Dynamics of CRISPR-Cas9 genome interrogation in living cells

Science

Volumn 350, Issue 6262, 2015, Pages 823-826

  Knight, Spencer C ^a   Xie, Liangqi ^a   Deng, Wulan ^b   Guglielmi, Benjamin ^a   Witkowsky, Lea B ^a   Bosanac, Lana ^a   Zhang, Elisa T ^a   Beheiry, Mohamed E ^c   Masson, Jean Baptiste ^b   Dahan, Maxime ^b,c   Liu, Zhe ^b   Doudna, Jennifer A ^a,d   Tjian, Robert ^a,b  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^c CNRS   (France)

^d LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CRISPR ASSOCIATED PROTEIN; CRISPR ASSOCIATED PROTEIN 9; DOUBLE STRANDED DNA; HETEROCHROMATIN PROTEIN 1; UNCLASSIFIED DRUG; BACTERIAL PROTEIN; CAS9 PROTEIN, FRANCISELLA NOVICIDA; CHROMATIN; ENDONUCLEASE;

CELLS AND CELL COMPONENTS; GENETIC ANALYSIS; GENOME; PROTEIN; RNA;

ANIMAL CELL; ANISOTROPY; ARTICLE; CELL NUCLEUS; CHROMATIN IMMUNOPRECIPITATION; CONTROLLED STUDY; CRISPR CAS SYSTEM; CRISPR CAS9 SYSTEM; DIFFUSION COEFFICIENT; HETEROCHROMATIN; INTERACTIONS WITH DNA; MAMMAL CELL; NONHUMAN; PRIORITY JOURNAL; RNA EDITING; STREPTOCOCCUS PYOGENES; TRANSCRIPTION REGULATION; 3T3 CELL LINE; ANIMAL; CHEMISTRY; CHROMATIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; DNA CLEAVAGE; GENETIC ENGINEERING; GENOME; METABOLISM; MOUSE; SINGLE CELL ANALYSIS; ULTRASTRUCTURE;

BACTERIA (MICROORGANISMS); EUKARYOTA; MAMMALIA;

3T3 CELLS; ANIMALS; BACTERIAL PROTEINS; CHROMATIN; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; CRISPR-CAS SYSTEMS; DNA CLEAVAGE; ENDONUCLEASES; GENETIC ENGINEERING; GENOME; MICE; SINGLE-CELL ANALYSIS;

EID: 84946919064     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.aac6572     Document Type: Article

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