Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization

Nature Immunology

Volumn 9, Issue 8, 2008, Pages 847-856

  Hornung, Veit ^a   Bauernfeind, Franz ^b   Halle, Annett ^a   Samstad, Eivind O ^a,c   Kono, Hajime ^a   Rock, Kenneth L ^a   Fitzgerald, Katherine A ^a   Latz, Eicke ^a,c  

^a UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

^b UNIVERSITY OF MUNICH   (Germany)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ALUMINUM SALT; CATHEPSIN B; CYTOPLASMIC RECEPTOR; PROTEIN NALP3; SILICON DIOXIDE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; ENVIRONMENTAL EXPOSURE; HUMAN; HUMAN CELL; IMMUNE RESPONSE; LUNG ALVEOLUS; LUNG FIBROSIS; LYSOSOME; MOLECULAR MECHANICS; MOUSE; PHAGOCYTOSIS; PHAGOSOME; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SILICOSIS;

ALUMINUM COMPOUNDS; ANIMALS; CARRIER PROTEINS; INFLAMMATION; INFLAMMATION MEDIATORS; MACROPHAGES; MICE; MICE, INBRED C57BL; SILICON DIOXIDE; SILICOSIS;

EID: 47849097202     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.1631     Document Type: Article

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