The NLRC4 inflammasome receptors for bacterial flagellin and type III secretion apparatus

Nature

Volumn 477, Issue 7366, 2011, Pages 596-602

  Zhao, Yue ^a,b   Yang, Jieling ^a,b   Shi, Jianjin ^b   Gong, Yi Nan ^b   Lu, Qiuhe ^b   Xu, Hao ^b   Liu, Liping ^b   Shao, Feng ^a,b  

^a PEKING UNION MEDICAL COLLEGE   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; FLAGELLIN; INFLAMMASOME; NUCLEOTIDE BINDING OLIGOMERIZATION DOMAIN LIKE RECEPTOR; PROTEIN NLRC4; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

BACTERIUM; GENETIC ANALYSIS; MOLECULAR ANALYSIS; PROTEIN; RODENT; SECRETION;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BACTERIAL INFECTION; BURKHOLDERIA; CHROMOBACTERIUM VIOLACEUM; CONTROLLED STUDY; IMMUNE SYSTEM; INNATE IMMUNITY; LEGIONELLA PNEUMOPHILA; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SALMONELLA; TYPE III SECRETION SYSTEM;

ANIMALS; APOPTOSIS REGULATORY PROTEINS; BACTERIAL SECRETION SYSTEMS; CALCIUM-BINDING PROTEINS; CARD SIGNALING ADAPTOR PROTEINS; CASPASE 1; CELL LINE; CHROMOBACTERIUM; FLAGELLIN; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; LEGIONELLA PNEUMOPHILA; MACROPHAGES; MICE; MICE, INBRED C57BL; NEURONAL APOPTOSIS-INHIBITORY PROTEIN;

BACTERIA (MICROORGANISMS); BURKHOLDERIA; CHROMOBACTERIUM VIOLACEUM; LEGIONELLA PNEUMOPHILA; SALMONELLA;

EID: 80053349020     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature10510     Document Type: Article

References (37)

1. Lamkanfi, M. & Dixit, V. M. Inflammasomes: guardians of cytosolic sanctity. Immunol. Rev. 227, 95-105 (2009).
2. Schroder, K. & Tschopp, J. The inflammasomes. Cell 140, 821-832 (2010).
3. Franchi, L. et al. Cytosolic flagellin requires Ipaf for activation of caspase-1 and interleukin 1b in salmonella-infected macrophages. Nature Immunol. 7, 576-582 (2006). (Pubitemid 43797338)
4. Miao, E. A. et al. Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1b via Ipaf. Nature Immunol. 7, 569-575 (2006). (Pubitemid 43797337)
5. Miao, E. A. et al. Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. Proc. Natl Acad. Sci. USA 107, 3076-3080 (2010).
6. Lightfield, K. L. et al. Critical function for Naip5 in inflammasome activation by a conserved carboxy-terminal domain of flagellin. Nature Immunol. 9, 1171-1178 (2008).
7. Amer, A. et al. Regulation of Legionella phagosome maturation and infection through flagellin and host Ipaf. J. Biol. Chem. 281, 35217-35223 (2006). (Pubitemid 46043249)
8. Broz, P. et al. Redundant roles for inflammasome receptors NLRP3 and NLRC4 in host defense against Salmonella. J. Exp. Med. 207, 1745-1755 (2010).
9. Milne, J. C., Blanke, S. R., Hanna, P. C. & Collier, R. J. Protective antigen-binding domain of anthrax lethal factor mediates translocation of a heterologous protein fused to its amino-or carboxy-terminus. Mol. Microbiol. 15, 661-666 (1995).
10. Broz, P., von Moltke, J., Jones, J. W., Vance, R. E. & Monack, D. M. Differential requirement for Caspase-1 autoproteolysis in pathogen-induced cell death and cytokine processing. Cell Host Microbe 8, 471-483 (2010).
11. Diez, E. et al. Birc1e is the gene within the Lgn1 locus associated with resistance to Legionella pneumophila. Nature Genet. 33, 55-60 (2003). (Pubitemid 36068682)
12. Wright, E. K. et al. Naip5 affects host susceptibility to the intracellular pathogen Legionella pneumophila. Curr. Biol. 13, 27-36 (2003).
13. Molofsky, A. B. et al. Cytosolic recognition of flagellin by mouse macrophages restricts Legionella pneumophila infection. J. Exp. Med. 203, 1093-1104 (2006).
14. Ren, T., Zamboni, D. S., Roy, C. R., Dietrich, W. F. & Vance, R. E. Flagellin-deficient Legionella mutants evade caspase-1-and Naip5-mediated macrophage immunity. PLoS Pathog. 2, e18 (2006).
15. Zamboni, D. S. et al. The Birc1e cytosolic pattern-recognition receptor contributes to the detection and control of Legionella pneumophila infection. Nature Immunol. 7, 318-325 (2006).
16. Fortier, A., de Chastellier, C., Balor, S. & Gros, P. Birc1e/Naip5 rapidly antagonizes modulation of phagosome maturation by Legionella pneumophila. Cell. Microbiol. 9, 910-923 (2007). (Pubitemid 46394902)
17. Lightfield, K. L. et al. Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. Infect. Immun. 79, 1606-1614 (2011).
18. Lamkanfi, M. et al. The Nod-like receptor family member Naip5/Birc1e restricts Legionella pneumophila growth independently of caspase-1 activation. J. Immunol. 178, 8022-8027 (2007). (Pubitemid 46898073)
19. Akhter, A. et al. Caspase-7 activation by the Nlrc4/Ipaf inflammasome restricts Legionella pneumophila infection. PLoS Pathog. 5, e1000361 (2009).
20. Franchi, L. et al. Critical role for Ipaf in Pseudomonas aeruginosa-induced caspase-1 activation. Eur. J. Immunol. 37, 3030-3039 (2007). (Pubitemid 350131283)
21. Sutterwala, F. S. et al. Immune recognition of Pseudomonas aeruginosa mediated by the IPAF/NLRC4 inflammasome. J. Exp. Med. 204, 3235-3245 (2007).
22. Miao, E. A., Ernst, R. K., Dors, M., Mao, D. P. & Aderem, A. Pseudomonas aeruginosa activates caspase1throughIpaf. Proc.NatlAcad. Sci.USA105, 2562-2567 (2008).
23. Suzuki, T. et al. Differential regulation of caspase-1 activation, pyroptosis, and autophagy via Ipaf and ASC in Shigella-infected macrophages. PLoS Pathog. 3, e111 (2007).
24. Damiano, J. S., Oliveira, V., Welsh, K. & Reed, J. C. Heterotypic interactions among NACHT domains: implications for regulation of innate immune responses. Biochem. J. 381, 213-219 (2004). (Pubitemid 38932227)
25. Miki, T. et al.Chromobacteriumpathogenicity island 1 type III secretion systemis a major virulence determinant for Chromobacteriumviolaceum-induced cell death in hepatocytes. Mol. Microbiol. 77, 855-872 (2010).
26. Worrall, L. J., Lameignere, E. & Strynadka, N. C. Structural overview of the bacterial injectisome. Curr. Opin. Microbiol. 14, 3-8 (2011).
27. Poyraz, O. et al. Protein refolding is required for assembly of the type three secretion needle. Nature Struct. Mol. Biol. 17, 788-792 (2010).
28. Hsu, L. C. et al. A NOD2-NALP1 complex mediates caspase-1-dependent IL-1b secretion in response to Bacillus anthracis infection and muramyl dipeptide. Proc. Natl Acad. Sci. USA 105, 7803-7808 (2008).
29. Poeck, H. et al. Recognition ofRNA virus by RIG-I results in activation ofCARD9and inflammasome signaling for interleukin 1b production. Nature Immunol. 11, 63-69 (2010).
30. Yao, Q. et al. A bacterial type III effector family uses the papain-like hydrolytic activity to arrest the host cell cycle. Proc. Natl Acad. Sci. USA 106, 3716-3721 (2009).
31. Cui, J. et al. Glutamine deamidation and dysfunction of ubiquitin/NEDD8 induced by a bacterial effector family. Science 329, 1215-1218 (2010).
32. Li, P. et al. Mice deficient in IL-1b-converting enzymeare defective in production of mature IL-1b and resistant to endotoxic shock. Cell 80, 401-411 (1995).
33. Mariathasan, S. et al. Differential activation of the inflammasome by caspase-1 adaptors ASC and Ipaf. Nature 430, 213-218 (2004). (Pubitemid 38902430)
34. Boyden, E. D. & Dietrich, W. F. Nalp1b controls mouse macrophage susceptibility to anthrax lethal toxin. Nature Genet. 38, 240-244 (2006). (Pubitemid 43177241)
35. Vojtek, A. B. & Cooper, J. A. Rho family members: activators of MAP kinase cascades. Cell 82, 527-529 (1995).
36. Dong, N., Liu, L.&Shao, F.Abacterial effector targets hostDH-PHdomainRhoGEFs and antagonizes macrophage phagocytosis. EMBO J. 29, 1363-1376 (2010).
37. Barrett, A. R. et al.Genetic tools for allelic replacement inBurkholderia species. Appl. Environ. Microbiol. 74, 4498-4508 (2008). (Pubitemid 352031032)