The PYRIN domain-only protein POP3 inhibits ALR inflammasomes and regulates responses to infection with DNA viruses

Nature Immunology

Volumn 15, Issue 4, 2014, Pages 343-353

  Khare, Sonal ^a   Ratsimandresy, Rojo A ^a   De Almeida, Lúcia ^a   Cuda, Carla M ^a   Rellick, Stephanie L ^b   Misharin, Alexander V ^a   Wallin, Melissa C ^a   Gangopadhyay, Anu ^a   Forte, Eleonora ^a   Gottwein, Eva ^a   Perlman, Harris ^a   Reed, John C ^c,d   Greaves, David R ^e   Dorfleutner, Andrea ^a   Stehlik, Christian ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

^b WEST VIRGINIA UNIVERSITY   (United States)

^c BURNHAM INSTITUTE   (United States)

^d Pharma Research and Early Development   (Switzerland)

^e UNIVERSITY OF OXFORD   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; INFLAMMASOME; INTERFERON; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; PYRIN DOMAIN PROTEIN POP3; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; CYTOKINE RELEASE; DNA VIRUS; HOST RESISTANCE; IN VIVO STUDY; MACROPHAGE; MONOCYTE; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; REGULATORY MECHANISM;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; AMINO ACID SEQUENCE; ANIMALS; CARRIER PROTEINS; CASPASE 1; DNA VIRUS INFECTIONS; DNA VIRUSES; HEK293 CELLS; HUMANS; IMMUNITY; INFLAMMASOMES; INTERFERON TYPE I; INTERFERON-GAMMA; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MULTIPROTEIN COMPLEXES; NUCLEAR PROTEINS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SEQUENCE ALIGNMENT; TRANSGENES; VIRAL PROTEINS;

EID: 84896638307     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.2829     Document Type: Article

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