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Volumn 106, Issue , 2016, Pages 337-354

Lipid-based nanocarriers for oral peptide delivery

Author keywords

Lipid formulation; Liposome; Nano microemulsion; Nanocapsule; Oral delivery; Peptide drug; Self emulsifying system; Solid lipid nanoparticle

Indexed keywords

COMMERCIAL VEHICLES; EMULSIFICATION; LIPOSOMES; NANOCAPSULES; PARTICLE SIZE; PARTICLE SIZE ANALYSIS; PROTEINS;

EID: 84963954616     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2016.04.001     Document Type: Review
Times cited : (222)

References (245)
  • 1
    • 84930947929 scopus 로고    scopus 로고
    • Global Markets and Manufacturing Technologies for Protein Drugs
    • [1] Global Markets and Manufacturing Technologies for Protein Drugs. http://www.bccresearch.com/market-research/biotechnology/protein-drugs-therapeutics-bio021d.html, 2013.
    • (2013)
  • 2
    • 85027386649 scopus 로고    scopus 로고
    • Protein and peptide-Based Therapeutics: Trends in Drug Discovery
    • [2] Protein and peptide-Based Therapeutics: Trends in Drug Discovery, http://www.bionity.com/en/studies/11884/protein-and-peptide-based-therapeutics-trends-in-drug-discovery-and-development.html.
  • 3
    • 39149124830 scopus 로고    scopus 로고
    • Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective
    • [3] Chen, M.L., Lipid excipients and delivery systems for pharmaceutical development: a regulatory perspective. Adv. Drug Deliv. Rev. 60:6 (2008), 768–777.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 768-777
    • Chen, M.L.1
  • 4
    • 79952222504 scopus 로고    scopus 로고
    • Lipid-based colloidal systems (nanoparticles, microemulsions) for drug delivery to the skin: materials and end-product formulations
    • [4] Souto, E.B., Doktorovova, S., Boonme, P., Lipid-based colloidal systems (nanoparticles, microemulsions) for drug delivery to the skin: materials and end-product formulations. J. Drug Deliv. Sci. Technol. 21:1 (2011), 43–54.
    • (2011) J. Drug Deliv. Sci. Technol. , vol.21 , Issue.1 , pp. 43-54
    • Souto, E.B.1    Doktorovova, S.2    Boonme, P.3
  • 5
    • 39149113817 scopus 로고    scopus 로고
    • Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies
    • [5] Pouton, C.W., Porter, C.J., Formulation of lipid-based delivery systems for oral administration: materials, methods and strategies. Adv. Drug Deliv. Rev. 60:6 (2008), 625–637.
    • (2008) Adv. Drug Deliv. Rev. , vol.60 , Issue.6 , pp. 625-637
    • Pouton, C.W.1    Porter, C.J.2
  • 6
    • 34548049221 scopus 로고    scopus 로고
    • Oral lipid-based formulations
    • [6] Hauss, D.J., Oral lipid-based formulations. Adv. Drug Deliv. Rev. 59:7 (2007), 667–676.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.7 , pp. 667-676
    • Hauss, D.J.1
  • 7
    • 84881568861 scopus 로고    scopus 로고
    • Recent developments in oral lipid-based drug delivery
    • [7] Thomas, N., Rades, T., Müllertz, A., Recent developments in oral lipid-based drug delivery. J. Drug Deliv. Sci. Technol. 23:4 (2013), 375–382.
    • (2013) J. Drug Deliv. Sci. Technol. , vol.23 , Issue.4 , pp. 375-382
    • Thomas, N.1    Rades, T.2    Müllertz, A.3
  • 8
    • 84871960343 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery
    • [8] Liu, D., Kobayashi, T., Russo, S., Li, F., Plevy, S.E., Gambling, T.M., et al. In vitro and in vivo evaluation of a water-in-oil microemulsion system for enhanced peptide intestinal delivery. AAPS J. 15:1 (2013), 288–298.
    • (2013) AAPS J. , vol.15 , Issue.1 , pp. 288-298
    • Liu, D.1    Kobayashi, T.2    Russo, S.3    Li, F.4    Plevy, S.E.5    Gambling, T.M.6
  • 9
    • 30644479576 scopus 로고    scopus 로고
    • Lecithin-based microemulsion of a peptide for oral administration: preparation, characterization, and physical stability of the formulation
    • [9] Čilek, A., Čelebi, N., Tirnaksiz, F., Lecithin-based microemulsion of a peptide for oral administration: preparation, characterization, and physical stability of the formulation. Drug Deliv. 13:1 (2006), 19–24.
    • (2006) Drug Deliv. , vol.13 , Issue.1 , pp. 19-24
    • Čilek, A.1    Čelebi, N.2    Tirnaksiz, F.3
  • 10
    • 0002321010 scopus 로고    scopus 로고
    • Chapter 6—plant glycolipids: structure, isolation and analysis
    • C. WW Woodhead Publishing
    • [10] E., H., Chapter 6—plant glycolipids: structure, isolation and analysis. WW, C., (eds.) Advances in Lipid Methodology, 2012, Woodhead Publishing, 211–332.
    • (2012) Advances in Lipid Methodology , pp. 211-332
  • 11
    • 0033805858 scopus 로고    scopus 로고
    • Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems
    • [11] Pouton, C.W., Lipid formulations for oral administration of drugs: non-emulsifying, self-emulsifying and ‘self-microemulsifying’ drug delivery systems. Eur. J. Pharm. Sci. 11:Suppl. 2 (2000), S93–S98.
    • (2000) Eur. J. Pharm. Sci. , vol.11 , pp. S93-S98
    • Pouton, C.W.1
  • 12
    • 84874945035 scopus 로고    scopus 로고
    • Approaches for enhancing oral bioavailability of peptides and proteins
    • [12] Renukuntla, J., Vadlapudi, A.D., Patel, A., Boddu, S.H., Mitra, A.K., Approaches for enhancing oral bioavailability of peptides and proteins. Int. J. Pharm. 447:1-2 (2013), 75–93.
    • (2013) Int. J. Pharm. , vol.447 , Issue.1-2 , pp. 75-93
    • Renukuntla, J.1    Vadlapudi, A.D.2    Patel, A.3    Boddu, S.H.4    Mitra, A.K.5
  • 13
    • 84863588864 scopus 로고    scopus 로고
    • Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression
    • [13] Tuvia, S., Atsmon, J., Teichman, S.L., Katz, S., Salama, P., Pelled, D., et al. Oral octreotide absorption in human subjects: comparable pharmacokinetics to parenteral octreotide and effective growth hormone suppression. J. Clin. Endocrinol. Metab. 97:7 (2012), 2362–2369.
    • (2012) J. Clin. Endocrinol. Metab. , vol.97 , Issue.7 , pp. 2362-2369
    • Tuvia, S.1    Atsmon, J.2    Teichman, S.L.3    Katz, S.4    Salama, P.5    Pelled, D.6
  • 15
    • 81255156925 scopus 로고    scopus 로고
    • Oral delivery of macromolecules: rationale underpinning gastrointestinal permeation enhancement technology (GIPET)
    • [15] Walsh, E.G., Adamczyk, B.E., Chalasani, K.B., Maher, S., O'Toole, E.B., Fox, J.S., et al. Oral delivery of macromolecules: rationale underpinning gastrointestinal permeation enhancement technology (GIPET). Ther. Deliv. 2:12 (2011), 1595–1610.
    • (2011) Ther. Deliv. , vol.2 , Issue.12 , pp. 1595-1610
    • Walsh, E.G.1    Adamczyk, B.E.2    Chalasani, K.B.3    Maher, S.4    O'Toole, E.B.5    Fox, J.S.6
  • 16
    • 85027386277 scopus 로고    scopus 로고
    • Novo Nordisk A/S successfully completes single dose phase 1 trial of a novel oral insulin (NN11956) and oral GLP-1 analogue (NN9928) using Merrion Pharmaceuticals GIPET technology
    • (accessed 09 Sep 2015)
    • [16] Pharma, M., Novo Nordisk A/S successfully completes single dose phase 1 trial of a novel oral insulin (NN11956) and oral GLP-1 analogue (NN9928) using Merrion Pharmaceuticals GIPET technology. http://www.merrionpharma.com/content/investors/archive/2014/290914.asp (accessed 09 Sep 2015), 2014.
    • (2014)
    • Pharma, M.1
  • 17
    • 85027386023 scopus 로고    scopus 로고
    • Clinicaltrials.gov. Trial to Compare NNC0123-0000-0338 in a Tablet Formulation and Insulin Glargine in Subjects with Type 2 Diabetes Currently Treated with Oral Antidiabetic Therapy
    • (last accessed 24 Sep 2015)
    • [17] Clinicaltrials.gov. Trial to Compare NNC0123-0000-0338 in a Tablet Formulation and Insulin Glargine in Subjects with Type 2 Diabetes Currently Treated with Oral Antidiabetic Therapy. https://clinicaltrials.gov/ct2/show/NCT02470039?term=GIPET&rank=5 (last accessed 24 Sep 2015), 2015.
    • (2015)
  • 18
    • 0028033391 scopus 로고
    • Intestinal permeability enhancement: efficacy, acute local toxicity, and reversibility
    • [18] Swenson, E.S., Milsen, W.B., Curtalo, W.J., Intestinal permeability enhancement: efficacy, acute local toxicity, and reversibility. Pharm. Res. 11:8 (1994), 1132–1142.
    • (1994) Pharm. Res. , vol.11 , Issue.8 , pp. 1132-1142
    • Swenson, E.S.1    Milsen, W.B.2    Curtalo, W.J.3
  • 19
    • 85047692219 scopus 로고
    • Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism
    • [19] Aungst, B.J., Novel formulation strategies for improving oral bioavailability of drugs with poor membrane permeation or presystemic metabolism. J. Pharm. Sci. 82:10 (1993), 979–987.
    • (1993) J. Pharm. Sci. , vol.82 , Issue.10 , pp. 979-987
    • Aungst, B.J.1
  • 20
    • 2442671307 scopus 로고    scopus 로고
    • Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo
    • [20] Cornaire, G., Woodley, J., Hermann, P., Cloarec, A., Arellano, C., Houin, G., Impact of excipients on the absorption of P-glycoprotein substrates in vitro and in vivo. Int. J. Pharm. 278:1 (2004), 119–131.
    • (2004) Int. J. Pharm. , vol.278 , Issue.1 , pp. 119-131
    • Cornaire, G.1    Woodley, J.2    Hermann, P.3    Cloarec, A.4    Arellano, C.5    Houin, G.6
  • 21
    • 0034633851 scopus 로고    scopus 로고
    • A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt: fatty acid micellar systems using the Caco-2 cell culture model
    • [21] Meaney, C.M., CM, O.'.D., A comparison of the permeation enhancement potential of simple bile salt and mixed bile salt: fatty acid micellar systems using the Caco-2 cell culture model. Int. J. Pharm. 207:1-2 (2000), 21–30.
    • (2000) Int. J. Pharm. , vol.207 , Issue.1-2 , pp. 21-30
    • Meaney, C.M.1    CM, O.'.D.2
  • 22
    • 81255198647 scopus 로고    scopus 로고
    • Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies
    • [22] Griffin, B.T., O'Driscoll, C.M., Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies. Ther. Deliv. 2:12 (2011), 1633–1653.
    • (2011) Ther. Deliv. , vol.2 , Issue.12 , pp. 1633-1653
    • Griffin, B.T.1    O'Driscoll, C.M.2
  • 24
    • 0027174290 scopus 로고
    • Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route
    • [24] Anderberg, E.K., Lindmark, T., Artursson, P., Sodium caprate elicits dilatations in human intestinal tight junctions and enhances drug absorption by the paracellular route. Pharm. Res. 10:6 (1993), 857–864.
    • (1993) Pharm. Res. , vol.10 , Issue.6 , pp. 857-864
    • Anderberg, E.K.1    Lindmark, T.2    Artursson, P.3
  • 25
    • 0033816196 scopus 로고    scopus 로고
    • Intestinal permeation enhancers
    • [25] Aungst, B.J., Intestinal permeation enhancers. J. Pharm. Sci. 89:4 (2000), 429–442.
    • (2000) J. Pharm. Sci. , vol.89 , Issue.4 , pp. 429-442
    • Aungst, B.J.1
  • 26
    • 0026571249 scopus 로고
    • Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity
    • [26] Swenson, E.S., Curtalo, W.J., Intestinal permeability enhancement for proteins, peptides and other polar drugs: mechanisms and potential toxicity. Adv. Drug Deliv. Rev. 8 (1992), 39–92.
    • (1992) Adv. Drug Deliv. Rev. , vol.8 , pp. 39-92
    • Swenson, E.S.1    Curtalo, W.J.2
  • 27
    • 12344312013 scopus 로고    scopus 로고
    • Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model
    • [27] Lane, M.E., O'Driscoll, C.M., Corrigan, O.I., Quantitative estimation of the effects of bile salt surfactant systems on insulin stability and permeability in the rat intestine using a mass balance model. J. Pharm. Pharmacol. 57:2 (2005), 169–175.
    • (2005) J. Pharm. Pharmacol. , vol.57 , Issue.2 , pp. 169-175
    • Lane, M.E.1    O'Driscoll, C.M.2    Corrigan, O.I.3
  • 28
    • 28244457371 scopus 로고    scopus 로고
    • Delivery of parathyroid hormone for the treatment of osteoporosis
    • [28] Morley, P., Delivery of parathyroid hormone for the treatment of osteoporosis. Expert Opin. Drug Deliv. 2:6 (2005), 993–1002.
    • (2005) Expert Opin. Drug Deliv. , vol.2 , Issue.6 , pp. 993-1002
    • Morley, P.1
  • 29
    • 84876059641 scopus 로고    scopus 로고
    • Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study
    • e59524
    • [29] Eldor, R., Arbit, E., Corcos, A., Kidron, M., Glucose-reducing effect of the ORMD-0801 oral insulin preparation in patients with uncontrolled type 1 diabetes: a pilot study. PLoS One, 8(4), 2013, e59524.
    • (2013) PLoS One , vol.8 , Issue.4
    • Eldor, R.1    Arbit, E.2    Corcos, A.3    Kidron, M.4
  • 30
    • 84925547628 scopus 로고    scopus 로고
    • Formulation strategies to improve oral peptide delivery
    • [30] Maher, S., Ryan, B., Duffy, A., Brayden, D.J., Formulation strategies to improve oral peptide delivery. Pharm. Pat. Anal. 3:3 (2014), 313–336.
    • (2014) Pharm. Pat. Anal. , vol.3 , Issue.3 , pp. 313-336
    • Maher, S.1    Ryan, B.2    Duffy, A.3    Brayden, D.J.4
  • 31
    • 15244353232 scopus 로고    scopus 로고
    • Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells
    • [31] Sha, X., Yan, G., Wu, Y., Li, J., Fang, X., Effect of self-microemulsifying drug delivery systems containing Labrasol on tight junctions in Caco-2 cells. Eur. J. Pharm. Sci. 24:5 (2005), 477–486.
    • (2005) Eur. J. Pharm. Sci. , vol.24 , Issue.5 , pp. 477-486
    • Sha, X.1    Yan, G.2    Wu, Y.3    Li, J.4    Fang, X.5
  • 32
    • 0027173738 scopus 로고
    • Epithelial transport of drugs in cell culture. VIII: effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells
    • [32] Anderberg, E.K., Artursson, P., Epithelial transport of drugs in cell culture. VIII: effects of sodium dodecyl sulfate on cell membrane and tight junction permeability in human intestinal epithelial (Caco-2) cells. J. Pharm. Sci. 82:4 (1993), 392–398.
    • (1993) J. Pharm. Sci. , vol.82 , Issue.4 , pp. 392-398
    • Anderberg, E.K.1    Artursson, P.2
  • 34
    • 71549130146 scopus 로고    scopus 로고
    • Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic
    • [34] Maher, S., Leonard, T.W., Jacobsen, J., Brayden, D.J., Safety and efficacy of sodium caprate in promoting oral drug absorption: from in vitro to the clinic. Adv. Drug Deliv. Rev. 61:15 (2009), 1427–1449.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , Issue.15 , pp. 1427-1449
    • Maher, S.1    Leonard, T.W.2    Jacobsen, J.3    Brayden, D.J.4
  • 35
    • 33748641168 scopus 로고    scopus 로고
    • Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET
    • [35] Leonard, T.W., Lynch, J., McKenna, M.J., Brayden, D.J., Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET. Expert Opin. Drug Deliv. 3:5 (2006), 685–692.
    • (2006) Expert Opin. Drug Deliv. , vol.3 , Issue.5 , pp. 685-692
    • Leonard, T.W.1    Lynch, J.2    McKenna, M.J.3    Brayden, D.J.4
  • 36
    • 15844414676 scopus 로고    scopus 로고
    • 4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric acid as a novel oral delivery agent for recombinant human growth hormone
    • [36] Leone-Bay, A., Ho, K.K., Agarwal, R., Baughman, R.A., Chaudhary, K., DeMorin, F., et al. 4-[4-[(2-Hydroxybenzoyl)amino]phenyl]butyric acid as a novel oral delivery agent for recombinant human growth hormone. J. Med. Chem. 39:13 (1996), 2571–2578.
    • (1996) J. Med. Chem. , vol.39 , Issue.13 , pp. 2571-2578
    • Leone-Bay, A.1    Ho, K.K.2    Agarwal, R.3    Baughman, R.A.4    Chaudhary, K.5    DeMorin, F.6
  • 37
    • 0032580536 scopus 로고    scopus 로고
    • Partially unfolded proteins efficiently penetrate cell membranes—implications for oral drug delivery
    • [37] Milstein, S.J., Leipold, H., Sarubbi, D., Leone-Bay, A., Mlynek, G.M., Robinson, J.R., et al. Partially unfolded proteins efficiently penetrate cell membranes—implications for oral drug delivery. J. Control. Release 53:1-3 (1998), 259–267.
    • (1998) J. Control. Release , vol.53 , Issue.1-3 , pp. 259-267
    • Milstein, S.J.1    Leipold, H.2    Sarubbi, D.3    Leone-Bay, A.4    Mlynek, G.M.5    Robinson, J.R.6
  • 39
    • 0004140235 scopus 로고    scopus 로고
    • Oral drug absorption: prediction and assessment
    • second ed. Informa Healthcare New York, London
    • [39] Dressman, J., Lennerna, H., Reppas, C., Oral drug absorption: prediction and assessment. Drugs and the pharmaceutical sciences, second ed., 2010, Informa Healthcare, New York, London.
    • (2010) Drugs and the pharmaceutical sciences
    • Dressman, J.1    Lennerna, H.2    Reppas, C.3
  • 40
    • 79952755884 scopus 로고    scopus 로고
    • Drug delivery research advances
    • Nova Science, Lancaster, Gazelle Drake Academic Hauppauge, N.Y.
    • [40] Mashkevich, B.O., Drug delivery research advances. 2007, Nova Science, Lancaster, Gazelle Drake Academic, Hauppauge, N.Y.
    • (2007)
    • Mashkevich, B.O.1
  • 41
    • 1842557505 scopus 로고    scopus 로고
    • Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers
    • [41] Ingels, F., Beck, B., Oth, M., Augustijns, P., Effect of simulated intestinal fluid on drug permeability estimation across Caco-2 monolayers. Int. J. Pharm. 274:1-2 (2004), 221–232.
    • (2004) Int. J. Pharm. , vol.274 , Issue.1-2 , pp. 221-232
    • Ingels, F.1    Beck, B.2    Oth, M.3    Augustijns, P.4
  • 42
    • 0027988721 scopus 로고
    • Effects of various protease inhibitors on the intestinal-absorption and degradation of insulin in rats
    • [42] Yamamoto, A., Taniguchi, T., Rikyuu, K., Tsuji, T., Fujita, T., Murakami, M., et al. Effects of various protease inhibitors on the intestinal-absorption and degradation of insulin in rats. Pharm. Res. 11:10 (1994), 1496–1500.
    • (1994) Pharm. Res. , vol.11 , Issue.10 , pp. 1496-1500
    • Yamamoto, A.1    Taniguchi, T.2    Rikyuu, K.3    Tsuji, T.4    Fujita, T.5    Murakami, M.6
  • 43
    • 41849105252 scopus 로고    scopus 로고
    • Lipid-based colloidal carriers for peptide and protein delivery–liposomes versus lipid nanoparticles
    • [43] Martins, S., Sarmento, B., Ferreira, D.C., Souto, E.B., Lipid-based colloidal carriers for peptide and protein delivery–liposomes versus lipid nanoparticles. Int. J. Nanomedicine 2:4 (2007), 595–607.
    • (2007) Int. J. Nanomedicine , vol.2 , Issue.4 , pp. 595-607
    • Martins, S.1    Sarmento, B.2    Ferreira, D.C.3    Souto, E.B.4
  • 44
    • 84930487568 scopus 로고    scopus 로고
    • Exploring the impact of drug properties on the extent of intestinal lymphatic transport—in vitro and in vivo studies
    • [44] Lawless, E., Griffin, B.T., O'Mahony, A., O'Driscoll, C.M., Exploring the impact of drug properties on the extent of intestinal lymphatic transport—in vitro and in vivo studies. Pharm. Res. 32:5 (2015), 1817–1829.
    • (2015) Pharm. Res. , vol.32 , Issue.5 , pp. 1817-1829
    • Lawless, E.1    Griffin, B.T.2    O'Mahony, A.3    O'Driscoll, C.M.4
  • 45
    • 0030840888 scopus 로고    scopus 로고
    • Delivery system design for improvement of intestinal absorption of peptide drugs
    • [45] Muranishi, S., Delivery system design for improvement of intestinal absorption of peptide drugs. Yakugaku Zasshi 117:7 (1997), 394–414.
    • (1997) Yakugaku Zasshi , vol.117 , Issue.7 , pp. 394-414
    • Muranishi, S.1
  • 46
    • 84946486670 scopus 로고    scopus 로고
    • From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity
    • [46] Trevaskis, N.L., Kaminskas, L.M., Porter, C.J., From sewer to saviour—targeting the lymphatic system to promote drug exposure and activity. Nat. Rev. Drug Discov. 14:11 (2015), 781–803.
    • (2015) Nat. Rev. Drug Discov. , vol.14 , Issue.11 , pp. 781-803
    • Trevaskis, N.L.1    Kaminskas, L.M.2    Porter, C.J.3
  • 47
    • 84886443643 scopus 로고    scopus 로고
    • Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption
    • [47] Attili-Qadri, S., Karra, N., Nemirovski, A., Schwob, O., Talmon, Y., Nassar, T., et al. Oral delivery system prolongs blood circulation of docetaxel nanocapsules via lymphatic absorption. Proc. Natl. Acad. Sci. U. S. A. 110:43 (2013), 17498–17503.
    • (2013) Proc. Natl. Acad. Sci. U. S. A. , vol.110 , Issue.43 , pp. 17498-17503
    • Attili-Qadri, S.1    Karra, N.2    Nemirovski, A.3    Schwob, O.4    Talmon, Y.5    Nassar, T.6
  • 48
    • 33750501785 scopus 로고    scopus 로고
    • Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin
    • [48] Zhang, N., Ping, Q., Huang, G., Xu, W., Cheng, Y., Han, X., Lectin-modified solid lipid nanoparticles as carriers for oral administration of insulin. Int. J. Pharm. 327:1-2 (2006), 153–159.
    • (2006) Int. J. Pharm. , vol.327 , Issue.1-2 , pp. 153-159
    • Zhang, N.1    Ping, Q.2    Huang, G.3    Xu, W.4    Cheng, Y.5    Han, X.6
  • 49
    • 84949555613 scopus 로고    scopus 로고
    • Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin
    • [49] Zhang, P., Xu, Y., Zhu, X., Huang, Y., Goblet cell targeting nanoparticle containing drug-loaded micelle cores for oral delivery of insulin. Int. J. Pharm. 496:2 (2015), 993–1005.
    • (2015) Int. J. Pharm. , vol.496 , Issue.2 , pp. 993-1005
    • Zhang, P.1    Xu, Y.2    Zhu, X.3    Huang, Y.4
  • 50
    • 0025882648 scopus 로고
    • Microemulsions for improved peptide absorption from the gastrointestinal tract
    • [50] Ritschel, W.A., Microemulsions for improved peptide absorption from the gastrointestinal tract. Methods Find. Exp. Clin. Pharmacol. 13:3 (1991), 205–220.
    • (1991) Methods Find. Exp. Clin. Pharmacol. , vol.13 , Issue.3 , pp. 205-220
    • Ritschel, W.A.1
  • 51
    • 77957044587 scopus 로고    scopus 로고
    • Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins
    • [51] Rizwan, S.B., Boyd, B.J., Rades, T., Hook, S., Bicontinuous cubic liquid crystals as sustained delivery systems for peptides and proteins. Expert Opin. Drug Deliv. 7:10 (2010), 1133–1144.
    • (2010) Expert Opin. Drug Deliv. , vol.7 , Issue.10 , pp. 1133-1144
    • Rizwan, S.B.1    Boyd, B.J.2    Rades, T.3    Hook, S.4
  • 52
    • 84915745284 scopus 로고    scopus 로고
    • Packing and mobility of hydrocarbon chains in phospholipid lyotropic liquid crystalline lamellar phases and liposomes: characterisation by positron annihilation lifetime spectroscopy (PALS)
    • [52] Dong, A.W., Fong, C., Waddington, L.J., Hill, A.J., Boyd, B.J., Drummond, C.J., Packing and mobility of hydrocarbon chains in phospholipid lyotropic liquid crystalline lamellar phases and liposomes: characterisation by positron annihilation lifetime spectroscopy (PALS). Phys. Chem. Chem. Phys. 17:1 (2015), 276–286.
    • (2015) Phys. Chem. Chem. Phys. , vol.17 , Issue.1 , pp. 276-286
    • Dong, A.W.1    Fong, C.2    Waddington, L.J.3    Hill, A.J.4    Boyd, B.J.5    Drummond, C.J.6
  • 53
    • 0032753055 scopus 로고    scopus 로고
    • Biological activity of insulin in GMO gels and the effect of agitation
    • [53] Sadhale, Y., Shah, J.C., Biological activity of insulin in GMO gels and the effect of agitation. Int. J. Pharm. 191:1 (1999), 65–74.
    • (1999) Int. J. Pharm. , vol.191 , Issue.1 , pp. 65-74
    • Sadhale, Y.1    Shah, J.C.2
  • 54
    • 0032737961 scopus 로고    scopus 로고
    • Stabilization of insulin against agitation-induced aggregation by the GMO cubic phase gel
    • [54] Sadhale, Y., Shah, J.C., Stabilization of insulin against agitation-induced aggregation by the GMO cubic phase gel. Int. J. Pharm. 191:1 (1999), 51–64.
    • (1999) Int. J. Pharm. , vol.191 , Issue.1 , pp. 51-64
    • Sadhale, Y.1    Shah, J.C.2
  • 55
    • 70349807814 scopus 로고    scopus 로고
    • Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics
    • [55] Rizwan, S.B., Hanley, T., Boyd, B.J., Rades, T., Hook, S., Liquid crystalline systems of phytantriol and glyceryl monooleate containing a hydrophilic protein: characterisation, swelling and release kinetics. J. Pharm. Sci. 98:11 (2009), 4191–4204.
    • (2009) J. Pharm. Sci. , vol.98 , Issue.11 , pp. 4191-4204
    • Rizwan, S.B.1    Hanley, T.2    Boyd, B.J.3    Rades, T.4    Hook, S.5
  • 56
    • 34447265979 scopus 로고    scopus 로고
    • A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats
    • [56] Boyd, B.J., Khoo, S.M., Whittaker, D.V., Davey, G., Porter, C.J., A lipid-based liquid crystalline matrix that provides sustained release and enhanced oral bioavailability for a model poorly water soluble drug in rats. Int. J. Pharm. 340:1-2 (2007), 52–60.
    • (2007) Int. J. Pharm. , vol.340 , Issue.1-2 , pp. 52-60
    • Boyd, B.J.1    Khoo, S.M.2    Whittaker, D.V.3    Davey, G.4    Porter, C.J.5
  • 57
    • 0038032150 scopus 로고    scopus 로고
    • Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art
    • [57] Müller, R.H., Mäder, K., Gohla, S., Solid lipid nanoparticles (SLN) for controlled drug delivery—a review of the state of the art. Eur. J. Pharm. Biopharm. 50:1 (2000), 161–177.
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , Issue.1 , pp. 161-177
    • Müller, R.H.1    Mäder, K.2    Gohla, S.3
  • 58
    • 85027386769 scopus 로고
    • Method for producing solid lipid microspheres having a narrow size distribution. US-Patent 5250236;.
    • [58] Gasco MR. Method for producing solid lipid microspheres having a narrow size distribution. US-Patent 5250236; 1993.
    • (1993)
    • Gasco, M.R.1
  • 59
    • 0010523873 scopus 로고
    • Medication Vehicles Made of Solid Lipid Particles (Solid Lipid Nanospheres-SLN). EP19920919477, WO/1993/005768
    • [59] Lucks, J.S., Müller, R.H., Medication Vehicles Made of Solid Lipid Particles (Solid Lipid Nanospheres-SLN). EP19920919477, WO/1993/005768. 1993.
    • (1993)
    • Lucks, J.S.1    Müller, R.H.2
  • 60
    • 84948164314 scopus 로고    scopus 로고
    • In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract
    • [60] Jannin, V., Dellera, E., Chevrier, S., Chavant, Y., Voutsinas, C., Bonferoni, C., Demarne, F., In vitro lipolysis tests on lipid nanoparticles: comparison between lipase/co-lipase and pancreatic extract. Drug Dev. Ind. Pharm. 41:10 (2015), 1582–1588.
    • (2015) Drug Dev. Ind. Pharm. , vol.41 , Issue.10 , pp. 1582-1588
    • Jannin, V.1    Dellera, E.2    Chevrier, S.3    Chavant, Y.4    Voutsinas, C.5    Bonferoni, C.6    Demarne, F.7
  • 61
    • 34547899919 scopus 로고    scopus 로고
    • Solid lipid nanoparticles as a drug delivery system for peptides and proteins
    • [61] Almeida, A.J., Souto, E., Solid lipid nanoparticles as a drug delivery system for peptides and proteins. Adv. Drug Deliv. Rev. 59:6 (2007), 478–490.
    • (2007) Adv. Drug Deliv. Rev. , vol.59 , Issue.6 , pp. 478-490
    • Almeida, A.J.1    Souto, E.2
  • 62
    • 0027958503 scopus 로고
    • Alteration of colonic absorption by long-chain unsaturated fatty acids. Influence of hydroxylation and degree of unsaturation
    • [62] Ramakrishna, B.S., Mathan, M., Mathan, V.I., Alteration of colonic absorption by long-chain unsaturated fatty acids. Influence of hydroxylation and degree of unsaturation. Scand. J. Gastroenterol. 29:1 (1994), 54–58.
    • (1994) Scand. J. Gastroenterol. , vol.29 , Issue.1 , pp. 54-58
    • Ramakrishna, B.S.1    Mathan, M.2    Mathan, V.I.3
  • 63
    • 84905048835 scopus 로고    scopus 로고
    • Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles
    • [63] Schütz, C.A., Staedler, D., Crosbie-Staunton, K., Movia, D., Chapuis Bernasconi, C., Kenzaoui, B.H., et al. Differential stress reaction of human colon cells to oleic-acid-stabilized and unstabilized ultrasmall iron oxide nanoparticles. Int. J. Nanomedicine 9 (2014), 3481–3498.
    • (2014) Int. J. Nanomedicine , vol.9 , pp. 3481-3498
    • Schütz, C.A.1    Staedler, D.2    Crosbie-Staunton, K.3    Movia, D.4    Chapuis Bernasconi, C.5    Kenzaoui, B.H.6
  • 64
    • 79956102907 scopus 로고    scopus 로고
    • 20 years of lipid nanoparticles (SLN & NLC): present state of development & industrial applications
    • [64] Müller, R.H., Shegokar, R., Keck, C.M., 20 years of lipid nanoparticles (SLN & NLC): present state of development & industrial applications. Curr. Drug Discov. Technol. 8:3 (2011), 207–227.
    • (2011) Curr. Drug Discov. Technol. , vol.8 , Issue.3 , pp. 207-227
    • Müller, R.H.1    Shegokar, R.2    Keck, C.M.3
  • 65
    • 80054804587 scopus 로고    scopus 로고
    • Solid lipid nanoparticles: an oral bioavailability enhancer vehicle
    • [65] Harde, H., Das, M., Jain, S., Solid lipid nanoparticles: an oral bioavailability enhancer vehicle. Expert Opin. Drug Deliv. 8:11 (2011), 1407–1424.
    • (2011) Expert Opin. Drug Deliv. , vol.8 , Issue.11 , pp. 1407-1424
    • Harde, H.1    Das, M.2    Jain, S.3
  • 66
    • 11144331447 scopus 로고    scopus 로고
    • Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique
    • [66] Trotta, M., Cavalli, R., Carlotti, M.E., Battaglia, L., Debernardi, F., Solid lipid micro-particles carrying insulin formed by solvent-in-water emulsion-diffusion technique. Int. J. Pharm. 288:2 (2005), 281–288.
    • (2005) Int. J. Pharm. , vol.288 , Issue.2 , pp. 281-288
    • Trotta, M.1    Cavalli, R.2    Carlotti, M.E.3    Battaglia, L.4    Debernardi, F.5
  • 67
    • 0037433842 scopus 로고    scopus 로고
    • Preparation of solid lipid nanoparticles by a solvent emulsification–diffusion technique
    • [67] Trotta, M., Debernardi, F., Caputo, O., Preparation of solid lipid nanoparticles by a solvent emulsification–diffusion technique. Int. J. Pharm. 257:1-2 (2003), 153–160.
    • (2003) Int. J. Pharm. , vol.257 , Issue.1-2 , pp. 153-160
    • Trotta, M.1    Debernardi, F.2    Caputo, O.3
  • 68
    • 34548312508 scopus 로고    scopus 로고
    • Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: development and influence on insulin stability
    • [68] Battaglia, L., Trotta, M., Gallarate, M., Carlotti, M.E., Zara, G.P., Bargoni, A., Solid lipid nanoparticles formed by solvent-in-water emulsion-diffusion technique: development and influence on insulin stability. J. Microencapsul. 24:7 (2007), 660–672.
    • (2007) J. Microencapsul. , vol.24 , Issue.7 , pp. 660-672
    • Battaglia, L.1    Trotta, M.2    Gallarate, M.3    Carlotti, M.E.4    Zara, G.P.5    Bargoni, A.6
  • 69
    • 0026679872 scopus 로고
    • Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesteryl acetate
    • [69] Sjöström, B., Bergenståhl, B., Preparation of submicron drug particles in lecithin-stabilized o/w emulsions I. Model studies of the precipitation of cholesteryl acetate. Int. J. Pharm. 88:1–3 (1992), 53–62.
    • (1992) Int. J. Pharm. , vol.88 , Issue.1-3 , pp. 53-62
    • Sjöström, B.1    Bergenståhl, B.2
  • 70
    • 0037296404 scopus 로고    scopus 로고
    • Design of lipid nanoparticles for oral delivery of hydrophilic macromolecules
    • [70] Garcia-Fuentes, M., Torres, D., Alonso, M.J., Design of lipid nanoparticles for oral delivery of hydrophilic macromolecules., 27(2-3), 2003, 159–168.
    • (2003) , vol.27 , Issue.2-3 , pp. 159-168
    • Garcia-Fuentes, M.1    Torres, D.2    Alonso, M.J.3
  • 71
    • 18844459351 scopus 로고    scopus 로고
    • New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin
    • [71] Garcia-Fuentes, M., Torres, D., Alonso, M.J., New surface-modified lipid nanoparticles as delivery vehicles for salmon calcitonin. Int. J. Pharm. 296:1-2 (2005), 122–132.
    • (2005) Int. J. Pharm. , vol.296 , Issue.1-2 , pp. 122-132
    • Garcia-Fuentes, M.1    Torres, D.2    Alonso, M.J.3
  • 72
    • 84879655628 scopus 로고    scopus 로고
    • Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle–double emulsion method via the combined use of different solid lipids
    • [72] Chen, C., Fan, T., Jin, Y., Zhou, Z., Yang, Y., Zhu, X., et al. Orally delivered salmon calcitonin-loaded solid lipid nanoparticles prepared by micelle–double emulsion method via the combined use of different solid lipids. Nanomedicine 8:7 (2012), 1085–1100.
    • (2012) Nanomedicine , vol.8 , Issue.7 , pp. 1085-1100
    • Chen, C.1    Fan, T.2    Jin, Y.3    Zhou, Z.4    Yang, Y.5    Zhu, X.6
  • 73
    • 34447259574 scopus 로고    scopus 로고
    • Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization
    • [73] Liu, J., Gong, T., Wang, C., Zhong, Z., Zhang, Z., Solid lipid nanoparticles loaded with insulin by sodium cholate-phosphatidylcholine-based mixed micelles: preparation and characterization. Int. J. Pharm. 340:1-2 (2007), 153–162.
    • (2007) Int. J. Pharm. , vol.340 , Issue.1-2 , pp. 153-162
    • Liu, J.1    Gong, T.2    Wang, C.3    Zhong, Z.4    Zhang, Z.5
  • 74
    • 62349104974 scopus 로고    scopus 로고
    • Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles
    • [74] Yuan, H., Jiang, S.P., Du, Y.Z., Miao, J., Zhang, X.G., Hu, F.Q., Strategic approaches for improving entrapment of hydrophilic peptide drugs by lipid nanoparticles. Colloids Surf. B: Biointerfaces 70:2 (2009), 248–253.
    • (2009) Colloids Surf. B: Biointerfaces , vol.70 , Issue.2 , pp. 248-253
    • Yuan, H.1    Jiang, S.P.2    Du, Y.Z.3    Miao, J.4    Zhang, X.G.5    Hu, F.Q.6
  • 75
    • 84894247697 scopus 로고    scopus 로고
    • PEG-stearate coated solid lipid nanoparticles as levothyroxine carriers for oral administration
    • [75] Kashanian, S., Rostami, E., PEG-stearate coated solid lipid nanoparticles as levothyroxine carriers for oral administration. J. Nanoparticle Res., 16(3), 2014.
    • (2014) J. Nanoparticle Res. , vol.16 , Issue.3
    • Kashanian, S.1    Rostami, E.2
  • 76
    • 70849112665 scopus 로고    scopus 로고
    • Preparation of solid lipid nanoparticles from w/o/w emulsions: preliminary studies on insulin encapsulation
    • [76] Gallarate, M., Trotta, M., Battaglia, L., Chirio, D., Preparation of solid lipid nanoparticles from w/o/w emulsions: preliminary studies on insulin encapsulation. J. Microencapsul. 26:5 (2009), 394–402.
    • (2009) J. Microencapsul. , vol.26 , Issue.5 , pp. 394-402
    • Gallarate, M.1    Trotta, M.2    Battaglia, L.3    Chirio, D.4
  • 77
    • 41849134910 scopus 로고    scopus 로고
    • Oral insulin delivery by means of solid lipid nanoparticles
    • [77] Sarmento, B., Martins, S., Ferreira, D., Souto, E.B., Oral insulin delivery by means of solid lipid nanoparticles. Int. J. Nanomedicine 2:4 (2007), 743–749.
    • (2007) Int. J. Nanomedicine , vol.2 , Issue.4 , pp. 743-749
    • Sarmento, B.1    Martins, S.2    Ferreira, D.3    Souto, E.B.4
  • 78
    • 84870361288 scopus 로고    scopus 로고
    • Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin
    • [78] Zhang, Z.-H., Zhang, Y.-L., Zhou, J.-P., Lv, H.-X., Solid lipid nanoparticles modified with stearic acid-octaarginine for oral administration of insulin. Int. J. Nanomedicine 7 (2012), 3333–3339.
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 3333-3339
    • Zhang, Z.-H.1    Zhang, Y.-L.2    Zhou, J.-P.3    Lv, H.-X.4
  • 79
    • 70449365026 scopus 로고    scopus 로고
    • Effects of poly (lactic-co-glycolic acid) as a co-emulsifier on the preparation and hypoglycaemic activity of insulin-loaded solid lipid nanoparticles
    • [79] Wang, S.L., Xie, S.Y., Zhu, L.Y., Wang, F.H., Zhou, W.Z., Effects of poly (lactic-co-glycolic acid) as a co-emulsifier on the preparation and hypoglycaemic activity of insulin-loaded solid lipid nanoparticles. IET Nanobiotechnol. 3:4 (2009), 103–108.
    • (2009) IET Nanobiotechnol. , vol.3 , Issue.4 , pp. 103-108
    • Wang, S.L.1    Xie, S.Y.2    Zhu, L.Y.3    Wang, F.H.4    Zhou, W.Z.5
  • 80
    • 84908370833 scopus 로고    scopus 로고
    • Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs
    • [80] Fan, T., Chen, C., Guo, H., Xu, J., Zhang, J., Zhu, X., et al. Design and evaluation of solid lipid nanoparticles modified with peptide ligand for oral delivery of protein drugs. Eur. J. Pharm. Biopharm. 88:2 (2014), 518–528.
    • (2014) Eur. J. Pharm. Biopharm. , vol.88 , Issue.2 , pp. 518-528
    • Fan, T.1    Chen, C.2    Guo, H.3    Xu, J.4    Zhang, J.5    Zhu, X.6
  • 81
    • 33644922361 scopus 로고    scopus 로고
    • Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery
    • [81] Prego, C., Fabre, M., Torres, D., Alonso, M.J., Efficacy and mechanism of action of chitosan nanocapsules for oral peptide delivery. Pharm. Res. 23:3 (2006), 549–556.
    • (2006) Pharm. Res. , vol.23 , Issue.3 , pp. 549-556
    • Prego, C.1    Fabre, M.2    Torres, D.3    Alonso, M.J.4
  • 82
    • 18044366409 scopus 로고    scopus 로고
    • A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery
    • [82] Garcia-Fuentes, M., Prego, C., Torres, D., Alonso, M.J., A comparative study of the potential of solid triglyceride nanostructures coated with chitosan or poly(ethylene glycol) as carriers for oral calcitonin delivery. Eur. J. Pharm. Sci. 25:1 (2005), 133–143.
    • (2005) Eur. J. Pharm. Sci. , vol.25 , Issue.1 , pp. 133-143
    • Garcia-Fuentes, M.1    Prego, C.2    Torres, D.3    Alonso, M.J.4
  • 83
    • 10044226252 scopus 로고    scopus 로고
    • Transmucosal macromolecular drug delivery
    • [83] Prego, C., García, M., Torres, D., Alonso, M.J., Transmucosal macromolecular drug delivery. J. Control. Release 101:1–3 (2005), 151–162.
    • (2005) J. Control. Release , vol.101 , Issue.1-3 , pp. 151-162
    • Prego, C.1    García, M.2    Torres, D.3    Alonso, M.J.4
  • 84
    • 1542358757 scopus 로고    scopus 로고
    • Preparation and characterization of solid lipid nanoparticles containing peptide
    • [84] Hu, F.Q., Hong, Y., Yuan, H., Preparation and characterization of solid lipid nanoparticles containing peptide. Int. J. Pharm. 273:1-2 (2004), 29–35.
    • (2004) Int. J. Pharm. , vol.273 , Issue.1-2 , pp. 29-35
    • Hu, F.Q.1    Hong, Y.2    Yuan, H.3
  • 85
    • 79952920907 scopus 로고    scopus 로고
    • The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process
    • [85] Yang, R., Gao, R., Li, F., He, H., Tang, X., The influence of lipid characteristics on the formation, in vitro release, and in vivo absorption of protein-loaded SLN prepared by the double emulsion process. Drug Dev. Ind. Pharm. 37:2 (2011), 139–148.
    • (2011) Drug Dev. Ind. Pharm. , vol.37 , Issue.2 , pp. 139-148
    • Yang, R.1    Gao, R.2    Li, F.3    He, H.4    Tang, X.5
  • 86
    • 77956314276 scopus 로고    scopus 로고
    • Preparation of gel-core-solid lipid nanoparticle: a novel way to improve the encapsulation of protein and peptide
    • [86] Yang, R., Gao, R.-C., Cai, C.-F., Xu, H., Li, F., He, H.-B., et al. Preparation of gel-core-solid lipid nanoparticle: a novel way to improve the encapsulation of protein and peptide. Chem. Pharm. Bull. 58:9 (2010), 1195–1202.
    • (2010) Chem. Pharm. Bull. , vol.58 , Issue.9 , pp. 1195-1202
    • Yang, R.1    Gao, R.-C.2    Cai, C.-F.3    Xu, H.4    Li, F.5    He, H.-B.6
  • 87
    • 84888315416 scopus 로고    scopus 로고
    • Solid lipid particles for oral delivery of peptide and protein drugs I—elucidating the release mechanism of lysozyme during lipolysis
    • [87] Christophersen, P.C., Zhang, L., Yang, M., Nielsen, H.M., Mullertz, A., Mu, H., Solid lipid particles for oral delivery of peptide and protein drugs I—elucidating the release mechanism of lysozyme during lipolysis. Eur. J. Pharm. Biopharm. 85:3 Pt A (2013), 473–480.
    • (2013) Eur. J. Pharm. Biopharm. , vol.85 , Issue.3 , pp. 473-480
    • Christophersen, P.C.1    Zhang, L.2    Yang, M.3    Nielsen, H.M.4    Mullertz, A.5    Mu, H.6
  • 88
    • 33748363105 scopus 로고    scopus 로고
    • Core/shell nanoparticles with lecithin lipid cores for protein delivery
    • [88] Oh, K.S., Han, S.K., Lee, H.S., Koo, H.M., Kim, R.S., Lee, K.E., et al. Core/shell nanoparticles with lecithin lipid cores for protein delivery. Biomacromolecules 7:8 (2006), 2362–2367.
    • (2006) Biomacromolecules , vol.7 , Issue.8 , pp. 2362-2367
    • Oh, K.S.1    Han, S.K.2    Lee, H.S.3    Koo, H.M.4    Kim, R.S.5    Lee, K.E.6
  • 89
    • 0001009759 scopus 로고
    • Mechanism of formation and structure of micro emulsions by electron microscopy
    • [89] Schulman, J.H., Stoeckenius, W., Prince, L.M., Mechanism of formation and structure of micro emulsions by electron microscopy. J. Phys. Chem. 63:10 (1959), 1677–1680.
    • (1959) J. Phys. Chem. , vol.63 , Issue.10 , pp. 1677-1680
    • Schulman, J.H.1    Stoeckenius, W.2    Prince, L.M.3
  • 90
    • 0000965958 scopus 로고
    • Transparent water-in-oil dispersions: the oleopathic hydro-micelle
    • [90] Hoar, T.P., Schulman, J.H., Transparent water-in-oil dispersions: the oleopathic hydro-micelle. Nature 152 (1943), 102–103.
    • (1943) Nature , vol.152 , pp. 102-103
    • Hoar, T.P.1    Schulman, J.H.2
  • 92
    • 44749087481 scopus 로고    scopus 로고
    • Design and production of nanoparticles formulated from nano-emulsion templates-a review
    • [92] Anton, N., Benoit, J.P., Saulnier, P., Design and production of nanoparticles formulated from nano-emulsion templates-a review. J. Control. Release 128:3 (2008), 185–199.
    • (2008) J. Control. Release , vol.128 , Issue.3 , pp. 185-199
    • Anton, N.1    Benoit, J.P.2    Saulnier, P.3
  • 93
    • 84856719507 scopus 로고    scopus 로고
    • Nanoemulsions versus microemulsions: terminology, differences, and similarities
    • [93] McClements, D.J., Nanoemulsions versus microemulsions: terminology, differences, and similarities. Soft Matter 8:6 (2012), 1719–1729.
    • (2012) Soft Matter , vol.8 , Issue.6 , pp. 1719-1729
    • McClements, D.J.1
  • 95
    • 84907851893 scopus 로고    scopus 로고
    • Challenges for industrialization of miniemulsion polymerization
    • [95] Asua, J.M., Challenges for industrialization of miniemulsion polymerization. Prog. Polym. Sci. 39:10 (2014), 1797–1826.
    • (2014) Prog. Polym. Sci. , vol.39 , Issue.10 , pp. 1797-1826
    • Asua, J.M.1
  • 96
    • 84880890918 scopus 로고    scopus 로고
    • Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals
    • [96] McClements, D.J., Nanoemulsion-based oral delivery systems for lipophilic bioactive components: nutraceuticals and pharmaceuticals. Ther. Deliv. 4:7 (2013), 841–857.
    • (2013) Ther. Deliv. , vol.4 , Issue.7 , pp. 841-857
    • McClements, D.J.1
  • 97
    • 0028898391 scopus 로고
    • New approach for the preparation of nanoparticles by an emulsification-diffusion method
    • [97] Leroux, J.C., Allémann, E., Doelker, E., Gurny, R., New approach for the preparation of nanoparticles by an emulsification-diffusion method. Eur. J. Pharm. Biopharm. 41:1 (1995), 14–18.
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , Issue.1 , pp. 14-18
    • Leroux, J.C.1    Allémann, E.2    Doelker, E.3    Gurny, R.4
  • 98
    • 85027386412 scopus 로고    scopus 로고
    • A method for the preparation of nanoparticles from nanoemulsions. WO2005102507 A1
    • [98] Shlomo, M., Liat, S., A method for the preparation of nanoparticles from nanoemulsions. WO2005102507 A1. 2005.
    • (2005)
    • Shlomo, M.1    Liat, S.2
  • 99
    • 0000615455 scopus 로고
    • The Stability of o/w type emulsions as functions of temperature and the HLB of emulsifiers: the emulsification by PIT-method
    • [99] Shinoda, K., Saito, H., The Stability of o/w type emulsions as functions of temperature and the HLB of emulsifiers: the emulsification by PIT-method. J. Colloid Interface Sci. 30:2 (1969), 258–263.
    • (1969) J. Colloid Interface Sci. , vol.30 , Issue.2 , pp. 258-263
    • Shinoda, K.1    Saito, H.2
  • 100
    • 0002815956 scopus 로고
    • The effect of temperature on the phase equilibria and the types of dispersions of the ternary system composed of water, cyclohexane, and nonionic surfactant
    • [100] Shinoda, K., Saito, H., The effect of temperature on the phase equilibria and the types of dispersions of the ternary system composed of water, cyclohexane, and nonionic surfactant. J. Colloid Interface Sci. 26:1 (1968), 70–74.
    • (1968) J. Colloid Interface Sci. , vol.26 , Issue.1 , pp. 70-74
    • Shinoda, K.1    Saito, H.2
  • 101
    • 0034601204 scopus 로고    scopus 로고
    • Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs
    • [101] Gershanik, T., Benita, S., Self-dispersing lipid formulations for improving oral absorption of lipophilic drugs. Eur. J. Pharm. Biopharm. 50:1 (2000), 179–188.
    • (2000) Eur. J. Pharm. Biopharm. , vol.50 , Issue.1 , pp. 179-188
    • Gershanik, T.1    Benita, S.2
  • 102
    • 81255198647 scopus 로고    scopus 로고
    • Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies
    • [102] Griffin, B., O'Driscoll, C., Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies. Ther. Deliv. 2:12 (2011), 1633–1653.
    • (2011) Ther. Deliv. , vol.2 , Issue.12 , pp. 1633-1653
    • Griffin, B.1    O'Driscoll, C.2
  • 103
    • 77957285711 scopus 로고    scopus 로고
    • Microemulsions for oral delivery of insulin: design, development and evaluation in streptozotocin induced diabetic rats
    • [103] Sharma, G., Wilson, K., van der Walle, C.F., Sattar, N., Petrie, J.R., Ravi Kumar, M.N., Microemulsions for oral delivery of insulin: design, development and evaluation in streptozotocin induced diabetic rats. Eur. J. Pharm. Biopharm. 76:2 (2010), 159–169.
    • (2010) Eur. J. Pharm. Biopharm. , vol.76 , Issue.2 , pp. 159-169
    • Sharma, G.1    Wilson, K.2    van der Walle, C.F.3    Sattar, N.4    Petrie, J.R.5    Ravi Kumar, M.N.6
  • 104
    • 70349303363 scopus 로고    scopus 로고
    • Formulation and characterization of an oily-based system for oral delivery of insulin
    • [104] Elsayed, A., Remawi, M.A., Qinna, N., Farouk, A., Badwan, A., Formulation and characterization of an oily-based system for oral delivery of insulin. Eur. J. Pharm. Biopharm. 73:2 (2009), 269–279.
    • (2009) Eur. J. Pharm. Biopharm. , vol.73 , Issue.2 , pp. 269-279
    • Elsayed, A.1    Remawi, M.A.2    Qinna, N.3    Farouk, A.4    Badwan, A.5
  • 105
    • 24344446947 scopus 로고    scopus 로고
    • An enteric-coated dry emulsion formulation for oral insulin delivery
    • [105] Toorisaka, E., Hashida, M., Kamiya, N., Ono, H., Kokazu, Y., Goto, M., An enteric-coated dry emulsion formulation for oral insulin delivery. J. Control. Release 107:1 (2005), 91–96.
    • (2005) J. Control. Release , vol.107 , Issue.1 , pp. 91-96
    • Toorisaka, E.1    Hashida, M.2    Kamiya, N.3    Ono, H.4    Kokazu, Y.5    Goto, M.6
  • 106
    • 0037452443 scopus 로고    scopus 로고
    • Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (s/o/w) emulsion
    • [106] Toorisaka, E., Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (s/o/w) emulsion. Int. J. Pharm. 252:1-2 (2003), 271–274.
    • (2003) Int. J. Pharm. , vol.252 , Issue.1-2 , pp. 271-274
    • Toorisaka, E.1
  • 107
    • 0012025252 scopus 로고    scopus 로고
    • Insulin in w/o/w multiple emulsions: preparation, characterization and determination of stability towards proteases in vitro
    • [107] Cunha, A.S., Grossior, J.L., Puisieux, F., Seiller, M., Insulin in w/o/w multiple emulsions: preparation, characterization and determination of stability towards proteases in vitro. J. Microencapsul. 14:3 (1997), 311–319.
    • (1997) J. Microencapsul. , vol.14 , Issue.3 , pp. 311-319
    • Cunha, A.S.1    Grossior, J.L.2    Puisieux, F.3    Seiller, M.4
  • 108
    • 0031710609 scopus 로고    scopus 로고
    • Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid
    • [108] Suzuki, A., Morishita, M., Kajita, M., Takayama, K., Isowa, K., Chiba, Y., et al. Enhanced colonic and rectal absorption of insulin using a multiple emulsion containing eicosapentaenoic acid and docosahexaenoic acid. J. Pharm. Sci. 87:10 (1998), 1196–1202.
    • (1998) J. Pharm. Sci. , vol.87 , Issue.10 , pp. 1196-1202
    • Suzuki, A.1    Morishita, M.2    Kajita, M.3    Takayama, K.4    Isowa, K.5    Chiba, Y.6
  • 109
    • 0032531673 scopus 로고    scopus 로고
    • Improving insulin enteral absorption using water-in-oil-in-water emulsion
    • [109] Morishita, M., Matsuzawa, A., Takayama, K., Isowa, K., Nagai, T., Improving insulin enteral absorption using water-in-oil-in-water emulsion. Int. J. Pharm. 172:1–2 (1998), 189–198.
    • (1998) Int. J. Pharm. , vol.172 , Issue.1-2 , pp. 189-198
    • Morishita, M.1    Matsuzawa, A.2    Takayama, K.3    Isowa, K.4    Nagai, T.5
  • 110
    • 2442421920 scopus 로고    scopus 로고
    • Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery
    • [110] Onuki, Y., Morishita, M., Takayama, K., Formulation optimization of water-in-oil-water multiple emulsion for intestinal insulin delivery. J. Control. Release 97:1 (2004), 91–99.
    • (2004) J. Control. Release , vol.97 , Issue.1 , pp. 91-99
    • Onuki, Y.1    Morishita, M.2    Takayama, K.3
  • 111
    • 0028038011 scopus 로고
    • Enhanced oral absorption of insulin from desolvated fatty acid-sodium glycocholate emulsions
    • [111] Mesiha, M., Plakogiannis, F., Vejosoth, S., Enhanced oral absorption of insulin from desolvated fatty acid-sodium glycocholate emulsions. Int. J. Pharm. 111:3 (1994), 213–216.
    • (1994) Int. J. Pharm. , vol.111 , Issue.3 , pp. 213-216
    • Mesiha, M.1    Plakogiannis, F.2    Vejosoth, S.3
  • 112
    • 0029094862 scopus 로고
    • Preparation and characterization of a peptide containing w/o emulsion
    • [112] Trenktrog, T., Müller, B.W., Preparation and characterization of a peptide containing w/o emulsion. Int. J. Pharm. 123:2 (1995), 199–207.
    • (1995) Int. J. Pharm. , vol.123 , Issue.2 , pp. 199-207
    • Trenktrog, T.1    Müller, B.W.2
  • 113
    • 0034527796 scopus 로고    scopus 로고
    • Oral multiple w/o/w emulsion formulation of a peptide salmon calcitonin: in vitro–in vivo evaluation
    • [113] Dogru, S.T., Çalis, S., Öner, F., Oral multiple w/o/w emulsion formulation of a peptide salmon calcitonin: in vitro–in vivo evaluation. J. Clin. Pharm. Ther. 25:6 (2000), 435–443.
    • (2000) J. Clin. Pharm. Ther. , vol.25 , Issue.6 , pp. 435-443
    • Dogru, S.T.1    Çalis, S.2    Öner, F.3
  • 114
    • 84870376218 scopus 로고    scopus 로고
    • Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs
    • [114] Sun, H., Liu, K., Liu, W., Wang, W., Guo, C., Tang, B., et al. Development and characterization of a novel nanoemulsion drug-delivery system for potential application in oral delivery of protein drugs. Int. J. Nanomedicine 7 (2012), 5529–5543.
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 5529-5543
    • Sun, H.1    Liu, K.2    Liu, W.3    Wang, W.4    Guo, C.5    Tang, B.6
  • 115
    • 44649083065 scopus 로고    scopus 로고
    • Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme
    • [115] Cheng, M.B., Wang, J.C., Li, Y.H., Liu, X.Y., Zhang, X., Chen, D.W., et al. Characterization of water-in-oil microemulsion for oral delivery of earthworm fibrinolytic enzyme. J. Control. Release 129:1 (2008), 41–48.
    • (2008) J. Control. Release , vol.129 , Issue.1 , pp. 41-48
    • Cheng, M.B.1    Wang, J.C.2    Li, Y.H.3    Liu, X.Y.4    Zhang, X.5    Chen, D.W.6
  • 116
    • 0028081549 scopus 로고
    • Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides
    • [116] Constantinides, P., Scalart, J.-P., Lancaster, C., Marcello, J., Marks, G., Ellens, H., et al. Formulation and intestinal absorption enhancement evaluation of water-in-oil microemulsions incorporating medium-chain glycerides. Pharm. Res. 11:10 (1994), 1385–1390.
    • (1994) Pharm. Res. , vol.11 , Issue.10 , pp. 1385-1390
    • Constantinides, P.1    Scalart, J.-P.2    Lancaster, C.3    Marcello, J.4    Marks, G.5    Ellens, H.6
  • 117
    • 0036391194 scopus 로고    scopus 로고
    • Oral delivery of proteins: progress and prognostication
    • [117] Shah, R.B., Ahsan, F., Khan, M.A., Oral delivery of proteins: progress and prognostication. Crit. Rev. Ther. Drug Carrier Syst. 19:2 (2002), 135–169.
    • (2002) Crit. Rev. Ther. Drug Carrier Syst. , vol.19 , Issue.2 , pp. 135-169
    • Shah, R.B.1    Ahsan, F.2    Khan, M.A.3
  • 118
    • 79551683531 scopus 로고    scopus 로고
    • Oral protein delivery: current status and future prospect
    • [118] Park, K., Kwon, I.C., Park, K., Oral protein delivery: current status and future prospect. React. Funct. Polym. 71:3 (2011), 280–287.
    • (2011) React. Funct. Polym. , vol.71 , Issue.3 , pp. 280-287
    • Park, K.1    Kwon, I.C.2    Park, K.3
  • 119
    • 84904860296 scopus 로고    scopus 로고
    • Nanostructured Biomaterials for Overcoming Biological Barriers: Royal Society of Chemistry
    • [119] Alonso, M.J., Csaba, N.S., Nanostructured Biomaterials for Overcoming Biological Barriers: Royal Society of Chemistry. 2012.
    • (2012)
    • Alonso, M.J.1    Csaba, N.S.2
  • 120
    • 79955629340 scopus 로고    scopus 로고
    • Nano-emulsions and micro-emulsions: clarifications of the critical differences
    • [120] Anton, N., Vandamme, T.F., Nano-emulsions and micro-emulsions: clarifications of the critical differences. Pharm. Res. 28:5 (2011), 978–985.
    • (2011) Pharm. Res. , vol.28 , Issue.5 , pp. 978-985
    • Anton, N.1    Vandamme, T.F.2
  • 122
    • 81255198647 scopus 로고    scopus 로고
    • Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies
    • [122] Griffin, B.T., O'Driscoll, C.M., Opportunities and challenges for oral delivery of hydrophobic versus hydrophilic peptide and protein-like drugs using lipid-based technologies. Ther. Deliv. 2:12 (2011), 1633–1653.
    • (2011) Ther. Deliv. , vol.2 , Issue.12 , pp. 1633-1653
    • Griffin, B.T.1    O'Driscoll, C.M.2
  • 123
    • 0037452443 scopus 로고    scopus 로고
    • Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (s/o/w) emulsion
    • [123] Toorisaka, E., Ono, H., Arimori, K., Kamiya, N., Goto, M., Hypoglycemic effect of surfactant-coated insulin solubilized in a novel solid-in-oil-in-water (s/o/w) emulsion. Int. J. Pharm. 252:1-2 (2003), 271–274.
    • (2003) Int. J. Pharm. , vol.252 , Issue.1-2 , pp. 271-274
    • Toorisaka, E.1    Ono, H.2    Arimori, K.3    Kamiya, N.4    Goto, M.5
  • 124
    • 80051781559 scopus 로고    scopus 로고
    • Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions
    • [124] Fan, Y., Li, X., Zhou, Y., Fan, C., Wang, X., Huang, Y., et al. Improved intestinal delivery of salmon calcitonin by water-in-oil microemulsions. Int. J. Pharm. 416:1 (2011), 323–330.
    • (2011) Int. J. Pharm. , vol.416 , Issue.1 , pp. 323-330
    • Fan, Y.1    Li, X.2    Zhou, Y.3    Fan, C.4    Wang, X.5    Huang, Y.6
  • 125
    • 84925488688 scopus 로고    scopus 로고
    • Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase
    • [125] Bakala-N'Goma, J.C., Williams, H.D., Sassene, P., Kleberg, K., Calderone, M., Jannin, V., et al. Toward the establishment of standardized in vitro tests for lipid-based formulations. 5. Lipolysis of representative formulations by gastric lipase. Pharm. Res. 32:4 (2015), 1279–1287.
    • (2015) Pharm. Res. , vol.32 , Issue.4 , pp. 1279-1287
    • Bakala-N'Goma, J.C.1    Williams, H.D.2    Sassene, P.3    Kleberg, K.4    Calderone, M.5    Jannin, V.6
  • 126
    • 84868549081 scopus 로고    scopus 로고
    • Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug saturation level (dose) on the performance of Type I, II, IIIA, IIIB and IV formulations during in vitro digestion
    • [126] Williams, H., Anby, M.U., Sassene, P., Kleberg, K., Bakala-N'Goma, J.C., Calderone, M., et al. Toward the establishment of standardized in vitro tests for lipid-based formulations. 2. The effect of bile salt concentration and drug saturation level (dose) on the performance of Type I, II, IIIA, IIIB and IV formulations during in vitro digestion. Mol. Pharm. 9:11 (2012), 3286–3300.
    • (2012) Mol. Pharm. , vol.9 , Issue.11 , pp. 3286-3300
    • Williams, H.1    Anby, M.U.2    Sassene, P.3    Kleberg, K.4    Bakala-N'Goma, J.C.5    Calderone, M.6
  • 127
    • 0028329964 scopus 로고
    • Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation
    • [127] Mueller, E.A., Kovarik, J.M., van Bree, J.B., Tetzloff, W., Grevel, J., Kutz, K., Improved dose linearity of cyclosporine pharmacokinetics from a microemulsion formulation. Pharm. Res. 11:2 (1994), 301–304.
    • (1994) Pharm. Res. , vol.11 , Issue.2 , pp. 301-304
    • Mueller, E.A.1    Kovarik, J.M.2    van Bree, J.B.3    Tetzloff, W.4    Grevel, J.5    Kutz, K.6
  • 128
    • 0036297426 scopus 로고    scopus 로고
    • A novel phase inversion-based process for the preparation of lipid nanocarriers
    • [128] Heurtault, B., Saulnier, P., Pech, B., Proust, J.-E., Benoit, J.-P., A novel phase inversion-based process for the preparation of lipid nanocarriers. Pharm. Res. 19:6 (2002), 875–880.
    • (2002) Pharm. Res. , vol.19 , Issue.6 , pp. 875-880
    • Heurtault, B.1    Saulnier, P.2    Pech, B.3    Proust, J.-E.4    Benoit, J.-P.5
  • 129
    • 84887371418 scopus 로고    scopus 로고
    • Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery
    • [129] Groo, A.-C., Saulnier, P., Gimel, J.-C., Gravier, J., Ailhas, C., Benoit, J.P., et al. Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery. Int. J. Nanomedicine 8 (2013), 4291–4302.
    • (2013) Int. J. Nanomedicine , vol.8 , pp. 4291-4302
    • Groo, A.-C.1    Saulnier, P.2    Gimel, J.-C.3    Gravier, J.4    Ailhas, C.5    Benoit, J.P.6
  • 130
    • 0023856501 scopus 로고
    • New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier
    • [130] Damgé, C., Michel, C., Aprahamian, M., Couvreur, P., New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carrier. Diabetes 37:2 (1988), 246–251.
    • (1988) Diabetes , vol.37 , Issue.2 , pp. 246-251
    • Damgé, C.1    Michel, C.2    Aprahamian, M.3    Couvreur, P.4
  • 131
    • 0035910876 scopus 로고    scopus 로고
    • Polyisobutylcyanoacrylate nanocapsules containing an aqueous core for the delivery of oligonucleotides
    • [131] Lambert, G., Fattal, E., Pinto-Alphandary, H., Gulik, A., Couvreur, P., Polyisobutylcyanoacrylate nanocapsules containing an aqueous core for the delivery of oligonucleotides. Int. J. Pharm. 214:1–2 (2001), 13–16.
    • (2001) Int. J. Pharm. , vol.214 , Issue.1-2 , pp. 13-16
    • Lambert, G.1    Fattal, E.2    Pinto-Alphandary, H.3    Gulik, A.4    Couvreur, P.5
  • 132
    • 33750027900 scopus 로고    scopus 로고
    • Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules
    • [132] Hillaireau, H., Le Doan, T., Besnard, M., Chacun, H., Janin, J., Couvreur, P., Encapsulation of antiviral nucleotide analogues azidothymidine-triphosphate and cidofovir in poly(iso-butylcyanoacrylate) nanocapsules. Int. J. Pharm. 324:1 (2006), 37–42.
    • (2006) Int. J. Pharm. , vol.324 , Issue.1 , pp. 37-42
    • Hillaireau, H.1    Le Doan, T.2    Besnard, M.3    Chacun, H.4    Janin, J.5    Couvreur, P.6
  • 133
    • 0030883391 scopus 로고    scopus 로고
    • A mechanistic study of the formation of polymer nanoparticles by the emulsification-diffusion technique
    • [133] Quintanar-Guerrero, D., Allémann, E., Doelker, E., Fessi, H., A mechanistic study of the formation of polymer nanoparticles by the emulsification-diffusion technique. Colloid Polym. Sci. 275:7 (1997), 640–647.
    • (1997) Colloid Polym. Sci. , vol.275 , Issue.7 , pp. 640-647
    • Quintanar-Guerrero, D.1    Allémann, E.2    Doelker, E.3    Fessi, H.4
  • 134
    • 0030987752 scopus 로고    scopus 로고
    • Development of positively charged colloidal drug carriers: chitosan-coated polyester nanocapsules and submicron-emulsions
    • [134] Calvo., P., Remufifin-Ldpez, C., Vila-Jato, J.L., Alonso, M.J., Development of positively charged colloidal drug carriers: chitosan-coated polyester nanocapsules and submicron-emulsions. Colloid Polym. Sci. 275 (1997), 46–53.
    • (1997) Colloid Polym. Sci. , vol.275 , pp. 46-53
    • Calvo., P.1    Remufifin-Ldpez, C.2    Vila-Jato, J.L.3    Alonso, M.J.4
  • 135
    • 33645241398 scopus 로고    scopus 로고
    • Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree
    • [135] Prego, C., Torres, D., Fernandez-Megia, E., Novoa-Carballal, R., Quinoa, E., Alonso, M.J., Chitosan-PEG nanocapsules as new carriers for oral peptide delivery. Effect of chitosan pegylation degree. J. Control. Release 111:3 (2006), 299–308.
    • (2006) J. Control. Release , vol.111 , Issue.3 , pp. 299-308
    • Prego, C.1    Torres, D.2    Fernandez-Megia, E.3    Novoa-Carballal, R.4    Quinoa, E.5    Alonso, M.J.6
  • 137
    • 0035072025 scopus 로고    scopus 로고
    • An improved interfacial coacervation technique to fabricate biodegradable nanocapsules of an aqueous peptide solution from polylactide and its block copolymers with poly(ethylene glycol)
    • [137] Ma, J., Feng, P., Ye, C., Wang, Y., Fan, Y., An improved interfacial coacervation technique to fabricate biodegradable nanocapsules of an aqueous peptide solution from polylactide and its block copolymers with poly(ethylene glycol). Colloid Polym. Sci. 279:4 (2001), 387–392.
    • (2001) Colloid Polym. Sci. , vol.279 , Issue.4 , pp. 387-392
    • Ma, J.1    Feng, P.2    Ye, C.3    Wang, Y.4    Fan, Y.5
  • 139
    • 33750059489 scopus 로고    scopus 로고
    • Chitosan nanocapsules as carriers for oral peptide delivery: effect of chitosan molecular weight and type of salt on the in vitro behaviour and in vivo effectiveness
    • [139] Prego, C., Torres, D., Alonso, M.J., Chitosan nanocapsules as carriers for oral peptide delivery: effect of chitosan molecular weight and type of salt on the in vitro behaviour and in vivo effectiveness. J. Nanosci. Nanotechnol. 6:9 (2006), 2921–2928.
    • (2006) J. Nanosci. Nanotechnol. , vol.6 , Issue.9 , pp. 2921-2928
    • Prego, C.1    Torres, D.2    Alonso, M.J.3
  • 140
    • 85027387181 scopus 로고    scopus 로고
    • Nanocapsular formulation of active pharmaceutical ingredients. WO2015189387 A1
    • [140] Lenherr, G., Csaba, N., Thwala, L., Niu, Z., Alonso, M.J., Nanocapsular formulation of active pharmaceutical ingredients. WO2015189387 A1. 2015.
    • (2015)
    • Lenherr, G.1    Csaba, N.2    Thwala, L.3    Niu, Z.4    Alonso, M.J.5
  • 141
    • 84872308929 scopus 로고    scopus 로고
    • Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats
    • [141] Li, X., Qi, J., Xie, Y., Zhang, X., Hu, S., Xu, Y., et al. Nanoemulsions coated with alginate/chitosan as oral insulin delivery systems: preparation, characterization, and hypoglycemic effect in rats. Int. J. Nanomedicine 8 (2013), 23–32.
    • (2013) Int. J. Nanomedicine , vol.8 , pp. 23-32
    • Li, X.1    Qi, J.2    Xie, Y.3    Zhang, X.4    Hu, S.5    Xu, Y.6
  • 142
    • 29144479372 scopus 로고    scopus 로고
    • Influence of surfactants on the parameters of polylactide nanocapsules containing insulin
    • [142] Zhu, Y., Zhang, G., Yang, H., Hong, X., Influence of surfactants on the parameters of polylactide nanocapsules containing insulin. J. Surfactant Deterg. 8:4 (2005), 353–358.
    • (2005) J. Surfactant Deterg. , vol.8 , Issue.4 , pp. 353-358
    • Zhu, Y.1    Zhang, G.2    Yang, H.3    Hong, X.4
  • 143
    • 0030877143 scopus 로고    scopus 로고
    • Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions
    • [143] Baluom, M., Friedman, D.I., Rubinstein, A., Absorption enhancement of calcitonin in the rat intestine by carbopol-containing submicron emulsions. Int. J. Pharm. 154:2 (1997), 235–243.
    • (1997) Int. J. Pharm. , vol.154 , Issue.2 , pp. 235-243
    • Baluom, M.1    Friedman, D.I.2    Rubinstein, A.3
  • 144
    • 70349921511 scopus 로고    scopus 로고
    • Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules
    • [144] Anton, N., Saulnier, P., Gaillard, C., Porcher, E., Vrignaud, S., Benoit, J.P., Aqueous-core lipid nanocapsules for encapsulating fragile hydrophilic and/or lipophilic molecules. Langmuir 25:19 (2009), 11413–11419.
    • (2009) Langmuir , vol.25 , Issue.19 , pp. 11413-11419
    • Anton, N.1    Saulnier, P.2    Gaillard, C.3    Porcher, E.4    Vrignaud, S.5    Benoit, J.P.6
  • 145
    • 1442335293 scopus 로고    scopus 로고
    • Evidence for restrictive parameters in formulation of insulin-loaded nanocapsules
    • [145] Cournarie, F., Chéron, M., Besnard, M., Vauthier, C., Evidence for restrictive parameters in formulation of insulin-loaded nanocapsules. Eur. J. Pharm. Biopharm. 57:2 (2004), 171–179.
    • (2004) Eur. J. Pharm. Biopharm. , vol.57 , Issue.2 , pp. 171-179
    • Cournarie, F.1    Chéron, M.2    Besnard, M.3    Vauthier, C.4
  • 146
    • 0030987752 scopus 로고    scopus 로고
    • Development of positively charged colloidal drug carriers: chitosan-coated polyester nanocapsules and submicron-emulsions
    • [146] Calvo, P., Remuñán-López, C., Vila-Jato, J.L., Alonso, M.J., Development of positively charged colloidal drug carriers: chitosan-coated polyester nanocapsules and submicron-emulsions. Colloid Polym. Sci. 275:1 (1997), 46–53.
    • (1997) Colloid Polym. Sci. , vol.275 , Issue.1 , pp. 46-53
    • Calvo, P.1    Remuñán-López, C.2    Vila-Jato, J.L.3    Alonso, M.J.4
  • 147
    • 80052970386 scopus 로고    scopus 로고
    • Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles
    • [147] Vrignaud, S., Benoit, J.P., Saulnier, P., Strategies for the nanoencapsulation of hydrophilic molecules in polymer-based nanoparticles. Biomaterials 32:33 (2011), 8593–8604.
    • (2011) Biomaterials , vol.32 , Issue.33 , pp. 8593-8604
    • Vrignaud, S.1    Benoit, J.P.2    Saulnier, P.3
  • 148
    • 12944289479 scopus 로고    scopus 로고
    • In vitro release of protein from poly(butylcyanoacrylate) nanocapsules with an aqueous core
    • [148] Li, S., He, Y., Li, C., Liu, X., In vitro release of protein from poly(butylcyanoacrylate) nanocapsules with an aqueous core. Colloid Polym. Sci. 283:5 (2004), 480–485.
    • (2004) Colloid Polym. Sci. , vol.283 , Issue.5 , pp. 480-485
    • Li, S.1    He, Y.2    Li, C.3    Liu, X.4
  • 149
    • 0036222307 scopus 로고    scopus 로고
    • In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion
    • [149] Watnasirichaikul, S., Rades, T., Tucker, I.G., Davies, N.M., In-vitro release and oral bioactivity of insulin in diabetic rats using nanocapsules dispersed in biocompatible microemulsion. J. Pharm. Pharmacol. 54:4 (2002), 473–480.
    • (2002) J. Pharm. Pharmacol. , vol.54 , Issue.4 , pp. 473-480
    • Watnasirichaikul, S.1    Rades, T.2    Tucker, I.G.3    Davies, N.M.4
  • 150
    • 0037139386 scopus 로고    scopus 로고
    • Effects of formulation variables on characteristics of poly (ethylcyanoacrylate) nanocapsules prepared from w/o microemulsions
    • [150] Watnasirichaikul, S., Rades, T., Tucker, I.G., Davies, N.M., Effects of formulation variables on characteristics of poly (ethylcyanoacrylate) nanocapsules prepared from w/o microemulsions. Int. J. Pharm. 235:1–2 (2002), 237–246.
    • (2002) Int. J. Pharm. , vol.235 , Issue.1-2 , pp. 237-246
    • Watnasirichaikul, S.1    Rades, T.2    Tucker, I.G.3    Davies, N.M.4
  • 151
    • 0033849510 scopus 로고    scopus 로고
    • Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions
    • [151] Watnasirichaikul, S., Davies, N., Rades, T., Tucker, I., Preparation of biodegradable insulin nanocapsules from biocompatible microemulsions. Pharm. Res. 17:6 (2000), 684–689.
    • (2000) Pharm. Res. , vol.17 , Issue.6 , pp. 684-689
    • Watnasirichaikul, S.1    Davies, N.2    Rades, T.3    Tucker, I.4
  • 152
    • 60749095944 scopus 로고    scopus 로고
    • Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation
    • [152] Graf, A., Rades, T., Hook, S.M., Oral insulin delivery using nanoparticles based on microemulsions with different structure-types: optimisation and in vivo evaluation. Eur. J. Pharm. Sci. 37:1 (2009), 53–61.
    • (2009) Eur. J. Pharm. Sci. , vol.37 , Issue.1 , pp. 53-61
    • Graf, A.1    Rades, T.2    Hook, S.M.3
  • 153
    • 0026074310 scopus 로고
    • The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats
    • [153] Michel, C., Aprahamian, M., Defontaine, L., Couvreur, P., DamgÉ, C., The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats. J. Pharm. Pharmacol. 43:1 (1991), 1–5.
    • (1991) J. Pharm. Pharmacol. , vol.43 , Issue.1 , pp. 1-5
    • Michel, C.1    Aprahamian, M.2    Defontaine, L.3    Couvreur, P.4    DamgÉ, C.5
  • 155
    • 0037151550 scopus 로고    scopus 로고
    • Absorption and efficiency of insulin after oral administration of insulin-loaded nanocapsules in diabetic rats
    • [155] Cournarie, F., Auchere, D., Chevenne, D., Lacour, B., Seiller, M., Vauthier, C., Absorption and efficiency of insulin after oral administration of insulin-loaded nanocapsules in diabetic rats. Int. J. Pharm. 242:1–2 (2002), 325–328.
    • (2002) Int. J. Pharm. , vol.242 , Issue.1-2 , pp. 325-328
    • Cournarie, F.1    Auchere, D.2    Chevenne, D.3    Lacour, B.4    Seiller, M.5    Vauthier, C.6
  • 156
    • 0037523228 scopus 로고    scopus 로고
    • Visualization of insulin-loaded nanocapsules: in vitro and in vivo studies after oral administration to rats
    • [156] Pinto-Alphandary, H., Aboubakar, M., Jaillard, D., Couvreur, P., Vauthier, C., Visualization of insulin-loaded nanocapsules: in vitro and in vivo studies after oral administration to rats. Pharm. Res. 20:7 (2003), 1071–1084.
    • (2003) Pharm. Res. , vol.20 , Issue.7 , pp. 1071-1084
    • Pinto-Alphandary, H.1    Aboubakar, M.2    Jaillard, D.3    Couvreur, P.4    Vauthier, C.5
  • 157
    • 41349092037 scopus 로고    scopus 로고
    • Protein delivery using nanoparticles based on microemulsions with different structure-types
    • [157] Graf, A., Jack, K.S., Whittaker, A.K., Hook, S.M., Rades, T., Protein delivery using nanoparticles based on microemulsions with different structure-types. Eur. J. Pharm. Sci. 33:4-5 (2008), 434–444.
    • (2008) Eur. J. Pharm. Sci. , vol.33 , Issue.4-5 , pp. 434-444
    • Graf, A.1    Jack, K.S.2    Whittaker, A.K.3    Hook, S.M.4    Rades, T.5
  • 158
    • 0028283741 scopus 로고
    • Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats
    • [158] Lowe, P.J., Temple, C.S., Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats. J. Pharm. Pharmacol. 46:7 (1994), 547–552.
    • (1994) J. Pharm. Pharmacol. , vol.46 , Issue.7 , pp. 547-552
    • Lowe, P.J.1    Temple, C.S.2
  • 159
    • 0030474308 scopus 로고    scopus 로고
    • Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in non obese diabetic mice
    • [159] Sai, P., Damgé, C., Rivereau, A.S., et al. Prophylactic oral administration of metabolically active insulin entrapped in isobutylcyanoacrylate nanocapsules reduces the incidence of diabetes in non obese diabetic mice. J. Autoimmun. 9:6 (1996), 713–721.
    • (1996) J. Autoimmun. , vol.9 , Issue.6 , pp. 713-721
    • Sai, P.1    Damgé, C.2    Rivereau, A.S.3
  • 160
    • 23744473464 scopus 로고    scopus 로고
    • Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization
    • [160] Krauel, K., Davies, N.M., Hook, S., Rades, T., Using different structure types of microemulsions for the preparation of poly(alkylcyanoacrylate) nanoparticles by interfacial polymerization. J. Control. Release 106:1-2 (2005), 76–87.
    • (2005) J. Control. Release , vol.106 , Issue.1-2 , pp. 76-87
    • Krauel, K.1    Davies, N.M.2    Hook, S.3    Rades, T.4
  • 161
    • 79951947663 scopus 로고    scopus 로고
    • Release and bioactivity of PACA nanoparticles containing D-Lys(6)-GnRH for brushtail possum fertility control
    • [161] Kafka, A.P., McLeod, B.J., Rades, T., McDowell, A., Release and bioactivity of PACA nanoparticles containing D-Lys(6)-GnRH for brushtail possum fertility control. J. Control. Release 149:3 (2011), 307–313.
    • (2011) J. Control. Release , vol.149 , Issue.3 , pp. 307-313
    • Kafka, A.P.1    McLeod, B.J.2    Rades, T.3    McDowell, A.4
  • 162
    • 81255166874 scopus 로고    scopus 로고
    • Liposomes and other vesicular systems: structural characteristics, methods of preparation, and use in nanomedicine
    • [162] Elizondo, E., Moreno, E., Cabrera, I., Cordoba, A., Sala, S., Veciana, J., et al. Liposomes and other vesicular systems: structural characteristics, methods of preparation, and use in nanomedicine. Prog. Mol. Biol. Transl. Sci. 104 (2011), 1–52.
    • (2011) Prog. Mol. Biol. Transl. Sci. , vol.104 , pp. 1-52
    • Elizondo, E.1    Moreno, E.2    Cabrera, I.3    Cordoba, A.4    Sala, S.5    Veciana, J.6
  • 163
    • 84869773544 scopus 로고    scopus 로고
    • Liposomal delivery of proteins and peptides
    • [163] Swaminathan, J., Ehrhardt, C., Liposomal delivery of proteins and peptides. Expert Opin. Drug Deliv. 9:12 (2012), 1489–1503.
    • (2012) Expert Opin. Drug Deliv. , vol.9 , Issue.12 , pp. 1489-1503
    • Swaminathan, J.1    Ehrhardt, C.2
  • 164
    • 85012373035 scopus 로고
    • Diffusion of univalent ions across the lamellae of swollen phospholipids
    • [164] Bangham, A.D., Standish, M.M., Watkins, J.C., Diffusion of univalent ions across the lamellae of swollen phospholipids. J. Mol. Biol. 13:1 (1965), 238–252.
    • (1965) J. Mol. Biol. , vol.13 , Issue.1 , pp. 238-252
    • Bangham, A.D.1    Standish, M.M.2    Watkins, J.C.3
  • 165
    • 0000631893 scopus 로고
    • Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope
    • [165] Bangham, A.D., Horne, R.W., Negative staining of phospholipids and their structural modification by surface-active agents as observed in the electron microscope. J. Mol. Biol. 8 (1964), 660–668.
    • (1964) J. Mol. Biol. , vol.8 , pp. 660-668
    • Bangham, A.D.1    Horne, R.W.2
  • 166
    • 84908131933 scopus 로고    scopus 로고
    • Liposomal drug delivery: a versatile platform for challenging clinical applications
    • [166] Madni, A., Sarfraz, M., Rehman, M., Ahmad, M., Akhtar, N., Ahmad, S., et al. Liposomal drug delivery: a versatile platform for challenging clinical applications. J. Pharm. Pharm. Sci. 17:3 (2014), 401–426.
    • (2014) J. Pharm. Pharm. Sci. , vol.17 , Issue.3 , pp. 401-426
    • Madni, A.1    Sarfraz, M.2    Rehman, M.3    Ahmad, M.4    Akhtar, N.5    Ahmad, S.6
  • 167
    • 33750003379 scopus 로고    scopus 로고
    • Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: development, characterization and interaction with leuprolide
    • [167] Carafa, M., Marianecci, C., Annibaldi, V., Di Stefano, A., Sozio, P., Santucci, E., Novel O-palmitoylscleroglucan-coated liposomes as drug carriers: development, characterization and interaction with leuprolide. Int. J. Pharm. 325:1-2 (2006), 155–162.
    • (2006) Int. J. Pharm. , vol.325 , Issue.1-2 , pp. 155-162
    • Carafa, M.1    Marianecci, C.2    Annibaldi, V.3    Di Stefano, A.4    Sozio, P.5    Santucci, E.6
  • 168
    • 84892585292 scopus 로고    scopus 로고
    • Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration
    • [168] Agrawal, A.K., Harde, H., Thanki, K., Jain, S., Improved stability and antidiabetic potential of insulin containing folic acid functionalized polymer stabilized multilayered liposomes following oral administration. Biomacromolecules 15:1 (2014), 350–360.
    • (2014) Biomacromolecules , vol.15 , Issue.1 , pp. 350-360
    • Agrawal, A.K.1    Harde, H.2    Thanki, K.3    Jain, S.4
  • 169
    • 77952714678 scopus 로고    scopus 로고
    • Silica nanoparticle coated liposomes: a new type of hybrid nanocapsule for proteins
    • [169] Mohanraj, V.J., Barnes, T.J., Prestidge, C.A., Silica nanoparticle coated liposomes: a new type of hybrid nanocapsule for proteins. Int. J. Pharm. 392:1-2 (2010), 285–293.
    • (2010) Int. J. Pharm. , vol.392 , Issue.1-2 , pp. 285-293
    • Mohanraj, V.J.1    Barnes, T.J.2    Prestidge, C.A.3
  • 170
    • 77950188555 scopus 로고    scopus 로고
    • Investigation of archaeosomes as carriers for oral delivery of peptides
    • [170] Li, Z., Chen, J., Sun, W., Xu, Y., Investigation of archaeosomes as carriers for oral delivery of peptides. Biochem. Biophys. Res. Commun. 394:2 (2010), 412–417.
    • (2010) Biochem. Biophys. Res. Commun. , vol.394 , Issue.2 , pp. 412-417
    • Li, Z.1    Chen, J.2    Sun, W.3    Xu, Y.4
  • 171
    • 33845438641 scopus 로고    scopus 로고
    • In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin
    • [171] Pardakhty, A., Varshosaz, J., Rouholamini, A., In vitro study of polyoxyethylene alkyl ether niosomes for delivery of insulin. Int. J. Pharm. 328:2 (2007), 130–141.
    • (2007) Int. J. Pharm. , vol.328 , Issue.2 , pp. 130-141
    • Pardakhty, A.1    Varshosaz, J.2    Rouholamini, A.3
  • 172
    • 0033047397 scopus 로고    scopus 로고
    • Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin
    • [172] Iwanaga, K., Ono, S., Narioka, K., Kakemi, M., Morimoto, K., Yamashita, S., et al. Application of surface-coated liposomes for oral delivery of peptide: effects of coating the liposome's surface on the GI transit of insulin. J. Pharm. Sci. 88:2 (1999), 248–252.
    • (1999) J. Pharm. Sci. , vol.88 , Issue.2 , pp. 248-252
    • Iwanaga, K.1    Ono, S.2    Narioka, K.3    Kakemi, M.4    Morimoto, K.5    Yamashita, S.6
  • 173
    • 0028282155 scopus 로고
    • Liposomes as a carrier for oral administration of insulin: effect of formulation factors
    • [173] Choudhari, K.B., Labhasetwar, V., Dorle, A.K., Liposomes as a carrier for oral administration of insulin: effect of formulation factors. J. Microencapsul. 11:3 (1994), 319–325.
    • (1994) J. Microencapsul. , vol.11 , Issue.3 , pp. 319-325
    • Choudhari, K.B.1    Labhasetwar, V.2    Dorle, A.K.3
  • 175
    • 0035937527 scopus 로고    scopus 로고
    • Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat
    • [175] Kisel, M.A., Kulik, L.N., Tsybovsky, I.S., Vlasov, A.P., Vorob'yov, M.S., Kholodova, E.A., et al. Liposomes with phosphatidylethanol as a carrier for oral delivery of insulin: studies in the rat. Int. J. Pharm. 216:1–2 (2001), 105–114.
    • (2001) Int. J. Pharm. , vol.216 , Issue.1-2 , pp. 105-114
    • Kisel, M.A.1    Kulik, L.N.2    Tsybovsky, I.S.3    Vlasov, A.P.4    Vorob'yov, M.S.5    Kholodova, E.A.6
  • 176
    • 79551528343 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of WGA-carbopol modified liposomes as carriers for oral peptide delivery
    • [176] Makhlof, A., Fujimoto, S., Tozuka, Y., Takeuchi, H., In vitro and in vivo evaluation of WGA-carbopol modified liposomes as carriers for oral peptide delivery. Eur. J. Pharm. Biopharm. 77:2 (2011), 216–224.
    • (2011) Eur. J. Pharm. Biopharm. , vol.77 , Issue.2 , pp. 216-224
    • Makhlof, A.1    Fujimoto, S.2    Tozuka, Y.3    Takeuchi, H.4
  • 177
    • 38349112036 scopus 로고    scopus 로고
    • Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes
    • [177] Thirawong, N., Thongborisute, J., Takeuchi, H., Sriamornsak, P., Improved intestinal absorption of calcitonin by mucoadhesive delivery of novel pectin-liposome nanocomplexes. J. Control. Release 125:3 (2008), 236–245.
    • (2008) J. Control. Release , vol.125 , Issue.3 , pp. 236-245
    • Thirawong, N.1    Thongborisute, J.2    Takeuchi, H.3    Sriamornsak, P.4
  • 178
    • 33745084278 scopus 로고    scopus 로고
    • The effect of particle structure of chitosan-coated liposomes and type of chitosan on oral delivery of calcitonin
    • [178] Thongborisute, J., Tsuruta, A., Kawabata, Y., Takeuchi, H., The effect of particle structure of chitosan-coated liposomes and type of chitosan on oral delivery of calcitonin. J. Drug Target. 14:3 (2006), 147–154.
    • (2006) J. Drug Target. , vol.14 , Issue.3 , pp. 147-154
    • Thongborisute, J.1    Tsuruta, A.2    Kawabata, Y.3    Takeuchi, H.4
  • 179
    • 24944542800 scopus 로고    scopus 로고
    • Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs
    • [179] Takeuchi, H., Matsui, Y., Sugihara, H., Yamamoto, H., Kawashima, Y., Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs. Int. J. Pharm. 303:1-2 (2005), 160–170.
    • (2005) Int. J. Pharm. , vol.303 , Issue.1-2 , pp. 160-170
    • Takeuchi, H.1    Matsui, Y.2    Sugihara, H.3    Yamamoto, H.4    Kawashima, Y.5
  • 180
    • 0037449495 scopus 로고    scopus 로고
    • Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats
    • [180] Takeuchi, H., Matsui, Y., Yamamoto, H., Kawashima, Y., Mucoadhesive properties of carbopol or chitosan-coated liposomes and their effectiveness in the oral administration of calcitonin to rats. J. Control. Release 86:2–3 (2003), 235–242.
    • (2003) J. Control. Release , vol.86 , Issue.2-3 , pp. 235-242
    • Takeuchi, H.1    Matsui, Y.2    Yamamoto, H.3    Kawashima, Y.4
  • 181
    • 84877018963 scopus 로고    scopus 로고
    • Comparative study of pluronic F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats
    • [181] Chen, D., Xia, D., Li, X., Zhu, Q., Yu, H., Zhu, C., et al. Comparative study of pluronic F127-modified liposomes and chitosan-modified liposomes for mucus penetration and oral absorption of cyclosporine A in rats. Int. J. Pharm. 449:1-2 (2013), 1–9.
    • (2013) Int. J. Pharm. , vol.449 , Issue.1-2 , pp. 1-9
    • Chen, D.1    Xia, D.2    Li, X.3    Zhu, Q.4    Yu, H.5    Zhu, C.6
  • 183
    • 79960193011 scopus 로고    scopus 로고
    • Oral peptide delivery by tetraether lipid liposomes
    • [183] Parmentier, J., Thewes, B., Gropp, F., Fricker, G., Oral peptide delivery by tetraether lipid liposomes. Int. J. Pharm. 415:1-2 (2011), 150–157.
    • (2011) Int. J. Pharm. , vol.415 , Issue.1-2 , pp. 150-157
    • Parmentier, J.1    Thewes, B.2    Gropp, F.3    Fricker, G.4
  • 184
    • 84891002990 scopus 로고    scopus 로고
    • Biotinylated liposomes as potential carriers for the oral delivery of insulin
    • [184] Zhang, X., Qi, J., Lu, Y., He, W., Li, X., Wu, W., Biotinylated liposomes as potential carriers for the oral delivery of insulin. Nanomedicine 10:1 (2014), 167–176.
    • (2014) Nanomedicine , vol.10 , Issue.1 , pp. 167-176
    • Zhang, X.1    Qi, J.2    Lu, Y.3    He, W.4    Li, X.5    Wu, W.6
  • 185
    • 84938635910 scopus 로고    scopus 로고
    • Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity
    • [185] Zhang, X., Qi, J., Lu, Y., Hu, X., He, W., Wu, W., Enhanced hypoglycemic effect of biotin-modified liposomes loading insulin: effect of formulation variables, intracellular trafficking, and cytotoxicity. Nanoscale Res. Lett., 9(1), 2014, 185.
    • (2014) Nanoscale Res. Lett. , vol.9 , Issue.1 , pp. 185
    • Zhang, X.1    Qi, J.2    Lu, Y.3    Hu, X.4    He, W.5    Wu, W.6
  • 186
    • 84862824387 scopus 로고    scopus 로고
    • Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose
    • [186] Niu, M., Lu, Y., Hovgaard, L., Guan, P., Tan, Y., Lian, R., et al. Hypoglycemic activity and oral bioavailability of insulin-loaded liposomes containing bile salts in rats: the effect of cholate type, particle size and administered dose. Eur. J. Pharm. Biopharm. 81:2 (2012), 265–272.
    • (2012) Eur. J. Pharm. Biopharm. , vol.81 , Issue.2 , pp. 265-272
    • Niu, M.1    Lu, Y.2    Hovgaard, L.3    Guan, P.4    Tan, Y.5    Lian, R.6
  • 187
    • 84888599853 scopus 로고    scopus 로고
    • Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study
    • [187] Niu, M., Tan, Y., Guan, P., Hovgaard, L., Lu, Y., Qi, J., et al. Enhanced oral absorption of insulin-loaded liposomes containing bile salts: a mechanistic study. Int. J. Pharm. 460:1-2 (2014), 119–130.
    • (2014) Int. J. Pharm. , vol.460 , Issue.1-2 , pp. 119-130
    • Niu, M.1    Tan, Y.2    Guan, P.3    Hovgaard, L.4    Lu, Y.5    Qi, J.6
  • 188
    • 84872763300 scopus 로고    scopus 로고
    • Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media
    • [188] Hu, S., Niu, M., Hu, F., Lu, Y., Qi, J., Yin, Z., et al. Integrity and stability of oral liposomes containing bile salts studied in simulated and ex vivo gastrointestinal media. Int. J. Pharm. 441:1-2 (2013), 693–700.
    • (2013) Int. J. Pharm. , vol.441 , Issue.1-2 , pp. 693-700
    • Hu, S.1    Niu, M.2    Hu, F.3    Lu, Y.4    Qi, J.5    Yin, Z.6
  • 189
    • 84908374133 scopus 로고    scopus 로고
    • Uptake and transport of insulin across intestinal membrane model using trimethyl chitosan coated insulin niosomes
    • [189] Moghassemi, S., Parnian, E., Hakamivala, A., Darzianiazizi, M., Vardanjani, M.M., Kashanian, S., et al. Uptake and transport of insulin across intestinal membrane model using trimethyl chitosan coated insulin niosomes. Mater. Sci. Eng., C 46 (2015), 333–340.
    • (2015) Mater. Sci. Eng., C , vol.46 , pp. 333-340
    • Moghassemi, S.1    Parnian, E.2    Hakamivala, A.3    Darzianiazizi, M.4    Vardanjani, M.M.5    Kashanian, S.6
  • 190
    • 16244422972 scopus 로고    scopus 로고
    • Investigation of lectin-modified insulin liposomes as carriers for oral administration
    • [190] Zhang, N., Ping, Q.N., Huang, G.H., Xu, W.F., Investigation of lectin-modified insulin liposomes as carriers for oral administration. Int. J. Pharm. 294:1-2 (2005), 247–259.
    • (2005) Int. J. Pharm. , vol.294 , Issue.1-2 , pp. 247-259
    • Zhang, N.1    Ping, Q.N.2    Huang, G.H.3    Xu, W.F.4
  • 191
    • 30644471556 scopus 로고    scopus 로고
    • Multivesicular liposomes for oral delivery of recombinant human epidermal growth factor
    • [191] Li, H., An, J., Park, J.-S., Han, K., Multivesicular liposomes for oral delivery of recombinant human epidermal growth factor. Arch. Pharm. Res. 28:8 (2005), 988–994.
    • (2005) Arch. Pharm. Res. , vol.28 , Issue.8 , pp. 988-994
    • Li, H.1    An, J.2    Park, J.-S.3    Han, K.4
  • 192
    • 0037376719 scopus 로고    scopus 로고
    • A spin labelling study of immunomodulating peptidoglycan monomer and adamantyltripeptides entrapped into liposomes
    • [192] Frkanec, R., Noethig-Laslo, V., Vranešić, B., Mirosavljević, K., Tomašić, J., A spin labelling study of immunomodulating peptidoglycan monomer and adamantyltripeptides entrapped into liposomes. Biochim. Biophys. Acta Biomembr. 1611:1-2 (2003), 187–196.
    • (2003) Biochim. Biophys. Acta Biomembr. , vol.1611 , Issue.1-2 , pp. 187-196
    • Frkanec, R.1    Noethig-Laslo, V.2    Vranešić, B.3    Mirosavljević, K.4    Tomašić, J.5
  • 193
    • 84910001826 scopus 로고    scopus 로고
    • Administration strategies for proteins and peptides
    • [193] Ibraheem, D., Elaissari, A., Fessi, H., Administration strategies for proteins and peptides. Int. J. Pharm. 477:1-2 (2014), 578–589.
    • (2014) Int. J. Pharm. , vol.477 , Issue.1-2 , pp. 578-589
    • Ibraheem, D.1    Elaissari, A.2    Fessi, H.3
  • 194
    • 1442349705 scopus 로고    scopus 로고
    • The effect of different lipid components on the in vitro stability and release kinetics of liposome formulations
    • [194] Anderson, M., Omri, A., The effect of different lipid components on the in vitro stability and release kinetics of liposome formulations. Drug Deliv. 11:1 (2004), 33–39.
    • (2004) Drug Deliv. , vol.11 , Issue.1 , pp. 33-39
    • Anderson, M.1    Omri, A.2
  • 195
    • 41549155028 scopus 로고    scopus 로고
    • Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins
    • [195] Grenha, A., Remuñán-López, C., Carvalho, E.L.S., Seijo, B., Microspheres containing lipid/chitosan nanoparticles complexes for pulmonary delivery of therapeutic proteins. Eur. J. Pharm. Biopharm. 69:1 (2008), 83–93.
    • (2008) Eur. J. Pharm. Biopharm. , vol.69 , Issue.1 , pp. 83-93
    • Grenha, A.1    Remuñán-López, C.2    Carvalho, E.L.S.3    Seijo, B.4
  • 196
    • 0038301700 scopus 로고    scopus 로고
    • Double liposomes: hypoglycemic effects of liposomal insulin on normal rats
    • [196] Katayama, K., Kato, Y., Onishi, H., Nagai, T., Machida, Y., Double liposomes: hypoglycemic effects of liposomal insulin on normal rats. Drug Dev. Ind. Pharm. 29:7 (2003), 725–731.
    • (2003) Drug Dev. Ind. Pharm. , vol.29 , Issue.7 , pp. 725-731
    • Katayama, K.1    Kato, Y.2    Onishi, H.3    Nagai, T.4    Machida, Y.5
  • 197
    • 32544450145 scopus 로고    scopus 로고
    • Novel mucosal insulin delivery systems based on fusogenic liposomes
    • [197] Goto, T., Morishita, M., Nishimura, K., Nakanishi, M., Kato, A., Ehara, J., et al. Novel mucosal insulin delivery systems based on fusogenic liposomes. Pharm. Res. 23:2 (2006), 384–391.
    • (2006) Pharm. Res. , vol.23 , Issue.2 , pp. 384-391
    • Goto, T.1    Morishita, M.2    Nishimura, K.3    Nakanishi, M.4    Kato, A.5    Ehara, J.6
  • 198
    • 84887204356 scopus 로고    scopus 로고
    • Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats
    • [198] Gradauer, K., Barthelmes, J., Vonach, C., Almer, G., Mangge, H., Teubl, B., et al. Liposomes coated with thiolated chitosan enhance oral peptide delivery to rats. J. Control. Release 172:3 (2013), 872–878.
    • (2013) J. Control. Release , vol.172 , Issue.3 , pp. 872-878
    • Gradauer, K.1    Barthelmes, J.2    Vonach, C.3    Almer, G.4    Mangge, H.5    Teubl, B.6
  • 199
    • 84871598033 scopus 로고    scopus 로고
    • Thiomer-coated liposomes harbor permeation enhancing and efflux pump inhibitory properties
    • [199] Gradauer, K., Dünnhaupt, S., Vonach, C., Szöllösi, H., Pali-Schöll, I., Mangge, H., et al. Thiomer-coated liposomes harbor permeation enhancing and efflux pump inhibitory properties. J. Control. Release 165:3 (2013), 207–215.
    • (2013) J. Control. Release , vol.165 , Issue.3 , pp. 207-215
    • Gradauer, K.1    Dünnhaupt, S.2    Vonach, C.3    Szöllösi, H.4    Pali-Schöll, I.5    Mangge, H.6
  • 200
    • 0037726624 scopus 로고    scopus 로고
    • Potentiality of double liposomes containing salmon calcitonin as an oral dosage form
    • [200] Yamabe, K., Kato, Y., Onishi, H., Machida, Y., Potentiality of double liposomes containing salmon calcitonin as an oral dosage form. J. Control. Release 89:3 (2003), 429–436.
    • (2003) J. Control. Release , vol.89 , Issue.3 , pp. 429-436
    • Yamabe, K.1    Kato, Y.2    Onishi, H.3    Machida, Y.4
  • 201
    • 51049100636 scopus 로고    scopus 로고
    • Comparison of reversible and nonreversible aqueous-soluble lipidized conjugates of salmon calcitonin
    • [201] Cheng, W., Lim, L.-Y., Comparison of reversible and nonreversible aqueous-soluble lipidized conjugates of salmon calcitonin. Mol. Pharm. 5:4 (2008), 610–621.
    • (2008) Mol. Pharm. , vol.5 , Issue.4 , pp. 610-621
    • Cheng, W.1    Lim, L.-Y.2
  • 202
    • 0034467999 scopus 로고    scopus 로고
    • Development of novel lipophilic derivatives of dadle (leucine enkephalin analogue): intestinal permeability characteristics of DADLE derivatives in rats
    • [202] Uchiyama, T., Kotani, A., Tatsumi, H., Kishida, T., Okamoto, A., Okada, N., et al. Development of novel lipophilic derivatives of dadle (leucine enkephalin analogue): intestinal permeability characteristics of DADLE derivatives in rats. Pharm. Res. 17:12 (2000), 1461–1467.
    • (2000) Pharm. Res. , vol.17 , Issue.12 , pp. 1461-1467
    • Uchiyama, T.1    Kotani, A.2    Tatsumi, H.3    Kishida, T.4    Okamoto, A.5    Okada, N.6
  • 204
    • 0031784784 scopus 로고    scopus 로고
    • Permeability characteristics of tetragastrins across intestinal membranes using the Caco-2 monolayer system: comparison between acylation and application of protease inhibitors
    • [204] Fujita, T., Kawahara, I., Quan, Y., Hattori, K., Takenaka, K., Muranishi, S., et al. Permeability characteristics of tetragastrins across intestinal membranes using the Caco-2 monolayer system: comparison between acylation and application of protease inhibitors. Pharm. Res. 15:9 (1998), 1387–1392.
    • (1998) Pharm. Res. , vol.15 , Issue.9 , pp. 1387-1392
    • Fujita, T.1    Kawahara, I.2    Quan, Y.3    Hattori, K.4    Takenaka, K.5    Muranishi, S.6
  • 205
    • 0030039663 scopus 로고    scopus 로고
    • Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: synergistic effects of acylation and absorption enhancers
    • [205] Fujita, T., Fujita, T., Morikawa, K., Tanaka, H., Iemura, O., Yamamoto, A., et al. Improvement of intestinal absorption of human calcitonin by chemical modification with fatty acids: synergistic effects of acylation and absorption enhancers. Int. J. Pharm. 134:1–2 (1996), 47–57.
    • (1996) Int. J. Pharm. , vol.134 , Issue.1-2 , pp. 47-57
    • Fujita, T.1    Fujita, T.2    Morikawa, K.3    Tanaka, H.4    Iemura, O.5    Yamamoto, A.6
  • 206
    • 0037467203 scopus 로고    scopus 로고
    • Reversible lipidization for the oral delivery of salmon calcitonin
    • [206] Wang, J., Chow, D., Heiati, H., Shen, W.-C., Reversible lipidization for the oral delivery of salmon calcitonin. J. Control. Release 88:3 (2003), 369–380.
    • (2003) J. Control. Release , vol.88 , Issue.3 , pp. 369-380
    • Wang, J.1    Chow, D.2    Heiati, H.3    Shen, W.-C.4
  • 207
    • 84862015361 scopus 로고    scopus 로고
    • A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine(5)-enkephalin, to the brain
    • [207] Lalatsa, A., Lee, V., Malkinson, J.P., Zloh, M., Schatzlein, A.G., Uchegbu, I.F., A prodrug nanoparticle approach for the oral delivery of a hydrophilic peptide, leucine(5)-enkephalin, to the brain. Mol. Pharm. 9:6 (2012), 1665–1680.
    • (2012) Mol. Pharm. , vol.9 , Issue.6 , pp. 1665-1680
    • Lalatsa, A.1    Lee, V.2    Malkinson, J.P.3    Zloh, M.4    Schatzlein, A.G.5    Uchegbu, I.F.6
  • 209
    • 0032403463 scopus 로고    scopus 로고
    • The effect of physical barriers and properties on the oral absorption of particulates
    • [209] Norris, D.A., Puri, N., Sinko, P.J., The effect of physical barriers and properties on the oral absorption of particulates. Adv. Drug Deliv. Rev. 34:2–3 (1998), 135–154.
    • (1998) Adv. Drug Deliv. Rev. , vol.34 , Issue.2-3 , pp. 135-154
    • Norris, D.A.1    Puri, N.2    Sinko, P.J.3
  • 210
  • 212
    • 84888203026 scopus 로고    scopus 로고
    • Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems
    • [212] Friedl, H., Dünnhaupt, S., Hintzen, F., Waldner, C., Parikh, S., Pearson, J.P., Development and evaluation of a novel mucus diffusion test system approved by self-nanoemulsifying drug delivery systems. J. Pharm. Sci. 102:12 (2013), 4406–4413.
    • (2013) J. Pharm. Sci. , vol.102 , Issue.12 , pp. 4406-4413
    • Friedl, H.1    Dünnhaupt, S.2    Hintzen, F.3    Waldner, C.4    Parikh, S.5    Pearson, J.P.6
  • 213
    • 0343962248 scopus 로고    scopus 로고
    • The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration
    • [213] Tobio, M., Sanchez, A., Vila, A., Soriano, I.I., Evora, C., Vila-Jato, J.L., Alonso, M.J., The role of PEG on the stability in digestive fluids and in vivo fate of PEG-PLA nanoparticles following oral administration. Colloids Surf. B: Biointerfaces 18 (2000), 315–323.
    • (2000) Colloids Surf. B: Biointerfaces , vol.18 , pp. 315-323
    • Tobio, M.1    Sanchez, A.2    Vila, A.3    Soriano, I.I.4    Evora, C.5    Vila-Jato, J.L.6    Alonso, M.J.7
  • 214
    • 84862519335 scopus 로고    scopus 로고
    • Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus
    • 138ra79
    • [214] Ensign, L.M., Tang, B.C., Wang, Y.Y., Tse, T.A., Hoen, T., Cone, R., et al. Mucus-penetrating nanoparticles for vaginal drug delivery protect against herpes simplex virus. Sci. Transl. Med., 4(138), 2012, 138ra79.
    • (2012) Sci. Transl. Med. , vol.4 , Issue.138
    • Ensign, L.M.1    Tang, B.C.2    Wang, Y.Y.3    Tse, T.A.4    Hoen, T.5    Cone, R.6
  • 215
    • 84859719708 scopus 로고    scopus 로고
    • Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers
    • [215] Ensign, L.M., Cone, R., Hanes, J., Oral drug delivery with polymeric nanoparticles: the gastrointestinal mucus barriers. Adv. Drug Deliv. Rev. 64:6 (2012), 557–570.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , Issue.6 , pp. 557-570
    • Ensign, L.M.1    Cone, R.2    Hanes, J.3
  • 216
    • 84910618859 scopus 로고    scopus 로고
    • Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse
    • [216] Maisel, K., Ensign, L., Reddy, M., Cone, R., Hanes, J., Effect of surface chemistry on nanoparticle interaction with gastrointestinal mucus and distribution in the gastrointestinal tract following oral and rectal administration in the mouse. J. Control. Release 197 (2015), 48–57.
    • (2015) J. Control. Release , vol.197 , pp. 48-57
    • Maisel, K.1    Ensign, L.2    Reddy, M.3    Cone, R.4    Hanes, J.5
  • 217
    • 84862599039 scopus 로고    scopus 로고
    • Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake
    • [217] Li, X., Chen, D., Le, C., Zhu, C., Gan, Y., Hovgaard, L., et al. Novel mucus-penetrating liposomes as a potential oral drug delivery system: preparation, in vitro characterization, and enhanced cellular uptake. Int. J. Nanomedicine 6 (2011), 3151–3162.
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 3151-3162
    • Li, X.1    Chen, D.2    Le, C.3    Zhu, C.4    Gan, Y.5    Hovgaard, L.6
  • 218
    • 84887371418 scopus 로고    scopus 로고
    • Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery
    • [218] Groo, A.-C., Saulnier, P., Gimel, J.-C., Gravier, J., Ailhas, C., Benoit, J.-P., et al. Fate of paclitaxel lipid nanocapsules in intestinal mucus in view of their oral delivery. Int. J. Nanomedicine 8 (2013), 4291–4302.
    • (2013) Int. J. Nanomedicine , vol.8 , pp. 4291-4302
    • Groo, A.-C.1    Saulnier, P.2    Gimel, J.-C.3    Gravier, J.4    Ailhas, C.5    Benoit, J.-P.6
  • 219
    • 84906309496 scopus 로고    scopus 로고
    • Mucus models to evaluate nanomedicines for diffusion
    • [219] Groo, A.-C., Lagarce, F., Mucus models to evaluate nanomedicines for diffusion. Drug Discov. Today 19:8 (2014), 1097–1108.
    • (2014) Drug Discov. Today , vol.19 , Issue.8 , pp. 1097-1108
    • Groo, A.-C.1    Lagarce, F.2
  • 220
    • 84870252557 scopus 로고    scopus 로고
    • Solid lipid nanoparticles production, characterization and applications
    • [220] Mehnert, W., Mäder, K., Solid lipid nanoparticles production, characterization and applications. Adv. Drug Deliv. Rev. 64 (2012), 83–101.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 83-101
    • Mehnert, W.1    Mäder, K.2
  • 221
    • 0034630042 scopus 로고    scopus 로고
    • Factors limiting the oral bioavailability of N-acetylglucosaminyl-N-acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion
    • [221] Lyons, K.C., Charman, W.N., Miller, R., Porter, C.J., Factors limiting the oral bioavailability of N-acetylglucosaminyl-N-acetylmuramyl dipeptide (GMDP) and enhancement of absorption in rats by delivery in a water-in-oil microemulsion. Int. J. Pharm. 199:1 (2000), 17–28.
    • (2000) Int. J. Pharm. , vol.199 , Issue.1 , pp. 17-28
    • Lyons, K.C.1    Charman, W.N.2    Miller, R.3    Porter, C.J.4
  • 222
    • 84912528709 scopus 로고    scopus 로고
    • A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells
    • [222] Brayden, D.J., Gleeson, J., Walsh, E.G., A head-to-head multi-parametric high content analysis of a series of medium chain fatty acid intestinal permeation enhancers in Caco-2 cells. Eur. J. Pharm. Biopharm. 88:3 (2014), 830–839.
    • (2014) Eur. J. Pharm. Biopharm. , vol.88 , Issue.3 , pp. 830-839
    • Brayden, D.J.1    Gleeson, J.2    Walsh, E.G.3
  • 223
    • 84908357169 scopus 로고    scopus 로고
    • Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative
    • [223] Brayden, D.J., Walsh, E., Efficacious intestinal permeation enhancement induced by the sodium salt of 10-undecylenic acid, a medium chain fatty acid derivative. AAPS J. 16:5 (2014), 1064–1076.
    • (2014) AAPS J. , vol.16 , Issue.5 , pp. 1064-1076
    • Brayden, D.J.1    Walsh, E.2
  • 224
    • 0017389172 scopus 로고
    • Modulation of adenylate cyclase activity of fibroblasts by free fatty acids and phospholipids
    • [224] Anderson, W.B., Jaworski, C.J., Modulation of adenylate cyclase activity of fibroblasts by free fatty acids and phospholipids. Arch. Biochem. Biophys. 180:2 (1977), 374–383.
    • (1977) Arch. Biochem. Biophys. , vol.180 , Issue.2 , pp. 374-383
    • Anderson, W.B.1    Jaworski, C.J.2
  • 225
    • 0025030097 scopus 로고
    • Oleic acid: its effects on stratum corneum in relation to (trans)dermal drug delivery
    • [225] Francoeur, M.L., Golden, G.M., Potts, R.O., Oleic acid: its effects on stratum corneum in relation to (trans)dermal drug delivery. Pharm. Res. 7:6 (1990), 621–627.
    • (1990) Pharm. Res. , vol.7 , Issue.6 , pp. 621-627
    • Francoeur, M.L.1    Golden, G.M.2    Potts, R.O.3
  • 226
    • 0027394324 scopus 로고
    • Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells
    • [226] Stillwell, W., Ehringer, W., Jenski, L., Docosahexaenoic acid increases permeability of lipid vesicles and tumor cells. Lipids 28:2 (1993), 103–108.
    • (1993) Lipids , vol.28 , Issue.2 , pp. 103-108
    • Stillwell, W.1    Ehringer, W.2    Jenski, L.3
  • 227
    • 84921666252 scopus 로고    scopus 로고
    • Solid lipid nanoparticles for oral drug delivery: chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake
    • [227] Luo, Y., Teng, Z., Li, Y., Wang, Q., Solid lipid nanoparticles for oral drug delivery: chitosan coating improves stability, controlled delivery, mucoadhesion and cellular uptake. Carbohydr. Polym. 122 (2015), 221–229.
    • (2015) Carbohydr. Polym. , vol.122 , pp. 221-229
    • Luo, Y.1    Teng, Z.2    Li, Y.3    Wang, Q.4
  • 228
    • 0033802503 scopus 로고    scopus 로고
    • Ileal uptake of polyalkylcyanoacrylate nanocapsules in the rat
    • [228] Damgé, C., Aprahamian, M., Humbert, W., Pinget, M., Ileal uptake of polyalkylcyanoacrylate nanocapsules in the rat. J. Pharm. Pharmacol. 52:9 (2000), 1049–1056.
    • (2000) J. Pharm. Pharmacol. , vol.52 , Issue.9 , pp. 1049-1056
    • Damgé, C.1    Aprahamian, M.2    Humbert, W.3    Pinget, M.4
  • 229
    • 0029782486 scopus 로고    scopus 로고
    • Improved oral delivery of desmopressin via a novel vehicle: mucoadhesive submicron emulsion
    • [229] Ilan, E., Amselem, S., Weisspapir, M., Schwarz, J., Yogev, A., Zawoznik, E., et al. Improved oral delivery of desmopressin via a novel vehicle: mucoadhesive submicron emulsion. Pharm. Res. 13:7 (1996), 1083–1087.
    • (1996) Pharm. Res. , vol.13 , Issue.7 , pp. 1083-1087
    • Ilan, E.1    Amselem, S.2    Weisspapir, M.3    Schwarz, J.4    Yogev, A.5    Zawoznik, E.6
  • 230
    • 42649101297 scopus 로고    scopus 로고
    • Surface characterization of lipid/chitosan nanoparticles assemblies, using X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry
    • [230] Grenha, A., Seijo, B., Serra, C., Remunan-Lopez, C., Surface characterization of lipid/chitosan nanoparticles assemblies, using X-ray photoelectron spectroscopy and time-of-flight secondary ion mass spectrometry. J. Nanosci. Nanotechnol. 8:1 (2008), 358–365.
    • (2008) J. Nanosci. Nanotechnol. , vol.8 , Issue.1 , pp. 358-365
    • Grenha, A.1    Seijo, B.2    Serra, C.3    Remunan-Lopez, C.4
  • 231
    • 80054696375 scopus 로고    scopus 로고
    • Preliminary evaluation of a novel oral delivery system for rhPTH1-34: in vitro and in vivo
    • [231] Guo, L., Ma, E., Zhao, H., Long, Y., Zheng, C., Duan, M., Preliminary evaluation of a novel oral delivery system for rhPTH1-34: in vitro and in vivo. Int. J. Pharm. 420:1 (2011), 172–179.
    • (2011) Int. J. Pharm. , vol.420 , Issue.1 , pp. 172-179
    • Guo, L.1    Ma, E.2    Zhao, H.3    Long, Y.4    Zheng, C.5    Duan, M.6
  • 232
    • 84902771662 scopus 로고    scopus 로고
    • In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin
    • [232] Hintzen, F., Perera, G., Hauptstein, S., Muller, C., Laffleur, F., Bernkop-Schnurch, A., In vivo evaluation of an oral self-microemulsifying drug delivery system (SMEDDS) for leuprorelin. Int. J. Pharm. 472:1-2 (2014), 20–26.
    • (2014) Int. J. Pharm. , vol.472 , Issue.1-2 , pp. 20-26
    • Hintzen, F.1    Perera, G.2    Hauptstein, S.3    Muller, C.4    Laffleur, F.5    Bernkop-Schnurch, A.6
  • 233
    • 34548214206 scopus 로고    scopus 로고
    • Therapeutic opportunities in colon-specific drug-delivery systems
    • [233] Patel, M., Shah, T., Amin, A., Therapeutic opportunities in colon-specific drug-delivery systems. Crit. Rev. Ther. Drug Carrier Syst. 24:2 (2007), 147–202.
    • (2007) Crit. Rev. Ther. Drug Carrier Syst. , vol.24 , Issue.2 , pp. 147-202
    • Patel, M.1    Shah, T.2    Amin, A.3
  • 234
    • 0023878386 scopus 로고
    • Enteral, oral, and rectal absorption of ceftriaxone using glyceride enhancers
    • [234] Beskid, G., Unowsky, J., Behl, C.R., Siebelist, J., Tossounian, J.L., McGarry, C.M., et al. Enteral, oral, and rectal absorption of ceftriaxone using glyceride enhancers. Chemotherapy 34:2 (1988), 77–84.
    • (1988) Chemotherapy , vol.34 , Issue.2 , pp. 77-84
    • Beskid, G.1    Unowsky, J.2    Behl, C.R.3    Siebelist, J.4    Tossounian, J.L.5    McGarry, C.M.6
  • 235
    • 0028067644 scopus 로고
    • Effect of medium-chain glycerides on physiological properties of rabbit intestinal epithelium in vitro
    • [235] Yeh, P.Y., Smith, P.L., Ellens, H., Effect of medium-chain glycerides on physiological properties of rabbit intestinal epithelium in vitro. Pharm. Res. 11:8 (1994), 1148–1154.
    • (1994) Pharm. Res. , vol.11 , Issue.8 , pp. 1148-1154
    • Yeh, P.Y.1    Smith, P.L.2    Ellens, H.3
  • 236
  • 237
    • 84878050516 scopus 로고    scopus 로고
    • Colon targeting: an emerging frontier for oral insulin delivery
    • [237] Patel, M.M., Colon targeting: an emerging frontier for oral insulin delivery. Expert Opin. Drug Deliv. 10:6 (2013), 731–739.
    • (2013) Expert Opin. Drug Deliv. , vol.10 , Issue.6 , pp. 731-739
    • Patel, M.M.1
  • 238
    • 0030612306 scopus 로고    scopus 로고
    • Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon
    • [238] Tozaki, H., Komoike, J., Tada, C., Maruyama, T., Terabe, A., Suzuki, T., et al. Chitosan capsules for colon-specific drug delivery: improvement of insulin absorption from the rat colon. J. Pharm. Sci. 86:9 (1997), 1016–1021.
    • (1997) J. Pharm. Sci. , vol.86 , Issue.9 , pp. 1016-1021
    • Tozaki, H.1    Komoike, J.2    Tada, C.3    Maruyama, T.4    Terabe, A.5    Suzuki, T.6
  • 239
    • 70349690331 scopus 로고    scopus 로고
    • Formulation and evaluation of insulin enteric microspheres for oral drug delivery
    • [239] Jindal, S.K., Singh, M., Goswami, M., Formulation and evaluation of insulin enteric microspheres for oral drug delivery. Acta Pharm. Sci. 51 (2009), 121–127.
    • (2009) Acta Pharm. Sci. , vol.51 , pp. 121-127
    • Jindal, S.K.1    Singh, M.2    Goswami, M.3
  • 240
    • 29244440892 scopus 로고    scopus 로고
    • Effects of absorption promoters on insulin absorption through colon-targeted delivery
    • [240] Katsuma, M., Watanabe, S., Kawai, H., Takemura, S., Sako, K., Effects of absorption promoters on insulin absorption through colon-targeted delivery. Int. J. Pharm. 307:2 (2006), 156–162.
    • (2006) Int. J. Pharm. , vol.307 , Issue.2 , pp. 156-162
    • Katsuma, M.1    Watanabe, S.2    Kawai, H.3    Takemura, S.4    Sako, K.5
  • 241
    • 33745096846 scopus 로고    scopus 로고
    • Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats
    • [241] Fetih, G., Fausia, H., Okada, N., Fujita, T., Attia, M., Yamamoto, A., Colon-specific delivery and enhanced colonic absorption of [Asu(1,7)]-eel calcitonin using chitosan capsules containing various additives in rats. J. Drug Target. 14:3 (2006), 165–172.
    • (2006) J. Drug Target. , vol.14 , Issue.3 , pp. 165-172
    • Fetih, G.1    Fausia, H.2    Okada, N.3    Fujita, T.4    Attia, M.5    Yamamoto, A.6
  • 242
    • 84942258290 scopus 로고    scopus 로고
    • In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill®) of salmon calcitonin
    • [242] Aguirre, T.A.S., Rosa, M., Coulter, I., Brayden, D.J.,. In vitro and in vivo preclinical evaluation of a minisphere emulsion-based formulation (SmPill®) of salmon calcitonin. Eur. J. Pharm. Sci. 79 (2015), 102–111.
    • (2015) Eur. J. Pharm. Sci. , vol.79 , pp. 102-111
    • Aguirre, T.A.S.1    Rosa, M.2    Coulter, I.3    Brayden, D.J.4
  • 243
    • 84969514875 scopus 로고    scopus 로고
    • Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres
    • [243] Keohane, K., Rosa, M., Coulter, I.S., Griffin, B.T., Enhanced colonic delivery of ciclosporin A self-emulsifying drug delivery system encapsulated in coated minispheres. Drug Dev. Ind. Pharm., 1-9, 2015.
    • (2015) Drug Dev. Ind. Pharm. , vol.1-9
    • Keohane, K.1    Rosa, M.2    Coulter, I.S.3    Griffin, B.T.4
  • 244
    • 23244463321 scopus 로고    scopus 로고
    • Liquid filled nanoparticles as a drug delivery tool for protein therapeutics
    • [244] Venkatesan, N., Yoshimitsu, J., Ito, Y., Shibata, N., Takada, K., Liquid filled nanoparticles as a drug delivery tool for protein therapeutics. Biomaterials 26:34 (2005), 7154–7163.
    • (2005) Biomaterials , vol.26 , Issue.34 , pp. 7154-7163
    • Venkatesan, N.1    Yoshimitsu, J.2    Ito, Y.3    Shibata, N.4    Takada, K.5
  • 245
    • 33748641168 scopus 로고    scopus 로고
    • Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET
    • [245] Leonard, T.W., Lynch, J., McKenna, M.J., Brayden, D.J., Promoting absorption of drugs in humans using medium-chain fatty acid-based solid dosage forms: GIPET. Expert Opin. Drug Deliv. 3:5 (2006), 685–692.
    • (2006) Expert Opin. Drug Deliv. , vol.3 , Issue.5 , pp. 685-692
    • Leonard, T.W.1    Lynch, J.2    McKenna, M.J.3    Brayden, D.J.4


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