An inherited mutation in NLRC4 causes autoinflammation in human and mice

Journal of Experimental Medicine

Volumn 211, Issue 12, 2014, Pages 2385-2396

  Kitamura, Akiko ^a   Sasaki, Yuki ^a   Abe, Takaya ^b   Kano, Hirotsugu ^c   Yasutomo, Koji ^a,d  

^a UNIVERSITY OF TOKUSHIMA   (Japan)

^b RIKEN Center for Biosystems Dynamics Research   (Japan)

^c TEIKYO UNIVERSITY MIZONOKUCHI HOSPITAL   (Japan)

^d JAPAN SCIENCE AND TECHNOLOGY AGENCY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE; INFLAMMASOME; INTERLEUKIN 17; INTERLEUKIN 1BETA; PROCASPASE 1; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CALCIUM BINDING PROTEIN; CASPASE RECRUITMENT DOMAIN SIGNALING PROTEIN; INTERLEUKIN 1BETA CONVERTING ENZYME; IPAF PROTEIN, MOUSE; NLRC4 PROTEIN, HUMAN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHRITIS; ARTICLE; BACTERIAL INFECTION; COLD EXPOSURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DERMATITIS; FAMILIAL COLD AUTOINFLAMMATORY SYNDROME; GENE EXPRESSION; GRAM NEGATIVE BACTERIUM; HUMAN; HUMAN CELL; INNATE IMMUNITY; MISSENSE MUTATION; MOUSE; MUTATOR GENE; NEUTROPHIL; NLRC4 GENE; NONHUMAN; PROMOTER REGION; PROTEIN CLEAVAGE; T LYMPHOCYTE; TRANSGENIC MOUSE; AMINO ACID SEQUENCE; ANIMAL; C57BL MOUSE; CELL CULTURE; CINCA SYNDROME; FEMALE; FLOW CYTOMETRY; GENETIC PREDISPOSITION; GENETICS; GENOTYPE; HEK293 CELL LINE; MALE; METABOLISM; MOLECULAR GENETICS; PEDIGREE; SEQUENCE HOMOLOGY; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS REGULATORY PROTEINS; BLOTTING, WESTERN; CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CASPASE 1; CELLS, CULTURED; CRYOPYRIN-ASSOCIATED PERIODIC SYNDROMES; FEMALE; FLOW CYTOMETRY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HEK293 CELLS; HUMANS; INFLAMMASOMES; INTERLEUKIN-17; INTERLEUKIN-1BETA; MALE; MICE, INBRED C57BL; MICE, TRANSGENIC; MOLECULAR SEQUENCE DATA; MUTATION, MISSENSE; NEUTROPHILS; PEDIGREE; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84911922142     PISSN: 00221007     EISSN: 15409538     Source Type: Journal    
DOI: 10.1084/jem.20141091     Document Type: Article

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