Prevention of muscular dystrophy in mice by CRISPR/Cas9-mediated editing of germline DNA

Science

Volumn , Issue 6201, 2014, Pages 1184-1188

  Long, Chengzu ^a   McAnally, John R ^a   Shelton, John M ^b   Mireault, Alex A ^a   Bassel Duby, Rhonda ^a   Olson, Eric N ^a  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; CASPASE 9; DYSTROPHIN;

DNA; GENE EXPRESSION; GENOME; GERMPLASM; MUSCLE; MUTATION; PROTEIN; RODENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CRISPR CAS SYSTEM; DNA CLEAVAGE; DNA END JOINING REPAIR; DNA MODIFICATION; DUCHENNE MUSCULAR DYSTROPHY; EMBRYO DEVELOPMENT; EXON; FIBROSING ALVEOLITIS; GERM LINE; GERMLINE MUTATION; HEART; HOMOLOGOUS RECOMBINATION; IMMUNOHISTOCHEMISTRY; INDEL MUTATION; MOSAICISM; MOUSE; MUSCLE FUNCTION; NONHUMAN; NUCLEIC ACID STRUCTURE, METABOLISM AND FUNCTION; PHENOTYPE; POINT MUTATION; PRIORITY JOURNAL; PROGENY; RESTRICTION FRAGMENT LENGTH POLYMORPHISM; SKELETAL MUSCLE; SOMATIC CELL; STOP CODON; TUMOR GROWTH; WESTERN BLOTTING; ANIMAL; GENE TARGETING; GENE THERAPY; GENETICS; GERM CELL; METHODOLOGY; PATHOLOGY; X CHROMOSOME LINKED MUSCULAR DYSTROPHIC MOUSE;

ANIMALIA; MUS;

ANIMALS; CASPASE 9; CRISPR-CAS SYSTEMS; DNA; DYSTROPHIN; EXONS; GENE TARGETING; GENETIC THERAPY; GERM CELLS; MICE; MICE, INBRED MDX; MUSCLE, SKELETAL; MUSCULAR DYSTROPHY, DUCHENNE;

EID: 84907200149     PISSN: 00368075     EISSN: 10959203     Source Type: Journal    
DOI: 10.1126/science.1254445     Document Type: Article

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