Autolytic proteolysis within the function to find domain (FIIND) is required for NLRP1 inflammasome activity

Journal of Biological Chemistry

Volumn 287, Issue 30, 2012, Pages 25030-25037

  Finger, Joshua N ^a   Lich, John D ^a   Dare, Lauren C ^a   Cook, Michael N ^a   Brown, Kristin K ^a   Duraiswamis, Chaya ^a   Bertin, John J ^a   Gough, Peter J ^a  

^a GLAXOSMITHKLINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CROHN DISEASE; DANGER SIGNALS; HUMAN DISEASE; HUMAN PATHOLOGIES; INFLAMMASOME; LEUCINE-RICH REPEATS; MOLECULAR PATHWAYS; NATURALLY OCCURRING; NUCLEOTIDE-BINDING DOMAIN; RHEUMATOID ARTHRITIS; SEQUENCE VARIATIONS; SINGLE NUCLEOTIDE POLYMORPHISMS; SPLICE VARIANTS;

AMINO ACIDS; GENES; NUCLEOTIDES;

PATHOLOGY;

BINDING PROTEIN; CASPASE RECRUITMENT DOMAIN PROTEIN; FUNCTION TO FIND DOMAIN; HISTIDINE; INFLAMMASOME; INTERLEUKIN 1BETA; MESSENGER RNA; PROTEIN NLRP1; SERINE; UNCLASSIFIED DRUG;

ALTERNATIVE RNA SPLICING; ARTICLE; AUTOLYSIS; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CROHN DISEASE; CYTOKINE PRODUCTION; CYTOKINE RELEASE; DISEASE ASSOCIATION; EXON; GENE; GENE SEQUENCE; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INFLAMMATION; INFLAMMATORY DISEASE; NLR GENE; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; RESIDUE ANALYSIS; RHEUMATOID ARTHRITIS; SIGNAL TRANSDUCTION; SINGLE NUCLEOTIDE POLYMORPHISM; VITILIGO;

ADAPTOR PROTEINS, SIGNAL TRANSDUCING; APOPTOSIS REGULATORY PROTEINS; HEK293 CELLS; HUMANS; IMMUNITY, INNATE; INFLAMMASOMES; POLYMORPHISM, SINGLE NUCLEOTIDE; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, TERTIARY; PROTEOLYSIS;

EID: 84864110446     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M112.378323     Document Type: Article

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