CRISPR-Cas9 targeting of PCSK9 in human hepatocytes in vivo - Brief report

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 36, Issue 5, 2016, Pages 783-786

  Wang, Xiao ^a   Raghavan, Avanthi ^a   Chen, Tao ^a   Qiao, Lyon ^a   Zhang, Yongxian ^b   Ding, Qiurong ^b   Musunuru, Kiran ^a,c,d  

^a HARVARD UNIVERSITY   (United States)

^b Chinese Academy of Sciences   (China)

^c BRIGHAM AND WOMEN S HOSPITAL   (United States)

^d BROAD INSTITUTE OF MIT AND HARVARD   (United States)

Author keywords

gene therapy; liver; molecular biology; mutagenesis; subtilisins

Indexed keywords

KEXIN; PROPROTEIN CONVERTASE SUBTILISIN KEXIN TYPE 9; SUBTILISIN; UNCLASSIFIED DRUG; CRISPR ASSOCIATED PROTEIN; DNA BINDING PROTEIN; FUMARYLACETOACETASE; HYDROLASE; IL2RG PROTEIN, MOUSE; INTERLEUKIN 2 RECEPTOR GAMMA; PCSK9 PROTEIN, HUMAN; PROPROTEIN CONVERTASE 9; RAG2 PROTEIN, MOUSE;

ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; ENZYME BLOOD LEVEL; HUMAN; HUMAN CELL; IN VIVO GENE TRANSFER; IN VIVO STUDY; LIVER CELL; MOUSE; MUTAGENESIS; NONHUMAN; PRIORITY JOURNAL; ANIMAL; BIOSYNTHESIS; BLOOD; C57BL MOUSE; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DEFICIENCY; DOWN REGULATION; ENZYMOLOGY; GENE EDITING; GENE TARGETING; GENETICS; GENOTYPE; KNOCKOUT MOUSE; METABOLISM; MUTATION; PROCEDURES; TRANSPLANTATION;

ANIMALS; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-ASSOCIATED PROTEINS; CRISPR-CAS SYSTEMS; DNA-BINDING PROTEINS; DOWN-REGULATION; GENE EDITING; GENE TARGETING; GENOTYPE; HEPATOCYTES; HUMANS; HYDROLASES; INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MUTATION; PROPROTEIN CONVERTASE 9;

EID: 84960192799     PISSN: 10795642     EISSN: 15244636     Source Type: Journal    
DOI: 10.1161/ATVBAHA.116.307227     Document Type: Article

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