Somatic mosaicism and allele complexity induced by CRISPR/Cas9 RNA injections in mouse zygotes

Developmental Biology

Volumn 393, Issue 1, 2014, Pages 3-9

  Yen, Shuo Ting ^a,b   Zhang, Min ^a   Deng, Jian Min ^b   Usman, Shireen J ^b   Smith, Chad N ^b   Parker Thornburg, Jan ^b   Swinton, Paul G ^c   Martin, James F ^a,c   Behringer, Richard R ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

^c TEXAS HEART INSTITUTE   (United States)

Author keywords

Gene targeting; Genome editing; Knockout; Melanocyte; Mosaic; Pigmentation

Indexed keywords

CAS9 PROTEIN; CRISPR ASSOCIATED PROTEIN; MESSENGER RNA; PEPTIDES AND PROTEINS; UNCLASSIFIED DRUG;

ALLELE; AMINO ACID SUBSTITUTION; ARTICLE; CARBOXY TERMINAL SEQUENCE; CAS9 GENE; CONTROLLED STUDY; EMBRYO; EXON; FEMALE; GENE; GENE LOCUS; GENE MUTATION; GENE SEQUENCE; GENE TARGETING; GENOTYPE; GENOTYPING TECHNIQUE; GERM LINE; IN VITRO STUDY; MALE; MOSAICISM; MOUSE; MUTAGENESIS; NONHUMAN; PHENOTYPE; PIGMENTATION; PRIORITY JOURNAL; SEQUENCE ANALYSIS; SOMATIC MOSAICISM; TYR4A GENE; TYR4B GENE; ZYGOTE;

ANIMALIA; MUS;

GENE TARGETING; GENOME EDITING; KNOCKOUT; MELANOCYTE; MOSAIC; PIGMENTATION;

ALBINISM; ALLELES; ANIMALS; BASE SEQUENCE; CASPASE 9; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEATS; FEMALE; GENE TARGETING; GENETIC ENGINEERING; HIGH-THROUGHPUT NUCLEOTIDE SEQUENCING; MALE; MELANINS; MICE; MICE, INBRED C57BL; MONOPHENOL MONOOXYGENASE; MOSAICISM; MUTAGENESIS; MUTATION; PIGMENTATION; RNA, GUIDE; RNA, MESSENGER; SEQUENCE ANALYSIS, DNA; ZYGOTE;

EID: 84905732049     PISSN: 00121606     EISSN: 1095564X     Source Type: Journal    
DOI: 10.1016/j.ydbio.2014.06.017     Document Type: Article

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