Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions

Science Translational Medicine

Volumn 3, Issue 82, 2011, Pages

  Dombrowski, Yvonne ^a   Peric, Mark ^a   Koglin, Sarah ^a   Kammerbauer, Claudia ^a   Göß, Christine ^a   Anz, David ^a   Simanski, Maren ^b   Gläser, Regine ^b   Harder, Jürgen ^b   Hornung, Veit ^c   Gallo, Richard L ^d   Ruzicka, Thomas ^a   Besch, Robert ^a   Schauber, Jürgen ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^c UNIVERSITY OF BONN   (Germany)

^d San Diego   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CATHELICIDIN ANTIMICROBIAL PEPTIDE LL 37; CYTOSOLIC DNA; DNA; GAMMA INTERFERON; INFLAMMASOME; INTERLEUKIN 1BETA; PROTEIN AIM2; UNCLASSIFIED DRUG; AIM2 PROTEIN, HUMAN; ANTIMICROBIAL PEPTIDE LL-37; CATHELICIDIN; NUCLEAR PROTEIN;

ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; HUMAN CELL; HUMAN TISSUE; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN INTERACTION; PSORIASIS; BIOSYNTHESIS; CYTOSOL; METABOLISM; PATHOLOGY; PROTEIN BINDING;

CATHELICIDINS; CYTOSOL; DNA; HUMANS; INFLAMMASOMES; INTERLEUKIN-1BETA; KERATINOCYTES; NUCLEAR PROTEINS; PROTEIN BINDING; PSORIASIS;

EID: 79955897768     PISSN: 19466234     EISSN: 19466242     Source Type: Journal    
DOI: 10.1126/scitranslmed.3002001     Document Type: Article

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34. Acknowledgments: We thank R. Wolf for provision of S100 peptides and V. Marcos and D. Hartl for excellent technical assistance. Funding: This study was funded by the Deutsche Forschungsgemeinschaft (Emmy Noether Program SCHA 979/3-1 to J.S. and GK 1202 to R.B. and Heisenberg program HA 3386/3-2 and HA 3386/5-1 to J.H.), the Fritz Thyssen Stiftung and the FoeFoLe program of the Ludwig-Maximilian-University (Munich) to J.S., and the German Cancer Aid (Deutsche Krebshilfe) and Dr. Mildred Scheel Foundation grants 107805 and 109218 to R.B. Author contributions: Y.D. and M.P. designed and performed the experiments, analyzed the data, and wrote the paper. S.K. performed the experiments and analyzed the data. C.K., C.G., and D.A. performed the experiments. M.S., R.G., J.H., T.R., and R.L.G. designed and performed the experiments and provided vital new reagents and samples. V.H. provided vital new reagents and samples. R.B. and J.S. designed the experiments, analyzed the data, and wrote the paper. Competing interests: The authors declare that they have no competing interests.