-
1
-
-
80052144513
-
Intracellular sensors of microbes and danger
-
Núñez, G. Intracellular sensors of microbes and danger. Immunol. Rev. 243, 5-8 (2011).
-
(2011)
Immunol. Rev.
, vol.243
, pp. 5-8
-
-
Núñez, G.1
-
2
-
-
84855989829
-
Infammasomes in health and disease
-
Strowig, T., Henao-Mejia, J., Elinav, E. & Flavell, R. Infammasomes in health and disease. Nature 481, 278-286 (2012).
-
(2012)
Nature
, vol.481
, pp. 278-286
-
-
Strowig, T.1
Henao-Mejia, J.2
Elinav, E.3
Flavell, R.4
-
3
-
-
32944468985
-
Gout-associated uric acid crystals activate the NALP3 infammasome
-
Martinon, F. et al. Gout-associated uric acid crystals activate the NALP3 infammasome. Nature 440, 237-241 (2006).
-
(2006)
Nature
, vol.440
, pp. 237-241
-
-
Martinon, F.1
-
4
-
-
77951800951
-
NLRP3 infammasomes are required for atherogenesis and activated by cholesterol crystals
-
Duewell, P. et al. NLRP3 infammasomes are required for atherogenesis and activated by cholesterol crystals. Nature 464, 1357-1361 (2010).
-
(2010)
Nature
, vol.464
, pp. 1357-1361
-
-
Duewell, P.1
-
5
-
-
77956958947
-
Activation of the NLRP3 infammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes
-
Masters, S.L. et al. Activation of the NLRP3 infammasome by islet amyloid polypeptide provides a mechanism for enhanced IL-1β in type 2 diabetes. Nat. Immunol. 11, 897-904 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 897-904
-
-
Masters, S.L.1
-
6
-
-
79751512463
-
The NLRP3 infammasome instigates obesity-induced infammation and insulin resistance
-
Vandanmagsar, B. et al. The NLRP3 infammasome instigates obesity-induced infammation and insulin resistance. Nat. Med. 17, 179-188 (2011).
-
(2011)
Nat. Med.
, vol.17
, pp. 179-188
-
-
Vandanmagsar, B.1
-
7
-
-
79955038882
-
Fatty acid-induced NLRP3-ASC infammasome activation interferes with insulin signaling
-
Wen, H. et al. Fatty acid-induced NLRP3-ASC infammasome activation interferes with insulin signaling. Nat. Immunol. 12, 408-415 (2011).
-
(2011)
Nat. Immunol.
, vol.12
, pp. 408-415
-
-
Wen, H.1
-
9
-
-
0025939480
-
Colchicine has opposite effects on interleukin-1β and tumor necrosis factor-alpha production
-
Allen, J.N. et al. Colchicine has opposite effects on interleukin-1β and tumor necrosis factor-alpha production. Am. J. Physiol. 26, 315-21 (1991).
-
(1991)
Am. J. Physiol.
, vol.26
, pp. 315-321
-
-
Allen, J.N.1
-
10
-
-
33748135979
-
Histone deacetylase inhibitors prevent exocytosis of interleukin-1β- containing secretory lysosomes: Role of microtubules
-
Carta, S. et al. Histone deacetylase inhibitors prevent exocytosis of interleukin-1β-containing secretory lysosomes: role of microtubules. Blood 108, 1618-1626 (2006).
-
(2006)
Blood
, vol.108
, pp. 1618-1626
-
-
Carta, S.1
-
11
-
-
78651393239
-
A role for mitochondria in NLRP3 infammasome activation
-
Zhou, R., Yazdi, A.S., Menu, P. & Tschopp, J. A role for mitochondria in NLRP3 infammasome activation. Nature 469, 221-225 (2011).
-
(2011)
Nature
, vol.469
, pp. 221-225
-
-
Zhou, R.1
Yazdi, A.S.2
Menu, P.3
Tschopp, J.4
-
12
-
-
0037452096
-
Dynamics and mechanics of the microtubule plus end
-
Howard, J. & Hyman, A.A. Dynamics and mechanics of the microtubule plus end. Nature 422, 753-758 (2003).
-
(2003)
Nature
, vol.422
, pp. 753-758
-
-
Howard, J.1
Hyman, A.A.2
-
13
-
-
70450228589
-
Regulators of the cytoplasmic dynein motor
-
Kardon, J.R. & Vale, R.D. Regulators of the cytoplasmic dynein motor. Nat. Rev. Mol. Cell Biol. 10, 854-865 (2009).
-
(2009)
Nat. Rev. Mol. Cell Biol.
, vol.10
, pp. 854-865
-
-
Kardon, J.R.1
Vale, R.D.2
-
14
-
-
84862814996
-
Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein
-
Firestone, A.J. et al. Small-molecule inhibitors of the AAA+ ATPase motor cytoplasmic dynein. Nature 484, 125-129 (2012).
-
(2012)
Nature
, vol.484
, pp. 125-129
-
-
Firestone, A.J.1
-
15
-
-
79952712223
-
Mitochondrial reactive oxygen species drive proinfammatory cytokine production
-
Naik, E. & Dixit, V.M. Mitochondrial reactive oxygen species drive proinfammatory cytokine production. J. Exp. Med. 208, 417-420 (2011).
-
(2011)
J. Exp. Med.
, vol.208
, pp. 417-420
-
-
Naik, E.1
Dixit, V.M.2
-
16
-
-
77957868249
-
Post-translational modifcations of microtubules
-
Wloga, D. & Gaertig, J. Post-translational modifcations of microtubules. J. Cell Sci. 123, 3447-3455 (2010).
-
(2010)
J. Cell Sci.
, vol.123
, pp. 3447-3455
-
-
Wloga, D.1
Gaertig, J.2
-
17
-
-
33750618516
-
Microtubule acetylation promotes kinesin-1 binding and transport
-
Reed, N.A. et al. Microtubule acetylation promotes kinesin-1 binding and transport. Curr. Biol. 16, 2166-2172 (2006).
-
(2006)
Curr. Biol.
, vol.16
, pp. 2166-2172
-
-
Reed, N.A.1
-
18
-
-
34047175919
-
Histone deacetylase 6 inhibition compensates for the transport defcit in Huntington's disease by increasing tubulin acetylation
-
Dompierre, J.P. et al. Histone deacetylase 6 inhibition compensates for the transport defcit in Huntington's disease by increasing tubulin acetylation. J. Neurosci. 27, 3571-3583 (2007).
-
(2007)
J. Neurosci.
, vol.27
, pp. 3571-3583
-
-
Dompierre, J.P.1
-
19
-
-
77955459468
-
ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules
-
Friedman, J. et al. ER sliding dynamics and ER-mitochondrial contacts occur on acetylated microtubules. J. Cell Biol. 190, 363-375 (2010).
-
(2010)
J. Cell Biol.
, vol.190
, pp. 363-375
-
-
Friedman, J.1
-
20
-
-
77956525850
-
MEC-17 is an α-tubulin acetyltransferase
-
Akella, J. et al. MEC-17 is an α-tubulin acetyltransferase. Nature 467, 218-222 (2010).
-
(2010)
Nature
, vol.467
, pp. 218-222
-
-
Akella, J.1
-
21
-
-
0037291214
-
+-dependent tubulin deacetylase
-
+- dependent tubulin deacetylase. Mol. Cell 11, 437-444 (2003).
-
(2003)
Mol. Cell
, vol.11
, pp. 437-444
-
-
North, B.1
-
22
-
-
0037161744
-
HDAC6 is a microtubule-associated deacetylase
-
Hubbert, C. et al. HDAC6 is a microtubule-associated deacetylase. Nature 417, 455-458 (2002).
-
(2002)
Nature
, vol.417
, pp. 455-458
-
-
Hubbert, C.1
-
23
-
-
84858376953
-
Mitochondria: In sickness and in health
-
Nunnari, J. & Suomalainen, A. Mitochondria: in sickness and in health. Cell 148, 1145-1159 (2012).
-
(2012)
Cell
, vol.148
, pp. 1145-1159
-
-
Nunnari, J.1
Suomalainen, A.2
-
24
-
-
0042914359
-
Critical role of cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin negericin
-
Hentze, H., Lin, X.Y., Choi, M.S.K. & Porter, A.G. Critical role of cathepsin B in mediating caspase-1-dependent interleukin-18 maturation and caspase-1-independent necrosis triggered by the microbial toxin negericin. Cell Death Differ. 10, 956-968 (2003).
-
(2003)
Cell Death Differ.
, vol.10
, pp. 956-968
-
-
Hentze, H.1
Lin, X.Y.2
Choi, M.S.K.3
Porter, A.G.4
-
25
-
-
25844504658
-
Role of sodium in mitochondrial depolarization induced by P2X7 receptor activation in submandibular glands
-
Gracia-Marcos, M. et al. Role of sodium in mitochondrial depolarization induced by P2X7 receptor activation in submandibular glands. FEBS Lett. 579, 5407-5413 (2005).
-
(2005)
FEBS Lett.
, vol.579
, pp. 5407-5413
-
-
Gracia-Marcos, M.1
-
26
-
-
43949108922
-
The lysosomal-mitochondria axis in free fatty acid-induced hepatic lipotoxicity
-
Li, Z. et al. The lysosomal-mitochondria axis in free fatty acid-induced hepatic lipotoxicity. Hepatology 47, 1495-1503 (2011).
-
(2011)
Hepatology
, vol.47
, pp. 1495-1503
-
-
Li, Z.1
-
27
-
-
80055021939
-
Adenovirus type 5 rupture of lysosome leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species
-
McGuire, K. et al. Adenovirus type 5 rupture of lysosome leads to cathepsin B-dependent mitochondrial stress and production of reactive oxygen species. J. Virol. 85, 10806-10813 (2011).
-
(2011)
J. Virol.
, vol.85
, pp. 10806-10813
-
-
McGuire, K.1
-
28
-
-
77950499364
-
Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network
-
Tanaka, A. Parkin-mediated selective mitochondrial autophagy, mitophagy: Parkin purges damaged organelles from the vital mitochondrial network. FEBS Lett. 584, 1386-1392 (2010).
-
(2010)
FEBS Lett.
, vol.584
, pp. 1386-1392
-
-
Tanaka, A.1
-
29
-
-
47849097202
-
Silica crystals and aluminum salts activate the NALP3 infammasome through phagosomal destabilization
-
Hornung, V. et al. Silica crystals and aluminum salts activate the NALP3 infammasome through phagosomal destabilization. Nat. Immunol. 9, 847-856 (2008).
-
(2008)
Nat. Immunol.
, vol.9
, pp. 847-856
-
-
Hornung, V.1
-
30
-
-
43249125839
-
Innate immune activation through Nalp3 infammasome sensing of asbestos and silica
-
Dostert, C. et al. Innate immune activation through Nalp3 infammasome sensing of asbestos and silica. Science 320, 674-677 (2008).
-
(2008)
Science
, vol.320
, pp. 674-677
-
-
Dostert, C.1
-
31
-
-
77951295418
-
Infuenza virus activates infammasomes via its intracellular M2 ion channel
-
Ichinohe, T. et al. Infuenza virus activates infammasomes via its intracellular M2 ion channel. Nat. Immunol. 11, 404-410 (2010).
-
(2010)
Nat. Immunol.
, vol.11
, pp. 404-410
-
-
Ichinohe, T.1
-
32
-
-
84860225554
-
GBP5 promotes NLRP3 infammasome assembly and immunity in mammals
-
Shenoy, A. et al. GBP5 promotes NLRP3 infammasome assembly and immunity in mammals. Science 336, 481-485 (2012).
-
(2012)
Science
, vol.336
, pp. 481-485
-
-
Shenoy, A.1
-
33
-
-
63649133278
-
AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating infammasome with ASC
-
Hornung, V. et al. AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating infammasome with ASC. Nature 458, 514-518 (2009).
-
(2009)
Nature
, vol.458
, pp. 514-518
-
-
Hornung, V.1
-
34
-
-
3142654767
-
Differential activation of the infammasome by caspase-1 adaptors ASC and Ipaf
-
Mariathasan, S. et al. Differential activation of the infammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218 (2004).
-
(2004)
Nature
, vol.430
, pp. 213-218
-
-
Mariathasan, S.1
-
35
-
-
77955390094
-
Redundant roles for infammasome receptors NLRP3 and NLRC4 in host defense against Salmonella
-
Broz, P. et al. Redundant roles for infammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J. Exp. Med. 207, 1745-1755 (2010).
-
(2010)
J. Exp. Med.
, vol.207
, pp. 1745-1755
-
-
Broz, P.1
-
36
-
-
43949108922
-
The lysosomal-mitochondria axis in free fatty acid-induced hepatic lipotoxicity
-
Li., Z. et al. The lysosomal-mitochondria axis in free fatty acid-induced hepatic lipotoxicity. Hepatology 47, 1495-503 (2008).
-
(2008)
Hepatology
, vol.47
, pp. 1495-1503
-
-
Li., Z.1
-
37
-
-
80053920774
-
+ intermediate, treats pathophysiology of diet-and age-induced diabetes in mice
-
+ intermediate, treats pathophysiology of diet-and age-induced diabetes in mice. Cell Metab. 14, 528-536 (2011).
-
(2011)
Cell Metab.
, vol.14
, pp. 528-536
-
-
Yoshino, J.1
Mills, K.F.2
Yoon, M.J.3
Imai, S.4
-
38
-
-
79954421862
-
Mitochondrial ROS fuel the infammasome
-
Sorbara, M.T. & Girardin, S.E. Mitochondrial ROS fuel the infammasome. Cell Res. 21, 558-560 (2011).
-
(2011)
Cell Res.
, vol.21
, pp. 558-560
-
-
Sorbara, M.T.1
Girardin, S.E.2
-
39
-
-
77953601881
-
Regulation of innate immune responses by autophagy-related proteins
-
Saitoh, T. & Akira, S. Regulation of innate immune responses by autophagy-related proteins. J. Cell Biol. 189, 925-935 (2010).
-
(2010)
J. Cell Biol.
, vol.189
, pp. 925-935
-
-
Saitoh, T.1
Akira, S.2
-
40
-
-
84857850213
-
Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy
-
Itakura, E. et al. Structures containing Atg9A and the ULK1 complex independently target depolarized mitochondria at initial stages of Parkin-mediated mitophagy. J. Cell Sci. 125, 1488-1499 (2012).
-
(2012)
J. Cell Sci.
, vol.125
, pp. 1488-1499
-
-
Itakura, E.1
-
41
-
-
77954225200
-
Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity
-
Zhao, Y. et al. Cytosolic FoxO1 is essential for the induction of autophagy and tumour suppressor activity. Nat. Cell Biol. 12, 665-675 (2010).
-
(2010)
Nat. Cell Biol.
, vol.12
, pp. 665-675
-
-
Zhao, Y.1
-
42
-
-
77951157657
-
Calorie restriction enhances cell adaption to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney
-
Kume, S. et al. Calorie restriction enhances cell adaption to hypoxia through Sirt1-dependent mitochondrial autophagy in mouse aged kidney. J. Clin. Invest. 120, 1043-1055 (2010).
-
(2010)
J. Clin. Invest.
, vol.120
, pp. 1043-1055
-
-
Kume, S.1
-
43
-
-
46249100836
-
Tissue specifc regulation of SIRT1 by calorie restriction
-
Chen, D. et al. Tissue specifc regulation of SIRT1 by calorie restriction. Genes Dev. 22, 1753-1757 (2008).
-
(2008)
Genes Dev.
, vol.22
, pp. 1753-1757
-
-
Chen, D.1
-
44
-
-
56249090667
-
Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production
-
Saitoh, T. et al. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1β production. Nature 456, 264-268 (2008).
-
(2008)
Nature
, vol.456
, pp. 264-268
-
-
Saitoh, T.1
|