A CRISPR path to engineering new genetic mouse models for cardiovascular research

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 6, 2016, Pages 1058-1075

  Miano, Joseph M ^a   Zhu, Qiuyu Martin ^a,b   Lowenstein, Charles J ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b MASSACHUSETTS GENERAL HOSPITAL   (United States)

Author keywords

epitope; frameshift mutation; genetics; genome editing; genotype; nucleotide

Indexed keywords

CAS9 ENZYME; ENDONUCLEASE; EPITOPE; RNA; SINGLE GUIDED RNA; UNCLASSIFIED DRUG; CRISPR ASSOCIATED PROTEIN;

ALLELE; CARDIOVASCULAR DISEASE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DISEASE MODEL; DNA MODIFICATION; FRAMESHIFT MUTATION; GENE DELETION; GENETIC ENGINEERING; GENOME; GENOTYPE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROKARYOTE; REVIEW; ANIMAL; CARDIOVASCULAR DISEASES; CRISPR CAS SYSTEM; GENE EDITING; GENE EXPRESSION REGULATION; GENE THERAPY; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MOSAICISM; PATHOPHYSIOLOGY; PHENOTYPE; PROCEDURES;

ANIMALS; CARDIOVASCULAR DISEASES; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DISEASE MODELS, ANIMAL; GENE EDITING; GENE EXPRESSION REGULATION; GENETIC THERAPY; GENOTYPE; HUMANS; MICE; MICE, KNOCKOUT; MOSAICISM; PHENOTYPE;

EID: 84964226757     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.304790     Document Type: Review

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