Biol , vol.29 , pp. 3975-3990
    • O'Regan, L.1    Fry, A.M.2
  • 115
    • 80052813504 scopus 로고    scopus 로고
    • Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis
    • Peng, K., P. Broz, J. Jones, L.M. Joubert, and D. Monack. 2011. Elevated AIM2-mediated pyroptosis triggered by hypercytotoxic Francisella mutant strains is attributed to increased intracellular bacteriolysis. Cell. Microbiol. 13:1586-1600. http://dx.doi.org/10.1111/j.1462-5822.2011.01643.x
    • (2011) Cell. Microbiol , vol.13 , pp. 1586-1600
    • Peng, K.1    Broz, P.2    Jones, J.3    Joubert, L.M.4    Monack, D.5
  • 117
    • 34548027736 scopus 로고    scopus 로고
    • Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration
    • Pétrilli, V., S. Papin, C. Dostert, A. Mayor, F. Martinon, and J. Tschopp. 2007. Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ. 14:1583-1589. http://dx.doi.org/10.1038/sj.cdd.4402195
    • (2007) Cell Death Differ , vol.14 , pp. 1583-1589
    • Pétrilli, V.1    Papin, S.2    Dostert, C.3    Mayor, A.4    Martinon, F.5    Tschopp, J.6
  • 118
    • 84866087868 scopus 로고    scopus 로고
    • AIM2/ASC triggers caspase-8-dependent apoptosis in Francisellainfected caspase-1-deficient macrophages
    • Pierini, R., C. Juruj, M. Perret, C.L. Jones, P. Mangeot, D.S. Weiss, and T. Henry. 2012. AIM2/ASC triggers caspase-8-dependent apoptosis in Francisellainfected caspase-1-deficient macrophages. Cell Death Differ. 19:1709-1721. http://dx.doi.org/10.1038/cdd.2012.51
    • (2012) Cell Death Differ , vol.19 , pp. 1709-1721
    • Pierini, R.1    Juruj, C.2    Perret, M.3    Jones, C.L.4    Mangeot, P.5    Weiss, D.S.6    Henry, T.7
  • 119
    • 84886384437 scopus 로고    scopus 로고
    • AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer
    • Ponomareva, L., H. Liu, X. Duan, E. Dickerson, H. Shen, R. Panchanathan, and D. Choubey. 2013. AIM2, an IFN-inducible cytosolic DNA sensor, in the development of benign prostate hyperplasia and prostate cancer. Mol. Cancer Res. 11:1193-1202. http://dx.doi.org/10.1158/1541-7786.MCR-13-0145
    • (2013) Mol. Cancer Res , vol.11 , pp. 1193-1202
    • Ponomareva, L.1    Liu, H.2    Duan, X.3    Dickerson, E.4    Shen, H.5    Panchanathan, R.6    Choubey, D.7
  • 120
    • 0035958867 scopus 로고    scopus 로고
    • Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1
    • Poyet, J.L., S.M. Srinivasula, M. Tnani, M. Razmara, T. Fernandes-Alnemri, and E.S. Alnemri. 2001. Identification of Ipaf, a human caspase-1-activating protein related to Apaf-1. J. Biol. Chem. 276:28309-28313. http://dx.doi.org/10.1074/jbc.C100250200
    • (2001) J. Biol. Chem , vol.276 , pp. 28309-28313
    • Poyet, J.L.1    Srinivasula, S.M.2    Tnani, M.3    Razmara, M.4    Fernandes-Alnemri, T.5    Alnemri, E.S.6
  • 121
    • 84872451259 scopus 로고    scopus 로고
    • The CARD plays a critical role in ASC foci formation and inflammasome signalling
    • Proell, M., M. Gerlic, P.D. Mace, J.C. Reed, and S.J. Riedl. 2013. The CARD plays a critical role in ASC foci formation and inflammasome signalling. Biochem. J. 449:613-621. http://dx.doi.org/10.1042/BJ20121198
    • (2013) Biochem. J , vol.449 , pp. 613-621
    • Proell, M.1    Gerlic, M.2    Mace, P.D.3    Reed, J.C.4    Riedl, S.J.5
  • 124
    • 84885439494 scopus 로고    scopus 로고
    • Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein
    • Rayamajhi, M., D.E. Zak, J. Chavarria-Smith, R.E. Vance, and E.A. Miao. 2013. Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein. J. Immunol. 191:3986-3989. http://dx.doi.org/10.4049/jimmunol.1301549
    • (2013) J. Immunol , vol.191 , pp. 3986-3989
    • Rayamajhi, M.1    Zak, D.E.2    Chavarria-Smith, J.3    Vance, R.E.4    Miao, E.A.5
  • 125
    • 33645791082 scopus 로고    scopus 로고
    • Flagellindeficient Legionella mutants evade caspase-1-and Naip5-mediated macrophage immunity
    • Ren, T., D.S. Zamboni, C.R. Roy, W.F. Dietrich, and R.E. Vance. 2006. Flagellindeficient Legionella mutants evade caspase-1-and Naip5-mediated macrophage immunity. PLoS Pathog. 2:e18. http://dx.doi.org/10.1371/journal.ppat.0020018
    • (2006) PLoS Pathog , vol.2
    • Ren, T.1    Zamboni, D.S.2    Roy, C.R.3    Dietrich, W.F.4    Vance, R.E.5
  • 128
    • 84943200249 scopus 로고    scopus 로고
    • Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux
    • Rühl, S., and P. Broz. 2015. Caspase-11 activates a canonical NLRP3 inflammasome by promoting K+ efflux. Eur. J. Immunol. 45:2927-2936. http://dx.doi.org/10.1002/eji.201545772
    • (2015) Eur. J. Immunol , vol.45 , pp. 2927-2936
    • Rühl, S.1    Broz, P.2
  • 129
    • 84954298362 scopus 로고    scopus 로고
    • In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity
    • Sagoo, P., Z. Garcia, B. Breart, F. Lemaître, D. Michonneau, M.L. Albert, Y. Levy, and P. Bousso. 2016. In vivo imaging of inflammasome activation reveals a subcapsular macrophage burst response that mobilizes innate and adaptive immunity. Nat. Med. 22:64-71. http://dx.doi.org/10.1038/nm.4016
    • (2016) Nat. Med , vol.22 , pp. 64-71
    • Sagoo, P.1    Garcia, Z.2    Breart, B.3    Lemaître, F.4    Michonneau, D.5    Albert, M.L.6    Levy, Y.7    Bousso, P.8
  • 133
    • 84943198707 scopus 로고    scopus 로고
    • Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells
    • Schmid-Burgk, J.L., M.M. Gaidt, T. Schmidt, T.S. Ebert, E. Bartok, and V. Hornung. 2015. Caspase-4 mediates non-canonical activation of the NLRP3 inflammasome in human myeloid cells. Eur. J. Immunol. 45:2911-2917. http://dx.doi.org/10.1002/eji.201545523
    • (2015) Eur. J. Immunol , vol.45 , pp. 2911-2917
    • Schmid-Burgk, J.L.1    Gaidt, M.M.2    Schmidt, T.3    Ebert, T.S.4    Bartok, E.5    Hornung, V.6
  • 134
    • 84952931119 scopus 로고    scopus 로고
    • A genome-wide CRI SPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation
    • Schmid-Burgk, J.L., D. Chauhan, T. Schmidt, T.S. Ebert, J. Reinhardt, E. Endl, and V. Hornung. 2016. A genome-wide CRI SPR (clustered regularly interspaced short palindromic repeats) screen identifies NEK7 as an essential component of NLRP3 inflammasome activation. J. Biol. Chem. 291:103-109. http://dx.doi.org/10.1074/jbc.C115.700492
    • (2016) J. Biol. Chem , vol.291 , pp. 103-109
    • Schmid-Burgk, J.L.1    Chauhan, D.2    Schmidt, T.3    Ebert, T.S.4    Reinhardt, J.5    Endl, E.6    Hornung, V.7
  • 136
    • 84908024529 scopus 로고    scopus 로고
    • Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa
    • Sellin, M.E., A.A. Müller, B. Felmy, T. Dolowschiak, M. Diard, A. Tardivel, K.M. Maslowski, and W.D. Hardt. 2014. Epithelium-intrinsic NAIP/NLRC4 inflammasome drives infected enterocyte expulsion to restrict Salmonella replication in the intestinal mucosa. Cell Host Microbe. 16:237-248. http://dx.doi.org/10.1016/j.chom.2014.07.001
    • (2014) Cell Host Microbe , vol.16 , pp. 237-248
    • Sellin, M.E.1    Müller, A.A.2    Felmy, B.3    Dolowschiak, T.4    Diard, M.5    Tardivel, A.6    Maslowski, K.M.7    Hardt, W.D.8
  • 137
    • 84885093565 scopus 로고    scopus 로고
    • Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system
    • Shah, S., A. Bohsali, S.E. Ahlbrand, L. Srinivasan, V.A. Rathinam, S.N. Vogel, K.A. Fitzgerald, F.S. Sutterwala, and V. Briken. 2013. Cutting edge: Mycobacterium tuberculosis but not nonvirulent mycobacteria inhibits IFN-β and AIM2 inflammasome-dependent IL-1β production via its ESX-1 secretion system. J. Immunol. 191:3514-3518. http://dx.doi.org/10.4049/jimmunol.1301331
    • (2013) J. Immunol , vol.191 , pp. 3514-3518
    • Shah, S.1    Bohsali, A.2    Ahlbrand, S.E.3    Srinivasan, L.4    Rathinam, V.A.5    Vogel, S.N.6    Fitzgerald, K.A.7    Sutterwala, F.S.8    Briken, V.9
  • 138
    • 37549002511 scopus 로고    scopus 로고
    • The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock
    • Shao, W., G. Yeretssian, K. Doiron, S.N. Hussain, and M. Saleh. 2007. The caspase-1 digestome identifies the glycolysis pathway as a target during infection and septic shock. J. Biol. Chem. 282:36321-36329. http://dx.doi.org/10.1074/jbc.M708182200
    • (2007) J. Biol. Chem , vol.282 , pp. 36321-36329
    • Shao, W.1    Yeretssian, G.2    Doiron, K.3    Hussain, S.N.4    Saleh, M.5
  • 139
    • 84857195479 scopus 로고    scopus 로고
    • Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction
    • Shi, C.-S., K. Shenderov, N.-N. Huang, J. Kabat, M. Abu-Asab, K.A. Fitzgerald, A. Sher, and J.H. Kehrl. 2012. Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction. Nat. Immunol. 13:255-263. http://dx.doi.org/10.1038/ni.2215
    • (2012) Nat. Immunol , vol.13 , pp. 255-263
    • Shi, C.-S.1    Shenderov, K.2    Huang, N.-N.3    Kabat, J.4    Abu-Asab, M.5    Fitzgerald, K.A.6    Sher, A.7    Kehrl, J.H.8
  • 140
    • 84949595485 scopus 로고    scopus 로고
    • NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component
    • Shi, H., Y. Wang, X. Li, X. Zhan, M. Tang, M. Fina, L. Su, D. Pratt, C.H. Bu, S. Hildebrand, et al. 2016. NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component. Nat. Immunol. 17:250-258. http://dx.doi.org/10.1038/ni.3333
    • (2016) Nat. Immunol , vol.17 , pp. 250-258
    • Shi, H.1    Wang, Y.2    Li, X.3    Zhan, X.4    Tang, M.5    Fina, M.6    Su, L.7    Pratt, D.8    Bu, C.H.9    Hildebrand, S.10
  • 141
    • 84906571225 scopus 로고    scopus 로고
    • Inflammatory caspases are innate immune receptors for intracellular LPS
    • Shi, J., Y. Zhao, Y. Wang, W. Gao, J. Ding, P. Li, L. Hu, and F. Shao. 2014. Inflammatory caspases are innate immune receptors for intracellular LPS. Nature. 514:187-192. http://dx.doi.org/10.1038/nature13683
    • (2014) Nature , vol.514 , pp. 187-192
    • Shi, J.1    Zhao, Y.2    Wang, Y.3    Gao, W.4    Ding, J.5    Li, P.6    Hu, L.7    Shao, F.8
  • 142
    • 84942892037 scopus 로고    scopus 로고
    • Cleavage of GSD MD by inflammatory caspases determines pyroptotic cell death
    • Shi, J., Y. Zhao, K. Wang, X. Shi, Y. Wang, H. Huang, Y. Zhuang, T. Cai, F. Wang, and F. Shao. 2015. Cleavage of GSD MD by inflammatory caspases determines pyroptotic cell death. Nature. 526:660-665. http://dx.doi.org/10.1038/nature15514
    • (2015) Nature , vol.526 , pp. 660-665
    • Shi, J.1    Zhao, Y.2    Wang, K.3    Shi, X.4    Wang, Y.5    Huang, H.6    Zhuang, Y.7    Cai, T.8    Wang, F.9    Shao, F.10
  • 143
    • 84898031590 scopus 로고    scopus 로고
    • Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes
    • Tenthorey, J.L., E.M. Kofoed, M.D. Daugherty, H.S. Malik, and R.E. Vance. 2014. Molecular basis for specific recognition of bacterial ligands by NAIP/NLRC4 inflammasomes. Mol. Cell. 54:17-29. http://dx.doi.org/10.1016/j.molcel.2014.02.018
    • (2014) Mol. Cell , vol.54 , pp. 17-29
    • Tenthorey, J.L.1    Kofoed, E.M.2    Daugherty, M.D.3    Malik, H.S.4    Vance, R.E.5
  • 144
    • 84893835896 scopus 로고    scopus 로고
    • Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation
    • Van Opdenbosch, N., P. Gurung, L. Vande Walle, A. Fossoul, T.D. Kanneganti, and M. Lamkanfi. 2014. Activation of the NLRP1b inflammasome independently of ASC-mediated caspase-1 autoproteolysis and speck formation. Nat. Commun. 5:3209. http://dx.doi.org/10.1038/ncomms4209
    • (2014) Nat. Commun , vol.5 , pp. 3209
    • Van Opdenbosch, N.1    Gurung, P.2    Vande Walle, L.3    Fossoul, A.4    Kanneganti, T.D.5    Lamkanfi, M.6
  • 145
    • 84961207801 scopus 로고    scopus 로고
    • Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish
    • Vincent, W.J., C.M. Freisinger, P.Y. Lam, A. Huttenlocher, and J.D. Sauer. 2016. Macrophages mediate flagellin induced inflammasome activation and host defense in zebrafish. Cell. Microbiol. 18:591-604. http://dx.doi.org/10.1111/cmi.12536
    • (2016) Cell. Microbiol , vol.18 , pp. 591-604
    • Vincent, W.J.1    Freisinger, C.M.2    Lam, P.Y.3    Huttenlocher, A.4    Sauer, J.D.5
  • 149
    • 0032548919 scopus 로고    scopus 로고
    • Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE
    • Wang, S., M. Miura, Y.K. Jung, H. Zhu, E. Li, and J. Yuan. 1998. Murine caspase-11, an ICE-interacting protease, is essential for the activation of ICE. Cell. 92:501-509. http://dx.doi.org/10.1016/S0092-8674(00)80943-5
    • (1998) Cell , vol.92 , pp. 501-509
    • Wang, S.1    Miura, M.2    Jung, Y.K.3    Zhu, H.4    Li, E.5    Yuan, J.6
  • 150
    • 28844494900 scopus 로고    scopus 로고
    • The CAT ERP ILL ER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor α-, and Mycobacterium tuberculosis-induced proinflammatory signals
    • Williams, K.L., J.D. Lich, J.A. Duncan, W. Reed, P. Rallabhandi, C. Moore, S. Kurtz, V.M. Coffield, M.A. Accavitti-Loper, L. Su, et al. 2005. The CAT ERP ILL ER protein monarch-1 is an antagonist of toll-like receptor-, tumor necrosis factor α-, and Mycobacterium tuberculosis-induced proinflammatory signals. J. Biol. Chem. 280:39914-39924. http://dx.doi.org/10.1074/jbc.M502820200
    • (2005) J. Biol. Chem , vol.280 , pp. 39914-39924
    • Williams, K.L.1    Lich, J.D.2    Duncan, J.A.3    Reed, W.4    Rallabhandi, P.5    Moore, C.6    Kurtz, S.7    Coffield, V.M.8    Accavitti-Loper, M.A.9    Su, L.10
  • 151
    • 79251522140 scopus 로고    scopus 로고
    • NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondiiinfected monocytic cells
    • Witola, W.H., E. Mui, A. Hargrave, S. Liu, M. Hypolite, A. Montpetit, P. Cavailles, C. Bisanz, M.F. Cesbron-Delauw, G.J. Fournié, and R. McLeod. 2011. NALP1 influences susceptibility to human congenital toxoplasmosis, proinflammatory cytokine response, and fate of Toxoplasma gondiiinfected monocytic cells. Infect. Immun. 79:756-766. http://dx.doi.org/10.1128/IAI.00898-10
    • (2011) Infect. Immun , vol.79 , pp. 756-766
    • Witola, W.H.1    Mui, E.2    Hargrave, A.3    Liu, S.4    Hypolite, M.5    Montpetit, A.6    Cavailles, P.7    Bisanz, C.8    Cesbron-Delauw, M.F.9    Fournié, G.J.10    McLeod, R.11
  • 152
  • 154
    • 84907270863 scopus 로고    scopus 로고
    • Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome
    • Xu, H., J. Yang, W. Gao, L. Li, P. Li, L. Zhang, Y.-N. Gong, X. Peng, J.J. Xi, S. Chen, et al. 2014. Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature. 513:237-241. http://dx.doi.org/10.1038/nature13449
    • (2014) Nature , vol.513 , pp. 237-241
    • Xu, H.1    Yang, J.2    Gao, W.3    Li, L.4    Li, P.5    Zhang, L.6    Gong, Y.-N.7    Peng, X.8    Xi, J.J.9    Chen, S.10
  • 155
    • 84947441282 scopus 로고    scopus 로고
    • Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock
    • Yang, D., Y. He, R. Muñoz-Planillo, Q. Liu, and G. Núñez. 2015. Caspase-11 requires the pannexin-1 channel and the purinergic P2X7 pore to mediate pyroptosis and endotoxic shock. Immunity. 43:923-932. http://dx.doi.org/10.1016/j.immuni.2015.10.009
    • (2015) Immunity , vol.43 , pp. 923-932
    • Yang, D.1    He, Y.2    Muñoz-Planillo, R.3    Liu, Q.4    Núñez, G.5
  • 156
    • 84883329029 scopus 로고    scopus 로고
    • Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation
    • Yang, J., Y. Zhao, J. Shi, and F. Shao. 2013. Human NAIP and mouse NAIP1 recognize bacterial type III secretion needle protein for inflammasome activation. Proc. Natl. Acad. Sci. USA. 110:14408-14413. http://dx.doi.org/10.1073/pnas.1306376110
    • (2013) Proc. Natl. Acad. Sci. USA , vol.110 , pp. 14408-14413
    • Yang, J.1    Zhao, Y.2    Shi, J.3    Shao, F.4
  • 159
    • 84891906749 scopus 로고    scopus 로고
    • Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection
    • Zaki, M.H., S.M. Man, P. Vogel, M. Lamkanfi, and T.D. Kanneganti. 2014. Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection. Proc. Natl. Acad. Sci. USA. 111:385-390. http://dx.doi.org/10.1073/pnas.1317643111
    • (2014) Proc. Natl. Acad. Sci. USA , vol.111 , pp. 385-390
    • Zaki, M.H.1    Man, S.M.2    Vogel, P.3    Lamkanfi, M.4    Kanneganti, T.D.5
  • 160
    • 84944747007 scopus 로고    scopus 로고
    • Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization
    • Zhang, L., S. Chen, J. Ruan, J. Wu, A.B. Tong, Q. Yin, Y. Li, L. David, A. Lu, W.L. Wang, et al. 2015. Cryo-EM structure of the activated NAIP2-NLRC4 inflammasome reveals nucleated polymerization. Science. 350:404-409. http://dx.doi.org/10.1126/science.aac5789
    • (2015) Science , vol.350 , pp. 404-409
    • Zhang, L.1    Chen, S.2    Ruan, J.3    Wu, J.4    Tong, A.B.5    Yin, Q.6    Li, Y.7    David, L.8    Lu, A.9    Wang, W.L.10
  • 161
    • 80053349020 scopus 로고    scopus 로고
    • The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus
    • Zhao, Y., J. Yang, J. Shi, Y.N. Gong, Q. Lu, H. Xu, L. Liu, and F. Shao. 2011. The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus. Nature. 477:596-600. http://dx.doi.org/10.1038/nature10510
    • (2011) Nature , vol.477 , pp. 596-600
    • Zhao, Y.1    Yang, J.2    Shi, J.3    Gong, Y.N.4    Lu, Q.5    Xu, H.6    Liu, L.7    Shao, F.8
  • 162
    • 78651393239 scopus 로고    scopus 로고
    • A role for mitochondria in NLRP3 inflammasome activation
    • Zhou, R., A.S. Yazdi, P. Menu, and J. Tschopp. 2011. A role for mitochondria in NLRP3 inflammasome activation. Nature. 469:221-225. http://dx.doi.org/10.1038/nature09663
    • (2011) Nature , vol.469 , pp. 221-225
    • Zhou, R.1    Yazdi, A.S.2    Menu, P.3    Tschopp, J.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.