Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death

Nature

Volumn 526, Issue 7575, 2015, Pages 660-665

  Shi, Jianjin ^a,b   Zhao, Yue ^b   Wang, Kun ^b   Shi, Xuyan ^b   Wang, Yue ^b   Huang, Huanwei ^b   Zhuang, Yinghua ^b   Cai, Tao ^b   Wang, Fengchao ^b   Shao, Feng ^b,c  

^a PEKING UNIVERSITY   (China)

^b NATIONAL INSTITUTE OF BIOLOGICAL SCIENCES   (China)

^c INSTITUTE OF BIOPHYSICS   (China)

Author keywords

[No Author keywords available]

Indexed keywords

CASPASE 11; CASPASE 4; CASPASE 5; CRISPR ASSOCIATED PROTEIN; GASDERMIN D; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; LIPOPOLYSACCHARIDE; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; CASPASE; GSDMA3 PROTEIN, MOUSE; GSDMD PROTEIN, HUMAN; GSDMD PROTEIN, MOUSE; PROTEIN; TUMOR PROTEIN;

AMINO ACID; APOPTOSIS; CELLS AND CELL COMPONENTS; DEFENSE MECHANISM; ENZYME ACTIVITY; GENOME; IMMUNITY; INHIBITION; INNATE BEHAVIOR; LIGAND; MUTATION; POLYSACCHARIDE; PROTEIN; RODENT; SKIN DISORDER;

ANIMAL CELL; ANIMAL EXPERIMENT; APOPTOSIS; ARTICLE; CELL AGING, CELL DEGENERATION AND CELL SURVIVAL; CELL DAMAGE; CELL DEATH; CYTOKINE RELEASE; MACROPHAGE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PYROPTOSIS; ANIMAL; ANTAGONISTS AND INHIBITORS; C57BL MOUSE; CELL LINE; CHEMISTRY; CRISPR CAS SYSTEM; DEFICIENCY; DRUG EFFECTS; ENZYME SPECIFICITY; ENZYMOLOGY; GENETICS; HUMAN; INFLAMMATION; MALE; METABOLISM; NECROSIS; PROTEIN PROCESSING; PROTEIN TERTIARY STRUCTURE; SECRETION (PROCESS);

BACTERIA (MICROORGANISMS);

ANIMALS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; CASPASE 1; CASPASES; CELL LINE; CRISPR-CAS SYSTEMS; HUMANS; INFLAMMASOMES; INFLAMMATION; INTERLEUKIN-1BETA; LIPOPOLYSACCHARIDES; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; NECROSIS; NEOPLASM PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEINS; SUBSTRATE SPECIFICITY;

EID: 84942892037     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/nature15514     Document Type: Article

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