NLRP3 activation and mitosis are mutually exclusive events coordinated by NEK7, a new inflammasome component

Nature Immunology

Volumn 17, Issue 3, 2016, Pages 250-258

  Shi, Hexin ^a   Wang, Ying ^a   Li, Xiaohong ^a   Zhan, Xiaoming ^a   Tang, Miao ^a   Fina, Maggy ^a   Su, Lijing ^a   Pratt, David ^a   Hui Bu, Chun ^a   Hildebrand, Sara ^a   Lyon, Stephen ^a   Scott, Lindsay ^a   Quan, Jiexia ^a   Sun, Qihua ^a   Russell, Jamie ^a   Arnett, Stephanie ^a   Jurek, Peter ^a   Chen, Ding ^a   Kravchenko, Vladimir V ^b   Mathison, John C ^b   Moresco, Eva Marie Y ^a   Monson, Nancy L ^a   Ulevitch, Richard J ^b   Beutler, Bruce ^a   more..

^a UNIVERSITY OF TEXAS AT DALLAS   (United States)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 18; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; INTERLEUKIN 6; PROTEIN NEK7; PROTEIN SERINE THREONINE KINASE; REACTIVE OXYGEN METABOLITE; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; UNCLASSIFIED DRUG; URATE; APOPTOSIS REGULATORY PROTEIN; CARRIER PROTEIN; CYTOKINE; CYTOSKELETON PROTEIN; NEK7 PROTEIN, HUMAN; NEK7 PROTEIN, MOUSE; NIMA RELATED KINASE; NLRP3 PROTEIN, HUMAN; NLRP3 PROTEIN, MOUSE; PYCARD PROTEIN, HUMAN; PYCARD PROTEIN, MOUSE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPERIMENTAL ALLERGIC ENCEPHALITIS; FEMALE; GENETIC ANALYSIS; INFLAMMATION; INTERPHASE; MALE; MITOCHONDRION; MITOSIS; MOUSE; NONHUMAN; OLIGOMERIZATION; PERITONEUM MACROPHAGE; PRIORITY JOURNAL; PROTEIN ASSEMBLY; PROTEIN BINDING; PROTEIN DOMAIN; ANIMAL; APOPTOSIS; C57BL MOUSE; CFU COUNTING; DENDRITIC CELL; EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS; FLOW CYTOMETRY; GENETICS; HEK293 CELL LINE; HUMAN; IMMUNOLOGY; IMMUNOPRECIPITATION; IN VITRO STUDY; KNOCKOUT MOUSE; MACROPHAGE; METABOLISM; MONOCYTE; SIZE EXCLUSION CHROMATOGRAPHY; SPINAL CORD;

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CARRIER PROTEINS; CASPASE 1; CHROMATOGRAPHY, GEL; COLONY-FORMING UNITS ASSAY; CYTOKINES; CYTOSKELETAL PROTEINS; DENDRITIC CELLS; ENCEPHALOMYELITIS, AUTOIMMUNE, EXPERIMENTAL; FEMALE; FLOW CYTOMETRY; HEK293 CELLS; HUMANS; IMMUNOPRECIPITATION; IN VITRO TECHNIQUES; INFLAMMASOMES; MACROPHAGES; MACROPHAGES, PERITONEAL; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MITOCHONDRIA; MITOSIS; MONOCYTES; NIMA-RELATED KINASES; NLR FAMILY, PYRIN DOMAIN-CONTAINING 3 PROTEIN; PROTEIN-SERINE-THREONINE KINASES; REACTIVE OXYGEN SPECIES; SPINAL CORD;

EID: 84949595485     PISSN: 15292908     EISSN: 15292916     Source Type: Journal    
DOI: 10.1038/ni.3333     Document Type: Article

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