Megabase-scale deletion using CRISPR/Cas9 to generate a fully haploid human cell line

Genome Research

Volumn 24, Issue 12, 2014, Pages 2059-2065

  Essletzbichler, Patrick ^a   Konopka, Tomasz ^b   Santoro, Federica ^a,d   Chen, Doris ^b   Gapp, Bianca V ^b   Kralovics, Robert ^b   Brummelkamp, Thijn R ^b,c   Nijman, Sebastian M B ^a,b   Bürckstümmer, Tilmann ^a  

^a Haplogen GmbH   (Austria)

^b ERICH SCHMID INSTITUTE OF MATERIALS SCIENCE   (Austria)

^c NETHERLANDS CANCER INSTITUTE   (Netherlands)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CAS9 ENZYME; ENDONUCLEASE; TRANSCRIPTOME; UNCLASSIFIED DRUG;

ARTICLE; CHROMOSOME 15; CHROMOSOME 19; CHROMOSOME ABERRATION; CHROMOSOME DELETION; CLUSTERED REGULARLY INTERSPACED SHORT PALINDROMIC REPEAT; CONTROLLED STUDY; FEASIBILITY STUDY; GENE SEQUENCE; GENETIC ENGINEERING; GENOTYPE; HAPLOIDY; HUMAN; HUMAN CELL; HUMAN GENOME; MOLECULAR CLONING; SINGLE NUCLEOTIDE POLYMORPHISM; SPECTRAL KARYOTYPING; CELL LINE; CRISPR CAS SYSTEM; GENE DELETION; GENE EXPRESSION PROFILING; GENETICS; GENOMICS; KARYOTYPE; PROCEDURES;

CELL LINE; CRISPR-CAS SYSTEMS; GENE EXPRESSION PROFILING; GENETIC ENGINEERING; GENOMICS; HAPLOIDY; HUMANS; KARYOTYPE; SEQUENCE DELETION;

EID: 84913530543     PISSN: 10889051     EISSN: 15495469     Source Type: Journal    
DOI: 10.1101/gr.177220.114     Document Type: Article

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