CRISPR/Cas9-mediated heterozygous knockout of the autism gene CHD8 and characterization of its transcriptional networks in neurodevelopment

Molecular Autism

Volumn 6, Issue 1, 2015, Pages

  Wang, Ping ^a   Lin, Mingyan ^a   Pedrosa, Erika ^a   Hrabovsky, Anastasia ^a   Zhang, Zheng ^a   Guo, Wenjun ^a   Lachman, Herbert M ^a   Zheng, Deyou ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

ASD; Autism; CHD8; CRISPR Cas9; Induced pluripotent stem cells; iPSC; Macrocephaly; Neurodevelopment; RNA seq; Schizophrenia

Indexed keywords

BETA CATENIN; WNT PROTEIN;

ARTICLE; AUTISM; BONE DEVELOPMENT; BRAIN SIZE; CEPHALOMETRY; CHD8 GENE; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; EXTRACELLULAR MATRIX; GENE; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENETIC ASSOCIATION; GENETIC TRANSCRIPTION; HEMIZYGOSITY; HUMAN; HUMAN CELL; MACROCEPHALY; MALE; NERVE CELL DIFFERENTIATION; NEURAL STEM CELL; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; SCHIZOPHRENIA;

EID: 84944382599     PISSN: None     EISSN: 20402392     Source Type: Journal    
DOI: 10.1186/s13229-015-0048-6     Document Type: Article

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