The Nalp3 inflammasome is essential for the development of silicosis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 26, 2008, Pages 9035-9040

  Cassel, Suzanne L ^a   Eisenbarth, Stephanie C ^b   Iyer, Shankar S ^a   Sadler, Jeffrey J ^a   Colegio, Oscar R ^b   Tephly, Linda A ^a   Carter, A Brent ^a   Rothman, Paul B ^a   Flavell, Richard A ^b   Sutterwala, Fayyaz S ^a,b,c  

^a UNIVERSITY OF IOWA   (United States)

^b YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF IOWA   (United States)

Author keywords

Asbestosis; Caspase 1; Interleukin 1 ; NLRP3

Indexed keywords

INTERLEUKIN 18 BINDING PROTEIN; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; POTASSIUM; PROTEIN SUBUNIT; REACTIVE OXYGEN METABOLITE; ASBESTOS; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; COLLAGEN; CYTOSKELETON PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PYCARD PROTEIN, MOUSE; SILICON DIOXIDE; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; ENZYME ACTIVATION; EXPOSURE; HUMAN; HUMAN CELL; INFLAMMATION; LUNG FIBROSIS; MACROPHAGE; MOUSE; NONHUMAN; PATHOGENESIS; PNEUMOCONIOSIS; POTASSIUM CELL LEVEL; PRIORITY JOURNAL; PROTEIN FAMILY; SILICOSIS; ANIMAL; C57BL MOUSE; CYTOTOXICITY; DRUG EFFECT; ENDOCYTOSIS; IMMUNOLOGY; INHALATIONAL DRUG ADMINISTRATION; LUNG; METABOLISM; PATHOLOGY; PERITONEUM MACROPHAGE; SECRETION;

ADMINISTRATION, INHALATION; ANIMALS; ASBESTOS; CARRIER PROTEINS; COLLAGEN; CYTOSKELETAL PROTEINS; CYTOTOXICITY, IMMUNOLOGIC; ENDOCYTOSIS; HUMANS; INFLAMMATION; INTERLEUKIN-1BETA; INTERLEUKIN-6; LIPOPOLYSACCHARIDES; LUNG; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED C57BL; POTASSIUM; REACTIVE OXYGEN SPECIES; SILICON DIOXIDE; SILICOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 47849132947     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0803933105     Document Type: Article

References (30)

1. Mossman BT, Churg A (1998) Mechanisms in the pathogenesis of asbestosis and silicosis. Am J Respir Crit Care Med 157:1666-1680.
2. Otsuki T, et al. (2007) Immunological effects of silica and asbestos. Cell Mol Immunol 4:261-268.
3. Wagner GR (1997) Asbestosis and silicosis. Lancet 349:1311-1315.
4. Kline JN, Schwartz DA, Monick MM, Floerchinger CS, Hunninghake GH (1993) Relative release of interleukin-1β and interleukin-1 receptor antagonist by alveolar macrophages. A study in asbestos-induced lung disease, sarcoidosis, and idiopathic pulmonary fibrosis. Chest 104:47-53.
5. Zhang Y, Lee TC, Guillemin B, Yu MC, Rom WN (1993) Enhanced interleukin-1β and tumor necrosis factor-α release and mRNA expression in macrophages from idiopathic pulmonary fibrosis or following asbestos exposure. J Immunol 150:4188-4196.
6. Sarih M, Souvannavong V, Brown SC, Adam A (1993) Silica induces apoptosis in macrophages and the release of interleukin-1α and interleukin-1β. J Leukocyte Biol 54:407-413.
7. Srivastava KD, et al. (2002) Crucial role of interleukin-1β and nitric oxide synthase in silica-induced inflammation and apoptosis in mice. Am J Respir Crit Care Med 165:527-533.
8. Yucesoy B, et al. (2001) Polymorphisms of the IL-1 gene complex in coal miners with silicosis. Am J Ind Med 39:286-291.
9. Mariathasan S, Monack DM (2007) Inflammasome adaptors and sensors: Intracellular regulators of infection and inflammation. Nat Rev Immunol 7:31-40.
10. Pétrilli V, Dostert C, Muruve DA, Tschopp J (2007) The inflammasome: A danger sensing complex triggering innate immunity. Curr Opin Immunol 19:615-622.
11. Martinon F, Burns K, Tschopp J (2002) The inflammasome: A molecular platform triggering activation of inflammatory caspases and processing of proIL-β. Mol Cell 10:417-426.
12. Sutterwala FS, et al. (2006) Critical role for NALP3/CIAS1/Cryopyrin in innate and adaptive immunity through its regulation of caspase-1. Immunity 24:317-327.
13. Mariathasan S, et al. (2006) Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 440:228-232.
14. Martinon F, Pétrilli V, Mayor A, Tardivel A, Tschopp J (2006) Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 440:237-241.
15. Fryzek JP, et al. (2003) A cohort mortality study among titanium dioxide manufacturing workers in the United States. J Occup Environ Med 45:400-409.
16. Mariathasan S, et al. (2004) Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430:213-218.
17. Zamboni DS, et al. (2006) The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nat Immunol 7:318-325.
18. Sutterwala FS, et al. (2007) Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J Exp Med 204:3235-3245.
19. Hamilton RF, Jr, Thakur SA, Holian A (2008) Silica binding and toxicity in alveolar macrophages. Free Radic Biol Med 44:1246-1258.
20. Hamilton RF, Jr., Thakur SA, Mayfair JK, Holian A (2006) MARCO mediates silica uptake and toxicity in alveolar macrophages from C57BL/6 mice. J Biol Chem 281:34218-34226.
21. Pétrilli V, et al. (2007) Activation of the NALP3 inflammasome is triggered by low intracellular potassium concentration. Cell Death Differ 14:1583-1589.
22. Terada LS (2006) Specificity in reactive oxidant signaling: Think globally, act locally. J Cell Biol 174:615-623.
23. Cruz CM, et al. (2007) ATP activates a reactive oxygen species-dependent oxidative stress response and secretion of proinflammatory cytokines in macrophages. J Biol Chem 282:2871-2879.
24. Gasse P, et al. (2007) IL-1R1/MyD88 signaling and the inflammasome are essential in pulmonary inflammation and fibrosis in mice. J Clin Invest 117:3786-3799.
25. Piguet PF, Vesin C, Grau GE, Thompson RC (1993) Interleukin 1 receptor antagonist (IL-1ra) prevents or cures pulmonary fibrosis elicited in mice by bleomycin or silica. Cytokine 5:57-61.
26. Keller M, Rüegg A, Werner S, Beer HD (2008) Active caspase-1 is a regulator of unconventional protein secretion. Cell 132:818-831.
27. Lara-Tejero, et al. (2006) Role of the caspase-1 inflammasome in Salmonella typhimurium pathogenesis. J Exp Med 203:1407-1412.
28. Kuida K, et al. (1995) Altered cytokine export and apoptosis in mice deficient in interleukin-1β converting enzyme. Science 267:2000-2003.
29. Monick MM, Carter AB, Hunninghake GW (1999) Human alveolar macrophages are markedly deficient in REF-1 and AP-1 DNA binding activity. J Biol Chem 274:18075-18080.
30. Bánfi B, et al. (2004) NOX3, a superoxide-generating NADPH oxidase of the inner ear. J Biol Chem 279:46065-46072.