Dietary modulation of the microbiome affects autoinflammatory disease

Nature

Volumn 516, Issue 7530, 2014, Pages 246-249

  Lukens, John R ^a   Gurung, Prajwal ^a   Vogel, Peter ^a   Johnson, Gordon R ^a   Carter, Robert A ^a   McGoldrick, Daniel J ^a   Bandi, Srinivasa Rao ^a   Calabrese, Christopher R ^a   Walle, Lieselotte Vande ^b,c   Lamkanfi, Mohamed ^b,c   Kanneganti, Thirumala Devi ^a  

^a ST JUDE CHILDREN S RESEARCH HOSPITAL   (United States)

^b Department of Medical Protein Research ^*  (Belgium)

^c GHENT UNIVERSITY   (Belgium)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 8; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; MYELOBLASTIN; CHOLESTEROL; CYTOSKELETON PROTEIN; PANCREATIC ELASTASE; PSTPIP2 PROTEIN, MOUSE; SIGNAL TRANSDUCING ADAPTOR PROTEIN;

ANTIBIOTICS; BODY CONDITION; BONE; DIET; DISEASE INCIDENCE; ENVIRONMENTAL FACTOR; ENZYME ACTIVITY; MUTATION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOINFLAMMATORY DISEASE; BACTERIAL GROWTH; BODY WEIGHT; BONE EROSION; CONTROLLED STUDY; DIETARY INTAKE; INTESTINE FLORA; MICROBIOME; MOUSE; NONHUMAN; OSTEOMYELITIS; PREVOTELLA; PRIORITY JOURNAL; PROTEIN EXPRESSION; WILD TYPE; ANIMAL; BAGG ALBINO MOUSE; BLOOD; DEFICIENCY; DIET THERAPY; DISEASE MODEL; DRUG EFFECTS; FEMALE; GENETICS; GROWTH, DEVELOPMENT AND AGING; IMMUNOLOGY; INFLAMMATION; INTESTINE; ISOLATION AND PURIFICATION; LIPID DIET; MALE; METABOLISM; MICROBIOLOGY; MICROFLORA; NEUTROPHIL; PATHOLOGY;

MUS; PREVOTELLA;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; ANIMALS; BODY WEIGHT; CASPASE 1; CASPASE 8; CHOLESTEROL; CYTOSKELETAL PROTEINS; DIET, HIGH-FAT; DISEASE MODELS, ANIMAL; FEMALE; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; INTESTINES; MALE; MICE; MICE, INBRED BALB C; MICROBIOTA; MYELOBLASTIN; NEUTROPHILS; OSTEOMYELITIS; PANCREATIC ELASTASE; PREVOTELLA;

EID: 84923207808     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature13788     Document Type: Article

References (29)

1. Lozano, R. et al. Global and regionalmortality from235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380, 2095-2128 (2012).
2. Ferguson, P. J. et al. A missense mutation in pstpip2 is associated with the murine autoinflammatory disorder chronic multifocal osteomyelitis. Bone 38, 41-47 (2006).
3. Chitu, V. et al. Primed innate immunity leads to autoinflammatory disease in PSTPIP2-deficient cmo mice. Blood 114, 2497-2505 (2009).
4. Grosse, J. et al. Mutation of mouse Mayp/Pstpip2 causes a macrophage autoinflammatory disease. Blood 107, 3350-3358 (2006).
5. Lukens, J. R. et al. Critical role for inflammasome-independent IL-1b production in osteomyelitis. Proc. Natl Acad. Sci. USA 111, 1066-1071 (2014).
6. Cassel, S. L. et al. Inflammasome-independent IL-1beta mediates autoinflammatory disease in Pstpip2-deficient mice. Proc.Natl Acad. Sci.USA111, 1072-1077 (2014).
7. Maslowski, K. M. & Mackay, C. R. Diet, gut microbiota and immune responses. Nature Immunol. 12, 5-9 (2011).
8. Montgomery, M. K. et al. Mouse strain-dependent variation in obesity and glucose homeostasis in response to high-fat feeding. Diabetologia 56, 1129-1139 (2013).
9. Turnbaugh, P. J. et al. An obesity-associated gut microbiome with increased capacity for energy harvest. Nature 444, 1027-1031 (2006).
10. David, L. A. et al. Diet rapidly and reproducibly alters the human gut microbiome. Nature 505, 559-563 (2014).
11. Dinarello, C. A. Interleukin-1 in the pathogenesis and treatment of inflammatory diseases. Blood. 117, 3720-3732 (2011).
12. Maelfait, J. et al. Stimulation of Toll-like receptor 3 and 4 induces interleukin-1b maturation by caspase-8. J. Exp. Med. 205, 1967-1973 (2008).
13. Gringhuis, S. I. et al. Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1b via a noncanonical caspase-8 inflammasome. Nature Immunol. 13, 246-254 (2012).
14. Antonopoulos, C., El Sanadi, C., Kaiser, W. J., Mocarski, E. S. & Dubyak, G. R. Proapoptotic chemotherapeutic drugs induce noncanonical processing and release of IL-1b via caspase-8 in dendritic cells. J. Immunol. 191, 4789-4803 (2013).
15. Gurung, P. et al. FADD and caspase-8 mediate priming and activation of the canonical and noncanonical Nlrp3 inflammasomes. J. Immunol. 192, 1835-1846 (2014).
16. Man, S. M. et al. Salmonella infection induces recruitment of Caspase-8 to the inflammasome to modulate IL-1b production. J. Immunol. 191, 5239-5246 (2013).
17. Joosten, L. A. et al. Inflammatory arthritis in caspase 1 gene-deficient mice: contribution of proteinase 3 to caspase 1-independent production of bioactive interleukin-1b. Arthritis Rheum. 60, 3651-3662 (2009).
18. Karmakar, M., Sun, Y., Hise, A. G., Rietsch, A. & Pearlman, E. Cutting edge: IL-1b processing during Pseudomonas aeruginosa infection is mediated by neutrophil serine proteases and is independent of NLRC4 and caspase-1. J. Immunol. 189, 4231-4235 (2012).
19. Varfolomeev, E. E. et al. Targeted disruption of the mouse Caspase 8 gene ablates cell death induction by the TNF receptors, Fas/Apo1, and DR3 and is lethal prenatally. Immunity 9, 267-276 (1998).
20. Yeh, W. C. et al. FADD: essential forembryo development and signaling fromsome, but not all, inducers of apoptosis. Science 279, 1954-1958 (1998).
21. Zhang, J., Cado, D., Chen, A., Kabra, N. H. & Winoto, A. Fas-mediated apoptosis and activation-induced T-cell proliferation are defective in mice lacking FADD/Mort1. Nature 392, 296-300 (1998).
22. Kaiser, W. J. et al. RIP3 mediates the embryonic lethality of caspase-8-deficient mice. Nature 471, 368-372 (2011).
23. Oberst, A. et al. Catalytic activity of the caspase-8-FLIPL complex inhibits RIPK3-dependent necrosis. Nature 471, 363-367 (2011).
24. Shornick, L. P. et al. Mice deficient in IL-1b manifest impaired contact hypersensitivity to trinitrochlorobenzone. J. Exp. Med. 183, 1427-1436 (1996).
25. Kanneganti, T. D. et al. Bacterial RNA and small antiviral compounds activate caspase-1 through cryopyrin/Nalp3. Nature 440, 233-236 (2006).
26. Salmena, L. et al. Essential role for caspase 8 in T-cell homeostasis and T-cellmediated immunity. Genes Dev. 17, 883-895 (2003).
27. Newton, K., Sun, X. & Dixit, V. M. Kinase RIP3 is dispensable for normal NF-kBs, signaling by the B-cell and T-cell receptors, tumor necrosis factor receptor 1, and Toll-like receptors 2 and 4. Mol. Cell. Biol. 24, 1464-1469 (2004).
28. Belaaouaj, A. et al. Mice lacking neutrophil elastase reveal impaired host defense against gram negative bacterial sepsis. Nature Med. 4, 615-618 (1998).
29. Kessenbrock, K. et al. Proteinase 3 and neutrophil elastase enhance inflammationin mice by inactivatingantiinflammatory progranulin. J. Clin. Invest. 118, 2438-2447 (2008).