Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

European Journal of Immunology

Volumn 40, Issue 6, 2010, Pages 1545-1551

  Kim, Sarah ^a   Bauernfeind, Franz ^a   Ablasser, Andrea ^a   Hartmann, Gunther ^a   Fitzgerald, Katherine A ^b   Latz, Eicke ^a,b   Hornung, Veit ^a  

^a UNIVERSITY HOSPITAL BONN   (Germany)

^b UNIVERSITY OF MASSACHUSETTS MEDICAL SCHOOL   (United States)

Author keywords

AIM2; Caspase 1; Inflammasome; Listeria monocytogenes; NLRP3

Indexed keywords

AIM2 PROTEIN; CRYOPYRIN; DNA; INFLAMMASOME; INTERLEUKIN 1BETA CONVERTING ENZYME; UNCLASSIFIED DRUG;

ARTICLE; BACTERIUM DETECTION; CELL DEATH; CELL DIVISION; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; LISTERIA MONOCYTOGENES; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; CARRIER PROTEINS; IMMUNOBLOTTING; LISTERIA INFECTIONS; LISTERIA MONOCYTOGENES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICROSCOPY, CONFOCAL; NUCLEAR PROTEINS;

EID: 77953305895     PISSN: 00142980     EISSN: 15214141     Source Type: Journal    
DOI: 10.1002/eji.201040425     Document Type: Article

References (38)

1. Akira, S., Uematsu, S. and Takeuchi, O., Pathogen recognition and innate immunity. Cell 2006. 124: 783-801.
2. Martinon, F., Mayor, A. and Tschopp, J., The inflammasomes: guardians of the body. Annu. Rev. Immunol. 2009. 27: 229-265.
3. Wilkins, C. and Gale, M., Jr., Recognition of viruses by cytoplasmic sensors. Curr. Opin. Immunol. 2010. 22: 41-47.
4. Bianchi, M. E., DAMPs, PAMPs and alarmins: all we need to know about danger. J. Leukoc. Biol. 2007. 81: 1-5.
5. Latz, E., The inflammasomes: mechanisms of activation and function. Curr. Opin. Immunol. 2010. 22: 28-33.
6. Dinarello, C. A., Immunological and inflammatory functions of the interleukin-1 family. Annu. Rev. Immunol. 2009. 27: 519-550.
7. Bergsbaken, T., Fink, S. L. and Cookson, B. T., Pyroptosis: host cell death and inflammation. Nat. Rev. Microbiol. 2009. 7: 99-109.
8. Martinon, F., Burns, K. and Tschopp, J., The inflammasome: a molecular platform triggering activation of inflammatory caspases and processing of proIL-beta. Mol Cell 2002. 10: 417-426.
9. Stutz, A., Golenbock, D. T. and Latz, E., Inflammasomes: too big to miss. J. Clin. Invest. 2009. 119: 3502-3511.
10. Dostert, C., Petrilli, V., Van Bruggen, R., Steele, C., Mossman, B. T. and Tschopp, J., Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica. Science 2008. 320: 674-677.
11. Halle, A., Hornung, V., Petzold, G. C., Stewart, C. R., Monks, B. G., Reinheckel, T., Fitzgerald, K. A. et al., The NALP3 inflammasome is involved in the innate immune response to amyloid-beta. Nat. Immunol. 2008. 9: 857-865.
12. Hornung, V., Bauernfeind, F., Halle, A., Samstad, E. O., Kono, H., Rock, K. L., Fitzgerald, K. A. and Latz, E., Silica crystals and aluminum salts activate the NALP3 inflammasome through phagosomal destabilization. Nat. Immunol. 2008. 9: 847-856.
13. Mariathasan, S., Weiss, D. S., Newton, K., McBride, J., O'Rourke, K., Roose-Girma, M., Lee, W. P., et al., Cryopyrin activates the inflammasome in response to toxins and ATP. Nature 2006. 440: 228-232.
14. Martinon, F., Petrilli, V., Mayor, A., Tardivel, A. and Tschopp, J., Gout-associated uric acid crystals activate the NALP3 inflammasome. Nature 2006. 440: 237-241.
15. Bauernfeind, F. G., Horvath, G., Stutz, A., Alnemri, E. S., MacDonald, K., Speert, D., Fernandes-Alnemri, T. et al., Cutting edge: NF-kappaB activating pattern recognition and cytokine receptors license NLRP3 inflammasome activation by regulating NLRP3 expression. J. Immunol. 2009. 183: 787-791.
16. Franchi, L., Eigenbrod, T. and Nunez, G., Cutting edge: TNF-alpha mediates sensitization to ATP and silica via the NLRP3 inflammasome in the absence of microbial stimulation. J. Immunol. 2009. 183: 792-796.
17. Zhou, R., Tardivel, A., Thorens, B., Choi, I. and Tschopp, J., Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat. Immunol. 2010. 11: 136-140.
18. Vazquez-Boland, J. A., Kuhn, M., Berche, P., Chakraborty, T., Dominguez-Bernal, G., Goebel, W., Gonzalez-Zorn, B. et al., Listeria pathogenesis and molecular virulence determinants. Clin. Microbiol. Rev. 2001. 14: 584-640.
19. Kim, Y. G., Park, J. H., Shaw, M. H., Franchi, L., Inohara, N. and Nunez, G., The cytosolic sensors Nod1 and Nod2 are critical for bacterial recognition and host defense after exposure to Toll-like receptor ligands. Immunity 2008. 28: 246-257.
20. Kobayashi, K. S., Chamaillard, M., Ogura, Y., Henegariu, O., Inohara, N., Nunez, G. and Flavell, R. A., Nod2-dependent regulation of innate and adaptive immunity in the intestinal tract. Science 2005. 307: 731-734.
21. O'Riordan, M., Yi, C. H., Gonzales, R., Lee, K. D. and Portnoy, D. A., Innate recognition of bacteria by a macrophage cytosolic surveillance pathway. Proc. Natl. Acad. Sci. USA 2002. 99: 13861-13866.
22. Opitz, B., Puschel, A., Beermann, W., Hocke, A. C., Forster, S., Schmeck, B., van Laak, V. et al., Listeria monocytogenes activated p38 MAPK and induced IL-8 secretion in a nucleotide-binding oligomerization domain 1-dependent manner in endothelial cells. J. Immunol. 2006. 176: 484-490. (Pubitemid 43023294)
23. Park, J. H., Kim, Y. G., Shaw, M., Kanneganti, T. D., Fujimoto, Y., Fukase, K., Inohara, N. and Nunez, G., Nod1/RICK and TLR signaling regulate chemokine and antimicrobial innate immune responses in mesothelial cells. J. Immunol. 2007. 179: 514-521. (Pubitemid 46986568)
24. Stockinger, S., Reutterer, B., Schaljo, B., Schellack, C., Brunner, S., Materna, T., Yamamoto, M. et al., IFN regulatory factor 3-dependent induction of type I IFNs by intracellular bacteria is mediated by a TLR-and Nod2-independent mechanism. J. Immunol. 2004. 173: 7416-7425. (Pubitemid 39628181)
25. Torres, D., Barrier, M., Bihl, F., Quesniaux, V. J., Maillet, I., Akira, S., Ryffel, B. and Erard, F., Toll-like receptor 2 is required for optimal control of Listeria monocytogenes infection. Infect. Immun. 2004. 72: 2131-2139.
26. Warren, S. E., Mao, D. P., Rodriguez, A. E., Miao, E. A. and Aderem, A., Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. J. Immunol. 2008. 180: 7558-7564.
27. Tsuji, N. M., Tsutsui, H., Seki, E., Kuida, K., Okamura, H., Nakanishi, K. and Flavell, R. A., Roles of caspase-1 in Listeria infection in mice. Int. Immunol. 2004. 16: 335-343.
28. Meixenberger, K., Pache, F., Eitel, J., Schmeck, B., Hippenstiel, S., Slevogt, H., N'Guessan, P. et al., Listeria monocytogenes-infected human peripheral blood mononuclear cells produce IL-1beta, depending on listeriolysin O and NLRP3. J. Immunol. 2010. 184: 922-930.
29. Franchi, L., Kanneganti, T. D., Dubyak, G. R. and Nunez, G., Differential requirement of P2X7 receptor and intracellular K+ for caspase-1 activation induced by intracellular and extracellular bacteria. J. Biol. Chem. 2007. 282: 18810-18818.
30. Way, S. S., Thompson, L. J., Lopes, J. E., Hajjar, A. M., Kollmann, T. R., Freitag, N. E. and Wilson, C. B., Characterization of flagellin expression and its role in Listeria monocytogenes infection and immunity. Cell. Microbiol. 2004. 6: 235-242.
31. Boyden, E. D. and Dietrich, W. F., Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nat. Genet. 2006. 38: 240-244.
32. Stetson, D. B. and Medzhitov, R., Recognition of cytosolic DNA activates an IRF3-dependent innate immune response. Immunity 2006. 24: 93-103.
33. Grillot-Courvalin, C., Goussard, S. and Courvalin, P., Wild-type intracellular bacteria deliver DNA into mammalian cells. Cell. Microbiol. 2002. 4: 177-186.
34. Barsig, J. and Kaufmann, S. H., The mechanism of cell death in Listeria monocytogenes-infected murine macrophages is distinct from apoptosis. Infect. Immun. 1997. 65: 4075-4081.
35. Cervantes, J., Nagata, T., Uchijima, M., Shibata, K. and Koide, Y., Intracytosolic Listeria monocytogenes induces cell death through caspase-1 activation in murine macrophages. Cell. Microbiol. 2008. 10: 41-52.
36. Zwaferink, H., Stockinger, S., Hazemi, P., Lemmens-Gruber, R. and Decker, T., IFN-beta increases listeriolysin O-induced membrane permeabilization and death of macrophages. J. Immunol. 2008. 180: 4116-4123.
37. Zwaferink, H., Stockinger, S., Reipert, S. and Decker, T., Stimulation of inducible nitric oxide synthase expression by beta interferon increases necrotic death of macrophages upon Listeria monocytogenes infection. Infect. Immun. 2008. 76: 1649-1656.
38. Hornung, V., Ablasser, A., Charrel-Dennis, M., Bauernfeind, F., Horvath, G., Caffrey, D. R., Latz, E. and Fitzgerald, K. A., AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC. Nature 2009. 458: 514-518.