NLRP4 negatively regulates autophagic processes through an association with Beclin1

Journal of Immunology

Volumn 186, Issue 3, 2011, Pages 1646-1655

  Jounai, Nao ^a   Kobiyama, Kouji ^a   Shiina, Masaaki ^a   Ogata, Kazuhiro ^a   Ishii, Ken J ^b,c   Takeshita, Fumihiko ^a  

^a YOKOHAMA CITY UNIVERSITY   (Japan)

^b OSAKA UNIVERSITY   (Japan)

^c OSAKA UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BECLIN 1; CARRIER PROTEINS AND BINDING PROTEINS; CRYOPYRIN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2; NLRC4 PROTEIN; NLRP10 PROTEIN; NLRP4 PROTEIN; TELOMERASE; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; BACTERIAL INFECTION; BINDING AFFINITY; ENDOSOME; HUMAN; MATURATION; NONHUMAN; PHAGOSOME; PODOSPORA ANSERINA; PRIORITY JOURNAL; PROTEIN DOMAIN; REGULATORY MECHANISM; RNA INTERFERENCE; STREPTOCOCCUS GROUP A; UPREGULATION;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; BLOOD BACTERICIDAL ACTIVITY; CELL LINE, TUMOR; DOWN-REGULATION; DRUG RESISTANCE, BACTERIAL; HEK293 CELLS; HELA CELLS; HUMANS; LYSOSOMES; MEMBRANE PROTEINS; MICE; PHAGOSOMES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; REPRESSOR PROTEINS; STREPTOCOCCAL INFECTIONS; STREPTOCOCCUS PYOGENES; VACUOLES;

EID: 79251588741     PISSN: 00221767     EISSN: 15506606     Source Type: Journal    
DOI: 10.4049/jimmunol.1001654     Document Type: Article

References (39)

1. Kuma, A., M. Hatano, M. Matsui, A. Yamamoto, H. Nakaya, T. Yoshimori, Y. Ohsumi, T. Tokuhisa, and N. Mizushima. 2004. The role of autophagy during the early neonatal starvation period. Nature 432: 1032-1036.
2. Komatsu, M., S. Waguri, T. Ueno, J. Iwata, S. Murata, I. Tanida, J. Ezaki, N. Mizushima, Y. Ohsumi, Y. Uchiyama, et al. 2005. Impairment of starvation-induced and constitutive autophagy in Atg7-deficient mice. J. Cell Biol. 169: 425-434.
3. Nishida, Y., S. Arakawa, K. Fujitani, H. Yamaguchi, T. Mizuta, T. Kanaseki, M. Komatsu, K. Otsu, Y. Tsujimoto, and S. Shimizu. 2009. Discovery of Atg5/Atg7-independent alternative macroautophagy. Nature 461: 654-658.
4. Nakagawa, I., A. Amano, N. Mizushima, A. Yamamoto, H. Yamaguchi, T. Kamimoto, A. Nara, J. Funao, M. Nakata, K. Tsuda, et al. 2004. Autophagy defends cells against invading group A Streptococcus. Science 306: 1037-1040.
5. Birmingham, C. L., V. Canadien, E. Gouin, E. B. Troy, T. Yoshimori, P. Cossart, D. E. Higgins, and J. H. Brumell. 2007. Listeria monocytogenes evades killing by autophagy during colonization of host cells. Autophagy 3: 442-451.
6. Yoshimori, T., and T. Noda. 2008. Toward unraveling membrane biogenesis in mammalian autophagy. Curr. Opin. Cell Biol. 20: 401-407.
7. Liang, C., P. Feng, B. Ku, I. Dotan, D. Canaani, B. H. Oh, and J. U. Jung. 2006. Autophagic and tumour suppressor activity of a novel Beclin1-binding protein UVRAG. Nat. Cell Biol. 8: 688-699.
8. Matsunaga, K., T. Saitoh, K. Tabata, H. Omori, T. Satoh, N. Kurotori, I. Maejima, K. Shirahama-Noda, T. Ichimura, T. Isobe, et al. 2009. Two Beclin 1-binding proteins, Atg14L and Rubicon, reciprocally regulate autophagy at different stages. Nat. Cell Biol. 11: 385-396.
9. Zhong, Y., Q. J. Wang, X. Li, Y. Yan, J. M. Backer, B. T. Chait, N. Heintz, and Z. Yue. 2009. Distinct regulation of autophagic activity by Atg14L and Rubicon associated with Beclin 1-phosphatidylinositol-3-kinase complex. Nat. Cell Biol. 11: 468-476.
10. Liang, C., J. S. Lee, K. S. Inn, M. U. Gack, Q. Li, E. A. Roberts, I. Vergne, V. Deretic, P. Feng, C. Akazawa, and J. U. Jung. 2008. Beclin1-binding UVRAG targets the class C Vps complex to coordinate autophagosome maturation and endocytic trafficking. Nat. Cell Biol. 10: 776-787.
11. Wilmanski, J. M., T. Petnicki-Ocwieja, and K. S. Kobayashi. 2008. NLR proteins: integral members of innate immunity and mediators of inflammatory diseases. J. Leukoc. Biol. 83: 13-30.
12. Suzuki, T., L. Franchi, C. Toma, H. Ashida, M. Ogawa, Y. Yoshikawa, H. Mimuro, N. Inohara, C. Sasakawa, and G. Nuñez. 2007. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog. 3: e111.
13. Kobiyama, K., F. Takeshita, N. Jounai, A. Sakaue-Sawano, A. Miyawaki, K. J. Ishii, T. Kawai, S. Sasaki, H. Hirano, N. Ishii, et al. 2010. Extrachromosomal histone H2B mediates innate antiviral immune responses induced by intracellular double-stranded DNA. J. Virol. 84: 822-832.
14. Martinon, F., K. Burns, and J. Tschopp. 2002. The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol. Cell 10: 417-426.
15. Takeshita, F., K. J. Ishii, K. Kobiyama, Y. Kojima, C. Cobgn, S. Sasaki, N. Ishii, D. M. Klinman, K. Okuda, S. Akira, and K. Suzuki. 2005. TRAF4 acts as a silencer in TLR-mediated signaling through the association with TRAF6 and TRIF. Eur. J. Immunol. 35: 2477-2485.
16. Miyoshi, H., U. Blömer, M. Takahashi, F. H. Gage, and I. M. Verma. 1998. Development of a self-inactivating lentivirus vector. J. Virol. 72: 8150-8157.
17. Miyoshi, H., M. Takahashi, F. H. Gage, and I. M. Verma. 1997. Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc. Natl. Acad. Sci. USA 94: 10319-10323.
18. Jounai, N., F. Takeshita, K. Kobiyama, A. Sawano, A. Miyawaki, K. Q. Xin, K. J. Ishii, T. Kawai, S. Akira, K. Suzuki, and K. Okuda. 2007. The Atg5 Atg12 conjugate associates with innate antiviral immune responses. Proc. Natl. Acad. Sci. USA 104: 14050-14055.
19. Takeshita, F., K. Suzuki, S. Sasaki, N. Ishii, D. M. Klinman, and K. J. Ishii. 2004. Transcriptional regulation of the human TLR9 gene. J. Immunol. 173: 2552-2561.
20. Sakaue-Sawano, A., H. Kurokawa, T. Morimura, A. Hanyu, H. Hama, H. Osawa, S. Kashiwagi, K. Fukami, T. Miyata, H. Miyoshi, et al. 2008. Visualizing spatiotemporal dynamics of multicellular cell-cycle progression. Cell 132: 487-498.
21. Geddes, B. J., L. Wang, W. J. Huang, M. Lavellee, G. A. Manji, M. Brown, M. Jurman, J. Cao, J. Morgenstern, S. Merriam, et al. 2001. Human CARD12 is a novel CED4/Apaf-1 family member that induces apoptosis. Biochem. Biophys. Res. Commun. 284: 77-82.
22. Komatsu, M., S. Waguri, M. Koike, Y. S. Sou, T. Ueno, T. Hara, N. Mizushima, J. Iwata, J. Ezaki, S. Murata, et al. 2007. Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice. Cell 131: 1149-1163.
23. Kimura, S., N. Fujita, T. Noda, and T. Yoshimori. 2009. Monitoring autophagy in mammalian cultured cells through the dynamics of LC3. Methods Enzymol. 452: 1-12.
24. Pattingre, S., A. Tassa, X. Qu, R. Garuti, X. H. Liang, N. Mizushima, M. Packer, M. D. Schneider, and B. Levine. 2005. Bcl-2 antiapoptotic proteins inhibit Beclin 1-dependent autophagy. Cell 122: 927-939.
25. Yamaguchi, H., I. Nakagawa, A. Yamamoto, A. Amano, T. Noda, and T. Yoshimori. 2009. An initial step of GAS-containing autophagosome-like vacuoles formation requires Rab7. PLoS Pathog. 5: e1000670.
26. Grenier, J. M., L. Wang, G. A. Manji, W. J. Huang, A. Al-Garawi, R. Kelly, A. Carlson, S. Merriam, J. M. Lora, M. Briskin, et al. 2002. Functional screening of five PYPAF family members identifies PYPAF5 as a novel regulator of NF-kappaB and caspase-1. FEBS Lett. 530: 73-78.
27. Fiorentino, L., C. Stehlik, V. Oliveira, M. E. Ariza, A. Godzik, and J. C. Reed. 2002. A novel PAAD-containing protein that modulates NF-kappa B induction by cytokines tumor necrosis factor-alpha and interleukin-1beta. J. Biol. Chem. 277: 35333-35340.
28. Zhang, P., M. Dixon, M. Zucchelli, F. Hambiliki, L. Levkov, O. Hovatta, and J. Kere. 2008. Expression analysis of the NLRP gene family suggests a role in human preimplantation development. PLoS ONE 3: e2755.
29. Hise, A. G., J. Tomalka, S. Ganesan, K. Patel, B. A. Hall, G. D. Brown, and K. A. Fitzgerald. 2009. An essential role for the NLRP3 inflammasome in host defense against the human fungal pathogen Candida albicans. Cell Host Microbe 5: 487-497.
30. Travassos, L. H., L. A. Carneiro, M. Ramjeet, S. Hussey, Y. G. Kim, J. G. Magalhaes, L. Yuan, F. Soares, E. Chea, L. Le Bourhis, et al. 2010. Nod1 and Nod2 direct autophagy by recruiting ATG16L1 to the plasma membrane at the site of bacterial entry. Nat. Immunol. 11: 55-62.
31. Cooney, R., J. Baker, O. Brain, B. Danis, T. Pichulik, P. Allan, D. J. Ferguson, B. J. Campbell, D. Jewell, and A. Simmons. 2010. NOD2 stimulation induces autophagy in dendritic cells influencing bacterial handling and antigen presentation. Nat. Med. 16: 90-97.
32. Abbott, D. W., A. Wilkins, J. M. Asara, and L. C. Cantley. 2004. The Crohn's disease protein, NOD2, requires RIP2 in order to induce ubiquitinylation of a novel site on NEMO. Curr. Biol. 14: 2217-2227.
33. Hampe, J., A. Franke, P. Rosenstiel, A. Till, M. Teuber, K. Huse, M. Albrecht, G. Mayr, F. M. De La Vega, J. Briggs, et al. 2007. A genome-wide association scan of nonsynonymous SNPs identifies a susceptibility variant for Crohn disease in ATG16L1. Nat. Genet. 39: 207-211.
34. Kuballa, P., A. Huett, J. D. Rioux, M. J. Daly, and R. J. Xavier. 2008. Impaired autophagy of an intracellular pathogen induced by a Crohn's disease associated ATG16L1 variant. PLoS ONE 3: e3391.
35. Saitoh, T., N. Fujita, M. H. Jang, S. Uematsu, B. G. Yang, T. Satoh, H. Omori, T. Noda, N. Yamamoto, M. Komatsu, et al. 2008. Loss of the autophagy protein Atg16L1 enhances endotoxin-induced IL-1beta production. Nature 456: 264-268.
36. Delgado, M. A., R. A. Elmaoued, A. S. Davis, G. Kyei, and V. Deretic. 2008. Toll-like receptors control autophagy. EMBO J. 27: 1110-1121.
37. Xu, Y., C. Jagannath, X. D. Liu, A. Sharafkhaneh, K. E. Kolodziejska, and N. T. Eissa. 2007. Toll-like receptor 4 is a sensor for autophagy associated with innate immunity. Immunity 27: 135-144.
38. MacMicking, J. D., G. A. Taylor, and J. D. McKinney. 2003. Immune control of tuberculosis by IFN-gamma-inducible LRG-47. Science 302: 654-659.
39. Singh, S. B., A. S. Davis, G. A. Taylor, and V. Deretic. 2006. Human IRGM induces autophagy to eliminate intracellular mycobacteria. Science 313: 1438-1441.