Functional validation of mouse tyrosinase non-coding regulatory DNA elements by CRISPR-Cas9-mediated mutagenesis

Nucleic Acids Research

Volumn 43, Issue 10, 2015, Pages 4855-4867

  Seruggia, Davide ^a,b   Fernández, Almudena ^a,b   Cantero, Marta ^a,b   Pelczar, Pawel ^c,d   Montoliu, Lluis ^a,b  

^a CENTRO NACIONAL DE BIOTECNOLOGÍA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

^c UNIVERSITY OF ZURICH   (Switzerland)

^d UNIVERSITY OF BASEL   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

MONOPHENOL MONOOXYGENASE; CRISPR ASSOCIATED PROTEIN; DEOXYRIBONUCLEASE;

5' UNTRANSLATED REGION; ADULT; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA FLANKING REGION; DNA FRAGMENTATION; GENE DELETION; GENE EXPRESSION PROFILING; GENE INACTIVATION; GENE SEQUENCE; IN VITRO STUDY; IN VIVO STUDY; INSULATOR ELEMENT; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; REGULATORY SEQUENCE; TYR GENE; VALIDATION STUDY; ANIMAL; CHROMOSOME INVERSION; DOUBLE STRANDED DNA BREAK; GENETICS; METABOLISM; PIGMENTATION; TRANSGENIC MOUSE;

MUS;

ANIMALS; CHROMOSOME INVERSION; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DEOXYRIBONUCLEASES; DNA BREAKS, DOUBLE-STRANDED; INSULATOR ELEMENTS; MICE; MICE, TRANSGENIC; MONOPHENOL MONOOXYGENASE; MUTAGENESIS; PIGMENTATION; SEQUENCE DELETION;

EID: 84931291783     PISSN: 03051048     EISSN: 13624962     Source Type: Journal    
DOI: 10.1093/nar/gkv375     Document Type: Article

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