Innate immune activation through Nalp3 inflammasome sensing of asbestos and silica

Science

Volumn 320, Issue 5876, 2008, Pages 674-677

  Dostert, Catherine ^a   Pétrilli, Virginie ^a   Van Bruggen, Robin ^b   Steele, Chad ^c   Mossman, Brooke T ^d   Tschopp, Jürg ^a  

^a UNIVERSITY OF LAUSANNE   (Switzerland)

^b UNIVERSITY OF AMSTERDAM   (Netherlands)

^c UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF VERMONT COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ASBESTOS; CELL PROTEIN; INTERLEUKIN 1BETA; PROTEIN NALP3; REACTIVE OXYGEN METABOLITE; RECOMBINANT INTERLEUKIN 1 RECEPTOR BLOCKING AGENT; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; SILICON DIOXIDE; AUTACOID; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE;

ASBESTOS; ATMOSPHERIC POLLUTION; DUST; ENZYME ACTIVITY; IMMUNE SYSTEM; RESPIRATORY DISEASE; SECRETION; SILICA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASBESTOSIS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; INFLAMMATORY CELL; INFLAMMATORY DISEASE; INNATE IMMUNITY; LUNG CANCER; LUNG FIBROSIS; MOUSE; NONHUMAN; PARTICULATE MATTER; PHAGOCYTOSIS; PNEUMONIA; PRIORITY JOURNAL; PROTEIN FUNCTION; SILICOSIS; ANIMAL; HUMAN; IMMUNITY; IMMUNOLOGY; INFLAMMATION; MACROPHAGE; PHYSIOLOGY; SECRETION;

MUS;

ANIMALS; ASBESTOS; CARRIER PROTEINS; HUMANS; IMMUNITY; INFLAMMATION; INFLAMMATION MEDIATORS; INTERLEUKIN-1BETA; MACROPHAGES; MICE; SILICON DIOXIDE;

EID: 43249125839     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1156995     Document Type: Article

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28. -/- mice. This work was supported by a NIH Program Project grant from the National Heart Lung and Blood Institute (P01HL67004) to B.T.M. and a grant for work in molecular oncology from the Commission for Technology and Innovation, National Centers of Competence in Research (CTI, NCCR), Switzerland, to J.T. and a MUGEN grant to J.T. C.D. is supported by an EMBO long-term fellowship, V.P. is supported by a Marie Curie Intra-European Fellowship.