One-step generation of mice carrying mutations in multiple genes by CRISPR/cas-mediated genome engineering

Cell

Volumn 153, Issue 4, 2013, Pages 910-918

  Wang, Haoyi ^a   Yang, Hui ^a   Shivalila, Chikdu S ^a,b   Dawlaty, Meelad M ^a   Cheng, Albert W ^a,b   Zhang, Feng ^c,d   Jaenisch, Rudolf ^a,b  

^a WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLULAR APOPTOSIS SUSCEPTIBILITY PROTEIN; MESSENGER RNA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; EMBRYONIC STEM CELL; GENE DISRUPTION; GENE INTERACTION; GENE MUTATION; GENE TARGETING; GENETIC ENGINEERING; GENOME; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALIA; MUS;

EID: 84877707375     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2013.04.025     Document Type: Article

References (34)

1. A.J. Bogdanove, and D.F. Voytas TAL effectors: customizable proteins for DNA targeting Science 333 2011 1843 1846
2. M.R. Capecchi Gene targeting in mice: functional analysis of the mammalian genome for the twenty-first century Nat. Rev. Genet. 6 2005 507 512
3. I.D. Carbery, D. Ji, A. Harrington, V. Brown, E.J. Weinstein, L. Liaw, and X. Cui Targeted genome modification in mice using zinc-finger nucleases Genetics 186 2010 451 459
4. D. Carroll, K.J. Beumer, J.J. Morton, A. Bozas, and J.K. Trautman Gene targeting in Drosophila and Caenorhabditis elegans with zinc-finger nucleases Methods Mol. Biol. 435 2008 63 77
5. N. Chang, C. Sun, L. Gao, D. Zhu, X. Xu, X. Zhu, J.W. Xiong, and J.J. Xi Genome editing with RNA-guided Cas9 nuclease in Zebrafish embryos Cell Res. 23 2013 465 472
6. F. Chen, S.M. Pruett-Miller, Y. Huang, M. Gjoka, K. Duda, J. Taunton, T.N. Collingwood, M. Frodin, and G.D. Davis High-frequency genome editing using ssDNA oligonucleotides with zinc-finger nucleases Nat. Methods 8 2011 753 755
7. S.W. Cho, S. Kim, J.M. Kim, and J.S. Kim Targeted genome engineering in human cells with the Cas9 RNA-guided endonuclease Nat. Biotechnol. 31 2013 230 232
8. L. Cong, F.A. Ran, D. Cox, S. Lin, R. Barretto, N. Habib, P.D. Hsu, X. Wu, W. Jiang, L.A. Marraffini, and F. Zhang Multiplex genome engineering using CRISPR/Cas systems Science 339 2013 819 823
9. N.G. Copeland, and N.A. Jenkins Harnessing transposons for cancer gene discovery Nat. Rev. Cancer 10 2010 696 706
10. X. Cui, D. Ji, D.A. Fisher, Y. Wu, D.M. Briner, and E.J. Weinstein Targeted integration in rat and mouse embryos with zinc-finger nucleases Nat. Biotechnol. 29 2011 64 67
11. M.M. Dawlaty, K. Ganz, B.E. Powell, Y.C. Hu, S. Markoulaki, A.W. Cheng, Q. Gao, J. Kim, S.W. Choi, D.C. Page, and R. Jaenisch Tet1 is dispensable for maintaining pluripotency and its loss is compatible with embryonic and postnatal development Cell Stem Cell 9 2011 166 175
12. M.M. Dawlaty, A. Breiling, T. Le, G. Raddatz, M.I. Barrasa, A.W. Cheng, Q. Gao, B.E. Powell, Z. Li, and M. Xu Combined deficiency of Tet1 and Tet2 causes epigenetic abnormalities but is compatible with postnatal development Dev. Cell 24 2013 310 323
13. G. Gasiunas, R. Barrangou, P. Horvath, and V. Siksnys Cas9-crRNA ribonucleoprotein complex mediates specific DNA cleavage for adaptive immunity in bacteria Proc. Natl. Acad. Sci. USA 109 2012 E2579 E2586
14. A.M. Geurts, G.J. Cost, Y. Freyvert, B. Zeitler, J.C. Miller, V.M. Choi, S.S. Jenkins, A. Wood, X. Cui, and X. Meng Knockout rats via embryo microinjection of zinc-finger nucleases Science 325 2009 433
15. T.P. Gu, F. Guo, H. Yang, H.P. Wu, G.F. Xu, W. Liu, Z.G. Xie, L. Shi, X. He, and S.G. Jin The role of Tet3 DNA dioxygenase in epigenetic reprogramming by oocytes Nature 477 2011 606 610
16. D.Y. Guschin, A.J. Waite, G.E. Katibah, J.C. Miller, M.C. Holmes, and E.J. Rebar A rapid and general assay for monitoring endogenous gene modification Methods Mol. Biol. 649 2010 247 256
17. P. Horvath, and R. Barrangou CRISPR/Cas, the immune system of bacteria and archaea Science 327 2010 167 170
18. W.Y. Hwang, Y. Fu, D. Reyon, M.L. Maeder, S.Q. Tsai, J.D. Sander, R.T. Peterson, J.R. Yeh, and J.K. Joung Efficient genome editing in zebrafish using a CRISPR-Cas system Nat. Biotechnol. 31 2013 227 229
19. W. Jiang, D. Bikard, D. Cox, F. Zhang, and L.A. Marraffini RNA-guided editing of bacterial genomes using CRISPR-Cas systems Nat. Biotechnol. 31 2013 233 239
20. M. Jinek, K. Chylinski, I. Fonfara, M. Hauer, J.A. Doudna, and E. Charpentier A programmable dual-RNA-guided DNA endonuclease in adaptive bacterial immunity Science 337 2012 816 821
21. J. Kool, and A. Berns High-throughput insertional mutagenesis screens in mice to identify oncogenic networks Nat. Rev. Cancer 9 2009 389 399
22. Z. Li, X. Cai, C.L. Cai, J. Wang, W. Zhang, B.E. Petersen, F.C. Yang, and M. Xu Deletion of Tet2 in mice leads to dysregulated hematopoietic stem cells and subsequent development of myeloid malignancies Blood 118 2011 4509 4518
23. P. Mali, L. Yang, K.M. Esvelt, J. Aach, M. Guell, J.E. DiCarlo, J.E. Norville, and G.M. Church RNA-guided human genome engineering via Cas9 Science 339 2013 823 826
24. M. McVey, and S.E. Lee MMEJ repair of double-strand breaks (director's cut): deleted sequences and alternative endings Trends Genet. 24 2008 529 538
25. M. Meyer, M.H. de Angelis, W. Wurst, and R. Kühn Gene targeting by homologous recombination in mouse zygotes mediated by zinc-finger nucleases Proc. Natl. Acad. Sci. USA 107 2010 15022 15026
26. K. Moran-Crusio, L. Reavie, A. Shih, O. Abdel-Wahab, D. Ndiaye-Lobry, C. Lobry, M.E. Figueroa, A. Vasanthakumar, J. Patel, and X. Zhao Tet2 loss leads to increased hematopoietic stem cell self-renewal and myeloid transformation Cancer Cell 20 2011 11 24
27. B. Shen, J. Zhang, H. Wu, J. Wang, K. Ma, Z. Li, X. Zhang, P. Zhang, and X. Huang Generation of gene-modified mice via Cas9/RNA-mediated gene targeting Cell Res. 2013 in press. Published online April 2, 2013
28. F. Soldner, J. Laganière, A.W. Cheng, D. Hockemeyer, Q. Gao, R. Alagappan, V. Khurana, L.I. Golbe, R.H. Myers, and S. Lindquist Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations Cell 146 2011 318 331
29. Y.H. Sung, I.J. Baek, D.H. Kim, J. Jeon, J. Lee, K. Lee, D. Jeong, J.S. Kim, and H.W. Lee Knockout mice created by TALEN-mediated gene targeting Nat. Biotechnol. 31 2013 23 24
30. L.S. Symington, and J. Gautier Double-strand break end resection and repair pathway choice Annu. Rev. Genet. 45 2011 247 271
31. L. Tesson, C. Usal, S. Ménoret, E. Leung, B.J. Niles, S. Remy, Y. Santiago, A.I. Vincent, X. Meng, and L. Zhang Knockout rats generated by embryo microinjection of TALENs Nat. Biotechnol. 29 2011 695 696
32. F.D. Urnov, E.J. Rebar, M.C. Holmes, H.S. Zhang, and P.D. Gregory Genome editing with engineered zinc finger nucleases Nat. Rev. Genet. 11 2010 636 646
33. B. Wefers, M. Meyer, O. Ortiz, M. Hrabé de Angelis, J. Hansen, W. Wurst, and R. Kühn Direct production of mouse disease models by embryo microinjection of TALENs and oligodeoxynucleotides Proc. Natl. Acad. Sci. USA 110 2013 3782 3787
34. B. Wiedenheft, S.H. Sternberg, and J.A. Doudna RNA-guided genetic silencing systems in bacteria and archaea Nature 482 2012 331 338