Guanylate-binding proteins promote activation of the AIM2 inflammasome during infection with Francisella novicida

Nature Immunology

Volumn 16, Issue 5, 2015, Pages 476-484

  Meunier, Etienne ^a   Wallet, Pierre ^b   Dreier, Roland F ^a   Costanzo, Stéphanie ^b   Anton, Leonie ^a   Rühl, Sebastian ^a   Dussurgey, Sébastien ^b   Dick, Mathias S ^a   Kistner, Anne ^a   Rigard, Mélanie ^b   Degrandi, Daniel ^c   Pfeffer, Klaus ^c   Yamamoto, Masahiro ^c   Henry, Thomas ^b   Broz, Petr ^a  

^a UNIVERSITY OF BASEL   (Switzerland)

^b UNIVERSITÉ LYON 1   (France)

^c HEINRICH HEINE UNIVERSITY   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AIM2 INFLAMMASOME; ALPHA INTERFERON; BACTERIAL DNA; BETA1 INTERFERON; GAMMA INTERFERON; GENOMIC DNA; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANINE NUCLEOTIDE BINDING PROTEIN 2; GUANINE NUCLEOTIDE BINDING PROTEIN 5; INFLAMMASOME; INTERLEUKIN 1BETA; LIGAND; SMALL INTERFERING RNA; STAT1 PROTEIN; SYNTHETIC DNA; UNCLASSIFIED DRUG; AIM2 PROTEIN, MOUSE; DNA BINDING PROTEIN; GBP2 PROTEIN, HUMAN; GBP5 PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL COUNT; BACTERIAL LOAD; BACTERIOLYSIS; CELL DEATH; CHROMOSOME 3; CONTROLLED STUDY; CYTOKINE RELEASE; CYTOSOL; DNA TRANSFECTION; FRANCISELLA NOVICIDA; GENE ACTIVATION; GENETIC SCREENING; HOST RESISTANCE; IN VITRO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PRIORITY JOURNAL; TULAREMIA; ANIMAL; CELL CULTURE; DISEASE MODEL; FRANCISELLA TULARENSIS; GENETICS; HUMAN; IMMUNOLOGY; KNOCKOUT MOUSE; METABOLISM; MICROBIOLOGY; PHYSIOLOGY;

ANIMALS; BACTERIOLYSIS; CELLS, CULTURED; CYTOSOL; DISEASE MODELS, ANIMAL; DNA-BINDING PROTEINS; FRANCISELLA TULARENSIS; GTP-BINDING PROTEINS; HUMANS; INFLAMMASOMES; MICE; MICE, KNOCKOUT; RNA, SMALL INTERFERING; TULAREMIA;

EID: 84928538482     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3119     Document Type: Article

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